• 한국건강관리협회지
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• 제3권2호
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• pp.280-287
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• 2005

The Government bean implementing the National Cancer Screening Program(NCSP) in 1999 and expanded its target population and target cancers. The target cancers of NCSP since 2004 are the five most common cancers in Korea: stomachm liver colorectal, breast, cervical cancer. One goal of the NCSP in 2005 is to include in its target population up to lower 50% of premiu of National Health Insurance. The Government and National Cancer Center have bee developing the protocol for the NCSP with associated related academic societies Health Centers operate the NCSP with National Health Insurance Cooperation. The Particioants of NCSP in 2004 are 1.34million, 14% of target population and the detection rate 2004 is 0.07%. NCSP has three challenges. Firstly, NCSP improves the participant rate through educating cancer screening increasing the access of screening(e.g. mobile screening unit), and increasing reimbursement fee Secondly NCSP assesses the quality of screening with related academic societies and implement the intervention for quality improvement. Thirdly, NCSP continues to increase the cost-effectiveness through modification of target population, screening interval, method, and information system.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.269-273
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• 2016

Presently, the world population of the elderly is growing. By improving health hygiene and welfare indicators, mortality and birth rates decrease and life expectancy increases, making the present century the century of elderly. Aging is one of the main risk factors for development of cancer, which itself is the second cause of death in old people. This study was conducted to assess the prevalence of cancer in the elderly covered by the Islamic Republic of Iran Broadcasting (IRIB) insurance program and to obtain suitable programs for cancer screening and early detection, increase patient survival, improve elderly care and to reclaim the cost of treatment in comparison to the national and international statistics. This is a cross-sectional study conducted on all elderly patients diagnosed with malignancy based on their pathology reports. In this study, of the total 75,500 patients covered by IRIB insurance, 17.2% belonged to the elderly group, males accounting for 53.3%. The most common cancers in old men were prostatic cancer (61.3%), colon cancer (10.3%) cancer of the hematologic system, bladder cancer (9.6%), lung cancer (9.1%), thyroid cancer (3.9%) and brain tumors (1.3%). In the elderly women, the most common cancers were breast cancer (80.1%), colon cancer (5.1%), thyroid cancers (4.4%), bladder and hematologic system malignancies (3.6), lung cancer (2.9%) and brain tumors (0.7%). In addition, the prevalence of cancer was almost the same as national and international statistics. With the exception of non-melanoma skin cancer no difference was shown in prevalence of cancer between IRIB elderly patients and the other groups of cancer patients in Iran.

• 대한핵의학회지
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• 제22권1호
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• pp.59-64
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• 1988

Because carcinoma of breast is known to readily metastasize to the bone, early detection of metastasis spread is very important. Two hundred thirty four consecutive patients who had $^{99m}Tc-MDP$ bone scans prior to treatment and during the follow up period were studied retrospectively to determine the contribution of the scans to staging, treatment and follow up examination between Jan. 1980 and Apr. 1987 in Seoul National University Hospital. 1) Positive bone scan rates in initial clinical stage I, II, III and IV were 0%, 4%, 14% and 53%, respectively. 2) The higher clinical stage is, the more cumulative risk of conversion to positive bone scan is during the same follow up period. 3) Conversion rate to positive bone scan in patients with lymph node metastasis is higher (50%) than those without metastasis (18%) (P < 0.001). We concluded that the bone scan in primary breast cancer was very useful to evaluate initial clinical stage and to perform the follow up examination.

• 한국방사선학회논문지
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• 제8권1호
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• pp.27-33
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• 2014

건강에 대한 관심의 증대로 의료영상이 빠르게 증가하고 있으며, 컴퓨터 기술의 발전으로 의료영상의 디지털화가 빠르게 진전되어 PACS가 의료현장에 도입되었다. 이러한 현상에 의한 의료영상 생산의 증가는 의료영상을 판독하여야 하는 영상의학과 전문의의 업무량을 증가하게 하였다. 이러한 추세에 따라 컴퓨터를 이용한 보조 진단의 필요성이 대두되어 의료영상 판독 분야에 CAD라는 용어가 생겨나게 되었다. 본 연구에서는 디지털 X-선 유방촬영장치에 의하여 획득된 영상의 판독을 위한 CAD 알고리즘을 제안하였다. 제안된 알고리즘을 Visual C++로 프로그램하여 실험하였다. 본 연구에 사용한 일곱 샘플영상을 CAD 알고리즘으로 실행한 결과 다섯 샘플의 결과는 양성종양 및 유방암으로 확인되었고 두 샘플 영상은 error처리 되었다. 본 연구에서 제시한 알고리즘과 이를 구현한 프로그램을 이용한다면 판독업무에 많은 도움이 될 것이며, 유방암의 조기발견에 크게 기여할 것으로 사료된다.

