• 한국의학물리학회지:의학물리
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• 제17권2호
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• pp.105-113
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• 2006

본 연구는 전산치료선량계획장치에서 중첩(Superposition)법을 사용해 비균질성 조직층을 통한 교정선량을 확인하기 위해 수행되었다. 조직등가물질로는 폐조직으로 콜크($\rho=0.2\;g/cc$)를, 근조직에는 n-Glucose, 골조직에는 $K2HPO4$를 사용한 시료의 전자밀도를 구하였으며, CT영상은 110 KVp와 130 KVp X선을 주사해서 얻고 CT번호(H)와 전자밀도의 함수관계를 조사하였다. 물에 대한 전자밀도비는 컴퓨터선량계획에 중요한 변수이므로 CT번호에 대응된 전자밀도비를 입력하고, 선량확인을 위해 펜텀 구성은 폴리스탈린 고체 펜텀 사이에 5.0 cm 층의 시료를 삽입하고 깊이 12.0 cm와 20.0 cm의 조직 선량을 구하여 실측과 비교하였다. 실험결과 CT번호-전자밀도비는 광전효과 현상에 영향을 크게 받게 되어 원자번호가 높은 재질에서 비선형적으로 나타났으며, 130 KVp에서 근조직에는 0.001026H+1.00을, 골조직에는 0.000304H+1.07을 얻었다. 균질 근조직에서 컴퓨터선량과 실측선량을 비교한 결과 중첩법과 FFT 콘볼루션(convolution) 법에서 6, 15 MV X선 모두 1.0% 오차 범위내에 있었으며, 폐조직층 통과한 경우 중첩법은 6 MV X선에서 평균 -1.2%, 골조직에는 평균 -2.9%를 보였고, 15 MV X선에서 2.7%와 2.2%를 얻었으며, FFT콘볼루션법은 6 MV X선에서 폐조직 2.8%, 골조직 -5.0%를 보였고, 15MV X선에서는 각각 6.0%, 0.2%를 보여 중첩법에 의한 치료계획선량이 신뢰성이 있음을 확인하였다. 본 실험을 통해 저자들은 각 임상기관에서 사용하고 있는 CT는 일정하지 않고 교정이 필요한 장비이므로, 발전된 치료계획시스템에 적용하고 있는 CT번호-전자밀도비에 대한 정기적인 확인이 필요하며, FFT 콘볼루션법에 비해 빔의 확산방향에 일치된 커널빔을 사용한 중첩법에서 오차가 적음을 확인하였다.

• Tuberculosis and Respiratory Diseases
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• 제72권3호
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• pp.310-317
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• 2012

Background: Airway obstruction and the extent of emphysema are reported to be responsible for reduced bone mineral density (BMD). Corresponding to different phenotypes of a pulmonary disease, different severity in extra pulmonary features may exist. We compared BMDs of subjects with or without airway obstruction and/or emphysema and investigated the relationships among BMD, the severity of airway obstruction, and the extent of emphysema. Methods: Using a university hospital database, we reviewed patients over 40 years old who performed spirometry, computed tomography of chest, and measurement of BMD of the lumbar (L) spine. According to the presence or absence of airway obstruction and/or emphysema, four groups were classified. Results: Among a total of 59 subjects, 33 (56%) had osteoporosis. The prevalence of osteoporosis in subjects with no airway obstruction and no emphysema, those with only emphysema, those with only airway obstruction, and those with both airway obstruction and emphysema were 42%, 57%, 64%, and 73%, respectively (p=0.047 by linear-by-linear association). The mean T-scores of BMD of L1 (p=0.032) and L1-4 spines were different among the four groups (p=0.034). Although the T-score of L1 BMD negatively correlated with the extent of emphysema (r=-0.275, p=0.035) and positively with each of body mass index (BMI) (r=0.520, p<0.001), forced expiratory volume in one second ($FEV_1$) (r=0.330, p=0.011), $FEV_1$/forced vital capacity (r=0.409, p=0.001), and forced expiratory flow at 25~75% of FVC ($FEF_{25-75%}$) (r=0.438, p=0.0001), respectively, multiple linear regression analysis indicated that BMI (p<0.001) and $FEF_{25-75%}$ were predictive of BMD (p=0.012). Conclusion: Low BMI and airway obstruction were strongly associated with reduced bone density rather than the extent of emphysema.

