• Journal of Pharmaceutical Investigation
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• v.16 no.4
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• pp.139-147
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• 1986

A singly charged methyl orange(MO) anion was found to be extracted with chlorpheniramine maleate(CPM) as a 1 : 1 complex in chloroform. Of various solvents, MO-chloroform system gave a yellow color for CPM, while in the absence of CPM, an organic phase showed almost no color. In this way, the spectrophotometric method was investigated for the determination of CPM by solvent extraction. The addition of alcoholic bolic acid solution to the solvent extract gave a higher color stability and transparency at least 5 days, but the extract alone lost its color intensity significantly. CPM is determined by measuring the absorbance of the extracts over a range of $1{\sim}7{\times}10^{-4}M\;(39{\sim}273\;{\mu}g/ml)$ in aqueous solution at 423 nm. The molar absorptivity was $2.26{\times}10^3\;l,\;mol^{-1},\;cm^{-1}$. The absorbance of the extract was constant in the range of pH $3.7{\sim}4.6$. This novel method was applied for the determination of CPM in artificial and commercial preparations in comparison with the analytical method of CPM tablets in K.P.IV. The results obtained showed that the former was better in accuracy and time consumption than the latter.

• Journal of the Korean Ceramic Society
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• v.41 no.10 s.269
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• pp.756-765
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• 2004

We present extraction process and reaction mechanism of boric acid from one of calcium borate ores, colemanite by reaction with sulfuric acid. Colemanite has been fully decomposed under pH 5 with sufficiency amount of sulfuric acid, more than the amount stoichiometrically required. Calcium sulfate was separated out, leaving boron in the liquid phase after sulfuric acid addition. The extraction process of boric acid was affected by dissolution temperature and time, amount of sulfuric acid and ammonium sulfate, pH and a degree of concentration before recrystallization. The $SiO_2$ of the impurities which colemanite contains was insoluble so that it was separated out with calcium sulfate from liquid phase. The species of $CaO,\;Al_2O_3,\;Fe_2O_3,\;MgO$ were remained in a liquid phase after reaction with sulfuric acid. These impurities were separated out by addition of ammonia to the liquid phase, funhermore, boric acid was produced by process of pH adjustments and acidification, concentration, and recrystallization.

• Korean Journal of Soil Science and Fertilizer
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• v.16 no.1
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• pp.72-76
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• 1983

Absorption pattern and sensitivity of radishes to boron were compared with different boron treatment: soil application, foliar spray and no boron application. Six radish cultivars were planted on April 7 and harvested on June 23. Borax 1.5 Kg per 10 a was applied to soil before seeding and the 150 litters of 0.5 ppm solution with bolic acid was sprayed on leaves 3 times during the growing period. Boron content in plant was markedly increased by the soil application but no significant difference in boron contents in plants was observed between foliar spray and no application, presumably because of the insufficient dose of foliar spray. The darkening rot in root, a boron deficiency, was negligible in radishes grown in soil application plots whereas a relatively higher percentage of boron deficient plant was found from foliar spray or no application plots. The appearance of root darkening rot occurred at the rapid root enlargement stage, apparently from 55 days to 65 days after seeding. The boron contents in plants of soil application plots slightly increased at this stage while those of no boron application and foliar spray decreased. This obviously verified that boron deficiency should cause root rots showing highly significant relationship.