• Korean Journal of Biological Psychiatry
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• v.5 no.1
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• pp.71-82
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• 1998

The neuropsychiatric sequelae of traumatic brain injury are effects on complex aspect of cognition, emotion and behavior. They include problems with attention and arousal, concentration, executive function, intellectual changes, memory inpairments, personality changes, affective disorders, anxiety disorders, psychosis, apathy, aggression, and irritability. There are many useful therapeutic approaches available for people who have been brain injuries. Although a multifactioral, multidisciplinary, collaborative approach to treatment is proposed, for purposes of exposition the author have divided treatment into psychopharmacological, cognitive, behavioral, psychological, and social interventions.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.525-528
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• 1999

Abstract - In this paper, a segmentation method for brain Magnetic Resonance(MR) image using region clustering technique with statistical distribution of gradient image and fuzzy rules is described. The brain MRI consists of gray matter and white matter, cerebrospinal fluid. But due to noise, overlap, vagueness, and various parameters, segmentation of MR image is a very difficult task. We use gradient information rather than intensity directly from the MR images and find appropriate thresholds for region classification using gradient approximation, rayleigh distribution function, region clustering, and merging techniques. And then, we propose the adaptive fuzzy rules in order to extract anatomical structures and diseases from brain MR image data. The experimental results shows that the proposed segmentation algorithm given better performance than traditional segmentation techniques.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.sup1
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• pp.46-52
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• 2009

As the most common nutrition deficiency, iron deficiency not only causes anemia but also influences the central nervous system development. Its pathogenesis is supposed to be the alteration of neurometabolism and neurotransmission in major brain structures, and the disruption of myelination. The first two years after birth is a crucial period for cognitive, behavior, and emotional development with fast brain growth. If iron deficiency occurs in this period, cognitive and psychomotor function cannot be restored in spite of adequate iron supplementation. Thus, iron deficiency in infancy should be considered as a serious disease.

• Journal of Korean Neurosurgical Society
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• v.41 no.6
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• pp.421-424
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• 2007

Two patients, one with glioblastoma multiforme [GM] in the right thalamus and the other with meningioma at the right frontal convexity, had suffered bilateral cortical blindness after transtentorial herniation. On one of those patients, bilateral cortical blindness had occurred due to acute obstructive hydrocephalus caused by GM and on the other patient, cortical blindness had developed after acute hemorrhage from meningioma. Bilateral occipital lobes of those patients showed signal change on the brain magnetic resonance image [MRI]. There were no ophthalmologic abnormalities on fundoscopy and ophthalmologic examination. After recovery of consciousness, cortical blindness was detected in both patients, and during gradual recovery period, visual function was slowly recovered. The pattern of visual evoked potential [VEP] at 7 weeks and 12 weeks after herniation was normalized gradually. Cortical blindness due to herniation was reversible, even though the high signals of bilateral visual cortex still existed on MRI 16 month later in case 2.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.35 no.1
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• pp.51-56
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• 2024

This review explores the complexities of autism spectrum disorder (ASD), primarily focusing on the significant eating challenges faced by children and adolescents with this neurodevelopmental condition. It is common for individuals with ASD to exhibit heightened sensitivity to various sensory aspects of food such as taste, texture, smell, and visual appeal, leading to restricted and less diverse diets. These dietary limitations are believed to contribute to an imbalance in the gut microbiota. This review elaborates on how these eating problems, coupled with the distinctive characteristics of ASD, might be influenced by and, in turn, influence the gut-brain axis, a bidirectional communication system between the gastrointestinal tract and the brain. This discussion aims to shed light on the multifaceted interactions and potential implications of diet, gut health, and neurological development and function in children and adolescents with ASD.

• Journal of Life Science
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• v.26 no.1
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• pp.129-139
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• 2016

Exercise increases the expression and interaction of major neurotrophic factors such as brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) at both central and peripheral tissues, which contributes to improved brain and neural plasticity and cognitive function. Previous findings have been to understand the effect of light or moderate intensity aerobic exercise on neurotrophic factors and cognitive function, not that of high intensity aerobic exercise. However, recent findings suggest that high intensity interval training is a safe, less time-consuming, efficient way to improve cardiorespiratory fitness and weight control, thus American College of Sport Medicine (ACSM)’s guidelines for exercise prescription for various adult populations also recommend the application of high intensity interval training to promote their overall health. High intensity interval training also enhances the expression of BDNF, IGF-1, and VEGF at the brain and peripheral tissues, which improves cognitive function. Increased frequency of intermittent hypoxia and increased usage of lactate as a supplementary metabolic resource at the brain and neural components are considered a putative physiological mechanism by which high intensity interval training improves neurotrophic factors and cognitive function. Therefore, future studies are required to understand how increased hypoxia and lactate usage leads to the improvement of neurotrophic factors and what the related biological mechanisms are. In addition, by comparing with the iso-caloric moderate continuous exercise, the superiority of high intensity interval training on the expression of neurotrophic factors and cognitive function should be demonstrated by associated future studies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.3
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• pp.695-701
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• 2008

