• 대한한방소아과학회지
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• 제34권3호
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• pp.1-17
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• 2020

Objectives The purpose of this study is to analyze clinical studies on effectiveness of herbal medicine in refractory nephrotic syndrome (RNS). Methods We searched the randomized controlled trials (RCTs) with herbal medicine treatment on RNS from the Pubmed, CNKI, OASIS, NDSL, J-stage, and CiNii. The demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study. Results 11 RCT studies were selected and analyzed. The children in the control group were given western medicine therapy, and the treatment group was given herbal medicine along with the same western medicine of the control group. The most commonly used herbal medicines were the prescriptions to treat 'Kidney Deficiency with Blood Stasis (腎虛兼瘀血)' which composed of 'Promoting blood circulation (化瘀)', 'Diuresis-inducing (利水)', or 'Heating Yang (溫陽)' medicine based on 'Replenishing Kidney or Spleen (補腎, 補脾)' medicine. In the treatment group, proteinuria and serum lipid was significantly decreased, serum albumin was significantly increased, and total effective rate was significantly higher than the control group. Hypercoagulation and relapse rate was also significantly reduced. Adverse events were significantly lower in the treatment group. Conclusions Herbal medicine treatment on pediatric RNS can be suggested as a new treatment for children who have less response to the conventional therapy. It can also supplement the limitations of the western medicine by reducing adverse events from the steroids and immuno-suppressive agents, and lower the relapse rate as well.

• 대한한방내과학회지
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• 제23권1호
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• pp.117-122
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• 2002

Objective : We conducted this study to analyze some of the trends of treatments from the recent Chinese medical journals and contribute them to the oriental medical experiments and clinical research for the future. Methods : By referring to the Chinese medical journals that were published in China from 1999 to March, 2002, we analyzed the effective rates on frequency, methods, medical treatment, and diseases. Result : The average effective rate was 90.93%, which was very high. Lately, there have been no big changes in the methods of treatment. The methods of coordinating stomach-Qi, supplying Yin element, replenishing bone marrow, tonifying essence of life, and removing blood stasis are used by means of reinforcing Qi, producing blood, tonilying spleen, and replenishing the kidney. Conclusions : The decreased in bone marrow and leucopenia, and the side effects of radiotherapy and chemotherapy were more effectively treated when we used Korean oriental medical treatments. In addition, more Korean oriental medical experiments and clinical studies are needed in Korea, in the future.

• 동의생리병리학회지
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• 제16권3호
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• pp.409-420
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• 2002

At once Medicine of East and West have the same purpose in treating, but there is a difference between the method of medical care and the view/slant on a disease each other. In the East Medicine, It is very difficult to explain the concept of Hwalhyulhwau but it is one of the way to cure cancer for long time. Be based on the theory of the East Medicine, research single medicine's anti-cancer effect among the natural products that has anti-cancer function. Moreover, for the purpose of finding new way to cure and prevent against cancer, we, the researchers, divided into four groups for this research: Group one: survey new substance with anti-cancer effects from natural products. Group two: research of anti-cancer mechanism through the experimental studies. Group three: research of immune responses in anti-canncer effects from natural products. Group four: research of the inhibitory effect on metastasis through the anti-angiogenesis. From the above results, we blended efficacious medidcines against cancer and made new prescriptions of Soam-I and Soam-II. Now, we are studying on these new prescriptions. We speculate that Soam-I and Soam-II may be used for a new conceptional anticancer therapy.

• 동의신경정신과학회지
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• 제19권2호
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• pp.165-193
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• 2008

Objective: The ECG which used for this paper, is analysis result from alogrisms of arrythmia, and we have studied that how we could certain Cold(寒)type or Heat(熱) type and that Deficiency(虛) type or Excess(實)type of organs from various special diseases, and we obtained like these results. Method & Conclusion: 1. we depend on our examination about Pulse(脈) because we can't discriminate arrythmia using ECG analysis instruments. 2. We obtained that Cold(寒) type diseases had wave that prolonged above normal baseline and ST wave which had downward aptitude. 3. We obtained that Heat(熱) type diseases had the fibrillation which had shortend wave that compare to normal and had downward aptitude or negative aptitude. 4. We obtained that Respiratory system (肺) diseases had wave that is within normal or is short of normal range and had much fluctuation in potential difference or trans on P wave. 5. The character of EKG which presented about diseases of gastric systems is prolonged above narmal range of wave, and the ECG had represented mixed wave with Heat(熱) type when accompany inflammatory in gastric system. 6. The wave of Blood Stasis(瘀血) type had upward aptitude of QRS wave, and the wave of anemia or blood loss type(少血) had downward aptitude of QRS wave, the wave which had both Cold(寒)) and Heat (熱) represented mixed waves. 7. The Knotted Pulse(結脈) and Intermittent Pulse(代脈)is corresponded with sinus brady cardia, and the Swift Pulsle(疾脈) is corresponded with fibrillation. 8. We pay attention to the relations of formations about pressures pulse from formations of EMD( electromechanical dissociation ). Result : From these results, we will have to study about ECG which using in tests of change of Parkinsons disease.

