• 자원환경지질
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• 제15권2호
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• pp.51-63
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• 1982

볼리비아국(國)의 우라늄광상(鑛床)은 주(主)로 Altiplano와 Cordillera Oriental에서 발견(發見)된다. Altiplano에서는 주(主)로 제3기(第三紀) 미색층(未色層)과 화산암(火山岩)에서 많은 방사능(放射能) 이상대(異常帶)가 발견(發見)되고 있으며 Cordillera Oriental에서는 고생대(古生代), 중생대(中生代) 및 제3기(第三紀)의 퇴적암류(堆積岩類)와 그리고 제3기(第三紀)의 열수광맥(熱水鑛脈) 및 섬장암질암(閃長岩質岩)에 중요(重要)한 이상대(異常帶)가 나타난다. 본리바아국(國)에서 산출(産出)되는 우라늄광상(鑛床)에 대(對)한 체계적(體系的)인 분류(分類)가 시도(施圖)되었으며 동시(同時)에 이들 상(鑛床)의 잠재성에 관(關)하여 검토(檢討)되었다. 볼리비아국(國)에서의 우라늄광상(鑛床)의 광범(廣範)한 분포(分布)와 함께 성인적(成因的) 다양성(多樣性)은 학술적(學術的) 및 경제적(經濟的)인 견지(見地)에서 지질학자(地質學者)들의 관심(關心)을 끌고 있다. 중요(重要)한 우라늄광상(鑛床)에 대(對)한 연구(硏究)는 별도논문(別途論文)으로 발표(發表)될 예정(豫定)이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5987-5991
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• 2015

Our previous study detected aflatoxins in red chili peppers from Chile, Bolivia, and Peru, each of which have a high incidence of gallbladder cancer (GBC). Since the aflatoxin B1 concentration was not so high in these peppers, it is important to clarify the presence of other mycotoxins. Here we attempted to determine any associations between the concentrations of aflatoxins and ochratoxin A (OTA) in red chili peppers, and the corresponding GBC incidences. We collected red chili peppers from three areas in Peru: Trujillo (a high GBC incidence area), Cusco (an intermediate GBC incidence area), and Lima (a low GBC incidence rate), and from Chile and Bolivia. Aflatoxins and OTA were extracted with organic solvents. The concentrations of aflatoxins B1, B2, G1, and G2, and OTA were measured by high-performance liquid chromatography. The values obtained were compared with the incidence of GBC in each area or country. All of the red chili peppers from the three areas showed contamination with aflatoxins below the Commission of the European Communities (EC) recommended limits ($5{\mu}g/kg$), but the OTA contamination of two samples was above the EC recommended limit ($15{\mu}g/kg$). The mean concentrations of OTA in the peppers from Chile (mean $355{\mu}g/kg$, range < $5-1,059{\mu}g/kg$) and Bolivia (mean $207{\mu}g/kg$, range $0.8-628{\mu}g/kg$), which has a high incidence of GBC, were higher than that in Peru ($14{\mu}g/kg$, range < $5-47{\mu}g/kg$), which has an intermediate GBC incidence. The OTA contamination in the red chili peppers from Chile, Bolivia, and Peru was stronger than that of aflatoxins. Our data suggest that OTA in red chili peppers may be associated with the development of GBC.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5167-5170
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• 2012

Chilean red chili peppers contaminated with aflatoxins were reported in a previous study. If the development of gallbladder cancer (GBC) in Chile is associated with a high level of consumption of aflatoxin-contaminated red chili peppers, such peppers from other countries having a high GBC incidence rate may also be contaminated with aflatoxins. We aimed to determine whether this might be the case for red chili peppers from Bolivia and Peru. A total of 7 samples (3 from Bolivia, 4 from Peru) and 3 controls (2 from China, 1 from Japan) were evaluated. Aflatoxins were extracted with acetonitrile:water (9:1, v/v) and eluted through an immuno-affinity column. The concentrations of aflatoxins B1, B2, G1, and G2 were measured using high-performance liquid chromatography (HPLC), and then the detected aflatoxins were identified using HPLC-mass spectrometry. In some but not all of the samples from Bolivia and Peru, aflatoxin B1 or aflatoxins B1 and B2 were detected. In particular, aflatoxin B1 or total aflatoxin concentrations in a Bolivian samples were above the maximum levels for aflatoxins in spices proposed by the European Commission. Red chili peppers from Bolivia and Peru consumed by populations having high GBC incidence rates would appear to be contaminated with aflatoxins. These data suggest the possibility that a high level of consumption of aflatoxin-contaminated red chili peppers is related to the development of GBC, and the association between the two should be confirmed by a case-control study.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회(1)
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• pp.182-183
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• 2005