• 한국통신학회논문지
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• 제29권3C호
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• pp.374-386
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• 2004

유방암은 최근에 빠르게 증가하고 있는 여성 암중의 하나이며 그 발명원인이 불명확하여 조기 검출만이 생존율을 높일 수 있는 유일한 방법이다. 본 논문에서는 효율적으로 미소석회질의 의심 영역을 검출할 수 있는 방법에 대하여 설명한다. 본 논문에서는 디지털 마모램 영상에 대한 통계적 분석으로부터 일반적인 미소석회질의 특성을 분석한 후 분석된 자료를 이용하여 다단 신경망을 구성한 후 의심영역으로 간주되는 ROI를 검출한다. ROI 검출을 위하여 4단계로 구성되는 알고리즘을 제안하며 전처리 과정, 다단계 thresholding, 선형필터를 이용한 1차 미소석회질 선별작업, 다단계 신경망을 이용한 2차 미소석회질 검출이 포함된다. 선형필터를 이용한 1차 선별작업에서는 모든 미소석회질을 검출할 수 있었고 유방조직 제거를 통한 신경망에서의 작업처리 감소율이 86％로 나타났다. 2단 신경망을 이용한 2차 미소석회질 검출단계에서 첫 번째 신경망에서는 미소석회질의 형태적 특성을 기반으로 11개의 특징 값들을 정의하였으며 모든 데이터에 대한 실험 결과 평균 96.66％의 인식률을 보였다. 그리고 두 번째 신경망에서는 첫 번째 인식 결과 값과 미소석회질의 군집특성을 이용하기 위해 첫 번째 인식결과를 토대로 조사된 군집분포 여부를 특징 값으로 사용하였으며 그 결과 1차 신경망보다 높은 평균 98.26％의 인식률을 보였다.

• 대한핵의학회지
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• 제34권6호
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• pp.478-486
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• 2000

목적: 조직 검사에서 유방암으로 확진된 환자 15명 (평균 연령 50.4세)을 대상으로 수술 전에 시행한 유방림프신티그라피(lymphoscintigraphy)와 수술 중 감마프로우브를 이용하여, 림프관 유입형태 및 전초림프절(sentinel lymph node)을 찾아, 전초 및 액와림프절을 각각 절제, 생검하여, 전초 림프절의 림프신티그라피 발현율, 전초림프절 전이와 액와림프절 전이의 상관 관계 등을 보고자 하였다. 대상 및 방법: 환자의 임상병기는 병기 I-II 이었고, 4례에서 액와림프절이 촉지되었다. 침습성 관암 13명, 수질암 및 포도당 풍부암이 각각 1명씩이었다. 유방림프신티그라피는 다음과 같이 시행하였다. 방사성의약품 Tc-99m antimony sulfide colloid $30{\sim}37MBq$을 총 0.4 ml 용량으로 만들어, 원발 종괴에서 $2{\sim}3mm$ 떨어진 위치의 12, 3, 6, 9시 방향에 각각 0.1 ml를 피내 주사하고 약 2분 동안 마사지하였다. 저에너지, 고해상도 평행 조준기를 이용하여 초기 동적 영상(10 sec/frame)을 10분간 시행하였으며, 이어서 5분 간격으로 $30{\sim}60$분에 걸쳐 초기 정적영상을 얻었고, 주사 후 2시간에 지연영상을 획득하였으며, 각각의 영상을 비교하여 전초림프절과 유입 림프관을 확인하였다. 유방림프신티그라피검사가 끝나면 즉시 수술실로 옮겨 전초림프절이라고 판독된 부위를 감마프로우브로 찾아 림프절의 계수와 배후 방사능을 측정하였고, 이 부위를 절개하여 조직을 떼어내 표지하고 생검하였으며, 그 외에 배후 방사능보다 높은 계수를 보인 부위가 있으면 따로 표지하여 조직 검사를 하였다. 모든 환자에서 원발 종양의 절제술과 액와림프절 절제술을 시행하였다. 결과: 전체 환자 15명 가운데 14명에서 유방림프신티그라피 및 수술 중 감마 프로우브로 전초림프절이 발견되었다(전초 림프절 검출율: 93.3%). 유방림프신티그라피로 발견된 평균 전초림프절수는 $2.47{\pm}2.00$개였으며, 감마프로우브를 이용하여 수술로 절제된 평균 전초림프절 수는 $2.36{\pm}1.96$개였다. 초기 동적 유방림프신티그라피에서 전초림프절로 유입되는 림프관이 총 15명 중 3명에서 관찰 할 수 있었으며(20%), 3명에서는 전초림프절이 2시간 지연 영상에서만 발견되었다(20%). 유방림프신티그라피에서 전초림프절이 나타난 시간은 평균 $33.4{\pm}48.4$분이었다. 전초림프절의 조직 생검 결과 14명 가운데 7명의 전초림프절에서 전이 소견이 관찰되었고(50%), 이 중 5명 환자의 액외림프절에서 전이가 보였다(예민도: 71.2%). 그러나 전초림프절에 전이가 있었던 7명 가운데 2명은 액와림프절에서 전이 소견은 관찰되지 않았다. 전초림프절에 전이가 없었던 7명 환자에서는 모두 액와림프절에서도 전이 소견을 관찰 할 수 없었다(특이도: 100%). 유방림프신티그라피 및 수술 중 감마프로우브로 전초림프절을 발견 할 수 없었던 1명에서 액와절제술 후 액와림프절 조직에서 림프절에 전이가 관찰되었다. 결론: 따라서 유방암 환자에서 유방림프신티그라피와 수술 중 감마프로우브를 이용한 전초림프절 생검은 액와림프절 전이 평가에 있어 높은 예민도와 특이도를 나타내므로 불필요한 액와림프절 절제술을 줄이는데 도움이 될 것이다.

