• Journal of Nutrition and Health
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• 제34권1호
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• pp.54-61
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• 2001

The Ca and P balance studies were carried out with two different diets varying Ca levels : the current Korean RDA level(normal Ca diet) and the high level (High Ca diet) which was determined by adding 2SD to mean Ca intake of all subjects. The subjects were sever healthy adult woman, aged from 25 to 32 years old. The metabolic studies were conducted for two weeks with a days recess in between : during the fist week with normal Ca diet and during the second week with high Ca diet. The composition of nutrients excepting Ca of both diets was similar to subjects usual intake. The result were summarized as follows: Mean daily Ca intake was 728.8mg from norma Ca diet and 945.5mg from high Ca diet. Fecal excretion of Ca increased significantly(p<0.05) on high Ca diet, but urinary excretion of Ca did not show any differences between the two diet periods. There were also no significant differences in Ca retention between the two diet periods but it tended to be greater during high Ca diet period: 112.1mg/day during normal Ca diet period vs 208.2mg/day during high Ca diet period. Mean apparent Ca absorption was 41.2% on normal Ca diet and 42.1% on high Ca diet, indicating it was not affected by high Ca intake level used in this study. On the contrary, P retention was significantly increased up to 109.4mg/day with high Ca diet as compared to- 41mg/day with normal Ca diet. There were no significant differences in fecal and urinary excretion of P but those to be lower during high Ca diet period. The above results showed that higher Ca intake more than current RDA(700mg/day), in the level of 945.5mg/day, could increase Ca retention through Ca absorption comparable to the rate appeared on RDA level intake. P retention was also improved by high Ca intake. Therefore, higher Ca intake than the current RDA level seemed to produce favorable effects on bone health in adult women. However, the current RDA level seemed to be relatively appropriate, considering the results that all the subjects but one maintained positive Ca balance with normal Ca diet. (Korean J Nutrition 34(1):54-61, 2001)

• Nutrition Research and Practice
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• 제8권6호
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• pp.662-669
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• 2014

BACKGROUND/OBJECTIVES: Osteoporosis and osteoporosis-related disease are drawing a lot of attention in Korea as one of the serious health problems. Bone health status may be influenced by the general dietary quality and dietary pattern. SUBJECTS/METHODS: To determine the relationship between dietary quality and intake patterns and bone health status, the %RNI, NAR, DDS, and food group intake patterns were assessed according to their bone health status for 847 postmenopausal women using the 2010 KNHANES data after eliminating those of likely changing their diet under the advice of doctors or those taking estrogen. RESULTS: Bone health became worse as dietary quality deteriorated. All NAR and %RNI values were highly associated with bone health levels and the consumption frequency of Ca sources, DDS and the food group intake patterns also confirmed the findings. CONCLUSIONS: This study confirmed that dietary quality and dietary patterns were important for bone health. Nutritional education on eating foods from the five basic food groups has to be emphasized to prevent osteoporosis among older women.

• Journal of Nutrition and Health
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• 제36권2호
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• pp.154-166
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• 2003

To investigate the effects of isoflavone supplementation on both bone mineral density and hormone variation in premenopausal women who had decreased bone mass, the 24 subjects were divided into two groups: one was the underweight group, consisting of 13 subjects, and the other was the normal weight group consisting of 11 subjects. For each group, we investigated the effects of isoflavone supplementation of 90 mg/day on both bone mineral density and hormone variation during 3 menstrual cycles. Anthropometric measurements, dietary recall, and analyses of blood and urine were assessed from baseline to post-treatment. The results were as follows: The average age of the underweight group was 21.8 years old and that of the normal weight group was 23.2 years old. The comparative results for the two groups at baseline were as follows: Onset of menarche, menstrual cycle, and menstrual length were not significantly different between the groups. Serum protein, total, HDL-, LDL-cholesterol, triglyceride, Ca, P, Mg, Cu, and Zn level were not significantly different between the groups. Serum estradiol, SHBG, LH, and FSH level were also not significantly different between the groups. Lumbar spine BMD by T scores of the underweight group was significantly lower than that of the normal weight group. Serum osteocalcin, urinary DPD, and urinary pH were not significantly different between the groups. The comparative results for the two groups at post-treatment were as follows: From baseline to post-treatment, the intake of energy, nutrients and isoflavone in food did not significantly change in either group. Serum protein, total cholesterol, HDL-, LDL-cholesterol, and triglyceride levels did not significantly change in either group. Serum Ca, Cu, and Zn levels were significantly lower in both groups and serum Mg level significantly decreased only in the underweight group. Serum estradiol levels were significantly lower in both groups, but serum SHBG, LH, and FSH levels did not significantly change in either group. Lumbar spine BMD by T score of the underweight group significantly increased to 15%, but that of the normal weight group did not significantly change. Serum osteocalcin of the underweight group significantly increased to 28%, while that of the normal weight group significantly increased to 40%. Urinary DPD of the normal weight group significantly increased to 12%. The results show that the BMD of the underweight group was lower than that of the normal weight group. Therefore, the underweight group had a disadvantage in obtaining maximum bone mineral density. The results also show that isoflavone supplementation during 3 menstrual cycles was effective in increasing the bone mineral density of the lumbar spine and affected bone metabolism markers in premenopausal underweight women. Therefore, it can be concluded that sufficient intake of isoflavone could be helpful in preventing decreases in bone mass among premenopausal women, especially underweight women.

