• YAKHAK HOEJI
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• v.36 no.1
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• pp.17-25
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• 1992

The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influences on the central nervous system and on body temperature at a high oral dose of 40 IU/kg in animals. It had neither analgesic nor antiepileptic actions at the high doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effects at a concentration of $1{\times}10^{-3}\;IU/ml$ in bath, and no inhibitory action at a dose of $1{\times}10^{-3}\;IU/ml$ against the contractions produced by histamine ($5{\times}10^{-5}\;g/ml$), serotonin($1{\times}10^{-5}\;g/ml$), acetylcholine($1{\times}10^{-5}\;g/ml$) and oxytocin($5{\times}10^{-3}\;IU/ml$). Furthermore, the intravenous injection of 20 IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects. On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80 IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.5
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• pp.416-421
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• 2015

This study was performed to comparative investigate the distribution of primary sensory and motor neurons associated with Daereung(PC7) acupoints by using neural tracing technique. A total 16 SD rats were used in the present study. After anesthesia, the rats received microinjection of 6 ㎕ of cholera toxin B subunit(CTB) into the corresponding sites of the acupoints Daereung(PC7), in the human body for observing the distribution of the related primary sensory neurons in dorsal root ganglia(DRGs) and motor neurons in the spinal cord(C3∼T4) and sympathetic ganglia. Three days after the microinjection, the rats were anesthetized and transcardially perfused saline and 4% paraformaldehyde, followed by routine section of the DRGs, sympathetic chain ganglia(SCGs) and spinal cord. Labeled neurons and nerve fibers were detected by immunohistochemical method and observed by light microscope equipped with a digital camera. The labeled neurons were recorded and counted. From this research, the distribution of primary sensory and motor neurons associated with Daereung(PC7) acupoints were concluded as follows. Muscle meridian related Daereung(PC7) controlled by spinal segments of C5∼T1, C6∼T4, respectively.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.4
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• pp.431-437
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• 2010

The purpose of this study is to compute the ground reaction forces during gait in the absence of force plates. The difficulties in using force plates for hemiparetic patients inspired us to initiate this study. Level-walking experiments were performed using a three-dimensional motion analysis system with synchronized force plates. Kinematic data were obtained from the three-dimensional trajectories of reflective markers. Gait events were also detected from the kinematic data. The human body was modeled as 13 rigid segments. The mass and the center of mass of each segment were determined from anthropometric data. Vertical ground-reaction forces obtained from the kinematic data were in good agreement with those obtained using the force plate. The computed and measured values of anterior and lateral ground reaction showed similar tendencies. The computation results can be used as the basic data for inverse dynamic analysis.

• Ocean and Polar Research
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• v.32 no.4
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• pp.361-367
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• 2010

The principal objective of this paper was to evaluate the steering characteristics of a tandem tracked vehicle, each side of which features two tandem tracks, when crawling on extremely cohesive soft soil. The tandem tracked vehicle is assumed to be a rigid-body with 6-dof. The dynamic analysis program of the tandem tracked vehicle was developed via Newmark's method and the incremental-iterative method. A terra-mechanics model of extremely cohesive soft soil was implemented according to the relationships of normal pressure to sinkage, of shear resistance to shear displacement, and of dynamic sinkage to shear displacement. In order to simplify the characteristics of contact interaction between track segments and cohesive soft soil, the characteristics of soil are equated to the properties of intact soil. In an effort to evaluate the steering characteristics of a tandem tracked vehicle crawling on extremely cohesive soft soil, a series of dynamic simulations were conducted for a tandem tracked vehicle model with respect to the front and rear steering angle, the steering ratio, and the initial velocity.

