• 대한의용생체공학회:의공학회지
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• 제22권4호
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• pp.369-375
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• 2001

The statistical regression model is one of the most frequently used clinical analysis methods. It has basic assumption of linearity, additivity and normal distribution of data. However, most of biological data in medical field are nonlinear and unevenly distributed. To overcome the discrepancy between the basic assumption of statistical model and actual biological data, we propose a new analytical method based on artificial neural network. The newly developed multilayer perceptron(MLP) is trained with 120 data set (60 normal, 60 patient). On applying test data, it shows the discrimination power of 0.76. The diabetic risk factors were also identified from the MLP neural network model and the logistic regression model. The signigicant risk factors identified by MLP model were post prandial glucose level(PP2), sex(male), fasting blood sugar(FBS) level, age, SBP, AC and WHR. Those from the regression model are sex(male), PP2, age and FBS. The combined risk factors can be identified using the MLP model. Those are total cholesterol and body weight, which is consistent with the result of other clinical studies. From this experiment we have learned that MLP can be applied to the combined risk factor analysis of biological data which can not be provided by the conventional statistical method.

• 한국의류학회지
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• 제43권3호
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• pp.416-426
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• 2019

This study measured and analyzed male firefighters hand sizes as well as suggested data for developing firefighting gloves with a good fit. Accordingly, body dimensions related to the hand were measured for 100 male firefighters. Twenty-three measuring items related to the hand and lower arm were selected. The firefighters' measurement data were compared to general adult male measurements from the 6th Korean Anthropometric data to analyze the hand sizes characteristics of firefighters. As a result, height, hand circumference, hand breadth, wrist circumference, elbow-wrist length, forearm-fingertip length and firefighter weight were significantly larger than adult males. A correlation analysis for 23 items was conducted to select items used as standards for setting a size when manufacturing firefighting gloves. Hand length and circumference were selected as representative hand parts for making firefighting gloves. Cross analysis between hand length and circumference were conducted to find the section showing the highest distribution ratio. As a result, the highest sections were between 19cm and 21cm for hand circumference and between 18.5cm and 19.5cm for hand length, which may be suggested as the most important ranges.

• Archives of Pharmacal Research
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• 제25권6호
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• pp.946-953
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• 2002

Bisphenol A [2, 2 bis (4-hydoxyphenyl) propane; BPA] is a widely used endocrine disruptors and has estrogenic: activities. Although interests on biological effect of BPA are rising, evidences of its effect on immune system are lacking. We investigated that the effect of BPA on immune parameters to postulate the mechanism, and BPA interruptions between neuroendocrine and immune system. BPA was administrated to mice by p.o. (as a drinking water) dose on 0.015, 1.5 and 30 mg/ml for 4 weeks. The BPA treatment did not result in any change in body weight, spleen weight and distribution of lymphocyte subpopulation collected from spleen. BPA induced prolactin production in spleen, and exposure of SPA increased the activity of splenocyte proliferation in response to Con A (p<0.001). The production of a strong Th-1 type cytokine ($IFN-{\gamma}$) was induced while Th-2 type (IL-4) was suppressed by SPA treatment. These were consistent with RT-PCR results of transcription factor GATA-3 and IRF-1. These findings suggested that stimulation of prolactin production by estrogenic effects of SPA would affect cytokine profiles, and lead to imbalanced cellular immune response. In addition, we could speculate that prolactin and cytokine is important mediator involved in network between neuroendocrine and immune system by BPA.