• 대한핵의학회지
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• 제13권1_2호
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• pp.45-53
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• 1979

Bone scans with $^{99m}Tc$-MDP (methylene diphosphonate) was analysed in 112 patients with various type of biopsy proven malignant tumor who visited Seoul National University Hospital from March 1979 to August 1979. The results were as follows; 1. Of the 112 cases, bone scans were positive in 61 cases (54.1%), while only 27 cases (24.1%) were positive in roentgenogram. 2. Of the 61 cases with positive bone scan, bone metastases were found in 25 cases by roentgenogram. Of the 51 cases with negative bone scan, bone metastasis was found in only 1 case by roentgenogram. 3. In comparison of bone scan and roentgenogram by number of regions, 137 regions were positive in bone scan or roentgenogram. Of these, 46 regions (33.5%) were both bone scan and roentgenogram positive, 89 regions (65.0%) were bone scan positive roentgenogram negative, and 2 regions were bone scan negative roentgenogram positive. 4. Bone scan and roentgenographic findings had significant correlation with the presence of bone pain but no significant correlation with the elevated level of serum alkaline phosphatase, acid phosphatase, Ca, and P. From above result, we found that bone scan was more sensitive than roentgenogram in early detection of bone metastasis in malignant tumors.

• 한국지역사회생활과학회지
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• 제16권1호
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• pp.135-148
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• 2005

This study was conducted to investigate the bioavailability of calcium derived from starfish as a new calcium source. Four-week old Sprague-Dawley female rats were divided 6 groups. The rats were received experimental diets containing two kinds of Ca sources, CaCO₃ or starfish, and three levels of Ca, low (0.1 %), medium (0.5%) and high (1.0%), respectively, for 6 weeks. The parameters which related to Ca bioavailability were measured : Serum Ca concentration, Alkaline phosphatase(ALP) and GOT activities ; tissue Ca contents, bone dimension and Ca, P, Mg contents; Ca retention and apparent absorption. Starfish Ca-fed rats did not show any difference from CaCO₃-fed rats in terms of growth, food intake and FER. Serum Ca, ALP and GOT activities as well as tissue Ca contents were not different between CaCO₃- and starfish Ca-fed groups. Although dimension of femur and lumbar was not different between CaCO₃- and starfish Ca-fed rats, ash content was high in starfish Ca-fed rats. Ca and P contents of femur and lumbar were not different between both groups. Starfish Ca-fed groups showed higher Mg contents than CaCO₃-fed groups in both femur and lumbar. Ca absorption rate and retention rate were significantly higher in starfish Ca-fed rats. These results indicate that Ca derived starfish did not show any negative effect on growth and Ca metabolism of rats compared to calcium carbonate. Starfish Ca can be recommended as a good Ca source on the basis of higher Ca absorption and bioavailability.

• International Journal of Oral Biology
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• 제45권4호
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• pp.162-168
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• 2020

Calcium is the most abundant stored mineral in the human body and is especially vital for bone health; thus, calcium deficiency can cause bone-related diseases, such as osteopenia and osteoporosis. However, a high concentration of serum calcium, which is commonly known as hypercalcemia, can also lead to weakened bones and, in severe cases, osteosarcoma. Therefore, it is necessary to maintain the concentration of calcium that is appropriate for bone biology. In the present study, we aimed to elucidate the effects of high concentration of calcium, approximately 2 folds the normal calcium level, on osteoblast differentiation. The CaCl2 treatment showed dose-dependent suppression of the alkaline phosphatase activity and mineralized nodule formation. Calcium showed cytotoxicity at an extremely high concentration, but a moderately high concentration of calcium that results in inhibitory effects to osteoblast differentiation showed no signs of cytotoxicity. We also confirmed that the CaCl2 treatment repressed the mRNA expression and protein abundance of various osteogenic genes and transcriptional factors. Considered together, these results indicate that a high concentration of calcium negatively regulates the osteoblast differentiation of C2C12 cells.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.130-132
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• 1996

It is well known when porous calcium phosphate ceramics are used as a bone graft substitute, new tissues or blood vessels are grown into the porous implant due to their excellent biocompatibility. In this study, the ${\beta}$-crystalline form of calcium metaphosphate, $Ca(PO_{3})_{2}$ is prepared by the controlled thermolysis of monocalcium phosphate, $Ca(H_{2}PO_{4})_{2}$. The diameter of cylindrical pores formed during cooling was controlled by a holding time at the melting point of a monocalcium phosphate and by the change of a recrystallization temperature, to obtained the most appropriate size (about $200{\mu}m$) of pores. It was observed that the increasing holding time at the melting point of monocalcium phosphate results in the decreases of pore sizes.

