• 제목/요약/키워드: Body Network

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고분 탐사를 통해 본 한·일 물리탐사의 성과와 과제 (Achievements and Tasks of Korea-Japan Geophysical Exploration through Burial mounds Exploration)

  • 신종우
    • 헤리티지:역사와 과학
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    • 제48권4호
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    • pp.74-93
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    • 2015
  • 한국의 고고학적 물리탐사는 1995년 일본 나라문화재연구소에서 활용 중인 물리탐사를 참고로 국내에 도입되었다. 도입 당시 한국에서는 건축, 토목분야에서 물리탐사가 활성화되어 있었지만 고고학에 접목시켜 탐사를 하는 전문가는 없었다. 이에 국립문화재연구소는 고고 물리탐사를 도입하기 시작하여 오늘날에 이르게 되었고, 그간 한국과 일본은 탐사 전문가 교류를 통해 공동 탐사 등을 진행하고 탐사방법의 개선과 탐사 결과의 신뢰성을 높여 왔다. 고고학적 물리탐사 방법에서 가장 많이 활용된 방법은 GPR 탐사법이다. 이는 투과 깊이는 낮지만 해상도가 뛰어나 발굴 착수 전에 활용성이 좋다. 하지만 GPR 탐사의 레이더 투과 깊이가 얕아 대형 고분 등에서 한계성이 있다. 한국과 일본의 물리탐사 전문가 교류 등을 통해 보다 깊은 곳까지 지하구조를 연구할 수 있도록 전기비저항 분석프로그램을 활용하여 고분탐사에 적용할 수 있었다. 이에 나주 복암리 고분을 비롯한 다수의 고분에서 GPR 탐사의 한계를 극복한 좋은 결과를 얻을 수 있었고 특히, 탐사 결과와 발굴조사 결과를 비교하여 고분 내의 매장 주체부 등의 위치를 확인하였다. 향후 한국과 일본은 다양한 공동연구 등을 통하여 탐사와 고고학과의 융복합 연구를 수행하고 고고 과학 분야의 새로운 네트워크를 형성하여야 할 것이다.

충청남도 공공도서관 보존서고 분석에 기초한 공동보존자료관 운영에 관한 연구 (A Study on the Operation of the Cooperative Repository Libraries Based on the Analysis of the Preservation Library at the Chungcheongnam-do Public Library)

  • 곽승진;노영희;강은영;김정택;곽우정
    • 한국비블리아학회지
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    • 제31권4호
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    • pp.191-212
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    • 2020
  • 본 연구에서는 충청남도 공공도서관 보존서고 현황 분석을 기반으로 한 충남도서관 공동보존자료관의 협력체계 및 이용서비스 구성 방안에 관한 연구를 수행하였다. 공동보존자료관의 협력 방안 구축과 서비스 제공 활성화를 도모하기 위해, 현재 충남도내 공공도서관 62개관의 장서 현황과 개별적으로 운영하고 있는 보존서고 현황을 파악하였다. 연구 결과, 공동보존자료관 운영과 관련된 제반 사항은 참여주체간의 협정 또는 협의에 의해 의사결정이 이루어져야 하며, 이와 더불어 공동보존자료관의 운영 또한 참여 주체간의 체계적 협력체계 하에서 이루어져야 하는 것으로 나타났다. 이를 위해 충남도서관 공동보존자료관은 협력체계를 구축하고, 협의체(협력네트워크)인 공동보존자료관 운영위원회를 구성하여 운영할 필요성이 있다. 또한, 이관기준 등 공동보존자료관 운영과 관련된 제반 사항은 공동보존자료관 운영위원회의 협의를 통해 규정화하여 시행하여야 한다.