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5449-5454
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• 2014

Although genetic characteristics are considered to be a factor influencing the geographic variation in the prevalence of gallbladder cancer (GBC), they have not been well studied in Bolivia, which has a high prevalence rate of GBC. The purpose of this study was to examine the frequency of TP53 and K-ras mutations in Bolivian patients with GBC and to compare them with our previous data obtained in other high-GBC-prevalence countries, namely Japan, Chile, and Hungary. DNA was extracted from cancer sites in paraffin-embedded tissue from 36 patients using a microdissection technique. TP53 mutations at exons 5 to 8 and K-ras mutations at codons 12, 13 and 61 were examined using direct sequencing techniques. The data obtained were compared with those in the other high-GBC-prevalence countries. Of the 36 patients, 18 (50.0%) had a TP53 mutation (one mutation in each of 17 patients and three mutations in one patient), and only one (2.8%) had a K-ras mutation. Of the 20 TP53 mutations, 12 were of the transition type (60.0%). This rate was significantly lower than that in Chile (12/12, P<0.05). In addition, three mutations were of the CpG transition type (15.0%), which is a feature of endogenous mutation. All three were found in the hot spot region of the TP53 gene. In contrast, G:C to T:A transversion was found in Bolivia, suggesting the presence of exogenous carcinogens. Our findings suggest that the development of GBC in Bolivia is associated with both exogenous carcinogens and endogenous mechanisms. The identification of an environmental risk factor for GBC is needed to confirm these findings.

• 비교문화연구
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• 제41권
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• pp.351-379
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• 2015

라틴아메리카 대륙에서 안데스 산맥지역은 다양한 원주민종족 집단이 집중적으로 분포되어 있다. 이러한 종족 중에서 아이마라족은 케추아족과 함께 가장 대표적인 원주민 집단을 구성한다. 특히 티티카카호수를 중심으로 페루와 볼리비아 양국 접경지역에 밀집되어 있는 아이마라 원주민은 각각 국가의 소속을 달리하지만 하나의 삶의 터전 속에 동일한 문화권을 형성하며 공통의 정체성을 추구해 왔다. 그동안 아이마라 원주민은 종족의 정체성을 구성하는 언어를 바탕으로 다른 원주민 집단과 구분되는 역사성과 특수성을 강조하며 동일종족으로서의 유대감을 유지해왔다. 그러나 최근 들어 양국 접경지역의 중심지인 푸노(Puno)주를 중심으로 아이마라 원주민의 종족갈등이 표면화 되고 있다. 독립이후 근대국가 건설과정에서 형성된 인위적인 영토 경계선으로 분리된 이후 라틴아메리카 원주민은 협조와 경쟁이라는 틀 속에서 문화적 유사성과 동시에 차이를 강조하기 시작하였다. 이러한 역사적 맥락과 함께 최근 들어 페루와 볼리비아 접경지역을 중심으로 동일한 종족이 서로 다른 국가의 틀에 묶이면서 발생하는 새로운 종족 갈등이 전개되고 있다. 아이마라 원주민은 외부와의 경쟁에서 문화와 역사적 특수성을 강조하며 자신들을 하나의 단일한 종족으로 인식하며 단결하지만, 내부의 이해관계를 둘러싸고 충돌할 경우 서로가 문화적 전통을 상실했다는 비난을 가하며 종족 내부에서도 차별과 구별의 정체성을 형성하는 경향을 나타냈다. 종족간의 갈등은 한 지역에 공존하고 있는 타 종족간의 갈등에서 비롯되는 경향이 있으나 페루와 볼리비아 아이마라 원주민의 경우 양국이 접경을 유지하고 있는 푸노주를 중심으로 오랜 역사를 통해 형성된 종족의 유대감이 현실의 조건에 의해 갈등구조로 변화하는 양상을 타나내고 있다. 이러한 점에 착안하여 본 연구는 아이마라 원주민 종족갈등의 심화원인을 분석하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.781-784
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• 2016

