• KSBB Journal
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• v.26 no.1
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• pp.69-77
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• 2011

In this study, poly (L-lactic acid) (PLLA) microparticles containing gemcitabine hydrochloride were prepared by a supercritical fluid process, called aerosol solvent extraction system (ASES), utilizing supercritical carbon dioxide as antisolvent. The influence of process parameters such as temperature, pressure, $CO_2$ and solution flow rate, solution concentration, and feed ratio of drug to polymer on the morphology and characteristics of the microparticles was studied in detail. The gemcitabine-loaded microparticles exhibited a spherical shape with a smooth surface. The entrapment efficiency of gemcitabine increased with increasing temperature, solution concentration and $CO_2$ flow rate and with decreasing drug/polymer feed ratio. The maximum drug loading obtained from the ASES process was found to be about 11%. The ASES-processed PLLA microparticles containing gemcitabine showed a relatively high initial burst due to the presence of surface pores on the microparticles and the poor affinity between drug and polymer.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.1367-1372
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• 2009

A proprietary device is adopted to break out the membrane of cell in the rigid polyurethane foam. As it is known, the membrane of cell is hardly tearing-off thoroughly in a mechanical way due to both its elastic characteristic and micro sized pores. In this study, a novel experimental approach is introduced to burst out all gases inside the cells of the rigid polyurethane foam by abrasively grinding micro-cells completely into fine powder. The biggest advantage of this approach is to be capable of releasing all gases out from the cell even in the micro pores. As clearly reflected from the repeatability, the accuracy of the result is highly improved and high confidence in the data sets as well. For the measurements of not only gas composition but partial pressure for each gas simultaneously as well, a precision gas mass spectrometer is used in-line directly to the abrasive grinding device. To control the starting point of the polyurethane foam, all samples were prepared on site in the laboratory. Manufactured time is one of the most critical factors in characterization of cell gas composition because it is known that one of gas composition, especially, carbon dioxide, is diffused out dramatically in a short period of time as soon as it is foamed.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.37 no.2 s.110
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• pp.70-77
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• 2005

For the purpose of developing liner board for water resistant corrugated board in the cold chain system, several types of base paper for corrugated board were purchased from the market and 6 different boards were produced in the mill by applying the chemicals, chosen in the previous studies, on the base paper. Then water-moisture resistance and physical properties of the boards were compared each other. The liner board which is dried at high temperature with pressure by Condebelt (CK paper) showed a superior performance in strength over common liner boards. Strength of the board increased by surface chemical treatment up to $60\%$ of compressive strength and $30\%$ of burst strength. Starch insolubilization with Ammonium Zirconium Carbonate and surface coating with a surface sizing agent and a moisture resistant chemical on CK paper showed the best result. Therefore this method was recommended to produce the outer liner board for water resistant corrugated board.

• Aerospace Engineering and Technology
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• v.11 no.1
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• pp.91-97
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• 2012

The structural analyses and experimental results for the bellows of a gas-generator liquid oxygen shut-off valve were presented. The bellows experiences axial compression and external high pressure loadings at cryogenic temperatures. The analyses were performed using EJMA (Expansion Joint Manufacturing Association) standard and the commercial FE (finite element) analysis program, Abaqus v6.9, at room and cryogenic temperatures. The spring modulus, the induced stress and the expected fatigue life of the bellows were compared respectively. The effects by the contact and the material plasticity on the FE analysis results were also analyzed. Also, FE analyses related to a burst test were presented.

• Journal of Pharmaceutical Investigation
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• v.38 no.1
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• pp.39-43
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• 2008

Cyclosporin A (CyA), a potent immunosuppressive drug used in allogeneic transplants and autoimmune disease, is a typical water-insoluble drug. Recently, nanoparticle carriers were investigated to improve the intestinal absorption of drugs. In this study, CyA-loaded nanostructured lipid carriers (NLCs) were prepared from a hot o/w emulsion using the high pressure homogenization method. The NLCs were consisted of cationic lipids, solid lipids, liquid lipids (oils), surfactant and stabilizer. Encapsulation efficiency of CyA in NLCs was approximately 71%. The average particle size and zeta potential of NLCs were below 250 nm and above +40 mV, respectively. The morphology of NLCs was confirmed by transmission electron microscopy (TEM) analysis. Compared to the CyA powder, higher in vitro release of CyA from NLCs was observed after burst release within 30 min. Thus, CyA-loaded NLCs could be applied not only for parenteral route but also for gastrointestinal administration, which needs further investigation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.4
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• pp.17-24
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• 2006

Hydrodynamic ram of aircraft fuel tanks is one of main ballistic battle damages of an aircraft and has great importance to airframe survivability design. Basic concept, physics and research history of hydrodynamic ram are investigated. The penetration and internal detonation of a simple fuel tank and ICW(Intermediate Complexity Wing) are analyzed by computational method. Structural rupture and fluid burst are analytically realized using general coupling and coupling surface interaction. The results such as fluid pressure, tank stress and displacement are shown and future research chances are suggested based on the study.