노인 구강건강증진 활동에 대한 치과위생사의 학습경험과 수행경험에 따른 수행가능성 및 필요성 조사 (A study on the performance and necessity of dental hygienists for oral health promotion activities for the elderly according to their learning experiences and performance experiences)

  • 송가인;신선정;신보미;유상희;배수명
    • 한국치위생학회지
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    • 제21권4호
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    • pp.467-479
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    • 2021
  • Objectives: The purpose of this study was to investigate the awareness of the performance and necessity of oral health promotion activities and seek ways to revitalize the professional role of dental hygienists in oral healthcare for the efficient oral care of the elderly. Methods: Eighty-five dental hygienists in charge of oral health promotion projects at public health centers and 38 dental hygienists in network dental clinical trials were investigated for their learning experience, performance experience, feasibility, and necessity of dental hygienists for general and oral health service items for the elderly. The collected data were analyzed using frequency analysis, chi-square test, and Mann-Whitney U test. Results: The degree of performance possibility according to the learning experience and performance experience of the dental hygienist for the whole body and oral health promotion activity items for the elderly showed that the degree of performance possibility was higher among those with experience compared to the non-experienced person, and it was statistically significantly higher (p<0.05). Conclusions: The dental hygienist's professional oral health service is a necessary system to improve practical knowledge and skills and to provide a wide range of professional oral health services for the elderly.

뇌와 척수에서 Cocaine-Amphetamine Regulated Transcript를 과발현하는 형질전환 생쥐 (Transgenic Mice Overexpressing Cocaine-Amphetamine Regulated Transcript in the Brain and Spinal Cord)

  • 최시호;이정웅;박흠대;장정원;정길생;이훈택
    • 한국가축번식학회지
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    • 제25권4호
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    • pp.389-397
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    • 2001
  • CART는 leptin에 의해 조절되는 포식인자이며 섭식과 운동 습성에 관계된 것으로 알려져 있다. 사람의 CART Leu34Phe 돌연변이는 비만의 표현형을 나타내었지만, 생쥐의 CART 돌연변이는 일반사료의 섭취 후 급격한 체중증가를 나타내지는 않았다 생체 내 신경세포에서 CART의 역할을 확인하기 위한 새로운 형질전환 모델을 확립하고자 분화하는 신경세포의 유전자 발현을 조절하는 NF-L promoter와 CART의 재조합 발현 벡터를 구축하였다. 형질전환 생쥐는 유전자 미세 주입법에 의하여 생산되었으며, PCR과 Southern blot의 방법으로 확인하였다. 이러한 형질전환 생쥐에서 CART의 과 발현을 수정 후 13.5일째 초기 배아와 생후 6주째 형질전환 생쥐의 뇌와 척수에서 확인하였다. 본 연구의 결과는 섭식 관련 유전자들이 상호 연관된 섭식행동에서 CART의 역할을 연구하는데 모델 동물로써 이용할 수 있을 것으로 사료된다.

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In-silico annotation of the chemical composition of Tibetan tea and its mechanism on antioxidant and lipid-lowering in mice

  • Ning Wang ;Linman Li ;Puyu Zhang;Muhammad Aamer Mehmood ;Chaohua Lan;Tian Gan ;Zaixin Li ;Zhi Zhang ;Kewei Xu ;Shan Mo ;Gang Xia ;Tao Wu ;Hui Zhu
    • Nutrition Research and Practice
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    • 제17권4호
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    • pp.682-697
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    • 2023
  • BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

장기요양보호를 이용하는 여성노인의 경험에 관한 탐색적 연구: 방문목욕 이용자를 중심으로 (An Exploratory Study on the Experience of the female Elderly using a Long-Term Care: Centering on Users of Home-Visit Bath)