• 한국약용작물학회지
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• 제14권3호
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• pp.183-187
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• 2006

고려인삼과 미국삼을 공시하여 Panax속 종간의 원료수삼 및 홍삼 등급에 기초하여 품질을 평가분석하였다. 1. 미국삼은 고려인삼에 비하여 근중이 적고 부정형 지근이 동체에서 많이 발생하는 관계로 체형이 불량하였다. 2. 홍삼수율은 고려인삼이 30.4%,미국삼이 33.8%로 미국삼이 높았고 홍삼의 본삼수율은 고려인삼이 80.4%, 미국삼이 72.2로 고려인삼이 높았다. 3. 원료수삼 1등급은 고려인삼이 미국삼에 비하여 2배정도 많았으나 2등급은 미국삼이 고려인삼에 비하여 많았다. 한편 고급홍삼인 천지삼율은 고려인삼이 미국삼에 비하여 높았다. 4. 홍삼 품질의 저하 원인은 고려인삼 미국삼 모두 내공과 내백 발생에 있었고 특히 미국삼은 내공에 비해 내백이 3배 가량 많이 발생하였다. 5. 홍삼의 지별 분포에서 고려인삼은 20지 이상의 대편급이 많았고 미국삼은 20지 이하의 소편급이 많았다.

• 대한한방내과학회지
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• 제22권4호
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• pp.513-517
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• 2001

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

• 대한물리의학회지
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• 제7권2호
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• pp.223-230
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• 2012

Purpose : The purpose of this study was to analyze weight bearing of cane and affected foot at different speeds during walking. Methods : Thirteen subjects (6 males, 7 females) with stroke enrolled in the study. A foot sensor and an instrumented cane were integrated to analyze the vertical peak force on the affected foot and the cane. Results : The applied vertical peak force on the cane were $12.02{\pm}4.80%$ (slow speed), $7.97{\pm}3.95%$ (comfortable speed), and $6.86{\pm}3.30%$ (fast speed) body weight, respectively. The results indicated significantly lower vertical peak force on the affected foot in the low speed walking condition when compared to the fast walking (p<.05) and the comfortable walking (p<.05) conditions. The correlations between TUG and vertical peak force on the cane and affected foot were .71, and -.70 (p<.01). There was a higher correlation between the vertical peak force on the cane and affected foot were -.87(p<.01). Conclusion : In conclusion, slower walking speed applied greater vertical peak force on the cane. On the contray, slower walking speed applied less vertical peak force on the affected foot. Further studies, duration of force should be measured at different speeds during walking in lower and higher functioning hemiparetic subjects, as its use may mask underlying gait impairment.

• 한국양식학회지
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• 제11권3호
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• pp.401-419
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• 1998

제주도의 8개지점(함덕, 온평, 위미, 법환, 화순, 대포, 한림, 외도)에서 해조장형성과 조식성의 대표적이 동물인 성게류(보라성게,Anthocidaris crassispina와 말똥성게 Hemicentrotus pulcherrimus)의 섭이형태에 대하여 연구하였다. 각 조사지점의 해조류 생체량이 조사되었으며, 성게류의 장내용물과 생물학적 측정치에 관련된 해조류 군락의 양적분포와 우점도가 조사되었다. 결론적으로 대포지점의 조사지점이 해조상으로는 가장 우세함에도 불구하고 성게의 생물학적인 특성인 체고, 체장, 체중 그리고 생식소 지수와의 관련이 없었다. 이는 성게류들이 조류의 풍도에만 의존하는 곳이 아니고 다른 먹이물질을 섭이함을 뜻한다. 성게의 음식물 선호도를 위해 섭이된 장내용물을 조사한 결과 부착성 조류와 유조(drifted algae) 및 다양한 동물들 (해면, 태충류, 갑각류 및 미확인된 캡슐에 싸인 알 등)과 펄이나 모래와 같은 저질들이 먹이물질로 조사되었다. 섭이된 음식물의 상대적인 양으로 볼 때, 해조류의 섭식률은 낮은 것으로 밝혀졌으며, 이로서 성게가 조장형성이나 갯녹음 현상을 일으키는 해조류의 우요 섭식자가 아닐 것으로 추정할 수 있다.

