• 수면정신생리
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• 제1권2호
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• pp.188-192
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• 1994

The author reports a 32 years old female patient with late luteal phase dysphoric disorder who received evening bright light treatment for 7 consecutive days during the late luteal phase of menstrual cycle. After the treatment, beneficial clinical effects were observed. This result suggests that bright light can be an alternative treatment for LLPDD. However, the placebo effects should be ruled out completely. Further controlled studies with more patients will be needed.

• 수면정신생리
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• 제15권1호
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• pp.12-16
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• 2008

Light therapy (also called light treatment or phototherapy) involves scheduled exposure to bright artificial light. Evidence-based treatments for sleep disorders especially for circadian rhythm sleep disorders include light therapy and pharmacotherapy. In clinical practice, many of patients with sleep problems tend to impair circadian rhythmicity. Considering that light is the most potent entraining agent of circadian rhythm, careful use of light therapy can be recommended for patients with several kinds of sleep disorders. I briefly review the possible therapeutic mechanisms and clinical applications of light therapy, focusing on circadian sleep disorders.

• 수면정신생리
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• 제5권2호
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• pp.170-176
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• 1998

Nowadays light therapy is accepted practice in the treatment for Seasonal Affective Disorder. The author reviewed the practical aspects of light therapy, latest treatment research on optimal parameters of light therapy and the mechanisms of action of light therapy. Therapeutic efficacy of light therapy using light visors & dawn simulators has been suggested but further studies are needed to clarify the efficacy. The treatment most strongly supported by research studies is light therapy using a light box to administer bright white light (2500 lux for 2 hours or 10000 lux for 30 minutes). Although some patients may be selective responders to morning light exposure, the optimal timing of light exposure still remains controversial. In practice, generally the duration of exposure can be increased or decreased as necessary and also the timing of exposure can be splitted (e.g. AM/PM usage) if optimal response is obtained. For most, a positive response of light therapy is usually noted within $4{\sim}5\;days$ and optimal response is obtained within 2 weeks. Generally the relapse of symptom occurs within days of discontinuation of light therapy, so to prevent relapse, light therapy should be continued throughout the winter season for typical seasonal affective disorder. Side effects of light therapy appear to be mild and well tolerated. Several theories for the mechanisms of action of light therapy at the basis of seasonal affective disorder had been suggested but remain still controversial. Further studies on the optimal parameters and the mechanisms of light therapy help us to better understand and treat not only seasonal affective disorders but also chronobiological disorders and nonseasonal affective disorders.

• 수면정신생리
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• 제6권1호
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• pp.46-51
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• 1999

목 적 : 광치료는 계절성 기분장애, 약간의 비계절성 주요 우울장애 및 월경전우울증 등의 치료에 이용되고 있다. 저자들은 일중주기리듬의 장애가 병인론으로 제시되고 있는 월경전 불쾌기분 장애에 대한 광치료 효과를 평가하기 위하여 광치료의 임상시도를 하였다. 방 법 : DSM-IV의 월경전 불쾌기분장애 진단기준에 충족되는 4명의 환자에서 광박스(light box,Apolo bright lite III)를 이용한 저녁 광치료(6:30-8:00pm) 시도하였다. 결 과 : 연구대상은 광치료 후, 그 정도에는 차이가 있으나, 월경전기 증상과 더불어 우울기분과 불안이 감소하는 변화를 보였다. 본 연구는 임상시도로 연구대상이 적고, 위약 효과의 통제가 없으며, 증상 평가 방법에 있어 어려움 등 한계가 있으나, 이러한 변화는 특히 비정형 우울증상이 있는 환자에서 두드러졌으며, 신체증상보다는 심리증상에 보다 효과적인 결과를 보였다. 결 론 : 광치료는 월경전불쾌기분 장애 환자의 약물학적 치료에 대안적 방법으로 볼 수 있겠다. 향후 보다 많은 수의 환자를 대상으로, 위약대조 교차연구(아침, 저녁 광치료)가 필요할 것으로 사료된다.

• Psychiatry investigation
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• 제15권12호
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• pp.1188-1202
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• 2018

Objective This study protocol aims to determine, using a rigorous approach in patients with bipolar disorder (BD) and non-seasonal major depressive episode (MDE), the characteristics of bright light therapy (BLT) administration (duration, escalation, morning and mid-day exposures) depending on the tolerance (hypomanic symptoms). Methods Patients with BD I or II and treated by a mood stabilizer are eligible. After 1 week of placebo, patients are randomized between either morning or mid-day exposure for 10 weeks of active BLT with glasses using a dose escalation at 7.5, 10, 15, 30 and 45 minutes/day. A further follow-up visit is planned 6 months after inclusion. Patients will be included by cohorts of 3, with at least 3 days of delay between them, and 1 week between cohorts. If none meet a dose limiting toxicity (DLT; i.e hypomanic symptoms), the initiation dose of the next cohort will be increased. If one patient meet a DLT, an additionnal cohort will start at the same dose. If 2 or 3 patients meet a DLT, from the same cohort or from two cohorts at the same dose initiation, the maximum tolerated dose is defined. This dose escalation will also take into account DLTs observed during the intra-subject escalation on previous cohorts, with a "Target Ceiling Dose" defined if 2 DLTs occured at a dose. Discussion Using an innovative and more ergonomic device in the form of glasses, this study aims to better codify the use of BLT in BD to ensure a good initiation and tolerance.

