• Title/Summary/Keyword: Bora

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Role of Liquid Biopsies in Colorectal Cancer (대장암에서 액체 생검의 역할)

  • Kim, Sang Hyun;Keum, Bora
    • Journal of Digestive Cancer Reports
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    • v.8 no.1
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    • pp.56-60
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    • 2020
  • In recent years, liquid biopsy has received immense attention. Liquid biopsy is a minimally invasive method used for obtaining biological fluids including urine, pleural fluid and, mostly, peripheral blood. Liquid biopsy involves various targets including circulating tumors cells (CTCs), circulating cell-free tumor DNA (ctDNA), and microRNA (miRNA). Colorectal cancer (CRC), like other solid tumors, shed tumor cells into the bloodstream. Analysis of these CTCs, as well as ctDNA is the primary objective of the liquid biopsy. Evaluation of CTC or ctDNA offers information about early tumor release, development of tumor metastasis and also about mechanisms involved in tumor resistance to treatment.

Parallelized Particle Swarm Optimization with GPU for Real-Time Ballistic Target Tracking (실시간 탄도 궤적 목표물 추적을 위한 GPU 기반 병렬적 입자군집최적화 기법)

  • Yunho, Han;Heoncheol, Lee;Hyeokhoon, Gwon;Wonseok, Choi;Bora, Jeong
    • IEMEK Journal of Embedded Systems and Applications
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    • v.17 no.6
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    • pp.355-365
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    • 2022
  • This paper addresses the problem of real-time tracking a high-speed ballistic target. Particle filters can be considered to overcome the nonlinearity in motion and measurement models in the ballistic target. However, it is difficult to apply particle filters to real-time systems because particle filters generally require much computation time. This paper proposes an accelerated particle filter using graphics processing unit (GPU) for real-time ballistic target tracking. The real-time performance of the proposed method was tested and analyzed on a widely-used embedded system. The comparison results with the conventional particle filter on CPU (central processing unit) showed that the proposed method improved the real-time performance by reducing computation time significantly.

Three Unreported Fungi Isolated From Reservoirs in Korea: Mortierella biramosa, Paraphoma radicina, and Sordaria macrospora

  • Bora Nam;Hyang Burm Lee;Young-Joon Choi
    • The Korean Journal of Mycology
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    • v.50 no.2
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    • pp.103-113
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    • 2022
  • Freshwater ecosystems have a large reserve of latent biological resources that play an essential ecological role, and have significant economic and social value. Fungi in freshwater are prospective materials that can be used in the food, medicine, and biomass energy fields. In this study, three promising fungal species were isolated from freshwater ecosystems in Korea. These isolates were identified as Mortierella biramosa, Paraphoma radicina, and Sordaria macrospora, based on their cultural and morphological characteristics, as well as molecular phylogenetic analyses. These species were previously unknown in Korea. The finding allows us to explore its physiological and biochemical characteristics in more detail and use them as biological resources.

Clinical Management of Gastric Neuroendocrine Tumors

  • In Kyung Yoo;Bora Keum
    • Journal of Digestive Cancer Research
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    • v.3 no.1
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    • pp.21-25
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    • 2015
  • Gastric neuroendocrine tumors (GNETs, also known as gastric carcinoids) are rare form of hormone-secreting neoplasms that present with varied clinical syndromes. There are four types of GNETs based on size, proliferation, localization, differentiation, and hormone production. Type I GNET is related to autoimmune atrophic gastritis and hypergastrinemia. Type II GNETs are related to multiple endocrine neoplasia (MEN)-1, Zollinger-Ellison syndrome and hypergastrinemia. Type 3 GNETs are not associated with any background pathology, and type 4 GNETs are poorly differentiated tumors. The most useful diagnostic and prognostic marker for gastrointestinal NETs is plasma chromogranin A (CgA) levels. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. For optimal management, the type, biology, and stage of the tumor must be considered. Here, we provide a comprehensive and up-to-date review of GNETs.

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Role of Innate Immunity in Colorectal Cancer

  • Bora Keum
    • Journal of Digestive Cancer Research
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    • v.6 no.1
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    • pp.11-15
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    • 2018
  • Chemotherapy and surgical resection are the mainstay of cancer treatment. Particularly for chemotherapy, although it is effective method to care, sometimes cure various cancers, there are many different status of cancer not being controlled by chemotherapy such as recurrence and resistance to chemotherapy. In order to overcome those difficulties during cancer therapy, immunotherapy targeting immune cells and immune associated factors to enhance cancer immunity has been highlighted. Innate immunity plays important roles on initial stage of cancer immunity that are detecting, killing cancer cells and initiating adaptive immunity for cancer. So many basic and clinical studies to manage innate immunity for cancer therapy have been going on, and most of them were to stimulate innate immune cells including dendritic cell, macrophage, monocyte, and natural killer cell in various ways. They showed promising results but still there are many things to be resolved before clinical application. Herein, I review the role of innate immune cells and therapeutic trials for colorectal cancer.