• 대한가정학회지
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• 제43권12호
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• pp.61-78
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• 2005

This study was peformed to assess the relationships among bone mineral density(BMD), nutrient intake and lifestyle factors in postmenopausal women. A trained nutritionist examined the interviewed usual dietary intake and physical activity of 85 subjects in Chungnam with a questionnaire interview, and BMDs of the lumbar spines($L_2-L_4$), femoral necks(FN), ward's triangles(WT) and trochanters(TR) were measured by dual energy X-ray absorptiometry (DEXA). The BMDs(T-score) of $L_2-L_4$, FN, and WT were $0.996g/cm^2(-1.601),\;0.697g/cm^2(-1.697)$, and $0.793g/cm^2(-1.512)$, respectively, which were assessed as osteopenia by T-score,. and TR was normal at $0.718g/cm^2(-0.675)$. Subjects included 85 in Chungnam were divided into three groups according to the BMD measurement of the $L_2-L_4$ and FN assessed by T-score. The percentages of the osteoporosis, osteopenia, and normal groups were $32.9\%,\;42.4\%$ and $24.7\%$ respectively. The average age was significantly the highest of the osteoporosis group than in the other two osteopenia or normal groups(P<0.001). Among lifestyle factors, the BMD of lifestyles was significantly related with exercise but it was not significant with medication., salt. intake, bone fracture, coffee consumption, drinking and smoking. The nutrient intake of the subjects was most nutrient intake adequate to the Korean RDA level for most nutrients excepting energy intakes and calcium. The BMD of lumbar spines $L_2-L_4$ showed significant positive association with the intake of most nutrients except carbohydrate, especially in the normal group. The Higher BMD levels were found for those with high intake of protein and vitamin B1. The BMDs of $L_2-L_4$, and FN were positively correlated with showed energy expenditure, exercise, miscellaneous activity, per weekend and week(P<0.05) in normal group but that was showed negatively correlated in the osteopenia group. Therefore, this study confirmed that one of the most effective ways to minimize bone less in postmenopausal women is to maintain an adequate intake of calcium and other nutrients and regular physical activity.

• 대한지역사회영양학회지
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• 제13권4호
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• pp.489-498
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• 2008

This study was carried out to identify bone mineral density(BMD), body composition, lifestyle and dietary habits of young women by physical measurement and questionnaires. The study subjects, 190 young women living in Seoul, were divided into three age groups: $20{\sim}24$ years(93), $25{\sim}29$ years(44) and $30{\sim}39$ years(53). There was no significant difference in mean body muscle mass, protein, mineral, body fat and BMI among the three age groups. The rate of low weight(18%) in 20 years group was higher that of the 30 years(11.3%). The mean BMD and T-score were $0.44g/cm^2$ and -0.66. BMD and T-score of the forearm bone were significantly higher in the $30{\sim}39$ years group. But BMD and T-score of calcanues were not significantly different among the three age groups. The rate of normal, osteopenia and osteoporosis subjects by BMD were 60.5%, 38.4%, 1.1%, respectively. The rate of osteopenia in $20{\sim}24$ years group was significantly higher than the other age groups. The rate of meal irregularity was significantly higher in $20{\sim}24$ years group. The rate of women who walk and are exposed to sunlight more than 1hr per day were significantly higher in $20{\sim}24$ years group than the others. However, the score of food behaviors is significantly higher(bad) in $20{\sim}24$ years group than the others. The relationship between BMD and frequency of food intake showed significant differences in beans, broom, seaweed and rice wine. In conclusion, the risk rate of BMD was very high, 40% of the subjects, and the risk rate of BMD was higher in 20 years group than 30 years group, and the rate of low weight in 20 years group was higher than in 30 years group. The food habits and behaviors were not healthy enough. Therefore, nutrition education is needed for bone health.

• Journal of Yeungnam Medical Science
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• 제37권1호
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• pp.40-46
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• 2020

Background: Postoperative pain occurring after hip arthroplasty has become common since the expanded use of cementless femoral stems. The characteristic pain develop in the anterolateral thigh area. This study aimed to predict anterior thigh pain based on the measurements of postoperative anteroposterior (AP) and lateral (Lat) radiographs of the hip joint. Methods: The present study included 26 patients (29 hips) who underwent total hip replacement or bipolar hemiarthroplasty between March 2010 and May 2016, whose complete clinical information was available. AP and Lat radiographs of the affected hip were taken on the day of surgery and 1 and 6 months postoperatively. Patients with improper radiographs were excluded. The distance from the femoral stem to the nearest cortical bone in the distal region of the stem was measured. The patient group with a visual analog scale (VAS) score of ≥6 points was designated as patients with anterior thigh pain. Results: Sex, age, weight, height, body mass index, and bone mineral density in the lumbar spine and femur did not have a significant effect on postoperative VAS scores (p>0.05). Presence of contact between the femoral stem and cortical bone was associated with postoperative anterior thigh pain. Conclusion: Hip AP and Lat radiographs are usually taken to confirm fixation and alignment of the femoral stem after hip arthroplasty. The measurement method introduced in this study can be utilized for predicting anterior thigh pain after hip arthroplasty.