  • 신건철
    • 한국노년학
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    • 제30권4호
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    • pp.1345-1357
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    • 2010
  • 본 연구에서는 장기요양보호 서비스 중 방문목욕을 이용하는 여성노인을 대상으로 방문목욕을 받으면서 경험하게 되는 신체적, 심리적 변화는 무엇인가에 대해 심층적으로 분석코자 하였다. 이를 위해 장기요양보호서 비스를 이용중인 8명의 여성노인을 대상으로 심층면접하고 서비스 이용과정 중 경험하게 되는 신체적, 심리적 경험을 질적자료로 활용하여 자료를 분석한 탐색적 연구이다. 연구결과를 살펴보면 다음과 같다. 첫째, 여성노인의 신체적 측면에서는 방문목욕서비스를 받는 동안 변화된 여성노인의 신체적 요인을 살펴보면 서비스 이용 후 몸이 건강해지고 편해졌으며 신체적으로도 나아지고 있다고 믿고 있었다. 둘째, 심리적 측면에서는 자신의 신체적 장애로 인해 방문목욕을 받는 것에 대해 자신의 몸을 보이는 것을 추잡하고 부끄럽게 여기다가 방문목욕을 편하게 여기게 되었다. 또한 요양보호사와의 상호작용을 통해 목욕서비스 이외에 정서적측면에서 지지를 받음으로 자신에 대한 존재가치를 긍정적으로 바라보는 모습이 나타났다. 그 결과 장애로 인해 부끄럽고 불편하며 추잡스럽게 자신을 여기던 부정적 태도에서 장애를 지닌 자신의 신체적 상태를 수용하고 받아들임으로 방문목욕서비스를 편하게 받아들이게 되는 변화의 과정이 나타나 장애수용이 현실적응에 큰 영향을 미치게 되는 계기임을 알 수 있었다. 이상의 결과를 근거하여 다음과 같이 제언하였다. 첫째, 장기요양보호에서 노인에 대한 체계적인 관리 및 정서적 안정을 높이기 위해서 자신의 장애를 수용하여 현실에 적응할 수 있도록 사회복지사의 개입과정이 도입되어야 할 것이다. 둘째, 노인에게 있어 긍정적 정서에 많은 영향을 미치는 대상이 요양보호사임을 고려할 때 단지 요양보호사로써의 역할을 벗어나 노인의 강점과 긍정성을 발견하고 강화시키는 멘토의 역할을 감당할 수 있도록 요양보호사에 대한 체계적인 교육시스템의 마련이 제안되어야 할 것이다. 셋째, 지역사회를 중심으로 장기요양기관, 방문요양기관, 복지관 등과 건강보험관리공단이 통합네트워크를 구성하여 권역별로 장기요양보호를 이용하는 가정 및 긴급·위기가정에 대해 지원하는 통합사례관리체계가 마련되어야 할 것이다.

Effects of Contrast Phases on Automated Measurements of Muscle Quantity and Quality Using CT

  • Dong Wook Kim;Kyung Won Kim;Yousun Ko;Taeyong Park;Jeongjin Lee;Jung Bok Lee;Jiyeon Ha;Hyemin Ahn;Yu Sub Sung;Hong-Kyu Kim
    • Korean Journal of Radiology
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    • 제22권11호
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    • pp.1909-1917
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    • 2021
  • Objective: Muscle quantity and quality can be measured with an automated system on CT. However, the effects of contrast phases on the muscle measurements have not been established, which we aimed to investigate in this study. Materials and Methods: Muscle quantity was measured according to the skeletal muscle area (SMA) measured by a convolutional neural network-based automated system at the L3 level in 89 subjects undergoing multiphasic abdominal CT comprising unenhanced phase, arterial phase, portal venous phase (PVP), or delayed phase imaging. Muscle quality was analyzed using the mean muscle density and the muscle quality map, which comprises normal and low-attenuation muscle areas (NAMA and LAMA, respectively) based on the muscle attenuation threshold. The SMA, mean muscle density, NAMA, and LAMA were compared between PVP and other phases using paired t tests. Bland-Altman analysis was used to evaluate the inter-phase variability between PVP and other phases. Based on the cutoffs for low muscle quantity and quality, the counts of individuals who scored lower than the cutoff values were compared between PVP and other phases. Results: All indices showed significant differences between PVP and other phases (p < 0.001 for all). The SMA, mean muscle density, and NAMA increased during the later phases, whereas LAMA decreased during the later phases. Bland-Altman analysis showed that the mean differences between PVP and other phases ranged -2.1 to 0.3 cm2 for SMA, -12.0 to 2.6 cm2 for NAMA, and -2.2 to 9.9 cm2 for LAMA.The number of patients who were categorized as low muscle quantity did not significant differ between PVP and other phases (p ≥ 0.5), whereas the number of patients with low muscle quality significantly differed (p ≤ 0.002). Conclusion: SMA was less affected by the contrast phases. However, the muscle quality measurements changed with the contrast phases to greater extents and would require a standardization of the contrast phase for reliable measurement.

Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury

  • V. Michael Holers;Rachel M. Frank;Michael Zuscik;Carson Keeter;Robert I. Scheinman;Christopher Striebich;Dmitri Simberg;Michael R. Clay;Larry W. Moreland;Nirmal K. Banda
    • IMMUNE NETWORK
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    • 제24권2호
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    • pp.17.1-17.16
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    • 2024
  • We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to meniscus tear (MT) and proposed this as a mechanism for a greater post-injury prevalence of post traumatic osteoarthritis (PTOA). To explore additional roles of complement proteins and regulators, we determined the presence of decay-accelerating factor (DAF), C5b, and membrane attack complexes (MACs, C5b-9) in discarded surgical synovial tissue (DSST) collected during arthroscopic ACL reconstructive surgery, MT-related meniscectomy, osteoarthritis (OA)-related knee replacement surgery and normal controls. Multiplexed immunohistochemistry was used to detect and quantify complement proteins. To explore the involvement of body mass index (BMI), after these 2 injuries, we examined correlations among DAF, C5b, MAC and BMI. Using these approaches, we found that synovial cells after ACL injury expressed a significantly lower level of DAF as compared to MT (p<0.049). In contrast, C5b staining synovial cells were significantly higher after ACL injury (p<0.0009) and in OA DSST (p<0.039) compared to MT. Interestingly, there were significantly positive correlations between DAF & C5b (r=0.75, p<0.018) and DAF & C5b (r=0.64 p<0.022) after ACL injury and MT, respectively. The data support that DAF, which should normally dampen C5b deposition due to its regulatory activities on C3/C5 convertases, does not appear to exhibit that function in inflamed synovia following either ACL injury or MT. Ineffective DAF regulation may be an additional mechanism by which relatively uncontrolled complement activation damages tissue in these injury states.

Current Pediatric Endoscopy Training Situation in the Asia-Pacific Region: A Collaborative Survey by the Asian Pan-Pacific Society for Pediatric Gastroenterology, Hepatology and Nutrition Endoscopy Scientific Subcommittee

  • Nuthapong Ukarapol;Narumon Tanatip;Ajay Sharma;Maribel Vitug-Sales;Robert Nicholas Lopez;Rohan Malik;Ruey Terng Ng;Shuichiro Umetsu;Songpon Getsuwan;Tak Yau Stephen Lui;Yao-Jong Yang;Yeoun Joo Lee;Katsuhiro Arai;Kyung Mo Kim; APPSPGHAN Endoscopy Scientific Subcommittee
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제27권4호
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    • pp.258-265
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    • 2024
  • Purpose: To date, there is no region-specific guideline for pediatric endoscopy training. This study aimed to illustrate the current status of pediatric endoscopy training in Asia-Pacific region and identify opportunities for improvement. Methods: A cross-sectional survey, using a standardized electronic questionnaire, was conducted among medical schools in the Asia-Pacific region in January 2024. Results: A total of 57 medical centers in 12 countries offering formal Pediatric Gastroenterology training programs participated in this regional survey. More than 75% of the centers had an average case load of <10 cases per week for both diagnostic and therapeutic endoscopies. Only 36% of the study programs employed competency-based outcomes for program development, whereas nearly half (48%) used volume-based curricula. Foreign body retrieval, polypectomy, percutaneous endoscopic gastrostomy, and esophageal variceal hemostasis, that is, sclerotherapy or band ligation (endoscopic variceal sclerotherapy and endoscopic variceal ligation), comprised the top four priorities that the trainees should acquire in the autonomous stage (unconscious) of competence. Regarding the learning environment, only 31.5% provided formal hands-on workshops/simulation training. The direct observation of procedural skills was the most commonly used assessment method. The application of a quality assurance (QA) system in both educational and patient care (Pediatric Endoscopy Quality Improvement Network) aspects was present in only 28% and 17% of the centers, respectively. Conclusion: Compared with Western academic societies, the limited availability of cases remains a major concern. To close this gap, simulation and adult endoscopy training are essential. The implementation of reliable and valid assessment tools and QA systems can lead to significant development in future programs.