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New Record of a Hepialid Moth Species, Korscheltellus lupulina (Lepidoptera: Hepialidae) from Korea

  • Jae-Young Lee;Bora Shin;Sung-Soo Kim;Sei-Woong Choi
    • Animal Systematics, Evolution and Diversity
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    • v.39 no.4
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    • pp.322-324
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    • 2023
  • The hepialid species, Korscheltellus lupulina (Linnaeus) is newly recorded from Korea. A female specimen of K. lupulina was collected on Jeju Island, southern Korea. This species can be distinguished by the whitish linear marking on the postmedian and dorsum of the forewing but these markings are often unseen in females. The female genitalia can be diagnosed by the semi-rounded ninth abdominal tergum, a pair of semi-rounded ninth abdominal sternum with weakly produced, semi-rounded central plate-shaped medial region, a pair of narrow band-shaped subanal plates, the short, thin ductus bursae, and the large, ball-shaped corpus bursae without a signum. Currently, there are four genera and five species of the Hepialidae distributed in Korea.

Morphology, Molecular Phylogeny, and Fungicide Sensitivity of Phytophthora nagaii and P. tentaculata in Korea

  • Seung Hyun Lee;Bora Nam;Dong Jae Lee;Young-Joon Choi
    • Mycobiology
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    • v.51 no.5
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    • pp.333-342
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    • 2023
  • Phytophthora species, classified under Oomycota, cause significant damage to various crops and trees. The present study introduced Phytophthora species, P. nagaii and P. tentaculata, new to Korea, which pose notable risks to their respective host plants. Our research provided a comprehensive description of these species taking into account their cultural features, morphological characteristics, and molecular phylogenetic analysis using the internal transcribed spacer rDNA region and cytochrome c oxidase subunit mtDNA genes (cox1 and cox2) sequences. In addition, this study first evaluated the sensitivity of P. nagaii and P. tentaculata to five anti-oomycete fungicides, finding both species most responsive to picarbutrazox and P. tentaculata resistant to fluazinam. The data can guide targeted treatment strategies and offer insights into effective control methods. The findings expand our understanding of the diversity, distribution, and management of Phytophthora species in Korea.

A New Record of Epipleminae (Lepidoptera, Uraniidae) from Korea

  • Sei-Woong Choi;Bora Shin;Jae-Young Lee;Sung-Soo Kim
    • Animal Systematics, Evolution and Diversity
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    • v.40 no.1
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    • pp.112-114
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    • 2024
  • We report one newly recorded species Warreniplema fumicosta (Warren) for the first time in Korea. In July, a single female specimen of Warreniplema fumicosta was collected at a high altitude on Mount Jirisan. This species can be distinguished by the light blackish forewing with the largely undulating ante- and postmedial lines, and the bicolorous hindwing with yellowish upper half dark brown lower half, and dark brown ante- and postmedial lines. So far, there have been 13 species belonging to seven genera of the Epipleminae subfamily that have been documented, and this includes W. fumicosta.

Notes on the Ahlbergia (Lepidoptera, Lycaenidae, Theclinae) from Korea, with Two Newly Recorded Species

  • Sung-Soo Kim;Jung-Dal Sohn;Young Joon Lee;Sang-Kyu Sohn;Bora Shin;Sei-Woong Choi
    • Animal Systematics, Evolution and Diversity
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    • v.40 no.1
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    • pp.94-101
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    • 2024
  • Four species of green hairstreak butterflies, namely Ahlbergia ferrea, A. tricaudata, A. frivaldszkyi, and A. leei, belonging to the genus Ahlbergia Bryk, 1946 (Papilionidea: Lycaenidae), are examined in Korea. It was discovered that Ahlbergia frivaldszkyi, which was previously incorrectly reported in Korea, is actually A. leei. We report two species, A. frivaldszkyi and A. tricaudata as new additions to the Korean fauna. Detailed diagnoses of these four species are provided, including descriptions of both male and female genitalia, along with a key for identifying the four species found in Korea.

The development of highly functional paints improving NIR reflectance by investigating silica particles size for pigment mixing (안료배합용 실리카 입자사이즈에 따른 근적외선 반사율을 향상시킨 고기능성 도료 제조)

  • Eunseok Woo;Yunseok Noh;Jinho Lee;Yong-Wook Choi;Bora Kim
    • Journal of the Korean institute of surface engineering
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    • v.57 no.2
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    • pp.98-104
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    • 2024
  • In order to overcome the urban heat island effect, highly functional paint is attracting attention as a promising means by shielding heat on the structure (building) surface. When a paint was prepared containing nano-sized silica particles, the heat-insulating performance was relatively higher than that of paints with other sizes. In addition, developed paints showed enhanced properties such as chemical resistance and abrasion resistance test because of the presence of nano-sized silica included in functional paint.