• 대한방사선기술학회지:방사선기술과학
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• 제22권2호
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• pp.41-46
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• 1999

Osteoporosis, which causes mainly fracture of the spine, proximal femur and distal radius by minimal trauma, is a major public health problem and its prevalence is steadily increasing in Korea according to the development of public health care. There are reliable methods for diagnosis based on bone densitometry. Early detection and intervention are important for reducing the incidence of fractures. A consensus definition of osteoporosis, based on bone density measurement, has been developed by the World Health Organization(WHO). In this study, bone mineral density(RMD) was measured by dual energy x-ray absorptiometry(DEXA) at the proximal femur and lumbar spine in 132 post-menopausal women. The purpose of this study is to find influential factors on the BMD of the proximal femur and the lumbar spine and to analyze correlation between BMD and the problematic factors. We obtained the following results : 1. Mean BMD score, T-score and Z-score of the proximal femur were $0.81(g/cm^2)$, -2.45(S.D.) and -2.09(S.D.) respectively and in the lumbar spine were $0.83(g/cm^2)$, -2.02(S.D.), -2.43(S.D.) respectively. 2. In correlation analysis between BMD and many factors, correlation coefficients were -0.467, 0.212, -0.321 and 0.241 in age, height, duration after menopause respectively. BMI and the residuals were comparatively small. 3. Correlation coefficients to age matched BMD, in height and body weight were 0.222 and 0.241, in age and duration after menopause were -0.268, -0.282. 4. The fracture threshold of proximal femur BMD to the 90th percentile was $0.845(g/cm^2)$. 5. At the result of multiple regression analysis, age, body weight, $BMI(kg/m^2)$ and duration after menopause described as significant variables.

• 한국식품영양과학회지
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• 제37권7호
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• pp.869-878
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• 2008

