• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.252-254
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• 2002

A new protocol for dosimetry in external beam radiotherapy is published by the Japan Society of Medical Physics (JSMP) in 2002. The protocol deals with proton and heavy ion beams as well as photon and electron beams, in accordance with IAEA Technical Report Series No. 398. To establish inter-institutional uniformity in proton beam dosimetry, an intercomparison program was carried out with the new protocol. The absorbed doses are measured with different cylindrical ionization chambers in a water phantom at a position of 30-mm residual range for a proton beam, that had range of 155 mm and a spread out Bragg peak (SOBP) of 60-mm width. As a result, the intercomparison showed that the use of the new protocol would improve the +/- 1.0 % (one standard deviation) and 2.7 % (maximum discrepancy) differences in absorbed doses stated by the participating institutions to +/- 0.3% and 0.9 %, respectively. The new protocol will be adopted by all of the participants.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.90-93
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• 2002

In particle radiotherapy, a shape of the beam to conform the irradiation field is statically defined by the compensator, collimator and potal devices at the outside of the patient body. However the target such as lung or liver cancer moves along with respiration. This increases the irradiated volume of normal tissue. Prior discussions about organ motions along with respiration have been mainly focused on inferior-superior movement that was usually perpendicular to beam axis. On the other hand, the change of the target depth along the beam axis is very important especially in particle radiotherapy, because the range end of beam (Bragg peak) is so sharp as to be matched to distal edge of the target. In treatment planning, the range of the particle beam inside the body is calculated using a calibration curve relating CT number and water equivalent path length (WEL) to correct the inhomogeneities of tissues. The variation in CT number along the beam path would cause the uncertainties of range calculation at treatment planning for particle radiotherapy. To estimate the uncertainties of the range calculation associated with patient breathing, we proposed the method using sequential CT images with respiration waveform, and analyzed organ motions and WELs at patients that had lung or liver cancer. The variation of the depth along the beam path was presented in WEL rather than geometrical length. In analyzed cases, WELs around the diaphragm were remarkably changed depending on the respiration, and the magnitude of these WEL variations was almost comparable to inferior-superior movement of diaphragm. The variation of WEL around the lung was influenced by heartbeat.

• 생명과학회지
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• 제17권8호통권88호
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• pp.1100-1103
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• 2007

합성항산화제 3종과 17종의 식물 추출물을 이용하여 양성자 빔을 1,000, 5,000, 10,000 Gray 수준으로 처리하여 에너지양에 따른 항산화 활성에 미치는 영향을 탐색 하고자 DPPH radical 소거능 과 ABTS cation radical 소거능의 활성에 대하여 조사하였다. 이중 6종류의 시료는 양성자 빔을 조사한 결과 활성이 감소하였으며, 2종류의 시료는 활성변화가 없었으며, 12종류의 시료는 활성이 증가하였다. DPPH radical 소거 효과는 1,000 Gray 에서 마황은 60%, 괄루인은 5,000 Gray 에서 77.8%로 활성이 증가하는 경향을 나타내었다. ABTS cation radical 소거효과에서 토천궁은 1,000 Gray의 양성자 빔을 조사한 결과 38.5% 활성이 감소하였으며, 합성 항산화제는 활성변화가 거의 없으나, 뼝쑥 추출물은 5,000 Gray에서 $IC_{50}$값이 2.4 ${\mu}g/ml$로 BHT의 $IC_{50}$값 2.3 ${\mu}g/ml$과 유사하였다.

• 전자공학회논문지D
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• 제35D권12호
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• pp.83-91
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• 1998

광섬유 코어로 입사된 빛이 임의의 경사 각도를 가지는 광섬유 브래그 격자를 만나면 광섬유 코어로 반사되는 주모드 외에 클래딩으로 결합되는 사이드모드가 발생한다. 이러한 사이드 모드는 클래딩 모드와 커플링 되어 특정 파장의 빛을 제거하여 없애는 장주기 광섬유 격자와 동일한 특성을 지닌다. 본 논문에서는 게르마늄이 많이 첨가된 depressed index type 광섬유와 수소처리를 하여 광민감성을 매우 높인 step index type 일반통신용 광섬유등 두 가지 광섬유에 대해 광섬유 브래그 격자의 정렬 각도에 따른 사이드 모드의 특성을 관찰하였다. 또한, 0.02°의 정밀도를 가진 회전판에 설치된 위상 마스크로 경사각도가 다른 각각의 광섬유 격자를 동일한 광섬유에 일렬로 새겨서 전체 손실 스펙트럼의 선폭과 피크값을 조절할 수 있었으며, 이를 이용하여 광섬유 광 증폭기의 ASE 대역 제거 필터 구성 실험을 수행하였다.