• 한국의류학회지
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• 제39권1호
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• pp.55-62
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• 2015

This study investigated the thermal insulation of an air-cell pack embedded jacket and down jackets to understand the potential of air-cell pack as a filler for winter outdoor wear. A thermal manikin measured the thermal insulation of the following jackets: HD (heavy down jacket, total weight (Tw) 750g, goose down weight (Dw) 350g), LD (light down jacket, Tw 560g, Dw 140g), AF (air-cell pack embedded jacket, Tw 490g, trunk goose down in LD was replaced to air cell), F (film jacket, Tw 469g, but removed the air in the air-cell pack from the AF), and Control (control jacket, Tw 438g, removed the air-cell pack film from the F). Thermal insulations of each experimental condition were measured in a static standing posture. Total thermal insulations (IT) were 1.29clo (HD), 1.23clo (LD), 1.16clo (AF), 1.20clo (F), and 1.08clo (Control). Body regional thermal insulation was higher in the chest and back than in the abdomen and hip in all conditions. The results suggest that an economical and versatile outdoor jacket with superior thermal insulation will be feasible if the air volume is properly controlled in air-cell pack embedded jackets in consideration of regional different distribution and used in combination with film and down.

• 대한한방부인과학회지
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• 제33권4호
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• pp.56-74
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• 2020

Objectives: The purpose of this study is to analyze the current characteristics of outpatients using herbal medicine for treating Sanhupung and provide treatment instructions in the clinical field. Methods: To analyze characteristics of outpatients with postpartum disease, I searched medical records from July 1, 2017 to June 30, 2020 using O94 (Sequelae of complication of pregnancy) in an oriental medicine hospital and 73 Sanpuhung patients were analyzed. Results: 1. The average age of Sanpuhung outpatients was 32.83±3.14 years old. The mean body weight difference between full-term pregnancy and visiting date was -7.79±4.23 kg. 2. The most chief complaints of Sanpuhung outpatients were musculo-skeletal symptoms in 57 (78.08%) patients followed by neuropsychiatric symptoms and circulatory symptoms. In musculo-skeletal symptoms, the most chief complaint area was wrist in 48 (65.75%) patients followed by waist, shoulder and knee. 3. 68 (93.15%) patients gave birth between 38 and 42 weeks of pregnancy, 33 (45.20%) patients gave birth by caesarean operation. Patients delivered in July visited the hospital most frequently for postpartum care. 4. 68 (93.15%) patients gave birth to single-born babies. The average birth weight was 3.13±0.45 kg. 5. In distribution from delivery to visitation period, the average was 65.08±103.2 days. The number of visits less than two times was 72 (98.63%). 6. A total of 73 outpatients got herbal medicine. Depending on the symptoms, herbal medicines were different from each other. Ikgibohyeol-tang-gagambang, Ojeok-san-gagambang and Gunggui-tang-gagambang were mostly used. Conclusions: These results could be helpful to treat Sanhupung patients in Korean gynecologic clinical fields.

• 한국융합학회논문지
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• 제9권2호
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• pp.303-311
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• 2018

스쿼트운동은 안전하고 효과적인 운동성과를 기대할 수 있는 중요한 프리웨이트운동의 하나로 하체강화운동에 가장 효과적인 운동으로 알려져 있다. 인터렉티브 스쿼트운동 장치를 활용하여 동적인 운동과정을 단순화하여 스쿼트 운동 동작을 모델링하고 이를 기반으로 한 생체신호 및 동작 분석을 수행할 수 있으며 또한 장치를 통해 사용자 자세교정을 통해 올바르고 효과 높은 스쿼트운동 과정을 확립할 수 있다. 제안된 모델링을 기반으로 설계된 풋플레이트에 위치한 로드셀의 검출된 신호를 활용하여 스쿼트동작을 생체신호검출과 검출된 신호처리과정을 거쳐 스쿼트운동의 오류동작을 검출해 내는 신호출력을 확보할 수 있다. 본 논문에서 제안된 인터랙티브 스쿼트운동장치의 설계방법과 동작의 안전성 분석방법은 생체역학 신호처리 방법에 기인하며 사용자의 스쿼트 운동자세를 해석을 위한 검출된 생체신호 및 동작신호를 통해 올바르지 못한 스쿼트 동작을 교정함으로서 바른 스쿼트 운동을 유도할 수 있으며 연구 결과를 VR 장치에 적용하거나 운동 평가를 위한 장치로 활용할 수 있다.