• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5301-5310
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• 2013

The biological mechanisms of cancer and associations with behavior of tumours need to be studied to understand progression and determine appropriate treatments. Here we investigated expression of VEGF, MMP-9 and E-cadherin in laryngeal SCCs and their relations with clinical behavior. This prospective study was based on 38 surgical specimens from patients with primary laryngeal SCC and data recorded in their cards. Expression of the three factors in tumor tissue was examined using immunohistochemistry and correlations with clinical parameters of primary tumors, regional lymph node metastases, stage of disease, histopathologic differentiation, and vascular/cartilage invasion were investigated. Regarding the cases with positive MMP-9 expression, the difference between well and moderately/poorly differentiated tumors was statistically significant. However, differences between early stage (stage I and II) and late-stage (stage III and IV) tumours, and between positive and negative for pLN metastasis were not. No significant relationship between positive VEGF and tumor differentiation or stage was apparent, but E-cadherin levels significantly differed between well and moderately/poorly differentiated tumours and with the presence of pLN metastasis. E-cadherin staining did not vary between MMP-9 positive and negative cases. In conclusion, MMP-9 may be a negative predictor of differentiation in laryngeal SCC, while E-cadherin is a predictor of differentiation and nodal metastases. Even if the difference between VEGF expression and tumor stage was not statistically significant, it seems that there exists some relationship, which might be clarified with a greater number of cases.

• Parasites, Hosts and Diseases
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• 제35권3호
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• pp.181-188
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• 1997

닭에 있어서 닭와포자충 갉염이 면역반응에 미치는 영향을 규명하기 위한 기초적 연구리 일환으로 파브리시우스낭의 병리조직학적 소견을 경시적으로 조사하고자 150마리의 2일령 SPF 병아리 (Drkalb-Warren, Sex-Sal-Link)에 닭와포자충의 오오시스트 $5{\;}{\times}{\;}10^5$를 한 번에 경구투여하였타. 분변 속의 오오시스트 배설양상은 정상적이었으며. 파브리시우스낭 지수는 전 실험기간에 걸쳐 거의 변동이 없얹다 많은 수의 원충체가 접종 후 4-16일에 이 낭상피의 미세융또 가장자리에서 관찰되었으며 많은 수의 비만세포가 출현한 다음 원충체가 급격하게 소실하염다. 원충체의 분포상황과 상피 및 인접점막 고유층의 위호산구 침윤은 일치하였다. 이 병소는 상피. 인접 점막고유층의 위호산구 침율과 점만상피 증식을 동반한 미만성 만성 표재성 화농성 파브리시우스낭영의 병리조직학적 소견이었다 이러한 파브리시우스낭염은 면역억제를 유발할 건으로 생각된다.

• Advances in nano research
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• 제13권6호
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• pp.513-525
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• 2022

In this study, it was aimed to evaluate direct oxidation of aqueous solution containing cefalexin antibiotic with new generation Sn/Sb/Ni: 500/8/1 anode. The fact that there is no such a study on treatment of cefalexin with these new anode made this study unique. According to the operating parameters evaluation COD graphs showed clearer results compared to TOC and CLX and thus, it was it was chosen as major parameter. Furthermore, pseudo-first degree kd values were calculated from CLX results to show more accurate and specific results. Experimental results showed that after 60 min of electrochemical oxidation, complete removal of COD and TOC was accomplished with 750 mg L^-1 KCl, at pH 7, 50 mA cm^-2 current density and 1 cm anode-cathode distance. Also, the stability of the Sn/Sb/Ni anode was evaluated by taking SEM and AFM images and XRD analysis before and after of electrochemical oxidation processes. According to the results, it was not occurred too much change on the anode surface even after 300 h of electrolysis. Thus, it was thought that the anode material was not corroded to a large extent. Furthermore, the removal efficiencies were very high for almost all the time and conditions. According to the results of the study, electrochemical oxidation with new generation Sn/Sb/Ni anodes for the removal of cefalexin antibiotic was found very successful and applicable due to require less reaction time complete mineralization and doesn't require pH adjustment step compared to other studies in literature. In future studies, different antibiotic types should be studied with this anode and maybe with real wastewaters to test applicability of the process in treatment of pharmaceutical wastewaters containing antibiotics, in a better way.