• Korean Journal of Applied Biomechanics
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• v.27 no.1
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• pp.19-23
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• 2017

Objective: The aim of this study was to investigate the relationship between the ball velocity and the upper extremity kinematics for both dominant and non-dominant side in inexperienced participants about an overarm throwing task. Method: Seven women who are inexperienced in overarm throwing participated in this study (Age: $25.1{\pm}2.4years$, Height: $160.8{\pm}3.5$; Weight $56.5{\pm}7.8$). Participants visit the laboratory for three days with one day rest between test sessions. Whole body 3-dimensional (3D) motion capture was recorded during the overarm throwing trials with ten cameras Vicon motion analysis system (T-10, T40, Oxford Metrics Ltd, UK). Total 45 overarm throwing were recorded for each side for each test session. Ball speed also was measured 3 meters away behind the subjects and recorded for every trial. Results: Mean ball velocity was higher for dominant hand compared to non-dominant hand (p <.05). Trunk segment variables (maximum angles and angular velocities) showed the most consistent relationship with the ball velocity. Conclusion: The importance of the trunk segment during the throwing activities can be seen in some individuals. But inconsistent results between subjects emphasize the importance of the individuals' movement patterns especially for bilateral sports. The future studies should be conduct about the sequence of segments, kinetic variables and effect of training.

• Applied Microscopy
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• v.33 no.2
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• pp.131-143
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• 2003

A Differentiating pathway of hemocytes in vitro and in vivo of grasshopper, Euprepocnemis shirakii was described using light and electron microscopes. In the interior of body, the stem cells of the hemopoietic organ differentiated into six types of cells respectively which are prohemoyte, plasmatocyte, granulocyte I, granulocyte II, spherulocyte and oenocytoid. The formation of these hemocytes was derived from the stem cells surrounded by a reticular cell. Hemopoietic tissue cultured in the insect media differentiated different hemocytes, but none of them underwent any mitotic division. Morphological features of the cultured cells in media were essentially the same as those of the hemocytes differentiated from the stem cells in vivo. These results were shown that each stem cell could differentiate into different types of hemocytes. It was confirmed that the stem cells possessed the pluripotent differentiation ability to directly each hemocyte, and that the once formed hemocytes in vivo and in vitro didn t undergo further transformation to other hemocytes. The maintenance of circulating hemocytes in grasshopper had been depended on the widely spreading hemopoietic organ situated in the upper surface of the dorsal alary muscle and located on the first to eighth segments.

• The Korean Journal of Physiology and Pharmacology
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• v.3 no.5
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• pp.491-499
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• 1999

This study was designed to evaluate the efficacy of dynamic parameters, such as correlation dimension $D_2,$ by comparing spectral electroencephalographic (EEG) parameters. These parameters are used to estimate the depth of halothane anesthesia as defined by the presence of body movement in response to a tail clamp. Six rats were used and each of them was exposed to halothane sequentially at the concentrations of 0%, 0.5%, 1.0% and 1.5% for 30 min. A tail clamp was applied every five min and the movements were recorded at each concentration level. The spectral parameters and the dynamic parameters were derived from 20-sec and 10-sec segments, respectively, from the last 5-mins of EEG recording at each concentration level. Correlation coefficients between the parameters and the movements were calculated. Standardized values of three parameters, betaL power, median power frequency (MPF), and $D_2$ were derived by calculation based on the number of animals showing the movement in response to a tail clamp. The betaL power had the largest correlation coefficient to spontaneous movement and to the response to a tail clamp than any other band parameter. MPF had a better correlation with the movement than 90% spectral edge frequency. Among the dynamic parameters, $D_2$ on the parietal cortex had a better correlation with the movement. The level of deviation and variation of standardized $D_2,$ MPF, and betaL were significant (p<0.01). The order of deviation and variation was; betaL power > MPF > $D_2.$ The correlation dimension serves as a better index for the depth of halothane anesthesia defined in forms of a response to external stimulation.