• 정신신체의학
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• 제8권1호
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• pp.103-109
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• 2000

저자들은 만성적인 피로감과 비특이적인 신체 증상을 나타내는 치료저항성 만성피로증후군 환자 1례를 경험하였다. 몇몇 연구들에서 만성피로증후군과 정서장애와의 관련성을 보고하고 있으나 계절성정서장에의 치료 도구로 인정받고 있는 만성피로증후군에서 광치료의 효용성에 대한 연구는 거의 없는 상태이다. 저자들은 2500lux의 광상자를 이용하여 본 증례의 환자에게 아침 광치료를 시도하여 임상적 증상의 호전을 경험하였기에 관련 문헌의 검토와 함께 보고하고자 한다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 추계학술대회 논문집 Vol.19
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• pp.347-348
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• 2006

This paper performed the basic study for developing the Photodynamic Therapy Equipment for medical treatment. The equipment have been manufactured by using the High Bright Light Emitting Diode and TLC5941 integrated circuit. As a result, 630nm Light Emitting Diode Module was made for the optimization of irradiation condition. And we confirmed the current change according to increase of the level of Light Emitting Diode Module.

• 동의생리병리학회지
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• 제16권6호
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• pp.1106-1109
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• 2002

The analysis on the therapic music of chinese five-sounds studied in order to the stand ardization of the five-sounds. The results were as follows; The central sound of Gung(宮) becomes Do. This music goes on slow speed from first to last and appears the bright, quiet and stable mood. The central sound of Sang(商) becomes Re. This music mainly uses the brass and the fist appears the heavy feeling but gradually becomes ascending mood. The central sound of Kang(角) becomes Mi. This music mainly uses the wood-wind imstrument and appears the most light and vivid feeling. The central sound of Chi(徵) becomes Sol. All instruments sound grandly in the first part, and subsequently sound gentle. The central sound of Woo(羽) becomes La. This music appears dark and tragic mood that is generally used in the minor key. It is played slowly on the whole and appears lyrical feeling in the process of controlling and quiet. In the future, the study on diagnosis and therapy through the standardization of the five-sounds will be continued.

• Journal of mucopolysaccharidosis and rare diseases
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• 제1권2호
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• pp.35-39
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• 2015

Sleep problems occur frequently among patients with Prader-Willi syndrome (PWS). The most common problem is excessive daytime sleepiness (EDS) that are closely related to of sleep-related breathing disorder (SRBD) such as obstructive sleep apnea (OSA) and congenital hypoventilation syndrome. Obesity, craniofacial dysmorphism and muscular hypotonia of patients with PWS may increase the risk of SRBD. Sleep apneas can interrupt the continuity of sleep, and these disruptions result in a decrease in both the quality and quantity of sleep. In addition to SRBD, other sleep disorders have been reported, such as hypersomnia, a primary abnormality of the rapid eye movement (REM) sleep and narcolepsy traits at sleep onset REM sleep. Patients with PWS have intrinsic abnormalities of sleep-wake cycles due to hypothalamic dysfunction. The treatment of EDS and other sleep disorders in PWS are similar to standard treatments. Correction of sleep hygiene such as sufficient amount of sleep, maintenance of regular sleep-wake rhythm, and planned naps are important. After comprehensive evaluation of sleep disturbances, CPAP or surgery should be recommended for treatment of SRBD. Remaining EDS or narcolepsy-like syndrome are controlled by stimulant medication. Bright light therapy might be beneficial for disturbed circadian sleep-wake rhythm caused by hypothalamic dysfunction.

• 수면정신생리
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• 제6권1호
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• pp.68-75
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• 1999

목 적 : 본 연구는 야간 광 노출시 야간교대근무자의 수면양상과 기분상태가 어떠한 변화를 보이는지와 광 노출의 부작용의 정도와 빈도를 알아보고자 하였다. 이런 과정을 통해 광 노출이 야간교대근무적응에 사용될 수 있는지를 밝히고자 하였다. 방 법 : 용인정신병원에 근무하는 야간교대근무 간호사 12명이 본 연구에 참여하였다. 본 연구는 야간근무 대조연구, 야간근무 광노출연구, 주간근무 대조연구의 3부분으로 구성 되었으며 1명의 간호사가 주간근무 대조연구에 참여하지 않은 것을 제외하고는 모든 간호사가 세 연구에 모두 참여하였다. 야간근무 광노출연구시 새벽 1시부터 새벽 5시까지 4시간동안 빛에 노출되었다. 수면양상은 활동기록기와 자동수면 분석프로그램을 통해, 기분상태와 광노출의 부작용은 자기보고척도에 의해 평가하였다. 결 과 : 수면기간시간, 총수면시간, 수면효율은 야간근무 대조연구에 비해 야간근무 광노출연구시 증가되었으며 야간근무 광노출연구는 주간근무 대조연구와 차이를 보이지 않았다. 야간근무 광노출연구시 수면효율의 일간변동도 야간근무 대조연구에 비해 현저하지 않고 안정된 양상을 보였다. 야간근무 광노출연구시 간호사들은 주간수면을 취한 후 저녁시간에 야간근무 대조연구에 비해 좀 더 기분이 고양되고 활기가 넘친다고 보고하였다. 광 노출이 진행되면서 광노출 부작용에 대한 내성이 생겨 부작용의 빈도나 정도가 감소하였으며 광노출 3일째 심한 정도의 부작용을 호소한 사람은 한명도 없었다. 결 론 : 광 노출시 주간수면은 주간근무시의 야간수면만큼 호전되는 것으로 관찰되었고 이러한 수면호전으로 인해 야간교대근무자들은 기분이 고양되고 좀 더 활기가 넘친다고 보고하였다. 광 노출의 부작용도 시간이 지남에 따라 감소하므로 야간교대근무 적응을 위해 광 노출법을 권장할 수 있을 것이다.