• 여성건강간호학회지
• /
• 제20권1호
• /
• pp.14-28
• /
• 2014

Purpose: This study was to identify relationships of maternal psychosocial factors including mother's mood state, childcare stress, social support and sleep satisfaction with breastfeeding adaptation and immune substances in breast milk, especially secretory immunoglobulin A (sIgA) and transforming growth factor-beta 2 (TGF-${\beta}2$). Methods: Data were collected from 84 mothers who delivered full-term infants by natural childbirth. Structured questionnaires and breast milk were collected at 2~4 days and 6 weeks postpartum. Data were analyzed using descriptive statistics, Pearson's correlation, multiple linear regression, and generalized estimating equation (GEE). Results: Scores for the breastfeeding adaptation scale were significantly related with child care stress, mood state and social support. Mother's anger was positively correlated with the level of sIgA in colostrum (p<.01). Immune substances of breastmilk was significantly influenced by time for milk collection (p<.001) and the type of breastfeeding (sIgA, p<.001, TGF-${\beta}2$, p=.003). Regression analysis showed that breastfeeding adaptation could be explained 59.1% by the type of breastfeeding, childcare stress, the Profile of Mood States, emotional support and sleep quality (F=16.67, p<.001). Conclusion: The findings from this study provide important concepts of breastfeeding adaptation program and explanation of psychosocial factors by immune substances in breast milk. Future research, specially, bio-maker research on breast milk should focus on the ways to improve breastfeeding adaptation.

• Clinical and Experimental Pediatrics
• /
• 제50권9호
• /
• pp.912-918
• /
• 2007

목 적 : 산모의 알레르기 질환 병력 유무와 초유와 모유 간에 차이가 있는지 살펴보고, 또한 이들의 모유수유 기간에 따른 자녀의 알레르기 질환 발생 유무의 차이를 보고, 생후 2세까지 발생한 알레르기 질환과 모유 내의 면역학적 인자간의 연관성을 알아보고자 하였다. 방 법 : 2002년 5월부터 2003년 2월까지 참여를 희망한 총 138명의 산모에서 알레르기 질환이 있는 산모 88명과 알레르기 질환이 없는 산모 50명으로 나누어 조사하였다. 생후 2일경 초유와 생후 4주경의 모유를 채취하여, 초유와 모유 내 IL-4, IL- 6, IL-8, IL-10, IL-13, RANTES, $TGF-{\beta}1$과 $TGF-{\beta}2$를 측정하였다. 이후 소아는 생후 2세까지 알레르기 질환의 발생에 대한 추적관찰을 하였으며, 초유와 모유 내의 사이토카인과의 연관성을 비교하였다. 결 과 : 알레르기 질환이 있는 산모 군에서 6개월 이상 모유 수유하는 경우가 34.4%(n=21)였고, 3개월 미만으로 수유한 경우가 55.6%(n=15)로 두군 간에 통계학적 차이는 보이지 않았다(P>0.05). 초유 내의 IL-8 농도만이(P=0.021) 알레르기 질환이 있는 산모에서 더 높게 측정되었다. 반면 초유 내의 $TGF-{\beta}1$와 $TGF-{\beta}2$ 농도는 알레르기 질환이 없는 산모에서 더 높게 측정되었다(P=0.013, P=0.001). 초유나 모유 내 사이토카인과 생후 2세까지 알레르기 질환이 발생한 소아 간에 통계학적인 차이를 보이지 않았다. 결 론 : 생후 2세까지 발생한 알레르기 질환과의 연관성 있는 사이토카인은 발견하지는 못했다. 알레르기 질환이 있는 산모와 알레르기 질환이 없는 산모 간에 차이를 보인 $TGF-{\beta}1$, $TGF-{\beta}2$와 IL-8이 알레르기 질환의 병인에 연관성 조사를 위해, 추후 이들에서 장기간 추적 관찰이 필요할 것으로 생각된다.

• 한국환경보건학회지
• /
• 제37권6호
• /
• pp.440-449
• /
• 2011

Objectives: This study was designed to determine the levels of polybrominated diphenyl ethers (PBDEs) in breast milk and to evaluate the relations with factors affecting these levels. Methods: The congener levels of PBDE in 22 samples of breast milk were analyzed using a high resolution gas chromatograph with a high resolution mass detector. In accordance with our standard operating procedures, the recoveries of internal standards had to range between 68% and 118%. Since the distribution of PBDE concentrations is close to log-normal, the data were logarithmically transformed before analysis. Test subjects were healthy primipara and multipara mothers with a mean age of 32 (SD = 2.7) in 2006. Results: Seven PBDE congeners (BDE-28, 47, 99, 100, 153, 154, and 183) were detected and identified in all of the pooled breast milk samples, indicating widespread contamination from PBDEs in the environment in Korea. Residue levels of total PBDEs (sum PBDEs from tri- to hepta-BDE) ranged from 0.84-13.1 ng/g lipid with median and geometric mean levels of 2.6 ng/g lipid and 2.74 ng/g lipid, respectively. PBDE congeners 47, 99 and 153 markedly predominated and accounted for about 75% of the amount of the PBDE congeners analyzed. BDE-47 was the dominant congener in most samples, whereas BDE-153 was predominant in a few (n = 7/22). BDE-47 was highly correlated with total PBDEs (r = 0.987, p < 0.01). In analyses of the differences of the means of log transformed breast milk PBDE levels for groups of potential covariates, only breast milk BDE-47 and BDE-99 levels were significantly associated with fish (p < 0.05) and meat consumption (p < 0.01). However, we did not find significant correlations between PBDE levels and maternal age, body mass index (BMI), parity, job presence and smoking status. Conclusions: Our findings are mainly limited due to the small sampling size and low doses of PBDEs exposure. Background and human exposure data of PBDEs is lacking, and longitudinal investigations into the environment and biota are encouraged to determine the health impact on future populations in Korea.