• Journal of Applied Biological Chemistry
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• 제50권4호
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• pp.264-269
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• 2007

Root extracts of Angelica gigas and A. acutiloba have been used traditionally for the treatment of gynecological diseases, as well as anemia, blood stasis, and inflammatory pain, as blood tonics in Oriental medicine. In the present study, we investigated the effects of A. gigas and A. acutiloba on inflammatory mediators in mouse macrophages and compared their activities. Many studies suggest that prostaglandin $E_2$ ($PGE_2$) biosynthesis and nitric oxide (NO) production play important roles in the processes of both inflammation and carcinogenesis. Ethanolic extracts from the roots of both species exhibited significant inhibitory effects on $PGE_2$ generation in lipopolysaccharide-stimulated RAW 264.7 cells. In particular, the extract from A. gigas was more effective than that from A. acutiloba. Although neither inhibited NO generation, the extract from A. acutiloba stimulated NO generation. Our results suggest that the roots of A. gigas might possess more anti-inflammatory and/or cancer chemopreventative activity than that of A. acutiloba due to the suppression of cyclooxygenase-2 (COX2)-mediated $PGE_2$ production. In addition, A. acutiloba might exert anti-tumor activity through an increase in macrophage-produced NO.

• 동의생리병리학회지
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• 제24권2호
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• pp.249-257
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• 2010

Crataegii Fructus is commonly used as a improving digestion, removing retention of food, promoting blood circulation and resolving blood stasis agent in East Asia. Cadmium (Cd) is widely distributed in the environment due to its use in industry. An exposure to Cd causes dysuria, polyuria, chest pain, hepatic and renal tubular diseases. The liver is the most important target organ when considering Cd-induced toxicity because Cd primarily accumulates in the liver. This study investigated the protective effect of Crataegii Fructus water extract against cadmium ($CdCl_2$, Cd)-induced liver toxicity in H4IIE cells, a rat hepatocyte-derived cell line and in rats. Cell viability was significantly reduced in Cd-treated H4IIE cells in a time and concentration-dependent manner. However, Crataegii Fructus water extract (CFE) protected the cells from Cd-induced cytotoxicity via inhibition of PARP cleavage. To induce acute toxicity in rats, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously injected into rats. The rats then received either a vehicle or silymarin (as a positive control) or CFE (50, 100 mg/kg/day) for 3 days, and were subsequently exposed to a single injection of Cd. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with CFE reduced ALT, AST and LDH. In histopathological analysis, CFE reduced the hepatic degenerative regions and the number of degenerative hepatocytes. These are considered as direct evidences that Crataegii Fructus has favorable inhibitory effects on the Cd-intoxicated liver damages. The efficacy of Crataegii Fructus shows slight lower than that of silymarin in the present study.

• 대한한의학방제학회지
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• 제9권1호
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• pp.105-136
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• 2001

Objectives : 'Pi Wei Lun' is the principal medical work of Li Dongyuan's writings, which contains most of his medical theories. There are sixty-three prescriptions in 'Pi Wei Lun', and fifty-two of them were originated from him. This study was planned to present assistance to those who apply Dongyuan's theory clinically. Methods : We investigated those fifty-two prescriptions literary, and studied them from a viewpoint of the principle and method of treatment. Results : Dongyuan's fifty-two prescriptions can be classified into eight groups from the viewpoint of the principles and methods of treatment which are composed of 'tonify the spleen and stomach & elevate the spleen Yang', 'elevate the spleen Yang & expel fire', 'elevate the spleen Yang & relieve dampness', 'promote blood flow to eliminate blood stasis', 'invigorate the spleen', 'replenish Ki & and dispel phlegm', 'purgation with drugs warm in nature', and 'the other' eight methods. Conclusions : From above, we concluded that Dongyuan considered 'the primordial energy of the spleen and stomach' as the most important when making up prescriptions, but, at the same time, he used diverse methods of treatment on the ground of differentiation of syndromes.

