• Title/Summary/Keyword: Blood pressure

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Peptide Inhibitors for Angiotensin I Converting Enzyme from Corn Gluten Digests. (옥수수 글루텐 효소 가수분해물의 Angiotensin I Converting Enzyme 활성 저해 펩타이드의 정제)

  • 오광석;이동건;홍정운;성하진
    • Microbiology and Biotechnology Letters
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    • v.31 no.1
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    • pp.51-56
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    • 2003
  • The angiotensin I converting enzyme (ACE) has an important role in the maintenance of blood pressure. The ACE inhibitory activities of foods have recently been studied. We tried to isolate ACE inhibitory peptides from the Flavourzyme (FZ), Pescalase (PE), and Thermolysine (TH) protease digests of corn gluten, which was restricted to the use the source of food for digestion problem. The FZ, PE, TH/PE protease hydrolyzed corn gluten and the inhibitory activities of the hydrolyzates for ACE were measured. Major fractions were isolated from the digests using ODS chromatography after treating with ethanol in step gradient. The ACE inhibitors were further purified by Bio-Gel P-2 column and reverse phase HPLC. Five inhibitory peptides were isolated. Their amino acids were sequenced as LPF ($IC_{50}$ = 40$\mu$M), GPP ($IC_{50}$ = 17.6$\mu$M), PNPY ($IC_{50}$ = 30.7$\mu$M), SPPPFYL ($IC_{50}$ = 63 $\mu$M), and SQPP ($IC_{50}$ = 17.2$\mu$M).

Sedative methods used during extraction of wisdom teeth in patients with a high level of dental anxiety

  • Seto, Mika;Furuta, Haruhiko;Sakamoto, Yumiko;Kikuta, Toshihiro
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.37 no.3
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    • pp.241-244
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    • 2011
  • Introduction: Intravenous sedation is performed to ensure smooth and safe surgery. Dental anxiety is a reaction to an unknown danger. The Spielberger's state-trait anxiety inventory (STAI) can be used to simultaneously evaluate the levels of state and trait anxiety. State anxiety is defined as subjective feelings of nervousness. This study assessed the presurgical anxiety using STAI and performed intravenous sedation for patients whose level of state anxiety was > stage IV. Based on our clinical experience, it is believed that higher doses of sedatives are needed to induce the desired levels of sedation in patients with a high level of state anxiety. Objectives: This study examined whether the sedative consumption of the patient with a high anxiety level increased. Patients and Methods: Patients with state anxiety scores of ${\geq}$51 were included in Group V, and those with state anxiety scores ranging from 42 to 50 were placed in Group IV. To induce sedation, intravenous access was established, and a bolus dose of 3.0 mg midazolam was administered intravenously. Sedation was maintained by administering a continuous infusion of propofol, which was aimed at achieving an Observer's Assessment of Alertness/Sedation scale of 10-12/20. In this study, midazolam was initially administered when the body movements appeared to occur or the blood pressure increased. This was followed by the administration of higher doses of propofol if low sedation was observed. Results: There were no significant differences in the patient demographics, duration of sedation, and doses of local anaesthetic agents between Groups IV and V. The midazolam dose and mean propofol dose needed to maintain comparable levels of sedation were significantly higher in Group V than in Group IV. Conclusion: In female patients, whose level of preoperative state anxiety is more than Stage V of STAI, a large quantity of sedatives is needed for intravenous sedation.

The Study on Correlation between Abdominal Fat Area and Obesity Index, Metabolic Syndrome Components in Obese Adult Women (복부지방면적과 비만지표, 대사증후군 구성요소와의 상관성 연구)

  • Ki, Sung-Hoon;Ye, Sung Ae;Song, Yun Kyung
    • Journal of Korean Medicine Rehabilitation
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    • v.26 no.1
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    • pp.103-111
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    • 2016
  • Objectives The waist circumference has been known as an obesity index reflecting the visceral fat. This study was conducted to investigate the obesity index of what can be predicted visceral fat obesity. Methods 121 test subjects who have $BMI{\geq}30$ or BMI 27~29.9 with having more than one high blood pressure, diabetes, and hyperlipidemia were gathered in the Gachon University Korean medical hospital. The relationship between obesity index, the abdominal fat area, and the metabolic syndrome component analyzed using Pearson correlation analysis. The obesity indices, that are largely used in clinics such as waist circumference (WC), HC (hip circumference), body mass index (BMI), waist-hip ratio (WHR) and waist-height ratio (WHtR). Total fat area (TFA), visceral fat area (VFA), subcutaneous area (SFA) and visceral fat/subcutaneous fat ratio (VSR) that was measured from CT. Results 1. Total fat area (TFA) was positively correlated WC, BMI, HC. 2. The subcutaneous fat area (SFA) was positively correlated HC, WC, BMI. 3. The visceral fat area (VFA) did not show a strong correlation with obesity indicators. Conclusions It was found indices of obesity and visceral fat area is a high correlation. BMI, WC was the obesity index showed a high correlation as the SFA, TFA.