• Advances in nano research
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• 제15권4호
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• pp.339-353
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• 2023

This work aims to present a solution for the buckling behavior of perforated nano/microbeams with deformable boundary conditions using nonlocal strain gradient theory (NLSGT). For the first time, a solution that can provide buckling loads based on the non-local and strain gradient effects of perforated nanostructures on an elastic foundation, while taking into account both deformable and rigid boundary conditions. Stokes' transformation and Fourier series are used to realize this aim and determine the buckling loads under various boundary conditions. We employ the NLSGT to account for size-dependent effects and utilize the Winkler model to formulate the elastic foundation. The buckling behavior of the perforated nano/microbeams restrained with lateral springs at both ends is studied for various parameters such as the number of holes, the length and filling ratio of the perforated beam, the internal length, the nonlocal parameter and the dimensionless foundation parameter. Our results indicate that the number of holes and filling ratio significantly affect the buckling response of perforated nano/microbeams. Increasing the filling ratio increases buckling loads, while increasing the number of holes decreases buckling loads. The effects of the non-local and internal length parameters on the buckling behavior of the perforated nano/microbeams are also discussed. These material length parameters have opposite effects on the variation of buckling loads. This study presents an effective eigenvalue solution based on Stokes' transformation and Fourier series of the restrained nano/microbeams under the effects of elastic medium, perforation parameters, deformable boundaries and nonlocal strain gradient elasticity for the first time.

• 대한관절경학회지
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• 제13권1호
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• pp.34-38
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• 2009

목적: 견봉하 충돌증후군에서 견봉하 점액낭의 염증과 견봉 모양 및 통증과의 연관성을 연구하였다. 대상 및 방법: 견봉하 충돌증후군으로 수술을 시행 한 24예를 대상으로 하였다. 18명은 남자, 6명은 여자였다. 평균 나이는 58.3세(44-71세)였다. 모든 환자는 수술 중 관절경 칼을 사용하여 $1{\times}1cm$크기의 견봉하 점액낭을 채취하여 조직검사를 시행하였다. 견봉 형태에 대한 방사선학적 분류는 Bigliani grading system에 의하여 평편형, 곡선형, 갈고리형으로 분류하였다. 환자의 통증 정도는 VAS(visual analog scale)에 의해 측정하였다. 병리조직학적으로 8가지 병리학적 인자를 사용하여, 점액낭의 염증을 급성 및 만성 분류하였고, 염증의 정도는 field에서 차지하는 비율을 사용하여3단계(mild, moderate, severe)로 분류하였다. 결과: 총 24례 중 병리학적으로 단계 1에 해당하는 증례는 9례, 단계 2는 15례였다. 단계 3에 해당하는 증례는 없었다. 병리학적 단계 1에 해당하는 증례 9례중 방사선학적 분류상 곡선형에 해당하는 경우는 6례, 갈고리형은 3례였다. 또한 병리학적 단계 2에 해당하는 증례 15례 중 방사선학적 분류 곡선형은 5례, 갈고리형은 10례였다. 환자의 견관절 통증 정도는 병리학적 단계 1에서 7점, 단계 2에서 8점이었다. 통계학적 분석 상, 병리학적 단계와 견봉의 형태와는 통계학적 의의가 있었다(p<0.05). 하지만 견관절 통증과는 연관성이 없었다(p>0.05). 결론: 본 연구는 견봉하 충돌증후군에서 견봉하 점액낭의 염증 정도와 견봉의 형태와는 연관성이 있는 것으로 생각된다. 하지만 점액낭의 염증 정도와 환자의 통증과는 연관성이 없었다.

