• 대한의생명과학회지
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• 제24권4호
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• pp.430-434
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• 2018

Candida glabrata is the second most prevalent causative agent for candidiasis following C. albicans. The opportunistic yeast, C. glabrata, is able to cause the critical bloodstream infections in hospitalized patients. Conventional identification methods for yeasts are often time consuming and labor intensive. Therefore, recent studies on sequence-based identification have been conducted. Recently, sequencing the D1/D2 domain of the large subunit ribosomal RNA gene and the internal transcribed spacers (ITS) 1 and ITS2 regions of the ribosomal DNA has proven useful for DNA-based identification of most species of fungi. In the present study, therefore, fungal ITS and D1/D2 domain regions were targeted and analyzed by DNA sequencing for the accurate identification of C. glabrata clinical isolates. A total of 102 C. glabrata clinical isolates from various clinical samples including bloodstream, catheterized urine, bile and other body fluids were used in the study. The results of the DNA sequence analysis showed that the mean standard deviation of species identity percent score between ITS and D1/D2 domain regions was $97.8%{\pm}2.9$ and $99.7%{\pm}0.46$, respectively. These results revealed that the D1/D2 domain region might be a better target for identifying C. glabrata clinical isolates based on DNA sequences than the ITS1 and ITS2 regions. However, in order to evaluate the usefulness of D1/D2 domain region for species identification of all Candida species, other Candida species such as C. albicans, C. tropicalis, C. dubliniensis, and C. krusei should be verified in further studies additionally.

• Korean Journal of Mathematics
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• 제20권4호
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• pp.371-379
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• 2012

Let D be an integral domain, $\bar{D}$ be the integral closure of D, * be a star operation of finite character on D, $*_w$ be the so-called $*_w$-operation on D induced by *, X be an indeterminate over D, $N_*=\{f{\in}D[X]{\mid}c(f)^*=D\}$, and $Kr(D,*)=\{0\}{\cup}\{\frac{f}{g}{\mid}0{\neq}f,\;g{\in}D[X]$ and there is an $0{\neq}h{\in}D[X]$ such that $(c(f)c(h))^*{\subseteq}(c(g)c(h))^*$}. In this paper, we show that D is a *-quasi-Pr$\ddot{u}$fer domain if and only if $\bar{D}[X]_{N_*}=Kr(D,*_w)$. As a corollary, we recover Fontana-Jara-Santos's result that D is a Pr$\ddot{u}$fer *-multiplication domain if and only if $D[X]_{N_*} = Kr(D,*_w)$.

• Korean Journal of Mathematics
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• 제18권4호
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• pp.335-342
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• 2010

Let D be an integral domain with quotient field K,$\mathcal{I}(D)$ be the set of nonzero ideals of D, and $w$ be the star-operation on D defined by $I_w=\{x{\in}K{\mid}xJ{\subseteq}I$ for some $J{\in}\mathcal{I}(D)$ such that J is finitely generated and $J^{-1}=D\}$. The D is called a Pr$\ddot{u}$fer $v$-multiplication domain if $(II^{-1})_w=D$ for all nonzero finitely generated ideals I of D. In this paper, we show that D is a Pr$\ddot{u}$fer $v$-multiplication domain if and only if $(A{\cap}(B+C))_w=((A{\cap}B)+(A{\cap}C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$, if and only if $(A(B{\cap}C))_w=(AB{\cap}AC)_w$ for all $A,B,C{\in}\mathcal{I}(D)$, if and only if $((A+B)(A{\cap}B))_w=(AB)_w$ for all $A,B{\in}\mathcal{I}(D)$, if and only if $((A+B):C)_w=((A:C)+(B:C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$ with C finitely generated, if and only if $((a:b)+(b:a))_w=D$ for all nonzero $a,b{\in}D$, if and only if $(A:(B{\cap}C))_w=((A:B)+(A:C))_w$ for all $A,B,C{\in}\mathcal{I}(D)$ with B, C finitely generated.

• 한국자기공명학회논문지
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• 제17권1호
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• pp.59-66
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• 2013

BldD, a developmental transcription factor from Streptomyces coelicolor, is a homodimeric, DNA-binding protein with 167 amino acids in each subunit. Each monomer consists of two structurally distinct domains, the N-terminal domain (BldD-NTD) responsible for DNA-binding and dimerization and the C-terminal domain (BldD-CTD). In contrast to the BldD-NTD, of which crystal structure has been solved, the BldD-CTD has been characterized neither in structure nor in function. Thus, in terms of structural genomics, structural study of the BldD-CTD has been conducted in solution, and in the present work, mainchain NMR assignments of the recombinant BldD-CTD (residues 80-167 of BldD) could be achieved by a series of heteronuclear multidimensional NMR experiments on a [$^{13}C/^{15}N$]-enriched protein sample. Finally, the secondary structure prediction by CSI and TALOS+ analysis using the assigned chemical shifts data identified a ${\beta}-{\alpha}-{\alpha}-{\beta}-{\alpha}-{\alpha}-{\alpha}$ topology of the domain. The results will provide the most fundamental data for more detailed approach to the atomic structure of the BldD-CTD, which would be essential for entire understanding of the molecular function of BldD.

• 대한수학회논문집
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• 제11권4호
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• pp.975-981
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• 1996

Let $D \subset C^2$ be a bounded convex domain with real analytic boundary. We get some Lipschitz regularity of the Cauchy transform on the convex domain D.

