• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1929-1934
• /
• 2015

Purpose: To determine the diagnostic yield of primary circulating tumor cells in women with suspicion of breast cancer, detected as a result of an abnormal mammography. Materials and Methods: Consecutive women presenting for breast biopsy as a result of a mammogram BiRADs of 3 or more, had an 8ml blood sample taken for primary circulating tumor cell (CTC) detection. Mononuclear cells were obtained using differential gel centrifugation and CTCs identified using standard immunocytochemistry using anti-mammoglobin. A test was determined to be positive if 1 CTC was detected. Results: A total of 144 women with a mean age of $54.7{\pm}15.6$ years participated, 78/144 (53.0%) had breast cancer on biopsy, 65/140 (46.3%) benign pathologies and 1(0.7%) non-Hogkins lymphoma. Increasing BiRADs scores were associated with increased cancer detection (p=0.004, RR 1.00, 4.24, 8.50). CTC mammoglobin positive had a sensitivity of 81.1% and specificity of 90.9%, with positive and negative predictive values of 90.9% and 81.1% respectively. Mammoglobin positive CTCs detected 87% of invasive cancers, while poorly differentiated cancers were negative for mammoglobin. Only 50% of in situ cancers and none of the intraductal cancers had CTCs detected. Menopausal status did not affect the diagnostic yield of the CTC test, which was higher in women with BiRADS 4 mammograms. There was a significant trend (p<0.0001 Chi squared for trends) in CTC detection frequency from intraductal, in situ and invasive (OR 1.00, 8.00, 472.00). Conclusions: The use of primary CTC detection in women suspected of breast cancer has potential uses, especially with invasive cancer, but it failed to detect intra-ductal cancer and 50% of in situ cancer. There was no difference in the diagnostic yield between pre and post menopausal women. To confirm its use in reducing biopsies in women with BIRADs 4a mammagrams and in the detection of interval invasive breast cancer, larger studies are needed.

• 한국전자파학회:학술대회논문집
• /
• 한국전자파학회 2005년도 종합학술발표회 논문집 Vol.15 No.1
• /
• pp.421-424
• /
• 2005

X-ray is currently most effective method in detecting small malignant breast tumors but has the several problems due to suppressing breast, ionizing radiation and not detecting small cancer. In this paper, a new method is proposed by using dielectric characteristics of pathological tissues and time delay of backscattered response. We have developed a detection algorithm and verified it by numerical simulation and measurement for a prototype system. For a prototype system, we have fabricated experimental model(artificial breast with a cancer) and UWB(ultra-wideband) antenna. The results of the measurement simulation show an excellent detection capability of a cancer tissue. It is found that a good UWB antenna is a key element of such detection system. Further study is ongoing to develop a commercial system.

• Journal of Breast Cancer
• /
• 제21권4호
• /
• pp.363-370
• /
• 2018

Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database. We selected candidates from the differentially expressed miRNAs and then evaluated every possible molecular signature formed by the candidates. The best signature was validated in independent serum samples from 113 early breast cancer patients and 47 healthy controls using reverse transcription quantitative real-time polymerase chain reaction. Results: The miRNA candidates in our method were revealed to be associated with breast cancer according to previous studies and showed potential as useful biomarkers. When validated in independent serum samples, the area under curve of the final miRNA signature (miR-21-3p, miR-21-5p, and miR-99a-5p) was 0.895. Diagnostic sensitivity and specificity were 97.9% and 73.5%, respectively. Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection.

• 한국융합학회논문지
• /
• 제8권12호
• /
• pp.49-53
• /
• 2017

유방암은 전체 여성의 암환자 중 두 번째로 많으며, 여성의 암으로 인한 사망 원인으로 가장 높은 것으로 나타났다. 유방암은 조기 발견 경우 완치율이 92%에 이른다. 하지만, 조기 발견을 하지 못할 경우 유방암은 전이율이 매우 높다. 암세포의 전이는 암의 진행이 많이 될수록 다른 장기로의 전이가 더욱 잘 되는 것으로 나타났다. 암의 조기 진단은 삶의 질을 높일 수 있는 중요한 요소이다. 유방암을 검사하는 방법으로는 맘모그래피(Mammography), 초음파, 맘모톰(momotome) 등이 있다. 그 중 맘모그래피는 검사자에게 통증이 적을 뿐 아니라, 쉽게 접근할 수 있어 유방암 검사에 유용하게 사용된다. 본 논문에서는 유방암 진단 데이터로 맘모그래프 데이터를 사용하였다. 본 논문에서는 뉴럴네트워크인 NEWFM(Neural network with weighted fuzzy membership function)를 사용하여 암 조기 진단을 위한 클래스를 분류하였다. NEWFM을 이용하여 데이터를 학습시킨 후 유방암 데이터 분류 결과 정확도가 84.4391%가 나타났다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제11권2호
• /
• pp.1134-1147
• /
• 2017

With the rise in popularity of photographic and video cameras, an increasing number of fields are now using thermal imaging cameras. One such application is in the diagnosis of breast cancer, as thermal imaging provides a low-cost and noninvasive method. Thermal imaging is particularly safe for pregnant women, and those with large, dense, or sensitive breasts. In addition, excessive doses of radiation, which may be used in traditional methods of breast cancer detection, can increase the risk of cancer. This paper presents one method of breast cancer detection. Breast images were taken using a thermal camera, with preliminary experiments conducted on Cambodian women. Then the experimental results were analyzed and compared using Shannon entropy and logistic regression.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권10호
• /
• pp.4861-4866
• /
• 2012

