• Journal of the Korean Ceramic Society
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• v.36 no.8
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• pp.813-819
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• 1999

Inner crack-like pores with controlled amount of Ca impurity level in the high purity alumina single crystal sapphire had been created by micro-fabrication technique which includes ion implantation photo-lithography Ar ion milling and hot press technique. The morphological change and the healing of crack-like pore in the Ca doped high purity single crystal alumina during high temperature heat treatment in vacuum were observed using optical microscopy. The hexagonal bridging ligaments were developed and the size of hexagonal bridging ligaments had been increased with temperature and Ca amount and had grown to their corner rounded. It appeared that the hexagonal bridging ligaments would have an equilbrium size with temperature and the amount of Ca addition. Three kinds of crack-like pore healing type were observed. Edge regression and ligament growth were observed from relatively low temperature in the crack-like pore. Edge regression were found in almost all of the crack-like pore but the ligament growth were found only in the several crack-like pores accelerating heating very fast. Flow type healing was observed above $1800^{\circ}C$ and It healed the crack-like pore very slowly.

• Journal of the Korean Society of Physical Medicine
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• v.4 no.4
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• pp.221-229
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• 2009

Purpose : The purpose of this study was to assess the effect of bridging stabilization exercises of trunk muscles activity on a Swiss ball according to change of position. Methods：30 healthy university students volunteered to participate in this study. Subjects were required to complete following three exercise positions. Exercise position 1; Supine bridge with Swiss ball, Exercise position 2; Side bridge with Swiss ball, Exercise position 3; Prone bridge with Swiss ball. Surface electromyography from selected trunk muscles was normalized to maximum voluntary isometric contraction. Results : A repeated measures of ANOVA with Duncan's correction was used to determine the influence of exercise type on muscle activity for rectus abdominis, external oblique, erector spinae. The erector spinae of exercise position 1 showed significantly higher muscle activity than exercise position 2, 3(p<.05). The external oblique of exercise position 2, 3 showed significantly higher muscle activity than exercise position 1(p<.05). The rectus abdominis of exercise position 3 showed significantly higher muscle activity than exercise position 1, 2(p<.05) Conclusion： These results indicate that muscle activity can be influenced by addition of a Swiss ball in bridging exercises. It is recommend to use a Swiss ball for trunk stabilization exercise.

• Journal of Pharmaceutical Investigation
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• v.40 no.2
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• pp.109-115
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• 2010

The purpose of the present study was to evaluate the bioequivalence of two choline alphoscerate soft capsules, Gliatilin soft capsule (Daewoong Pharmaceuticals Co., Ltd.) and Cholicerin soft capsule (Sam Chun Dang Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Serum concentrations of choline after oral administration of choline alphoscerate were determined using a validated LC/MS/MS method. This method showed linear response over the concentration range of 0.5-20 ${\mu}g$/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 100 ${\mu}L$ of serum was 0.5 ${\mu}g$/mL which was sensitive enough for pharmacokinetic studies. Thirty six healthy male Korean volunteers received each medicine at the choline alphoscerate dose of 1200 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Blood samples were taken at predetermined time intervals up to 8 hr. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 8 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Cholicerin/Gliatilin were log0.9998-log1.1172 and log0.9938-1.0944, respectively. These values were within the acceptable bioequivalence intervals of log0.80-log1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Cholicerin soft capsule and Gliatilin soft capsule are bioequivalent.

• The Journal of the Korea Contents Association
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• v.15 no.5
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• pp.283-294
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• 2015

The study examines the effect of IT education on on-line social relationship of older adults. The study group composed of 114 older adults who received IT education (computer class, internet class, and smart-phone class) at two community welfare centers in Seoul. In order to compare the effect of IT education of the study group, the control group who did not receive any IT education was recruited (N = 30). Social Capital Scale was used to measure on-line social relationship. The on-line social relationship was composed of social bonding type and social bridging type. Results showed that the study group significantly higher scores than did the control group on three subscales (emotional support, access to scare or limited resources, and out-group antagonism) of social bonding type except one subscale (ability to mobilize solidarity). With regard to social bridging type of social relationship, the study group significantly higher scores that did the control group on all four subscales (outward looking, contact with a broad rage of people, a view of oneself as part of a broader group, and diffuse reciprocity with a broader community). The findings highlight the importance of IT education for older adults to expand and increase social bonding and social bridging of social relationship.

• Information Systems Review
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• v.21 no.3
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• pp.131-149
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• 2019

As smart phones, tablets, and other digital devices become more pervasive, theoretical arguments around digital divide, which has previously focused on "access," is now expanding to effectively "utilize," actively "produce" and "share" information. Such discussion is significant because the impact on inter-personal and social networks depends on how digital divides are used, which can then recreate or exacerbate social inequality structures. This study examines the effect of individual's social relations and two types of social capital (i.e., bonding and bridging) on economic and socio-participatory usage of digital devices. An empirical analysis of dataset from 740 surveys reveals that the more horizontal the social relations of the individual, the more both bonding and bridging social capital increase. However, rather than the social relationship of the individual directly influencing the two types of digital device usage, it has an indirect effect on both economic and socio-participatory usage of digital devices. In particular, mediating effects of both bonding and bridging social capital exist in the case of economic usage of digital devices, whereas bonding social capital only has mediating effects on economic usage of digital devices. We discuss the role of social capital on digital devices usage and present the theoretical and practical implications.