최대골질량에 근접할 수 있는 20대 여성들의 골격건강 상태는 중년기 이후 급증하는 골절이나 골다공증 발병과 밀접한 관련이 있다. 본 연구는 골격계질환 예방을 위하여 청년층의 식사지침 설정에 필요한 기초자료를 얻고자, 20대 여대생들의 골밀도를 측정하여 정상군과 골질환군으로 분류한 후, 신체계측과 식사섭취 상태 등을 조사 비교하고, 골밀도와 관련된 제 요인들을 분석하였다. 대상자들의 골밀도는 WHO에서 분류한 T-score값에 따라 정상군 59명($-0.42{\pm}0.45$), 골감소증군(골다공증 2명+골감소증 41명, $-1.52{\pm}0.41$) 43명이었으며, 골다공증과 골감소증을 나타낸 대상자는 전체 대상자의 약 42%로 나타났다. 평균 연령은 21.43세, 신장, 체중 및 체질량지수(BMI)는 각각 $161.25{\pm}4.77\;cm$, $56.05{\pm}9.20\;kg$과 21.5($kg/m^2$)이었으며 전체 대상자 중 60명(58.8%)만이 정상체중군에 속하였고 골감소증군에서 저체중자의 비율이 높게 나타났다. 정상군과 골감소증군의 신체계측치를 비교했을 때, 체중, 체단백질(protein mass), 무기질(mineral mass), 골격근량(skeletal muscle mass), 제지방량(fat free mass) 및 체수분(total body water) 함량 등이 골감소증군에서 유의적으로(p<0.05) 낮게 나타났다. 영양소 섭취 상태를 분석한 결과에서는 한국인영양섭취기준(KDRIs)의 75% 이하로 섭취하고 있는 영양소에는 비타민 C(73%), 엽산(49%), 칼슘(66%)과 칼륨(45%) 등이었고, 영양섭취기준에 비해 높게 섭취하고 있는 영양소에는 단백질(136%), 비타민B6(120%), 인(122%) 및 나트륨(충분섭취량의 256%) 등이었다. 체중 1 kg당 영양소섭취량을 분석 비교한 결과에서는 두 군간 유의적인 차이는 나타나지 않았으나, 정상군에 비해 골감소증군에서 에너지섭취량이 다소 높았고, 칼슘은 섭취량자체는 많았지만 동물성칼슘의 비율이 낮게 나타났고, 마그네슘(Mg)의 섭취량도 적게 나타났다. 식품군별 섭취량과 섭취빈도를 분석한 결과에서는, 정상군과 골질환군에서 섭취량에는 유의적인 차이가 없었으나 우유와 유제품의 섭취빈도가 골감소증군에서 다소 낮게 나타났다. Tscore와 관련성을 보인 신체계측지수는 체중(p<0.01), PIBW(p<0.05), 신장(p<0.01), 체단백질(p<0.001), 체지방량(plt;0.05), 무기질(p<0.001), 체수분(p<0.001), 근육량(p<0.001), 제지방량(p<0.001), BMI(p<0.05), 골격근량(p<0.001), 허리둘레(plt;0.05) 및 엉덩이둘레(plt;0.05) 등이었으며, 체중 1 kg당 영양소섭취량과의 관련성에서는 에너지, 단백질, 지질, 당질, 인, 나트륨 및 칼륨이 유의적으로($p<0.05{\sim}p<0.01$) 음(-)의 관련성을 나타내었고, 섭취빈도와의 관련성에서는 우유 및 유제품의 섭취빈도는 양(+)의, 버섯류의 섭취빈도는 음(-)의 유의적인(p<0.05) 관련성을 보였다. 이상의 결과에서 최대의 골질량에 근접해야하는 20대 여대생의 골격건강상태는 약 42%의 대상자가 골감소증군으로 나타나, 중년층의 골질환 발병율과 거의 같은 수준을 보였다. 따라서 이에 대한 예방대책이 조속히 이루어져야 할 것으로 생각된다. 골격건강 상태에 영향을 주는 요인으로는 적정 체중유지가 중요한데, 전체 대상자의 약 59%만이 적정체중 범위에 있었고, 골감소증군에서 저체중자의 비율이 높게 나타나 건강체중유지에 대한 교육도 강조되어져야 할 것이다. 식사관련요인에서는 각 영양소의 섭취량 자체도 중요하지만 특히 칼슘, 인, 나트륨, 칼륨 및 마그네슘등의 경우 각 영양소 상호간의 섭취 비율이 골격건강에 더 많은 영향을 주는 것으로 사료된다. 취약한 칼슘섭취상태를 보완하기 위한 주요 급원식품으로는, 우유와 유제품의 공급이 우선시되어야 함을 확인할 수 있었다.

• 대한본초학회지
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• 제39권3호
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• pp.85-95
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• 2024

Objectives : We proposed the hypothesis that administering Trigonella foenum-graecum seed extract (TSE) could alleviate menopausal symptoms and osteoporosis resulting from estrogen deficiency. Methods : Ovariectomized (OVX) rats were administered TSE at doses of 300 or 600 mg/kg body weight for 8 weeks, followed by measurement of serum lipid profile and serum bone markers using ELISA kits. Additionally, analysis of related genes in the femur and uterus was performed using Western blot and real-time PCR. Additionally, micro-CT analysis was performed to investigate the protective effect of TSE against bone loss due to oophorectomy. Results : The administration of TSE led to significant reductions in triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, and glucose levels in the serum of OVX rats. Furthermore, TSE increased estradiol levels in the serum and notably improved the levels of biochemical markers associated with bone metabolism. Additionally, TSE exerted significant regulatory effects on the mRNA levels of alkaline phosphatase (ALP) and receptor activator of nuclear factor kappa-B ligand (RANKL)-genes closely associated with bone metabolism in the femur. TSE also demonstrated pronounced effects on uterine tissue, with improvements observed in gene expression related to estrogen receptors. Conclusion : Our findings confirm the efficacy of TSE in ameliorating menopause symptoms by modulating elements associated with both bone and lipid metabolism in the serum, uterine tissue, and femur of OVX rats. The present findings suggest that TSE may offer potential therapeutic effects for symptoms related to menopause and osteoporosis in females.