• Journal of Nutrition and Health
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• 제35권1호
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• pp.124-136
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• 2002

As the elderly population has increased in recent years in Korea chronic degenerative diseases prevalent in the aged have garnered attention in relation to food behavior. In general, dietary intakes of elderly Koreans were inadequate in quality as well as in quantity. Especially, intakes of Ca, vitamin A, and riboflavin along with total energy were insufficient. They tended to consume high carbohydrate and low fat energy rates which may be resulted from long standing vegetable-based flood patterns. Relationships between dietary intakes and indices of cardiovascular diseases revealed that blood pressures and serum lipids patterns tended to be poor in individuals having high abdominal fat accumulations which seemed to be related with dietary consumption of high carbohydrate and insufficient intake of many nutrients. These results suggested that a nutritionally balanced diet including animal sources floods is needed in order to prevent an abdominal obesity and cardiovascular diseases. The bone health status of the Korean elderly appeared poor. It was more serious in women recording a higher prevalence rate of osteopenia and osteoporosis than in men. There were strong associations between dietary factors and bone health status. Bone mineral density was found to be higher with higher intakes of protein energy rate, the total amount of feeds, and many nutrients including Ca and p, indicating that a good quality diet is essential in maintaining healthy bone status in later life. mental health condition of the elderly as measured by cognitive function and the degree of depression was also inadequate and had strong association with dietary consumption. The positive results were obtained in individuals having an adequate dict. Therefore, it could be summarized that the physical as well as mental health in elderly Koreans are highly related with their dietary patterns. Thus, the older adults need te consume nutritionally well balanced diet in sufficient amount, which contains various flood items including significant amounts of animal source floods in a daily diet in order to maintain healthy condition.

• Journal of Nutrition and Health
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• 제29권7호
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• pp.806-820
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• 1996

The relationship between exercise and hone mineral density (BMD) was investigated in 153 healthy women. The BMD of lumbar spine, femur(neck, ward's triangle, trochanter) and total body was determined by dual energy X-ray absorptiometry in a group subjects(65) aged 19-59 years who had been exercising(swimming or aerobic dancing) regularly for at least 2 years as well as in a similar group of nonexercising control subjects(88). Weight, height, total lean body mass(=weight-total fat body mass-bone mineral content), animal and meat Ca, Ca index, energy expenditure, BMD, PYD/Cr were significantly higher in the exercisers than the controls. There were significantly negative correlations between age, ALP and osteocalcin and BMD, but significantly positive correlations between weight, BMI, total fat body mass and total lean body mass and BMD. Stepwise multiple regression analysis revealed that total lean body mass may be a better independent predictor to BMD than total fat body mass. The nutrient intakes were more closely related to BMD in the exercisers than the controls, but energy expenditure was more closely related to BMD in the controls than the exercisers Stepwise multiple regression analysis revealed that BMD was closely related to menopause, osteocalcin, age, weight in both groups but energy intake in the exercisers alone, energy expenditure in control alone. In premenopausal women, the exercisers had significantly greater BMD than the controls. But, in postmenopausal women, no significant difference between two groups was detected. When compared to BMD of the subjects with same age range to minimize the effect of age, aerobic dancing appears to be capable of exerting a positive effect on BMD in a group of subjects aged 19-44. However, no relationship of the swimming to BMD could be identified in a group of subjects aged 37-59. The results of this study suggest that the usefulness of exercisng appears to be significantly greater in preemenopausal women than postmenoparusal women and weight bearing activity, aerobic dancing is associated with increasing BMD at the weight bearing sites and could be beneficial in the prevention of bone loss. But the usefulness of swimming on bone should be further investgated.

• Preventive Nutrition and Food Science
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• 제14권3호
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• pp.208-213
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• 2009

The achievement of maximal peak bone mineral density (BMD) in early life is one of the most important strategies for the prevention of osteoporosis, which is affected by nutritional status. However, it has been reported that young Korean women do not consume the optimal levels of nutrients because of the frequent practice of body weight reduction. Therefore, this study was conducted to investigate the relationship between nutrient intakes and BMD in young Korean women. Bone mineral density was measured at the lumbar spine by dual-energy X-ray absorptiometry. Information on health status, lifestyle and physical activity was obtained by questionnaire. Dietary intake was ascertained from a 3-day dietary record. The study sample included 112 Korean women aged 20$\sim$39 yr. In accordance with the energy intake of subjects, individuals who had an energy intake that was greater than 80% of the Korean Dietary Reference Intake (KDRI) were assigned to the control group (Control), while those who had an energy intake lower than 80% of the KDRI were assigned to the low intake group (LI). The intake of all nutrients in the LI group was significantly lower than that of the Control. Control subjects also showed nutrient intakes higher than the KDRI, except for Ca and folate. However, LI subjects showed intakes of energy, fiber, Ca, Fe, K, Zn, vitamin A, vitamin B1, vitamin B2 and folate that were lower than the KDRI. The BMD of the lumbar spine in LI subjects was significantly lower than that of the Control subjects. These results suggested that lower nutrient intake has a negative impact on BMD in young women.