• The Journal of the Korea Contents Association
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• v.9 no.12
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• pp.348-356
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• 2009

The purpose of this study was to examine the effect of bridging using Swiss ball, whole body vibration (WBV), and mat on trunk and lower extremity muscle activity and postural stability. The results were as follows: 1) EMG activity of internal oblique increased significantly in WBV condition compared with mat condition (p<.05). 2) EMG activity of rectus femoris and medial gastrocnemius increased significantly in Swiss ball condition and WBV condition compared with mat condition (p<.05). 3) The muscle activity of medial hamstrings increased significantly in Swiss ball condition compared with mat condition (p<.05). 4) The limit of stability in three groups increased significantly in all directions after 4-week intervention (p<.05). 5). There were no significant differences in the limit of stability among three groups after 4-week intervention (p>.05). Therefore the trunk and lower extremity muscle activity increased in Swiss ball and WBV conditions, and postural stability was improved in three groups after intervention period.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.4
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• pp.1013-1022
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• 1995

A hybrid composite (APAL;Aramid Patched ALuminum alloy, CPAL;Carbon Patched ALluminum alloy), consisting of a Al 2024-T3 aluminum alloy plate sandwiched between two aramid/epoxy and carbon/epoxy laminate, was developed. Fatigue crack growth behavior was examined at stress ratios of R=0.2, 0.5. The APAL and CPAL showed superior fatigue crack growth resistance, which may be attributed to the crack bridging effect imposed by the intact fibers in the crack wake.

• Journal of Pharmaceutical Investigation
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• v.37 no.5
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• pp.315-321
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two lercanidipine hydrochloride tablets, Zanidip tablet (LG Life Sciences Ltd., Korea, reference drug) and Samchundang Lercanidipine tablet 10 mg (Sam Chun Dang Pharm. Co. Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (amlodipine maleate) to human serum, serum samples were extracted using hexan-isoamyl alcohol (100:1, v/v). Compounds were analyzed by liquid chromatography/tandem mass spectrometry. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL which was sensitive enough for pharmacokinetic studies. Thirty healthy male Korean volunteers received each medicine at the lercanidipine hydrochloride dose of 20 mg in a $2\;{\times}\;2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of lercanidipine were monitored by an LC/MS/MS fer over a period of 24 hr after the administration. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Samchundang Lercanidipine/Zanidip were log 0.9505-log 1.2258 and log 0.9987-log 1.2013, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Samchundang Lercanidipine tablet 10 mg and Zanidip tablet are bioequivalent.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.4
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• pp.187-197
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• 2022

Purpose: This study aimed to investigate the changes in the muscle activity of the trunk stabilizer muscles before and after incorporating Pilates breathing during three types of Pilates chair exercises. Methods: This study included 33 healthy men and women in their 20's; they were recruited according to the inclusion and exclusion criteria. sEMG was used to measure the changes in the muscle activity in the internal oblique/transverse abdominis, rectus abdominis, and erector spinae during the three types of Pilates chair movements (footwork, twist footwork, and bridging) without and with the Pilates breathing integration. The muscle activities of the trunk stabilizers between without and with Pilates breathing were statistically analyzed and compared. Results: The internal oblique/transverse abdominis showed an increase and a significant difference in the muscle activity in all three movements of footwork, twist footwork, and bridging after the Pilates breathing integration (p<.001). The muscle activity of the rectus abdominis (p<.05) and the erector spinae (p<.05) also increased and showed a significant difference after the Pilates breathing incorporation, except in the bridging movement for the erector spinae. The increase in the rate after integrating Pilates breathing was relatively greater in internal oblique/transverse abdominis than in other muscles. Conclusion: When Pilates breathing was applied, the activities of the trunk stabilizer muscles increased significantly and immediately in all three movements of Pilates chair footwork, twist footwork, and bridging. This means that the use of breathing is expected to have a positive and immediate effect on the activation of trunk stabilizers, thus indicating that it can possibly be an effective re-enforcing tool to promote trunk stability when it is integrated to the Pilates chair exercise. Incorporating Pilates breathing also seemed to have a tendency to activate the deep trunk stabilizer muscles more than the superficial stabilizer muscles.

• Journal of Korea Society of Industrial Information Systems
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• v.12 no.5
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• pp.1-13
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• 2007

In this research, we found out that bridging nodes have great effect on the robustness of protein-protein interaction networks. Until now, many researchers have focused on node's degree as node's essentiality. Hub nodes in the scale-free network are very essential in the network robustness. Some researchers have tried to relate node's essentiality with node's betweenness centrality. These approaches with betweenness centrality are reasonable but there is a positive relation between node's degree and betweenness centrality value. So, there are no differences between two approaches. We first define a bridging node as the node with low connectivity and high betweenness value, we then verify that such a bridging node is a primary factor in the network robustness. For a biological network database from Internet, we demonstrate that the removal of bridging nodes defragment an entire network severally and the importance of the bridging nodes in the network robustness.