• BMB Reports
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• 제46권2호
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• pp.65-72
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• 2013

In situ detection of RNAs is becoming increasingly important for analysis of gene expression within and between intact cells in tissues. International genomics efforts are now cataloging patterns of RNA transcription that play roles in cell function, differentiation, and disease formation, and they are demon-strating the importance of coding and noncoding RNA transcripts in these processes. However, these techniques typically provide ensemble averages of transcription across many cells. In situ hybridization-based analysis methods complement these studies by providing information about how expression levels change between cells within normal and diseased tissues, and they provide information about the localization of transcripts within cells, which is important in understanding mechanisms of gene regulation. Multi-color, single-molecule fluorescence in situ hybridization (smFISH) is particularly useful since it enables analysis of several different transcripts simultaneously. Combining smFISH with immunofluorescent protein detection provides additional information about the association between transcription level, cellular localization, and protein expression in individual cells.

• Child Health Nursing Research
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• 제23권2호
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• pp.147-157
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• 2017

Purpose: This study was done to investigate the relationship between knowledge, attitude, and practice toward breast self-examination (BSE) among middle and high school girls. Methods: A cross-sectional descriptive study was conducted using self-report questionnaires. Participants were 412 students, 137 middle and 275 high school girls. Data were collected from December 7 to 23, 2016 and analyzed using t-test and Spearman correlation coefficient. Results: The percentage of correct answers for knowledge about breast self-examination among middle and high school girls was 29.2%. The mean score for practice ($5.89{\pm}0.10$) among middle and high school girls was low. For knowledge, there were significant differences according to grade (t=5.93, p<.001), having heard about BSE (t=4.02, p<.001), experience of BSE (t=2.51, p=.012), and need for education (t=3.37, p=.001). In practice, there were significant differences according to having heard about BSE (t=3.64, p<.001), experience of BSE (t=2.64, p=.017). Knowledge level of BSE positively correlated with practice of BSE (r=.21, p<.001). Conclusion: Research results suggest that education on BSE for middle and high school girls is needed to increase the possibility of early detection of breast cancer.

• 여성건강간호학회지
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• 제9권1호
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• pp.18-27
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• 2003

Purpose : Cancer is th e most frequent cause of death in Korea. Cancer screening can save lives through early detection. This study was to investigate major cancer screening rates and the reasons for not having been screening. Method : 210 participants of registered nurses from 5 general hospitals in Busan, Korea were completed a structured self-administered questionnaire. Data were analyzed using descriptive statistics with SPSS WIN 10.0. Results : The cancer screening rates of the subjects were 53.8% in Pap smear test for cervical cancer, 41.0% in gastroendoscopy for stomach cancer, 15.7% in mammograpy for breast cancer, and 3.8% in colonoscopy. And the higher proportions of having regular screening were 9, 5% in Pap smear test and 2.9% in gastroendoscopy. The primary reason related to not having a screening test was 'seems to be healthy'. Conclusion : The findings showed the necessity of recognizing and educating Korean nurses to have a regular cancer screening for their health management.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5759-5762
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• 2012

The objective of the study was to evaluate the efficacy of a health check-up program among Thai people at the National Cancer Institute in the years 2008-2009. The program included history taking, physical examination, chest X-ray, EKG, and laboratory tests. A total of 28,240 women and 9,665 men were included in the study, with mean ages of 44.5 and 46.9 years, respectively. The study showed that obesity, as assessed by a BMI over 25.0 kg/m2, in men and women was present in 41.4% and 30%, respectively. Biochemical study revealed that anemia was prevalent in 21.6% of men and 20.1% of women. High plasma glucose level (>115 mg/dL), cholesterol level (>200 mg/dL), triglyceride level (>190 mg/dL) in men was 13.8%, 63.8%, 22.6% and 7.7%, 61.1%, 8.9% in women. Hepatitis B virus infection was found 7.5% in men and 4.1% in women. In this study, 177 new cancer cases were detected, of which 35 were breast, 19 were cervical and 26 were colorectal, most of these cancers being detected at early stage. In addition, precancerous states was also found including 718 cases of benign and 99 cases of adenoma in situ. In conclusion, an annual check up may detect abnormalities that have no obvious clinical symptoms of disease. Early detection of asymptomatic neoplasms and precursor lesions should contribute to a prompt provision of treatment and further decline of death from cancer.