• Corrosion Science and Technology
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• v.7 no.3
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• pp.162-167
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• 2008

Degradable implants have been in use for bone surgery for decades. However, degradable metal implants are one of the new research areas of biomaterials science. Magnesium has good biocompatibility due to its low toxicity, and it is a corroding, i.e. dissolvable, metal. Furthermore, magnesium is needed in human body, and naturally found in bone tissue. There have been some published reports also asserting the potential bone cell activation or bone healing effect of high magnesium ion concentrations. The classic method for achieving intertransverse process fusion involves autogenous iliac crest bone graft. Several investigations have been performed to enhance this type of autograft fusion. However, there is no research which has been undertaken to investigate the efficiency of pure magnesium particles in posterolateral spinal fusion. In this study, corrosion behavior of magnesium metal at the bone interface, the possibility of new bone cell formation and the degree of effectiveness in producing intertransverse process lumbar fusion in a sheep model have been investigated. Cortical bone screws were machined from magnesium alloy AZ31 extruded rod and implanted to hip-bones of sheep via surgery. Three months after surgery, the bone segments carrying these screws were removed from the sacrificed animals. Samples were sectioned to reveal Mg/bone interfaces and investigated using optical microscope, SEM-EDS and radiography. Optical and SEM images showed that there was a significant amount of corrosion on the magnesium screw. The elemental mapping results indicate, due to the presence of calcium and phosphorus elements, that there exists new bone formation at the interface. Furthermore, sixteen sheep were subjected to intertransverse process spinal fusions with pedicle screw fixation at various locations along their spines. Each animal was treated with 5cc autograft bone at one fusion level and 1cc magnesium+5cc autograft bone at the other. Six months after surgery, bone formation was evaluated by gross inspection and palpation, and radiological, histological, scanning electron microscopic and x-ray diffraction analyses. It may be stated that the potential for using useful corrosion of magnesium alloys in medical applications is expected to be significant.

• Journal of Digital Contents Society
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• v.5 no.3
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• pp.239-244
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• 2004

New developments in IT already impact wide segments of a young and mobile population. It is evident that applications of information technology can be of equal benefit to the aged and the disabled. `Eye-Gaze'(EGI) technology was designed for people with paralysis in the upper body. There is a compeling need for a dedicated Korean Language interface for this system. The purpose of this study is to research 'Barrier Free' software using a control group of the mobility impaired to assess the Eye-Gaze Interface in the context of more conventional input methods. TheEGI of this study uses Quick Glance System of Eye Tech Digital Systems. The study will be evaluated on criteria based upon the needs of those with specific disabilities and mobility problems associated with aging. We also intend to explore applications of the Eye-Gaze Interface for English and Japanese devises, based upon our study using the Hangul phonology.

• Korean Journal of Applied Biomechanics
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• v.15 no.4
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• pp.105-115
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• 2005

Recently among several tennis techniques forehand stroke has been greatly changed in the aspect of spin, grip and stance. The most fundamental factor among the three factors is the stance which consists of open, square and closed stance. The purpose of this study was to investigate the relations between the segments of the body, the three dimensional anatomical angle according to open, close, and square stance patterns during forehand stroke in tennis. For the movement analysis three dimensional cinematographical method(APAS) was used and for the calculation of the kinematic variables a self developed program was used with the LabVIEW 6.1 graphical programming(Johnson, 1999) program. By using Eular's equations the three dimensional anatomical Cardan angles of the joint and racket head angle were defined. In conclusion, the first hypothesis, "In three dimensional maximum linear velocity of racket head would be significant difference among the stance patterns during forehand stroke in tennis" was rejected. The second hypothesis, "In three dimensional anatomical angular displacement of trunk would be significant difference among the stance patterns during forehand stroke in tennis" was rejected and the result showed that the internal-external rotation showed most important role among the three dimensional anatomical angular displacement of trunk The third hypothesis, "In three dimensional anatomical angular displacement of upperlimb would be significant difference among the stance patterns during forehand stroke in tennis" was rejected and the result showed that The three dimensional anatomical angular displacement of shoulder joint showed most important role in forehand stroke. Flexion-extension and internal-external rotation the open stance showed the largest angular displacement and is follwed by square stance and closed stance. The fourth hypothesis, "In three dimensional anatomical angular velocity of upperlimb would be significant difference among the stance patterns during forehand stroke in tennis" was rejected and the result showed that X-axis angular velocity and Z-axis angular velocity the square stance showed the largest angular velocity of the trunk and X-axis angular velocity and Y-axis angular velocity the closed stance showed the largest angular velocity of the shoulder joint.