• 전기화학회지
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• 제14권1호
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• pp.9-15
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• 2011

The composite membranes comprising of sulfonated polymers as matrix and ionic liquids as ion-conducting medium in replacement of water are studied to investigate the effect of annealing of the sulfonated polymers. The polymeric membranes are prepared on recast Nafion containing the ionic liquid, 1-ethyl-3-methylimidazolium tetrafluoroborate ($EMIBF_4$). The composite membranes are characterized by thermogravitational analyses, ion conductivity and small-angle X-ray scattering. The composite membranes annealed at $190^{\circ}C$ for 2 h after the fixed drying step showed better ionic conductivity, but no significant increase in thermal stability. The mean Bragg distance between the ionic clusters, which is reflected in the position of the ionomer peak (small-angle scattering maximum), is larger in the annealed composite membranes containing $EMIBF_4$ than the non-annealed ones. It might have been explained to be due to the different level of ion-clustering ability of the hydrophilic parts (i.e., sulfonic acid groups) in the non- and annealed polymer matrix. In addition, the ionic conductivity of the membranes shows higher for the annealed composite membranes containing $EMIBF_4$. It can be concluded that the annealing of the composite membranes containing ionic liquids due to an increase in ion-clustering ability is able to bring about the enhancement of ionic conductivity suitable for potential use in proton exchange membrane fuel cells (PEMFCs) at medium temperatures ($150-200^{\circ}C$) in the absence of external humidification.

• 대한방사선기술학회지:방사선기술과학
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• 제40권4호
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• pp.621-626
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• 2017

본 논문에서는 방사선치료 시 용적 선량 평가에 응용할 수 있는 광 도시메트리 시스템을 구축하고 100 MeV 고선속 양성자 빔에 대한 특성 평가를 수행하였다. 광 도시메트리 시스템은 액체 유기 섬광체와 카메라 렌즈, 고감도 저잡음 화상(complementary metal-oxide-semiconductor; CMOS) 카메라로 구성되며, 2 m 거리에 영상의 화각(field of view; FOV)이 15 cm가 되도록 설계 및 제작하였다. 구축된 광 도시메트리 시스템은 100 MeV 양성자 빔에 대하여 1~40 Gy 선량 범위에서 선량-출력의 직선성을 확인하였으며, 심부선량백분율 데이터와 등선량 곡선을 획득하였다. 본 연구에서는 용매의 인체조직등가성에 제한점이 있지만 광 도시메트리 절차를 확립하였으며, 새로운 용적 선량 평가법의 제안으로 그 의미가 있다.

• Smart Structures and Systems
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• 제18권3호
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• pp.405-423
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• 2016

In this study, the feasibility of using telecommunication single-mode optical fiber (SMF) as a distributed fiber optic strain and crack sensor was evaluated in concrete pavement monitoring. Tensile tests on various sensors indicated that the $SMF-28e^+$ fiber revealed linear elastic behavior to rupture at approximately 26 N load and 2.6% strain. Six full-scale concrete panels were prepared and tested under truck and three-point loads to quantify the performance of sensors with pulse pre-pump Brillouin optical time domain analysis (PPP-BOTDA). The sensors were protected by precast mortar from brutal action during concrete casting. Once air-cured for 2 hours after initial setting, half a mortar cylinder of 12 mm in diameter ensured that the protected sensors remained functional during and after concrete casting. The strains measured from PPP-BOTDA with a sensitivity coefficient of $5.43{\times}10^{-5}GHz/{\mu}{\varepsilon}$ were validated locally by commercial fiber Bragg grating (FBG) sensors. Unlike the point FBG sensors, the distributed PPP-BOTDA sensors can be utilized to effectively locate multiple cracks. Depending on their layout, the distributed sensors can provide one- or two-dimensional strain fields in pavement panels. The width of both micro and major cracks can be linearly related to the peak strain directly measured with the distributed fiber optic sensor.

