• Journal of Pharmaceutical Investigation
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• v.41 no.3
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• pp.185-190
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• 2011

The purpose of this study was to evaluate the phagocytic uptake of surface modified PLGA microspheres containing ovalbumin (OVA) into dendritic cell. In order to find the most suitable formulation for targeted delivery to antigen presenting cells (APC), OVA was encapsulated by a double emulsion solvent evaporation method with three PLGA microspheres (PLGA 50:50, PLGA 75:25 and PLGA 85:15) and two surface modified microspheres by chitosan and sodium dodecyl sulfate (SDS). Physicochemical properties were evaluated in terms of size, zeta potential, encapsulation efficiency, different scanning calorimeter (DSC), x-ray diffraction, morphology, and OVA release test from microspheres. Phagocytic activity was estimated using dendritic cells and analyzed by fluorescence activated cell sorter (FACS). The result showed that zeta potential of PLGA particles was changed to positive by the chitosan modification. The release profile of chitosan modified PLGA microspheres exhibited sustained release after initial burst. The chitosan modified microspheres had higher phagocytic uptake than the other microspheres. Such physicochemical properties and phagocytic uptake studies lead us to conclude that chitosan modified microspheres is more suitable formulation for the targeted delivery of antigens to APC compared with the other microspheres.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.1
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• pp.64.4-65
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• 2016

Observations of the early photons from evolution of optical afterglows or internal shock provides the crucial clues on the nature of the bursts and environments. Hundreds of GRBs afterglow observations in multi-wavelength region have been made mainly thanks to the fast (~ 60 seconds after the trigger) localisation GRB by Swift and its fast alert to the ground telescope. It helps to improve our understandings tremendously, however many enigmas still remain, such as burst mechanism, transition prompt emission to the afterglow, early optical flash, rise phase of the early optical light curve and some missing afterglows. They could be addressed by fast slewing and multi colour and IR follow-up by future telescopes. The primary aim of UFFO/Lomonosov is to follow up optical fast ever, within a couple of seconds after trigger by onboard X-ray telescope. Its optical FOV is $30{\times}30degrees$. As a key instrument, the Slewing Mirror to redirect the optical beam from GRBs rapidly to the Ritchey-Chretien telescope. The status and launch schedule of the UFFO/Lomonosov and its test performance will be reported and prospects for the next missions will be discussed.

• 제어로봇시스템학회:학술대회논문집
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• 1998.10a
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• pp.295-300
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• 1998

In this paper, a real time diagnostic algorithm fur estimating the impact location by loose parts is proposed. It is composed of two modules such as the alarm discrimination module (ADM) and the impact-location estimation module(IEM). ADM decides whether the detected signal that triggers the alarm is the impact signal by loose parts or the noise signal. When the decision from ADM is concluded as the impact signal, the beginning time of burst-type signal, which the impact signal has usually such a form in time domain, provides the necessary data fur IEM. IEM by use of the arrival time method estimates the impact location of loose parts. The overall results of the estimated impact location are displayed on a computer monitor by the graphical mode and numerical data composed of the impact point, and thereby a plant operator can recognize easily the status of the impact event. This algorithm can perform the diagnosis process automatically and hence the operator's burden and the possible operator's error due to lack of expert knowledge of impact signals can be reduced remarkably. In order to validate the application of this method, the test experiment with a mock-up (flat board and reactor) system is performed. The experimental results show the efficiency of this algorithm even under high level noise and potential application to Loose Part Monitoring System (LPMS) for improving diagnosis capability in nuclear power plants.

• Transactions of the Korean hydrogen and new energy society
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• v.23 no.5
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• pp.484-492
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• 2012

The TMS(Thermal Management System) heater in a fuel cell vehicle has been developed to prevent a decline of fuel cell durability and cold start durability. Main functions of the COD(Cathode Oxygen Depletion) heater are depletion of oxygen in a cathode as heat energy and consumption of electric power for rapid warming up of a fuel cell stack. This paper covers subjects including the design specification of a heater, heater controller for detection of overheat and reliability assessment including coolant pressure cycle test of a heater. To verify the design concept, burst pressure and deformation analysis of plastic housing were carried out. Also, temperature distribution analysis of heater surface and coolant inside of housing were carried out to verify the design concept. By designing the plastic housing instead of a steel housing, the 30% weight lightening and 50% cost reduction were attained. A module-based design of a TMS system including a heater or reducing the watt density of a heater is a problem to be solved in the near future work.

• Environmental Engineering Research
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• v.18 no.1
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• pp.37-43
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• 2013

Water distribution pipes installed underground have potential risks of pipe failure and burst. After years of use, pipe walls tend to be corroded due to aggressive soil environments where they are located. The present study aims to assess the degree of external corrosion of a distribution pipe network. In situ data obtained through test pit excavation and direct sampling are carefully collated and assessed. A statistical approach is useful to predict severity of pipe corrosion at present and in future. First, criteria functions defined by discriminant function analysis are formulated to judge whether the pipes are seriously corroded. Data utilized in the analyses are those related to soil property, i.e., soil resistivity, pH, water content, and chloride ion. Secondly, corrosion factors that significantly affect pipe wall pitting (vertical) and spread (horizontal) on the pipe surface are identified with a view to quantifying a degree of the pipe corrosion. Finally, a most reliable model represented in the form of a multiple regression equation is developed for this purpose. From these analyses, it can be concluded that our proposed model is effective to predict the severity and rate of pipe corrosion utilizing selected factors that reflect the fuzzy soil environment.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2008.04a
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• pp.191-197
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• 2008