• 한국수산과학회지
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• 제48권6호
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• pp.913-919
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• 2015

In vertebrates, the vitamin D receptor (VDR), a member of the nuclear receptor superfamily, binds the biologically active ligand $1{\alpha},25-(OH)_2$-vitamin $D_3$ (1,25 $D_3$). Nearly all vertebrates, including Agnatha, possess a VDR with high ligand selectivity for 1,25 $D_3$ and related metabolites. Although a putative ancestral VDR gene is present in the genome of the chordate invertebrate Ciona intestinalis, the functional characteristics of marine invertebrate VDR are still obscure. To elucidate the ascidian Halocynthia roretzi VDR (HrVDR), we cloned full-length HrVDR cDNA and investigated the transcriptional activity of HrVDR in HEK293 cells. HrVDR consists of 1,680 nucleotides (559 amino acids [aa]), including a short N-terminal region (A/B domain; 26 aa), DNA-binding domain (C domain; 72 aa), hinge region (D domain; 272 aa), and C-terminal ligand-binding domain (E domain; 161 aa). The amino acid sequence identity of HrVDR was greatest to that of C. intestinalis VDR (56%). In the luciferase reporter assays, the transcriptional activity of HrVDR was not significantly increased by 1,25 $D_3$, whereas the farnesoid X receptor agonist GW4064 increased the transactivation of HrVDR. These results suggest the presence of a novel ligand for and a distinct ligand-binding domain in ascidian VDR.

• 대한수학회보
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• 제55권4호
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• pp.1093-1101
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• 2018

Let (RDTF, M) be a Milnor square. In this paper, it is proved that R is a ${\mathcal{C}}$-hereditary domain if and only if both D and T are ${\mathcal{C}}$-hereditary domains; R is an almost perfect domain if and only if D is a field and T is an almost perfect domain; R is a Matlis domain if and only if T is a Matlis domain. Furthermore, to give a negative answer to Lee, s question, we construct a counter example which is a C-hereditary domain R with $w.gl.dim(R)={\infty}$.

• 대한수학회지
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• 제49권1호
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• pp.17-30
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• 2012

Let D be an arbitrary domain in $\mathbb{C}^n$, n > 1, and $M{\subset}{\partial}D$ be an open piece of the boundary. Suppose that M is connected and ${\partial}D$ is smooth real-analytic of finite type (in the sense of D'Angelo) in a neighborhood of $\bar{M}$. Let f : $D{\rightarrow}\mathbb{C}^n$ be a holomorphic correspondence such that the cluster set $cl_f$(M) is contained in a smooth closed real-algebraic hypersurface M' in $\mathbb{C}^n$ of finite type. It is shown that if f extends continuously to some open peace of M, then f extends as a holomorphic correspondence across M. As an application, we prove that any proper holomorphic correspondence from a bounded domain D in $\mathbb{C}^n$ with smooth real-analytic boundary onto a bounded domain D' in $\mathbb{C}^n$ with smooth real-algebraic boundary extends as a holomorphic correspondence to a neighborhood of $\bar{D}$.

• 대한수학회보
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• 제54권6호
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• pp.1969-1980
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• 2017

Let ${\Gamma}$ be a nonzero torsionless commutative cancellative monoid with quotient group ${\langle}{\Gamma}{\rangle}$, $R={\bigoplus}_{{\alpha}{\in}{\Gamma}}R_{\alpha}$ be a graded integral domain graded by ${\Gamma}$ such that $R_{{\alpha}}{\neq}\{0\}$ for all ${\alpha}{\in}{\Gamma},H$ be the set of nonzero homogeneous elements of R, C(f) be the ideal of R generated by the homogeneous components of $f{\in}R$, and $N(H)=\{f{\in}R{\mid}C(f)_v=R\}$. In this paper, we introduce the notion of graded t-almost Dedekind domains. We then show that R is a t-almost Dedekind domain if and only if R is a graded t-almost Dedekind domain and RH is a t-almost Dedekind domains. We also show that if $R=D[{\Gamma}]$ is the monoid domain of ${\Gamma}$ over an integral domain D, then R is a graded t-almost Dedekind domain if and only if D and ${\Gamma}$ are t-almost Dedekind, if and only if $R_{N(H)}$ is an almost Dedekind domain. In particular, if ${\langle}{\Gamma}{\rangle}$ isatisfies the ascending chain condition on its cyclic subgroups, then $R=D[{\Gamma}]$ is a t-almost Dedekind domain if and only if R is a graded t-almost Dedekind domain.

• 대한수학회지
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• 제48권1호
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• pp.49-61
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• 2011

Let D be an integral domain with quotient field K, X be a nonempty set of indeterminates over D, * be a star operation on D, $N_*$={f $\in$ D[X]|c(f)$^*$= D}, $*_w$ be the star operation on D defined by $I^{*_w}$ = ID[X]${_N}_*$ $\cap$ K, and [*] be the star operation on D[X] canonically associated to * as in Theorem 2.1. Let $A^g$ (resp., $A^{[*]g}$, $A^{[*]g}$) be the global (resp.,*-global, [*]-global) transform of a ring A. We show that D is a $*_w$-Noetherian domain if and only if D[X] is a [*]-Noetherian domain. We prove that $D^{*g}$[X]${_N}_*$ = (D[X]${_N}_*$)$^g$ = (D[X])$^{[*]g}$; hence if D is a $*_w$-Noetherian domain, then each ring between D[X]${_N}_*$ and $D^{*g}$[X]${_N}_*$ is a Noetherian domain. Let $\tilde{D}$ = $\cap${$D_P$|P $\in$ $*_w$-Max(D) and htP $\geq$2}. We show that $D\;\subseteq\;\tilde{D}\;\subseteq\;D^{*g}$ and study some properties of $\tilde{D}$ and $D^{*g}$.