The Effects of Individual Counseling for Bus-drivers to Cerebrovascular and Cardiovascular Disease Prevention: Secondary Data Analysis (버스운수업 종사자의 뇌심혈관질환 예방을 위한 개별상담 효과: 이차자료분석)

  • Jung, Hye-Sun;Eum, Mi-Jung;Jang, Insun
    • Korean Journal of Occupational Health Nursing
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    • v.24 no.4
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    • pp.281-289
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    • 2015
  • Purpose: This study was conducted to examine the effects of individual counseling for bus-drivers on cerebrovascular and cardiovascular disease prevention. Methods: The one-group pretest-posttest design was used. This study presents a secondary analysis of data collected in 'contents of cerebrovascular and cardiovascular disease prevention program for bus-drivers in one workplace in Seoul, Korea. The data were collected from 56 bus drivers, using questionnaires from September 10th to November 20th, 2014. The analysis was conducted with ${\chi}^2$ test and paired samples t-test using SPSS/Win 21.0. Results: After the intervention, the participants showed a significant decrease in the level of systolic blood pressure (p=.003) and a significant increase in the total cholesterol level (p=.030). The distribution of cardiovascular risk groups changed after the intervention: 5.3% decreased in the high risk group, 16.1% decreased in the medium risk group, and 3.5% decreased in the low risk group, while 25.0% increased in the normal group. Conclusion: The comprehensive individual counseling including simple screening, tailored education and counseling is effective to manage their lifestyle risk factors, resulting in better maintenance of their health as well as preventing cerebrovascular and cardiovascular disease.

A statistical analysis of the fat mass experimental data using random coefficient model (변량계수모형을 이용한 체지방 실험자료에 관한 통계적 분석)

  • Jo, Jin-Nam
    • Journal of the Korean Data and Information Science Society
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    • v.22 no.2
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    • pp.287-296
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    • 2011
  • Thirty six female students participated in the experiment of the fat mass weight loss. they kept diary for foods they ate every day, took a picture of the foods, transmitted the picture to the experimenter by the camera phone, and consulted him about fat mass loss once a week for 8 weeks period. Fat mass weight and its related factors of the students had been measured repeatedly every week during 8 weeks, The repeated measurement data were used for applying various random coefficient models. And hence optimal random coefficient model was selected. From the optimal model, the baseline, body mass index, diastolic blood pressure, total cholesterol and time of the fixed factors were very significant. The fixed quadratic time effect existed. The variance components corresponding to the subject effect, linear time effect of the random coefficients were all positive. Thus random coefficients up to the linear terms were considered as the optimal model. The treatment effect reduced the weight loss to an average of 2.1kg at the end of the period.

The Relationship Between Obesity, Overweight, and the Human Development Index in World Health Organization Eastern Mediterranean Region Countries

  • Ataey, Amin;Jafarvand, Elnaz;Adham, Davoud;Moradi-Asl, Eslam
    • Journal of Preventive Medicine and Public Health
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    • v.53 no.2
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    • pp.98-105
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    • 2020
  • Objectives: Obesity is regarded as one of the most prominent health threats worldwide and a serious risk factor for non-communicable diseases, such as diabetes mellitus type 2, high blood pressure, cardiovascular diseases, and some types of cancer. Given the role that societal development-as reflected by the Human Development Index (HDI)-may play in the prevalence of obesity and overweight, this study aimed to investigate the degree to which the prevalence of obesity and overweight is affected by HDI and its components. Methods: In this ecological study, the required data on HDI and its components were gathered from the latest report of the United Nations Development Program, and data on obesity and overweight were acquired from the latest reports published on the World Health Organization website. Statistical analyses were conducted using SPSS version 24.0. Results: The prevalence of obesity was determined to be significantly higher among females than males, and the gross national index per capita was found to be significantly higher for males than females (p<0.05). Significant positive correlations were found between HDI and its components and sex, as well as indices of obesity and overweight. Conclusions: A significant positive correlation exists between HDI and obesity. As policy-makers attempt to improve the general welfare of the people, they should be aware of potential unwanted effects of development on the risk of obesity and overweight among the population.

Analysis of learning preferenece using student's sympathetic-parasympathetic response (학습자의 교감/부교감 반응 분석에 의한 학습 선호도 분석에 관한 연구)

  • Kim, Bo-Yeon;Cha, Jae-Hyuk
    • Journal of Digital Contents Society
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    • v.8 no.3
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    • pp.355-363
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    • 2007
  • One of major factors for learning achievement is the student's learning preference according to his character type. In course of learning, if a student studies e-learning contents opposed to his preference, then he would be under stress and his blood pressure and heart beat be changed. For measuring unwillingness, we used spectral components in frequency domain known as stress measure. For 13 children attending kindergarten we examined S(sensing)/ N(intuition) of MBTI and presented same learning contents during 10 minutes. During learning we gathered ECG signals, changed into HRV(heart rate variability), transformed time-varying HRV signal into spectral density in frequency domain. And then, we divided it into three areas of low(LF), middle(MF), and high-frequency(HF) and calculated stress measures by rates of those frequency area. We compared estimated stress measures of S group with them of N group whether students in different group preferred different contents or not. Experimental shows that students according to MBTI type prefer different contents.

