• Archives of Pharmacal Research
• /
• v.8 no.1
• /
• pp.39-41
• /
• 1985

Bromocycloetherification of a series of 3-and 4-olefinic alcohols using NBS-acetonitrile gave corresponding bromo-tetrahydrofuran with high regio and steroselectivity.

• Bulletin of the Korean Chemical Society
• /
• v.14 no.1
• /
• pp.32-38
• /
• 1993

3-(3-Bromotetrahydrofuran-2-yl)-3-cephem 7 was obtained from 3-(2-hydroxyethyl)vinyl-3-cephem 6 by the cyclization reaction using N-bromosuccinimide. Compound 5 was prepared by Wittig reaction, namely a coupling of cephem-derived triphenylphosphonium salt 3 with aldehyde component 4 in the presence of base.