This is a review article which looks into details what the actual scenario of the problem of breast cancer in our country is. As the problem is on the rise, what is the level of the preparedness at our end to tackle the problem. The articles reviews the epidemiology of breast, high risk factors, detection, diagnosis and treatment facilities also along with that screening facilities and their ground reality, awareness of the women from different walks regarding various issues of breast cancer and what intervention can be made to combat the disease.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권10호
• /
• pp.5731-5734
• /
• 2013

Background: The object of this study was to examine whether a new protocol including step-sectioning and immunohistochemistry (IHC) staining of axillary sentinel nodes (SN) would lead to detection of more metastases in patients with breast cancer. Materials and Methods: Sixty-nine tumor free sentinel lymph nodes were examined. Step frozen sectioning was performed on formalin fixed SN and stained both by hematoxylin and eosin (H and E) and cytokeratin markers using IHC. Any tumoral cell in IHC stained slides were considered as a positive result. Metastases up to 0.2 mm were considered as isolated tumor cells and 0.2 up to 2 mm as micrometastasis. Results: Mean age of the patients was $48.7{\pm}12.2$ years. Step sectioning of the SN revealed 11 involved by metastasis which was statistically significant (p<0.001). Furthermore, 15 (21.7%) of the patients revealed positive results in IHC staining for pan-CK marker and this was also statistically significant (p=0.001). Ten patients had tumoral involvement in lymph nodes harvested from axillary dissection and 4 out of 15 lymph nodes with positive result for CK marker were isolated tumor cells. However, 4 of 10 patients with tumor positive lymph nodes in axillary dissection were negative for CK marker and in contrast 6 of the pan-CK positive SN were in patients with tumor-free axillary lymph nodes. Conclusions: Both IHC and step sectioning improve the detection rate of metastases. Considering the similar power of these two methods, we recommend using either IHC staining or step sectioning for better evaluation of harvested SNs.

• 한국전자파학회논문지
• /
• 제25권4호
• /
• pp.442-450
• /
• 2014

본 논문은 피부를 포함하는 유방 모델에서 정합 액체의 전파 특성에 관한 연구 내용이다. 정합 액체의 분석을 위해 6개 타입의 정합 액체를 제안된 1-D 유방 모델에 적용하여 3~6 GHz의 주파수 대역에서 분석 연구를 수행하였다. 균일한 평면파가 1-D 유방 모델 내부의 복합 매질의 경계면에 입사되어 반사/투과되어 나타나는 전파 특성과 각 정합 액체의 전송 선로 손실을 분석하였다. 본 논문에서 연구한 방법은 유방암 진단 시스템, 인체 조직을 이용한 암 진단 분야 및 기타 의료기기 분야에 활용될 수 있으며, 본 논문에서는 유방암 진단 시스템에 적용하였다. 본 연구는 향후 유방암 진단 시스템에 적용될 적절한 정합 액체를 선정하고, 성능을 분석하는데 유용하게 적용될 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권1호
• /
• pp.227-232
• /
• 2015

Background: Breast cancer is the commonest cancer among Sri Lankan females, accounting for 26% of the cancer incidence in women. Early detection of breast cancer is conducted by public health midwives (PHMs) in the Well Woman Clinics. The aim of the present study was to determine the effectiveness of an educational intervention on improving knowledge, attitudes and practices (KAP) on breast cancer screening among PHMs in the district of Gampaha. Materials and Methods: Two Medical Officer of Health (MOH) areas in Gampaha district were selected using random sampling as intervention (IG) and control (CG) groups. All the PHMs in the two MOH areas participated in the study, with totals of 38 in IG and 47 in CG. They were exposed to an educational intervention with the objective of using them to subsequently conduct the same among 35-59 year women in the community. Following the intervention, post-intervention assessments were conducted at one month and six months to assess the effectiveness of the intervention. Results: The overall median scores for KAP among PHMs respectively were as follows. Pre-intervention: IG:58%(IQR: 53-69%), 90%(IQR: 70-100%) and 62%(IQR: 57-70%). CG: 64%(IQR: 56-69%), 90%(IQR: 70-90%) and 62%( IQR: 50-77%). Post-intervention: one month, IG:96%(IQR: 93-96%), 100%(IQR: 100-100%), and 85%(IQR: 81-89%). CG:67%(IQR: 60- 73%), 90%(IQR: 80-100%) and 65%(IQR: 50-73%). Post-intervention: six months, IG: 93% (IQR: 91-93%), 100%(IQR: 90-100%), and 81%(IQR: 77-89%). CG: 67%(IQR: 58- 71%), 90%(IQR: 90-100%), and 62%( IQR: 58-73%). All the above post-intervention scores of PHMs in the IG were significantly higher in comparison to CG (p<0.001). Conclusions: This planned educational intervention had a significant impact on improving KAP of PHMs for early detection of breast cancer in the Gampaha district.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권3호
• /
• pp.1067-1074
• /
• 2014

In Morocco, breast cancer is the most prevalent cancer in women and a major public health problem. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. It is therefore interesting to establish the genetic and molecular profile of Moroccan patients with breast cancer. In this paper, we will highlight some pertinent hypotheses that may enhance breast cancer care in Moroccan patients. This review will give a precise description of breast cancer in Morocco and propose some new markers for detection and prediction of breast cancer prognosis.