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A Systematic Review of Interventions with Low-Income School-Age Children and Adolescents (저소득층 학령기 아동·청소년 대상 건강관련 중재에 관한 체계적 문헌고찰)

  • Hwang, Ji-hye;Choi, HyunJee;Jeong, Hyo Jin;Kim, Chorong;Woo, YunJung
    • Perspectives in Nursing Science
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    • v.15 no.2
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    • pp.92-106
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    • 2018
  • Purpose: The purpose of this study was to review health-related interventions in nursing studies for low-income school-age children and adolescents. Methods: Searches among CINAHL, MEDLINE, PubMed, EMBASE, DBpia, and RISS identified 27 intervention studies published from January 2000 to April 2018. Results: Twenty-seven intervention studies were identified: 12 included psychosocial adaptations and 15 included the healthy lifestyle promotion and disease prevention. The settings were mainly schools and community welfare centers. Many studies were based on social cognitive theory and interventions were provided in a group format. Depression, self-esteem, resilience, self-efficacy for vegetable and fruit consumption, physical activity, and health-related knowledge improved significantly after the health-related interventions. However, the findings were inconsistent with regard to anxiety, peer relationships, body mass index (BMI), blood pressure, cholesterol, and glucose. Conclusion: There is potential for enhancing outcomes for psychosocial, physical health, and health-related knowledge among low-income school-age children and adolescents. Integrated interventions addressing the physical as well as psychological health of low-income children and adolescents should be conducted. It would be prudent to consider the ethnicity and family background of the child or adolescent. However, rigorous study designs and scientific validation are needed for further evidence.

Clinical Analysis of Patients with Cardiotoxicity Caused by Himalayan Mad Honey (히말라야산 석청 복용 후 발생한 심장독성 환자들의 임상적 특성 분석)

  • Kim, Sung Ho;Seo, Dong Woo;Ryoo, Seung Mok;Kim, Won Young;Oh, Bum Jin;Lim, Kyoung Soo;Sohn, Chang Hwan
    • Journal of The Korean Society of Clinical Toxicology
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    • v.11 no.2
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    • pp.119-126
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    • 2013
  • Purpose: The aim of this study was to evaluate the clinical characteristics and outcome of patients who presented to the emergency department (ED) with cardiotoxicity caused by ingestion of Himalayan mad honey. Methods: Medical records of 12 patients who presented to the ED from January 1, 2005 to December 31, 2012 with cardiotoxicity caused by ingestion of Himalayan mad honey were retrospectively reviewed. Results: The mean age of patients was 54.5 years and 58.3% were men. The median amount of mad honey ingested was 30.0 cc, and the mean time from ingestion to onset of symptoms was 39.4 minutes. All patients had hypotension and bradycardia upon arrival in the ED. The initial electrocardiogram showed sinus bradycardia in seven patients, junctional bradycardia in four patients, and atrial fibrillation with slow ventricular response in one patient. Four patients were treated with intravenous normal saline solution only. Eight patients were treated with intravenous normal saline solution and atropine sulfate in a dose ranging from 0.5 to 2.0 mg. Blood pressure and pulse rate returned to normal limits within 24 hours in all patients. Conclusion: Our study showed that all patients with cardiotoxicity caused by ingestion of Himalayan mad honey had severe hypotension, bradycardia, and bradyarrythmias, including sinus bradycardia and junctional bradycardia and all patients responded well to conservative treatment, including intravenous normal saline solution and intravenous atropine sulfate.

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Proteome-based Identification of Proteins Regulated by Aldosterone in Rat Kidney Cortex (프로테오믹스 기술을 통한 쥐의 신장 피질에서 알도스테론(Aldosterone)에 의해 조절되는 단백질 동정)

  • Song, Mi-Na;Jeon, Hong-Bae;Choi, Hyo-Jung;Kwon, Tae-Hwan;Baek, Moon-Chang
    • YAKHAK HOEJI
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    • v.54 no.3
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    • pp.180-186
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    • 2010
  • Aldosterone, mineralocorticoid hormone, has important functions related to the regulation of blood pressure and balance of fluids and electrolytes in the distal region of the nephron. By genomic and non-genomic action of aldosterone, the physiological kidney functions are modulated. However, many of them except several kind of sodium channel have not been identified and analyzed yet. In this study, proteomic technologies with two-dimensional gel electrophoresis (2-DE) gel using aldosterone rat model were applied to analyze and identify the aldosterone dependently expressed proteins in rat kidney cortex. As a result, the established aldosterone rat model exhibited the normal physiological responses to aldosterone and modulated proteins were identified, which included 15 increased and 3 decreased proteins on 2-DE analysis. Among them, 11 proteins were identified as changed proteins by LC-MS/MS analysis. These proteins identified as aldosterone induced proteins were involved in several cellular pathways such as cytoskeleton remodeling, energy metabolism, amino acid metabolism, and chaperone process. In conclusion, our data could provide the insights into the new mechanism underlying regulation of kidney functions by aldosterone.