• 대한한방부인과학회지
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• 제19권2호
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• pp.18-33
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• 2006

Purpose : Endometriosis has been thought to be related with blood stasis in uterus. Onkyung-tang is a herb which has effectiveness of activating blood, warmy and regulating mensturation, therefore in the present study, the effects of Onkyung-tang on endometriosis were investigated. Methods : The endometrial tissue was autografted to Rat's small intestine. Rats with surgically induced endometriosis was orally administerd with Onkyung-tang for 40 days. Size of ectopic uterine implants at the serosal wall and concentration of progesterone, estradiol, $TNF-{\alpha}$ and IL-2, 4, 6, 10 in serum were examined and compared with the control group. Results : The size of ectopic uterine implants of treated group was much smaller than that of control group. The concentration of estradiol, $TNF-{\alpha}$ and IL-4 level were significantly decreased in experimental group compared with the control group. IL-10 level was significantly increased in experimental group compared with the control group. There was no significant difference in progesterone, IL-2, 6 level in experimental group and control group as well. Conclusion : My data suggest that Onkyung-tang reduce the size of ectopic uterine implants at the serosal wall and inhibit the growth of ectopic uterine implants. Judging from the above results, it can be suggested that Onkyung-tang should be a useful agent for inhibiting the proliferation of uterine endometrial tissue.

• 혜화의학회지
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• 제9권1호
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• pp.661-689
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• 2000

We came to the conculsion after considering all of information from many kinds of books on the cause, pathogenesis and treatment of Flaccidity-syndrome. The results were as follows : 1. Flaccidity-syndrome means limb-relaxation due to muscle atony that isn't able to constraction. It's begun as mild degree from extremities, in some cases ended to quadriplegia or expire. 2. Cause factor and pathogenesis of Flaccidity-syndrome is various. After Lung fluid consuption caused by heat-evil was refered in The Yellow Emperor's Canon of Internal Medicine. They were refered as cause factor that Main channel asthenia, excess of sexual intercourse, wetness-evil, heat-evil gets into the interior, asthenia of the spleen and stomach. Since Ming Dynasty, It's classified to wetness-heat evil, wetness-phlegm, deficiency of vital energy, deficiency of blood, deficiency of yin, blood stasis and indygestion, etc. 3. In the view of treatment of Flaccidity-syndrome, Yangming was selected in The Yellow Emperor's Canon of Internal Medicine, and it's been mean to clear away wetness-heat evil located at Yangming. In the method of acupuncture it was same on the base, and many skills have been used that electronic acupuncture, point-injection theraphy, acupuncture point block, catgut implantaion at acupuncture point, cutaneous acupuncture, auriculo-acupuncture and head acupuncture by the through post generation. 4. Flaccidity-syndrome was defined to weak, disuse and non-pain. Beacause it was non-pain, so medicine to expel wind-evil was prevented to use. But through post generation Flaccidity-syndrome has been treated that is able to cause pain or numness as arthralgia-syndrome. Therefore there is tendency that medicine to expel wind-evil is capable within pathological basement of Flaccidity-syndrome in recent. 5. In the view of west-medicine, Flaccidity-syndrome is diplegia or quadriplegia with sensory disorder, muscle atropy in some cases. And there are spinal disease, peripheral nerve disease, muscular disease, nerve-muscle copula disease. The symptoms are able to amyotomia, numness, sensory disorder, pain.

• 대한한의진단학회지
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• 제17권3호
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• pp.179-188
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• 2013

Objectives This study was designed to development the diagnosis indicators for the fatigue group without disease using analysis of questionnaire data. Methods The subjects were divided into three groups, the fatigue group with disease, the fatigue group without disease, non-fatigue group without disease. Thirteen kinds of questionnaire (Fatigue visual analogue scale, Fatigue severity scale, Pain visual analogue scale, Short-form McGill pain questionnaire score, Headache impact Test-6, Neck disability index, Oswestry low back pain disability questionnaire score, Blood stasis assessment scale, Physical activities questionnaire score, Beck depression inventory, Anger expression inventory score, Mood disability scale, Job stress scale) were carried out for the subjects. Results The results of this study are ; 1) The weight, the systolic and diastolic blood pressure were different among three groups. 2) Among nine questionnaires related to the physical or life conditions, the averages of eight questionnaires were not same one another. 3) Among four questionnaires related to the mental condition or autonomic nervous system, the averages of Beck depression inventory were not same one another. Conclusion The fatigue group without disease can be diagnosed through using the both the questionnaires related to the physical or life condition and the those related to the mental condition or autonomic nervous system.