The Plurinational State of Bolivia (Bolivia) has a high incidence rate of gallbladder cancer (GBC). However, the genetic and environmental risk factors for GBC development are not well understood. We aimed to assess whether or not cytochrome P450 (CYP1A1), glutathione S-transferase mu 1 (GSTM1), theta 1 (GSTT1) and tumor suppressor protein p53 (TP53) genetic polymorphisms modulate GBC susceptibility in Bolivians. This case-control study covered 32 patients with GBC and 86 healthy subjects. GBC was diagnosed on the basis of histological analysis of tissues at the Instituto de Gastroenterologia Boliviano-Japones (IGBJ); the healthy subjects were members of the staff at the IGBJ. Distributions of the CYP1A1 rs1048943 and TP53 rs1042522 polymorphisms were assayed using PCR-restriction fragment length polymorphism assay. GSTM1 and GSTT1 deletion polymorphisms were detected by a multiplex PCR assay. The frequency of the GSTM1 null genotype was significantly higher in GBC patients than in the healthy subjects (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.03-5.37; age-adjusted OR, 3.53; 95% CI, 1.29-9.66; age- and sex-adjusted OR, 3.40; 95% CI, 1.24-9.34). No significant differences were observed in the frequencies of CYP1A1, GSTT1, or TP53 polymorphisms between the two groups. The GSTM1 null genotype was associated with increased GBC risk in Bolivians. Additional studies with larger control and case populations are warranted to confirm the association between the GSTM1 deletion polymorphism and GBC risk suggested in the present study.

• 무역상무연구
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• 제30권
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• pp.123-144
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• 2006

MERCOSUR (Southern Cone Common Market, Latin American trade organization established in 1991, full members: Argentina, Brazil, Paraguay, and Uruguay; associate members: Bolivia, Chile, Colombia, Ecuador, Peru, and Venezuela) is the world's third largest economic union. It is a vital region that Korean corporations should enter to preoccupy the Latin American market. Since China and Japan are recently moving strongly to advance into MERCOSUR, Korea needs to work out measures to cope with the situation. In trading with MERCOSUR, it is very important to establish a strategic base in the market from a long-term perspective rather than to approach the market only as an exporting market. From this viewpoint, Korea should regard MERCOSUR as a market with which it should cooperate in terms of resources, beyond a market from which it imports raw materials. Helped by its advancement strategies varying according to regional markets and price competitiveness, China is bolstering its market share in these regions. In addition, China has built production bases focused on electric and electronics products. It is also increasing its investments in MERCOSUR as a stable raw material-providing base. To make inroads into MERCOSUR successfully, therefore, Korean enterprises should not regard it as a market where it disposes of stock goods, but should instead export technologically competitive goods to this region. Likewise, Korean companies should expand their investments in automotive parts and machinery in MERCOSUR. Furthermore, Korea should closely study international trading policies of MERCOSUR to clear away any possible obstacles of exports to this region and to prepare countermeasures so as to avoid possible damage from import regulations of MERCOSUR.

• 자원리싸이클링
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• 제23권3호
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• pp.21-29
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• 2014

본 논문은 마그네슘 함량이 매우 높은 특징을 갖는 볼리비아 우유니호 염수로부터 리튬을 회수하는 공정의 설계에 필요한 기초 자료를 얻을 목적으로 수행되었으며, 농축된 용액에 수산화칼슘의 첨가하여 수산화마그네슘을 침전시키는 반응에 있어서 용존 이온의 농도에 미치는 반응온도, 반응시간, pH 등 제 인자들의 영향을 조사하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8_spc호
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• pp.1244-1255
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• 2019

Dairy goat production continues to be a socially, economically and culturally important part of the livestock industry in North, Central and South America and the Caribbean islands. Goat milk, cheese and other dairy products offer consumers food products with nutritional, health and environmental benefits. In North America, Mexico produces the greatest volume of goat milk, but most is for family or local consumption that is typical of a mixed farming system adopted by subsistence farmers in dry areas. The United States is not yet a large global goat milk producer, but the sector has expanded rapidly, with dairy goat numbers doubling between 1997 and 2012. The number of dairy goats has also increased dramatically in Canada. Commercial farms are increasingly important, driven by rising demand for good quality and locally sourced goat cheese. In South America, Brazil has the most developed dairy goat industry that includes government assistance to small-scale producers and low-income households. As of 2017, FAO identified Haiti, Peru, Jamaica, and Bolivia as having important goat milk production in the Western Hemisphere. For subsistence goat producers in the Americas on marginal land without prior history of chemical usage, organic dairy goat production can be a viable alternative for income generation, with sufficient transportation, sanitation and marketing initiatives. Production efficiency, greenhouse gas emission, waste disposal, and animal welfare are important challenges for dairy goat producers in the Americas.