정보시스템의 지속적 사용에서 경험의 역할에 대한 분석 (An Analysis of the Roles of Experience in Information System Continuance)

  • 이웅규
    • Asia pacific journal of information systems
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    • 제21권4호
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    • pp.45-62
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    • 2011
  • The notion of information systems (IS) continuance has recently emerged as one of the most important research issues in the field of IS. A great deal of research has been conducted thus far on the basis of theories adapted from various disciplines including consumer behaviors and social psychology, in addition to theories regarding information technology (IT) acceptance. This previous body of knowledge provides a robust research framework that can already account for the determination of IS continuance; however, this research points to other, thus-far-unelucidated determinant factors such as habit, which were not included in traditional IT acceptance frameworks, and also re-emphasizes the importance of emotion-related constructs such as satisfaction in addition to conscious intention with rational beliefs such as usefulness. Experiences should also be considered one of the most important factors determining the characteristics of information system (IS) continuance and the features distinct from those determining IS acceptance, because more experienced users may have more opportunities for IS use, which would allow them more frequent use than would be available to less experienced or non-experienced users. Interestingly, experience has dual features that may contradictorily influence IS use. On one hand, attitudes predicated on direct experience have been shown to predict behavior better than attitudes from indirect experience or without experience; as more information is available, direct experience may render IS use a more salient behavior, and may also make IS use more accessible via memory. Therefore, experience may serve to intensify the relationship between IS use and conscious intention with evaluations, On the other hand, experience may culminate in the formation of habits: greater experience may also imply more frequent performance of the behavior, which may lead to the formation of habits, Hence, like experience, users' activation of an IS may be more dependent on habit-that is, unconscious automatic use without deliberation regarding the IS-and less dependent on conscious intentions, Furthermore, experiences can provide basic information necessary for satisfaction with the use of a specific IS, thus spurring the formation of both conscious intentions and unconscious habits, Whereas IT adoption Is a one-time decision, IS continuance may be a series of users' decisions and evaluations based on satisfaction with IS use. Moreover. habits also cannot be formed without satisfaction, even when a behavior is carried out repeatedly. Thus, experiences also play a critical role in satisfaction, as satisfaction is the consequence of direct experiences of actual behaviors. In particular, emotional experiences such as enjoyment can become as influential on IS use as are utilitarian experiences such as usefulness; this is especially true in light of the modern increase in membership-based hedonic systems - including online games, web-based social network services (SNS), blogs, and portals-all of which attempt to provide users with self-fulfilling value. Therefore, in order to understand more clearly the role of experiences in IS continuance, analysis must be conducted under a research framework that includes intentions, habits, and satisfaction, as experience may not only have duration-based moderating effects on the relationship between both intention and habit and the activation of IS use, but may also have content-based positive effects on satisfaction. This is consistent with the basic assumptions regarding the determining factors in IS continuance as suggested by Oritz de Guinea and Markus: consciousness, emotion, and habit. The principal objective of this study was to explore and assess the effects of experiences in IS continuance, with special consideration given to conscious intentions and unconscious habits, as well as satisfaction. IN service of this goal, along with a review of the relevant literature regarding the effects of experiences and habit on continuous IS use, this study suggested a research model that represents the roles of experience: its moderating role in the relationships of IS continuance with both conscious intention and unconscious habit, and its antecedent role in the development of satisfaction. For the validation of this research model. Korean university student users of 'Cyworld', one of the most influential social network services in South Korea, were surveyed, and the data were analyzed via partial least square (PLS) analysis to assess the implications of this study. In result most hypotheses in our research model were statistically supported with the exception of one. Although one hypothesis was not supported, the study's findings provide us with some important implications. First the role of experience in IS continuance differs from its role in IS acceptance. Second, the use of IS was explained by the dynamic balance between habit and intention. Third, the importance of satisfaction was confirmed from the perspective of IS continuance with experience.