• 대한방사선기술학회지:방사선기술과학
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• 제33권4호
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• pp.349-354
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• 2010

2010년 3월부터 6월까지 I병원과 N병원에서 22명을 대상으로 DXA와 QCT에 의한 동일개체에서의 요추골밀도를 측정하여 비교분석하였고, 통계학적인 방법으로는 SPSS for Windows 프로그램(version 12.0)을 사용하여 빈도분석과 t-test로 골밀도와 연령, 신장, 체중의 상관관계를 분석하여 다음과 같은 결과를 얻었다. 연구대상자의 분포는 남자 19명, 여자 3명으로 모두 22명이며, 연령은 28세 부터 37세로 분포하였다. 평균연령은 32.14세이고, 이들의 평균신장은 170.59 cm이며, 평균체중은 69.41 kg으로 나타났다. 또한 DXA방법과 QCT방법에 의한 층위별 평균골밀도는 L2-L4에서 상관계수가 0.378로 뚜렷한 양적 상관관계가 나타났다. 연령별 분석에서는 QCT방법보다는 DXA방법이 10.8% 더 유용한 것으로 나타났고, 신장별 분석에서는 DXA방법보다는 QCT방법이 3.4% 더 유용한 것으로 나타났으며, 체중별 분석에서는 DXA방법보다는 QCT방법이 1.2% 더 유용한 것으로 나타났다. 이상의 본 연구 결과에서 골밀도 측정에 있어서 연령별에서는 DXA방법이 유용하고, 신장과 체중별에서는 QCT방법이 다소 유용한 것으로 나타났다. 따라서 골밀도 측정에 있어 환자의 연령, 신장, 체중 등에 따라 정확한 측정방법의 선택이 고려되어야 할 것으로 사료된다.

• 핵의학기술
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• 제27권2호
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• pp.99-109
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• 2023

Purpose: CT scan makes up for the weak point of the nuclear medicine image having a low resolution and also were used for attenuation correction on image reconstruction. Recently, many studies try to make use of CT images additionally, one of them is to measure the bone mineral density(BMD) using Quantitative CT(QCT) software. BMD exams are performed to scan lumbar and femur with DXA(Dual-Energy X-Ray Absorptiometry) in order to diagnose bone disease such as osteopenia, osteoporosis. The purpose of this study is to identify the usefulness of QCT_BMD analyzed with low dose CT images on L-spine Bone SPECT/CT comparing with DXA_BMD. Materials and Methods: Fifty five women over 50 years old (mean 66.4 ± 9.1) who took the both examinations(L-spine Bone SPECT/CT with SIEMENS Intevo 16 and DXA scan with GE Lunar prodigy advance) within 90 days from April 2017 to July 2022, BMD, T-score and disease classification were analyzed. Three-dimensional BMD was analyzed with low dose CT images acquired on L-spine Bone SPECT/CT scan on Mindways QCT PRO^TM software and two-dimensional BMD was analyzed on DXA scan. Basically, Lumbar 1-4 were analyzed and the patients who has lesion or spine implants on L-spine were excluded for this study. Pearson's correlation analysis was performed in BMD and T-score, chi-square test was performed in disease classification between QCT and DXA. Results: On 55 patients, the minimum of QCT_BMD was 18.10, maximum was 166.50, average was 82.71 ± 31.5 mg/cm³. And the minimum of DXA-BMD was 0.540, maximum was 1.302, average was 0.902 ± 0.201 g/cm², respectively. The result shows a strong statistical correlation between QCT_BMD and DXA_BMD(p<0.001, r=0.76). The minimum of QCT_T-score was -5.7, maximum was -0.1, average was -3.2 ± 1.3 and the minimum of DXA_T-score was -5.0, maximum was 1.7, average was -2.0 ± 1.3, respectively. The result shows a statistical correlation between QCT T-score and DXA T-score (p<0.001, r=0.66). On the disease classification, normal was 5, osteopenia was 25, osteoporosis was 25 in QCT and normal was 10, osteopenia was 25, osteoporosis was 20 in DXA. There was under-estimation of bone decrease relatively on DXA than QCT, but there was no significant differences statistically by chi-square test between QCT and DXA. Conclusion: Through this study, we could identify that the QCT measurement with low dose CT images QCT from L-Spine Bone SPECT/CT was reliable because of a strong statistical correlation between QCT_BMD and DXA_BMD. Bone SPECT/CT scan can provide three-dimensional information also BMD measurement with CT images. In the future, rather than various exams such as CT, BMD, Bone scan are performed, it will be possible to provide multipurpose information via only SPECT/CT scan. In addition, it will be very helpful clinically in the sense that we can provide a diagnosis of potential osteoporosis, especially in middle-aged patients.