This study has been made to research on the brain wave characteristics of baduk expert by BCI(Brain Computer Interface). The test was based on the researches from 1th September, 2005 to 30th December, 2005, compared with the ones of the standardized general public. The number of the general public are 695 (elementary school students 423, middle and high school students 161, adults 111) and the number of the baduk players are 57 (researchstudents 15, Korean baduk club students 16, professional baduk players 26). The research data show that the baduk players have the higher indexes than the general public in Self Regulation quotient p=.002, Attention Quotient(left) p=.002, Emotion Quotient p=.027, Stress Quotient(left) p=.002 and Brain Quotient p=.006. There are some differences in brain functions between baduk players and the ordinary people. Difference in functions of the brain among baduk experts is also analyzed. That result shows that there is no different brain function between professional baduk player.

• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.422-433
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• 2018

Objective: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain function in a bottom-up manner. Here, the changes in the response of the hypothalamic-pituitary-adrenal axis and inflammation-related markers in the brain in colitis were studied. Methods: Dextran sodium sulfate (DSS) was used to generate a mouse model of colitis. Mice were treated with DSS for 3 or 7 days and sacrificed. We analyzed the gene expression of brain-derived neurotrophic factor (BDNF), cyclooxygenase 2 (COX-2), and glial fibrillary acidic protein (GFAP), and the expression of GFAP, in the hippocampus, hypothalamus, and amygdala. Additionally, the levels of C-reactive protein (CRP) and serum cortisol/corticosterone were measured. Results: Alteration of inflammatory-related markers varied depending on the brain region and exposure time. In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS. However, in the hypothalamus, COX-2 mRNA was upregulated only 3 days after treatment. In the amygdala, BDNF and COX-2 mRNAs were downregulated. CRP and corticosterone expression increased with DSS treatment at day 7. Conclusion: IBD could lead to neuroinflammation in a bottom-up manner, and this effect varied according to brain region. Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment. Therefore, early and active intervention is required to prevent psychological and behavioral changes caused by IBD, and region-specific studies can help understand the precise mechanisms by which IBD affects the brain.

• Science of Emotion and Sensibility
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• v.27 no.2
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• pp.105-112
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• 2024

Forward head posture (FHP) is a representative postural deformation problem in people today, causing various physical and mental problems, but the effect of FHP on discomfort or distraction during rest is not well known. Accordingly, this study aims to demonstrate the effect of FHP on these brain functions by analyzing brain wave signals at rest. Thirty-three heavy users of computers participated in this study, and all of them exhibited functional FHP when using computers. All participants performed using both normal posture and FHP, and their brain waves were measured at rest while maintaining each posture for five minutes without stimulation. Brain wave signals were acquired using EEG with 32 channels, and through frequency analysis, changes in delta and beta waves, known to be closely related to discomfort and attention, were compared and analyzed depending on the posture. As a result, FHP showed a significant decrease in delta waves in nine channels compared to the normal posture, and a significant increase in beta waves in 14 channels, showing that FHP does affect brain function at rest. These changes are consistent with those that occur under conditions of psychological discomfort and distraction, and they appear to be because the increased discomfort caused by musculoskeletal changes in the FHP also affects brain activity. These can provide important results showing that posture correction can help improve brain function and psychological state at rest.

• Journal of Korean Neurosurgical Society
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• v.58 no.1
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• pp.22-29
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• 2015

Objective : Perinatal hypoxic-ischemic encephalopathy (HIE) and prolonged febrile seizures (pFS) are common neurologic problems that occur during childhood. However, there is insufficient evidence from experimental studies to conclude that pFS directly induces hippocampal injury. We studied cognitive function and histological changes in a rat model and investigated which among pFS, HIE, or a dual pathologic effect is most detrimental to the health of children. Methods : A rat model of HIE at postnatal day (PD) 7 and a pFS model at PD10 were used. Behavioral and cognitive functions were investigated by means of weekly open field tests from postnatal week (PW) 3 to PW7, and by daily testing with the Morris water maze test at PW8. Pathological changes in the hippocampus were observed in the control, pFS, HIE, and HIE+pFS groups at PW9. Results : The HIE priming group showed a seizure-prone state. The Morris water maze test revealed a decline in cognitive function in the HIE and HIE+pFS groups compared with the pFS and control groups. Additionally, the HIE and HIE+pFS groups showed significant hippocampal neuronal damage, astrogliosis, and volume loss, after maturation. The pFS alone induced minimal hippocampal neuronal damage without astrogliosis or volume loss. Conclusion : Our findings suggest that pFS alone causes no considerable memory or behavioral impairment, or cellular change. In contrast, HIE results in lasting memory impairment and neuronal damage, gliosis, and tissue loss. These findings may contribute to the understanding of the developing brain concerning conditions caused by HIE or pFS.