• Clinical and Experimental Pediatrics
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• 제51권1호
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• pp.26-32
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• 2008

목 적 : 1998년과 2005년 신체발육표준 제정사업 자료를 이용하여 2007년 소아청소년 성장곡선의 개발과정에서에 이용된 성장곡선 및 혈압분포 개발 방법론을 제시하고자 하였다. 방 법 : 성장곡선은 1998년과 2005년 자료를 이용해서 각 백분위수의 성장곡선 모형을 추정하고 LMS를 방법을 이용하여 최종 성장곡선을 생산하였다. 연령과 신장별 혈압 성장곡선은 2005년 자료를 이용하여 남녀별로 고정효과 회귀모형을 적용하여 산출하였다. 결 과 : 2007 소아청소년 성장곡선 및 혈압분포 표를 제시할 수 있었다. 결 론 : 2007년 성장곡선과 혈압분포 표는 현재 가용한 자료와 최신의 통계적 방법을 최대한 활용한 국내 최초의 결과로서 향후 지속적인 발전을 위한 논의와 연구가 필요하다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권3호
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• pp.276-285
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• 2020

Purpose: Non-alcoholic fatty liver disease (NAFLD) ranges in severity from simple steatosis to steatohepatitis. Early detection of NAFLD is important for preventing the disease from progressing to become an irreversible end-stage liver disease. We developed a nomogram that allows for non-invasive screening for NAFLD in obese children. Methods: Anthropometric and laboratory data of 180 patients from our pediatric obesity clinic were collected. Diagnoses of NAFLD were based on abdominal ultrasonographic findings. The nomogram was constructed using predictors from a multivariate analysis of NAFLD risk factors. Results: The subjects were divided into non-NAFLD (n=67) and NAFLD groups (n=113). Factors, including sex, body mass index, abdominal circumference, blood pressure, insulin resistance, and levels of aspartate aminotransferase, alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γGT), uric acid, triglycerides, and insulin, were significantly different between the two groups (all p<0.05) as determined using homeostatis model assessment of insulin resistance (HOMA-IR). In our multivariate logistic regression analysis, elevated serum ALT, γGT, and triglyceride levels were significantly related to NAFLD development. The nomogram was established using γGT, uric acid, triglycerides, HOMA-IR, and ALT as predictors of NAFLD probability. Conclusion: The newly developed nomogram may help predict NAFLD risk in obese children. The nomogram may also allow for early NAFLD diagnosis without the need for invasive liver biopsy or expensive liver imaging, and may also allow clinicians to intervene early to prevent the progression of NAFLD to become a more advanced liver disease.