• 대한족부족관절학회지
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• 제12권2호
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• pp.197-202
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• 2008

Purpose: Haglund's disease represents a painful heel caused by mechanically induced inflammation of the retrocalcaneal bursa and insertional Achilles tendinosis may coexist. Traditional open surgery can cause complications such as skin breakdown, painful scar and altered sensation around the heel. Endoscopic treatment offers the advantages that are related to minimally invasive procedure and we evaluate the clinical results and operative techniques of endoscopic decompression of retrocalcaneal space for Haglund's disease. Materials and Methods: Our retrospective study included seven heels in six consecutive patients for which nonoperative treatment had failed and endoscopic decompression was performed. The mean age was forty-one years (range, 28 to 53 years). All of the patients had typical complaints of inflammation of the retrocalcaneal bursa and Fowler-Philip angle of more than $75^{\circ}$ and positive parallel pitch lines were present on the lateral calcaneal radiograph. The endoscopic procedure consists of the resection of inflamed retrocalcaneal bursa and enough bone to prevent impingement of the bursa between the calcaneus and Achilles tendon. All patients were evaluated with radiologic angle, visual analogue scale (VAS) for pain and Ogilvie-Harris functional score. The mean follow-up was 18 months (range, 15 to 21 months). Results: The mean operation time was 61 minutes (range, 50 to 85 minutes). VAS for pain and Fowler-Philip angle were decreased from preoperative 8.7 and $82^{\circ}$ to postoperative 2.3 and $57^{\circ}$, respectively. One patient with ankylosing spondylitis had a fair result, 2 patients had good results and the remaining 3 patients had excellent results according to Ogilvie-Harris functional score. There were no surgical complications such as infection, Achilles tendon avulsion or abnormal heel sensation. Conclusion: The endoscopic decompression for Haglund's disease was demonstrated to have several advantages including low morbidity, allowance of functional rehabilitation, short recovery time and quick sports resumption. However a comparative study is needed to determine the value of endoscopic decompression and particular caution should be exerted for the enthesiopathy.

• Asian-Australasian Journal of Animal Sciences
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• 제30권7호
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• pp.920-929
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• 2017

Objective: The bursa of Fabricius (BF) is a central humoral immune organ belonging specifically to avians. Recent studies had suggested that miRNAs were active regulators involved in the immune processes. This study was to investigate the possible differences of the BF at miRNA level between two genetically disparate duck breeds. Methods: Using Illumina next-generation sequencing, the miRNAs libraries of ducks were established. Results: The results showed that there were 66 differentially expressed miRNAs and 28 novel miRNAs in bursa. A set of abundant miRNAs (i.e., let-7, miR-146a-5p, miR-21-5p, miR-17~92) which are involved in immunity and disease were detected and the predicted target genes of the novel miRNAs were associated with duck high anti-adversity ability. By gene ontology analysis and enriching KEGG pathway, the targets of differential expressed miRNAs were mainly involved in immunity and disease, supporting that there were differences in the BF immune functions between the two duck breeds. In addition, the metabolic pathway had the maximum enriched target genes and some enriched pathways that were related to cell cycle, protein synthesis, cell proliferation and apoptosis. It indicted that the difference of metabolism may be one of the reasons leading the immune difference between the BF of two duck breeds. Conclusion: This data lists the main differences in the BF at miRNAs level between two genetically disparate duck breeds and lays a foundation to carry out molecular assisted breeding of poultry in the future.

• 대한견주관절학회:학술대회논문집
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• 대한견주관절학회 2006년도 제14차 학술대회
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• pp.55-55
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• 2006

• 대한견주관절학회:학술대회논문집
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• 대한견주관절학회 2009년도 제17차 학술대회
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• pp.221-221
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• 2009

• 대한골관절종양학회지
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• 제20권1호
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• pp.27-31
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• 2014

골연골종은원위 대퇴골, 근위 상완골, 근위 경골에 흔히 발생한다고 알려져 있으며 늑골에 발생한 골연골종은 상대적으로 드물게 보고되고 있다. 본 증례에서는 좌측 제6늑골 체부에 생긴 골연골종에 의한 우발성 점액낭과 그 주변에 생긴 연부조직 가성 종류가 발음성 견갑골 증후를 야기하여 관혈적 제거수술을 시행한 1례를 문헌 고찰과 함께 보고하고자 한다.