• Advances in nano research
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• 제7권4호
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• pp.233-240
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• 2019

The present research work reports in-vitro anti-cancer activity of biologically synthesized ZnO nanoparticles (ZnO NPs) against human carcinoma cells viz SCC-40, SK-MEL-2 and SCC-29B using Sulforhodamine-B (SRB) Assay. ZnO NPs were synthesized by a unique and novel biological route using Temperature-gradient phenomenon where the extract of combination of Catharanthus roseus (L.) G. Don (C. roseus), Azadirachta indica (A. indica), Ficus religiosa (F. religiosa) and NaOH solution were used as synthesis medium. The morphology of the ZnO NPs was characterized by Transmission Electron Microscopy (TEM). TEM images reveal that particle size of the samples reduces from 76 nm to 53 nm with the increase in reaction temperature and 68 nm to 38 nm with the increase in molar concentration of NaOH respectively. XRD study confirms the presence of elements and reduction in crystallite size with increase in reaction temperature and NaOH concentration. The diffraction peaks show broadening and a slight shift towards lower Bragg angle ($2{\theta}$) which represents the reduction in crystallite size as well as presence of uniform strain. The FTIR spectra of the extract show transmittance peak fingerprint of Zn-O bond and presence of bioactive molecules These NPs exhibit inhibition greater than 50% for SCC-40, SK-MEL-2 and SCC-29B cell lines and more than 50% cell kill for SCC-29B cells at concentrations < $80{\mu}g/ml$. Nanoparticles with smallest size have shown better anti-cancer activity and peculiar cell-selectivity. The combination of extracts of these plants with ZnO NPs can be used in targeted drug delivery as an effective anti-cancer agent, a potential application in cancer treatment.

• 한국의학물리학회지:의학물리
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• 제33권4호
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• pp.108-113
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• 2022

Purpose: Proton therapy has been used for optimal cancer treatment by adapting its Bragg-peak characteristics. Recently, a tissue-sparing effect was introduced in ultrahigh-dose-rate (FLASH) radiation; the high-energy transmission proton beam is considered in proton FLASH therapy. In measuring high-energy/ultrahigh-dose-rate proton beam, Faraday Cup is considered as a dose-rate-independent measurement device, which has been widely studied. In this paper, the feasibility of the simply designed Faraday Cup (Poor Man's Faraday Cup, PMFC) for transmission proton FLASH therapy is investigated. Methods: In general, Faraday cups were used in the measurement of charged particles. The simply designed Faraday Cup and Advanced Markus ion chamber were used for high-energy proton beam measurement in this study. Results: The PMFC shows an acceptable performance, including accuracy in general dosimetric tests. The PMFC has a linear response to the dose and dose rate. The proton fluence was decreased with the increase of depth until the depth was near the proton beam range. Regarding secondary particles backscatter from PMFC, the effect was negligible. Conclusions: In this study, we performed an experiment to investigate the feasibility of PMFC for measuring high-energy proton beams. The PMFC can be used as a beam stopper and secondary monitoring system for transmission proton beam FLASH therapy.

• 한국의학물리학회지:의학물리
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• 제33권4호
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• pp.80-87
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• 2022

Purpose: Proton therapy has different relative biological effectiveness (RBE) compared with X-ray treatment, which is the standard in radiation therapy, and the fixed RBE value of 1.1 is widely used. However, RBE depends on a charged particle's linear energy transfer (LET); therefore, measuring LET is important. We have developed a LET measurement method using the inefficiency characteristic of an EBT3 film on a proton beam's Bragg peak (BP) region. Methods: A Gafchromic EBT3 film was used to measure the proton beam LET. It measured the dose at a 10-cm pristine BP proton beam in water to determine the quenching factor of the EBT3 film as a reference beam condition. Monte Carlo (MC) calculations of dose-averaged LET (LET_d) were used to determine the quenching factor and validation. The dose-averaged LETs at the 12-, 16-, and 20-cm pristine BP proton beam in water were calculated with the quenching factor. Results: Using the passive scattering proton beam nozzle of the National Cancer Center in Korea, the LET_d was measured for each beam range. The quenching factor was determined to be 26.15 with 0.3% uncertainty under the reference beam condition. The dose-averaged LETs were measured for each test beam condition. Conclusions: We developed a method for measuring the proton beam LET using an EBT3 film. This study showed that the magnitude of the quenching effect can be estimated using only one beam range, and the quenching factor determined under the reference condition can be applied to any therapeutic proton beam range.