• Journal of Korean Society for Quality Management
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• v.45 no.4
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• pp.649-664
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• 2017

Purpose: This paper introduces the technology of prognostics for Industry 4.0 and presents its application procedure for fitness-for-service assessment of natural gas pipelines according to ISO 13374 framework. Methods: Combining data-driven approach with pipe failure models, we present a hybrid scheme for the gas pipeline prognostics. The probability of pipe failure is obtained by using the PCORRC burst pressure model and First Order Second Moment (FOSM) method. A fuzzy inference system is also employed to accommodate uncertainty due to corrosion growth and defect occurrence. Results: With a modified field dataset, the probability of failure on the pipeline is calculated. Then, its residual useful life (RUL) is predicted according to ISO 16708 standard. As a result, the fitness-for-service of the test pipeline is well-confirmed. Conclusion: The framework described in ISO 13374 is applicable to the RUL prediction and the fitness-for-service assessment for gas pipelines. Therefore, the technology of prognostics is helpful for safe and efficient management of gas pipelines in Industry 4.0.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.21 no.2
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• pp.137-141
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• 1985

In this paper, the author investigate viscous effects on the characteristics of TP620 hydrofoil. The pressure distribution on the foil section in non-cavitating flow should be considered its characteristics of displacement thickness due to viscous effects. Theoretical potential theory, which neglects viscous effects do not agree with this analysis, especially at leading edge region of the foil. And, the efficiency of TP620 hydrofoil considering viscous effects is a little lower than that of the foil, which neglected viscous effects.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.138-151
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• 2022

Cladding ballooning and rupture are the important phenomena at the early stage of a severe accident. Most severe accident analysis codes determine the cladding rupture based on simple parameter models. In this paper, a FRTMB module was developed using the thermal-mechanical model to analyze the fuel mechanical behavior. The purpose is to judge the cladding rupture with the severe accident analysis code. The FRTMB module was integrated into the self-developed severe accident analysis code ISAA to simulate the PHEBUS FPT3 experiment. The predicted rupture time and temperature of the cladding were basically consistent with the measured values, which verified the correctness and effectiveness of the FRTMB module. The results showed that the rising of gas pressure in the fuel rod and high temperature led to cladding ballooning. Consequently, the cladding hoop strain exceeded the strain limit, and the cladding burst. The developed FRTMB module can be applied not only to rod-type fuel, but also to plate-type fuel and other types of reactor fuel rods. Moreover, the FRTMB module can improve the channel blockage model of ISAA code and make contributions to analyzing the effect of clad ballooning on transient and subsequent parts of core degradation.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.1051-1054
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• 2000

We developed the micro CSF (celebrospinal fluid) shunt valve with surface and bulk micromachining technology in polymer MEMS. This micro CSF shunt valve was formed with four micro check valves to have a membrane connected to the anchor with the four bridges. The up-down movement of the membrane made the CSF on & off and the valve characteristic such as open pressure was controlled by the thickness and shape of the bridge and the membrane. The membrane, anchor and bridge layer were made of the $O_2$ RIE (reactive ion etching) patterned Parylene thin film to be about 5~10 microns in thickness on the silicon wafer. The dimension of the rectangular nozzle is 0.2＊0.2 $\textrm{mm}^2$ and the membrane 0.45 mm in diameter. The bridge width is designed variously from 0.04 mm to 0.12 mm to control the valve characteristics. To protect the membrane and bridge in the CSF flow, we developed the packaging system for the CSF micro shunt valve with the deep RIE of the silicon wafer. Using this package, we can control the gap size between the membrane and the nozzle, and protect the bridge not to be broken in the flow. The total dimension of the assembled system is 2.5＊2.5 $\textrm{mm}^2$ in square, 0.8 mm in height. We could precisely control the burst pressure and low rate of the valve varing the design parameters, and develop the whole CSF shunt system using this polymer MEMS fabricated CSF shunt valve.