• 셀메드
• /
• 제4권3호
• /
• pp.19.1-19.6
• /
• 2014

The most important reason mentioned for the early discontinuation of breast feeding and introduction of supplementary bottles is Perceived Insufficient Milk (PIM), which is relatively common in women. This is of public health concern because the use of breast milk substitutes increases the risk of morbidity and mortality among infants in developing countries and shortens birth intervals. Thus, a literary search in classical text for aetiopathogenesis, symptoms and treatment of PIM were appraised to implement in contemporary era. The classical Unani texts viz., Al Qanon fit Tib (Canon of Medicine), Al Hawi (Continens Liber), Zakheera Kharzam Shahi, Tarjuma Kamilus Sana, Tibbe Akbar, Akseer Azam, and Kitabul Kulliyat were reviewed. Further certain galactogogue herbs which are in use since antiquity such as fenugreek, cotton seeds, cumin, asparagus, black cumin etc were explored in different search engines on website for proven galactogogue activity. The causes of PIM are abnormal temperament of body or breast, anaemia, anxiety, depression, malnutrition etc. The principle treatment is treating the cause viz., the temperament is corrected by diet and drugs in abnormal temperament, elimination of humour is required in dominance of humour etc. The aforementioned drugs are proven scientifically for their galactogogue activity. The classical texts are having valuable information regarding PIM, which can be implemented in present era. Aforementioned Unani drugs are proven scientifically for with their galactogogue effect, however, clinical trials are scarce. Therefore, further randomized controlled clinical trials are recommended.

• Clinical and Experimental Pediatrics
• /
• 제59권sup1호
• /
• pp.41-44
• /
• 2016

We report here a case of maternal 3-methylcrotonyl-coenzyme A carboxylase (3-MCC) deficiency in a Korean woman. Her 2 infants had elevated 3-hydroxyisovalerylcarnitine (C5-OH) on a neonatal screening test by liquid chromatography-tandem mass spectrometry (LC-MS/MS), but normal results were found on urine organic acid analysis. The patient was subjected to serial testing and we confirmed a maternal 3-MCC deficiency by blood spot and breast milk spot test by LC-MS/MS, serum amino acid analysis, urine organic acid and molecular genetic analysis that found c.838G>T (p.Asp280Tyr) homozygous mutation within exon 9 of the MCCB gene. Especially, we confirmed marked higher levels of C5-OH on breast milk spot by LC-MS/MS, in the case of maternal 3-MCC deficiency vs. controls.

• 모자간호학회지
• /
• 제4권1호
• /
• pp.68-79
• /
• 1994

This study measured variables influencing the breast feeding patterns of lactating mothers over a 40 day period In 1993 in the Jeonla area. The Methodology used was a questionnaire covering 92 items based on statistical discriminant analysis. The results were as follows : The successful group was measured against the unsuccessful group over a 4month lactation period ; The successful group was measured over a 4month lactation period ; the unsuccessful less than 4month lactation period. Principal factor analysis was used to generate comparative data factors which were ; 1) nonunderstanding of mother's breast feeding, 2) physical and psychological stress, 3) insufficient milk supply, 4) mother's negative acceptance of baby, 5) lack of spousal support, 6) sore nipple and breast pain, 7) baby's negative acceptance, 8) lack of familial support, 9) baby's diarrhea and watery milk. Discriminant statistical analysis of sever factors included ; 1) insufficient milk supply 2) sore nipple and breast pain, 3) pre-natal planning of breast feeding method, 4) mother's occupation 5) breast feeding method of previous infant, 6) nipple type, and 7) infant birth order. This analysis predicted a 78.9% successful breast feeding. Criterion correlation analysis revealed ; D=-1.780+.165$\times$(Fac3)+.135$\times$(Fac6)+.927$\times$(prenatal planning of breast feeding method)+.900$\times$(mother's occupation)+.675$\times$ (breast feeding method of previous infant)+1.0l4$\times$(nipple type)+.378$\times$(infant birth order). We classified the unsuccessful group as more than .63937 and the successful group less than -.82742 of the D value obtained from the above criterion correlation in order to check the success or the non-success of breast feeding mothers. The rate of correct classification of the grouped cases employing a statistical discriminant analysis was significantly improved to 78.9% when these cases were compared with the actual grouped classification.