In this study, as a fuel filter for automobiles, base paper which can filtrate the polluted particles must satisfy with the standards of each vehicle. and a filter of impregnation paper made that combining the base paper with the resin. Therefore, They were wanted to found out the factors that affect base paper and impregnation paper according to content of HPZ, Mulberry pulp(MP), Laub holze bleached kraft pulp(LBKP). The most important things we wanted to find out in base paper and impregnation paper test were weight, thickness, air permeability, burst and tensile strength, maximum pore size and mean pore size, stiffness. we wanted to measure a rate of change of these condition by adjusting a rate of mixing for HPZ, MP and LBKP. Moreover, It suited for an impregnation paper mixed with a rate of mulberry pulp 20%, HPZ 40% and LBKP 40%. Used resins in this study was Phenol, Acryl, PVAc. And as every resins, sample was divided into existence and nothing of embossing. as a fuel filter for automobiles, It was appeared that the suitable condition of base paper was a rate of mixing for HPZ(40%), MP(20%) and LBKP(40%).

• Structural Engineering and Mechanics
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• v.27 no.3
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• pp.277-292
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• 2007

Based on the composite finite element simulation and a series of hydrostatic pressure and burst tests, autofrettage effects on strength and deformation of fiber reinforced pressure vessel with metallic liners have been studied in the paper (autofrettage: during the course of one pressure taking effect, the increasing internal stress in metallic liner can surpass the yielding point and the plastic deformation will happen, which result in that when there is no internal pressure, there are press stress in liner while tensile stress in fiber lamination). By making use of a composite finite element Ansys code and a series of experiments, the autofrettage pressure is determined in order to make the aluminium liner be totally in elastic state, under given hydrostatic test pressure. The stress intensity factors of the longitudinal crack in aluminum liner end under internal pressure and thermal loads have been computed and analyzed before and after the autofrettage processing. Through numerical calculation and experiment investigations, it is found that a correct choice for autofrettage pressure can improve the gas-tightness and fatigue strength of FRP vessel.

• Journal of the Korean Society for Precision Engineering
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• v.11 no.2
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• pp.32-40
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• 1994

In this study by using EMAT(electro magnetic acoustic transducer)the artificial slit is installed on 12B-SUS pipe test piece. By making 4 cycle SH-burst (EMA) incidence to 45 .deg. angle, the signal data of pulse, received from EMAT are translated into digital-signal-processing- method SSP(Split Spectrum Processing) and Deconvolution method. The main conclusions obtained are as follows; (1) the signal data received from EMAT are translated with digital signal proc- essing of SSP-method and Deconvolution-method and this method shows exellent results more than Ultrasonic testing method does; (2) noise can well be removed by SSP with signal data, and resolution and S/N ratio are advanced; (3) when used with Ultrasonic wave general stainless steel has proporties of multiscattering and reflection phenomena, but resolution is progressed by using Deconvolution method;and (4) as addition-averaging-processing mumber is increasing, the resolution and S/N ratio are improved and the satisfactory signal is obtained.

• Composites Research
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• v.36 no.2
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• pp.132-139
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• 2023

A linerless composite propellant tank was designed and manufactured by using the carbon fiber-reinforced composite materials which have superior strength-to-weight ratio in order to reduce weight of the tank. In this research, we designed a sub-scale composite propellant tank with a diameter of 800 mm to withstand an MEOP of 1.7 MPa. We manufactured the boss of the tank by using the same composite materials to reduce the thermal expansion difference between the boss and the secondary-bonded composite layers of the barrel in the cryogenic environment. We used the collapsible mandrel to manufacture the tank without any liner. The mandrel was made from epoxy-based composite tooling prepregs to reduce weight of the mandrel. We manufactured the test tanks by laying up the carbon fiber fabric prepregs manually on the mandrel and then applying the autoclave cure process. We performed a proof test, a helium tightness test, a repeated pressurization test, and a burst test in room temperature. The test results demonstrate that the proposed design and manufacture process satisfies all strength requirements as well as an anti-leakage requirement.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.5
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• pp.71-81
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• 2008

In this paper, we propose a novel Globally Asynchronous, Locally Dynamic System(GALDS) bus and demonstrate its performance. The proposed GALDS bus is the bidirectional multitasking bus with the segmented bus architecture supporting the concurrent operation of multi-masters and multi-slaves. By analyzing system tasks, the bus architecture chooses the optimal frequency for each If among multiples of bus frequency and thus we can reduce the overall power consumption. For efficient data communications between IPs operating in different frequencies, we designed an asynchronous and bidirectional FIFO based on an asynchronous wrapper with hand-shaking interface. In addition, since systems can be easily expandable by inserting bus segments, the proposed architecture has advantages in IP reusability and structural flexibility As a test example, a four-segment bus haying four masters and four slaves were designed by using Verilog HDL. We demonstrate multitasking operations with read/write data transfers by simulation when the ratios of operation frequency are 1:1, 1:2, 1:4 and 1:8. The data transfer mode is a 16 burst increment mode compatible with Advanced Microcontroller Bus Architecture(AMBA). The maximum operation latency of the proposed GALDS bus is 22 clock cycles for the bus write operation, and 44 clock cycles for read.