• Journal of Nutrition and Health
• /
• 제30권8호
• /
• pp.1018-1024
• /
• 1997

In order to investigate calcium , phosphorous and magnesium intake of breast-fed infants, consumed volumes of human milk and those mineral contents of the milk were examined at 0.5, 1, 2, 3, 4 and 5 months of lactation. Calcium , phosphorus and magnesium contents of human milk during the first 5 months of lactation averaged 26.0, 13.7 and 3.70mg/100g, respectively. Calcium intake of infants averaged 192.3 and 171.0mg/day which represented 39.7 and 33.5% of the RDA for boys and girls, respectively. Phosphorus intake of infants averaged 100.7 and 85.2mg/day which represented 26.2% and 23.4 % of the RDA for boys and girls respectively. The calcium /phosphorus ratio of human milk averaged 2.00 during lactation. The results of this survey suggest that, the reevaluation of calcium , phosphorus and magnesium intake and recommended dietary allowance of these nutrients during infancy is merited.

• Journal of Nutrition and Health
• /
• 제26권4호
• /
• pp.414-422
• /
• 1993

The longitudinal changes on human milk intake of exclusively breast-fed infants(boys=15, girls=12) from 0.5 to 6 months after parturition have been studied by test-weighing method in Cheongju and Anseong area. Infant milk intake per day tended to increase during lactation. The mean intake at 0.5, 1, 2, 3, 4, 5, and 6 months were 532, 695, 734, 756, 785, 767, and 710g, respectively. The average intakes were 752 and 660g for boys and girls, respectively. The overall mean intake was 711g/day. The milk intake between boys and girls at 1, 2, 4 months, and mean value was significantly different(p<0.05). Infant milk intake had a significant positive correlation with human milk volume of lactating women, but no correlation with maternal age, weight before delivery, height, and birth weight.

• Journal of Nutrition and Health
• /
• 제31권1호
• /
• pp.88-95
• /
• 1998

Kong chain $\omega$3 & $\omega$6 fatty acids and taurine have been suggested to have structural and /or functional roles in the brain. The purpose of this study was to evaluate the changes in the percentage of fatty acids and taurine concentration in human milk obtained from Korean mothers(n=37) as lactation proceeds from birth to 5wks postpartum , and to determine the correlation between taurine concentration and fatty acid composition in breast milk. Level of fatty acids and taurine in breast milk were measured by GLC and HPLC, respectively. The percentages of medium -chain saturated fatty acids(10 : 0, 12 : 0 & 14: 0) were increased significantly , while percentages of long-chain saturated fatty acids(22 :0 & 24 : 0), and most of the long chain $\omega$6 and $\omega$3 fatty acids(20 : 3$\omega$6 , 20 :4$\omega$6, 22 :4$\omega$6 , 22 :5$\omega$6, 22 :5$\omega$3 & 22 : 6$\omega$3) were decreased significantly in mature milk (5 wks postpartum ) as compared to the colostrum. Taurine concentrations in colostrum and mature milk from Korean mothers were 549 $\pm$58 and 233 $\pm$41nmol/ml , respectively. Taurine concentrations in human milk was negatively correlated with the percentages of medium -chain saturated fatty acids ( 10 : 0 &12 : 0), and positively correlated with the percentages of long-chain saturated fatty acids( 16 :0, 20 : 0, 22 : 0& 24 : 0) and long-chain monounsaturated fatty acids( 20 : 1, 22 : 1 & 24 ; 1). Taurine concentration in human milk was positively correlated with elongation indices of both $\omega$6 and $\omega$3 fatty acids, and negatively correlated with the desaturation index of $\omega$6 fatty acids. These close relationships between fatty acids compositions and taurine level in human milk are worth pursing further investigation, especially with regard to their common roles in retina and brain development.

• 대한지역사회영양학회지
• /
• 제5권4호
• /
• pp.569-577
• /
• 2000

This study was carried out to investigate the feeding practices, growth status and correlation with maternal perceptions of breast feeding and lactation with infuts' feeding methods in the Pocheon area. The subjects were 103 infants ranging from 3 to 21 postpartum months and their mothers. The results obtained were as follows : In this survey, 36.9% of the infants were breast-feeding, while 53.4% of them were bottle-feeding, and 9.7% of them were mixed-feeding. The reason for bottle-feeding was due mainly to the lack of breast-milk secretion. Z-scores of weight-f3r-age and height-for-age were similar to Korean standards, but malnutrition and overnutrition were also noticed by kaup index and WLI. The average maternal perceptions of breast-feeding and lactation was 3.7 out of 10 possible points, the breast-feeding group scored 4.7, and formula-feeding and mixed-feeding group scored 3.0. That of BF group was higher than FF+MF groups and was positively correlated with growth status. Therefore to ensure proper growth of infants and to promote breast-feeding, efforts should be given to community nutritional services including nutrition education for the importance of colostrum and breast-milk, practical breast-feeding methods, and nutritional management during pregnancy. Also nutrition education for mothers will be continued to 1-3 postpartum months to promote successful breast-feeding.