• 제목/요약/키워드: Blood Uric Acid

검색결과 214건 처리시간 0.027초

Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats

  • Menyiy, Nawal El;Al-Waili, Noori;Ghouizi, Asmae El;Al-Waili, Wail;Lyoussi, Badiaa
    • Nutrition Research and Practice
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    • 제12권6호
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    • pp.535-540
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    • 2018
  • BACKGROUND/OBJECTIVES: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats. MATERIALS/METHODS: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg.B.WT. respectively; the fourth group was treated by paracetamol (200 mg/kg.B.WT.); the fifth group was treated by propolis (50 mg/kg.B.WT.) for eight days and then received similar dose of propolis for following seven days with paracetamol at a dose of 200 mg/kg.B.WT. daily for the seven days; and the sixth group was treated with propolis (100 mg/kg.B.WT.) for eight days and then received similar dose of propolis for following seven days with paracetamol at a dose of 200 mg/kg.B.WT. daily for the seven days. All the animals were treated for a period of 15 days. At the end of the experimental period, blood samples were collected for measurement of the liver enzymes, serum albumin, protein and creatinine, blood urea nitrogen, hematological parameters, and urine volume, protein and albumin. RESULTS: Paracetamol over dose significantly lowered hemoglobin, serum total protein, albumin, and uric acid, while it significantly increased blood creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, white blood cells, and platelet count as compared to the control. However, these alterations were significantly attenuated by the use of propolis extract and the effect was dose dependent. Interestingly, propolis prevented paracetamol induced proteinuria, low hemoglobin and body weight loss. CONCLUSIONS: Propolis significantly prevented paracetamol induced renal, hepatic and hematological toxicity and might be useful in the management of liver and renal diseases particularly proteinuria.

알톨 대사에 미치는 인삼의 영향 (Effect of Ginseng on the Alcohol Metabolism in Alcohol Treated Rat)

  • 허근;최종원
    • 약학회지
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    • 제28권1호
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    • pp.49-51
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    • 1984
  • After pretreatment with ginseng followed by induction of acute intoxication of alcohol, the activities of alcohol dehydrogenase (ADH), microsomal ethanol-oxidizing system (MEOS) and aldehyde dehydrogenase(Ald DH) increased respectively compared to the groups treated with alcohol alone. In case that ginseng was given to rats fed with 5% alcohol instead of water for 60 days, the activities of ADH and MEOS increased compared to the groups treated. On the contrary, the activity of Ald DH in mitochondrial fraction decreased to an extent of about 35% in chronic alcoholism, but after pretreatment of ginseng the activity was restored to the control level. On the other hand, the catalase activity was not significantly affected by either treatment. Ginseng butanol fraction significantly increased the serum isocitrate dehydrogenase activity which is inhibited by alcohol-treated in rat. Alcohol-induced lactate dehydrogenase activity was decreased to control level in liver by ginseng treatment. And the serum level of lactic acid also decreased by ginseng treatment in alcohol-intoxicated rat. Ginseng butanol fraction markedly decreased the xanthine oxidase activity in the ethanol-treated rat liver. It was also observed that ginseng reduced the blood concentration of uric acid on experimentally reduced hyperuricemia by alcohol treatment. Uricase activity was not affected by either treatment. Ginseng butanol fraction decreased the hepatic aniline hydroxylase activity which was induced by alcohol-treated rat. These results suggest that the treatment with ginseng can be promoted the recovery from alcohol intoxication and some therapeutic effect on alcoholinduced metabolic disease.

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뇌혈관질환과 관상동맥성 심질환의 위험요인에 관한 환자-대조군 연구 (The Case-Control Study on the Risk Factors of Cerebrovascular Diseases and Coronary Heart Diseases)

  • 박종구;김헌주;박금수;이성수;장세진;신계철;권상옥;고상백;이은경
    • Journal of Preventive Medicine and Public Health
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    • 제29권3호
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    • pp.639-655
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    • 1996
  • Cerebrovascular disease and coronary heart disease are the first and the fourth common causes of death among adults in Korea. Reported risk factors of these diseases are mostly alike. But some risk factors of one of these diseases may prevent other diseases. Therefore, we tried to compare and discriminate the risk factors of these diseases. We recruited four case groups and four control groups among the inpatients who were admitted to Wonju Christian Hospital from March, 1994 to November, 1995. Four control groups were matched with each of four case groups by age and sex. The number of patients in each of four case and control groups were 106 and 168 for acute myocardial infarction(AMI), 84 and 133 for subarachnoid hemorrhage(SAH), 102 and 148 for intracerebral hemorrhage(ICH), and 91 and 182 for ischemic stroke(IS) respectively. Factors whose levels were significantly higher in AMI and IS than in responding control group (RCG) were education, economic status, and triglyceride. Factors whose levels were significantly lower in hemorrhagic stroke than in RCG were age of monarch, and prothrombin time. The factor whose level was higher in AMI than ill RCG was uric acid. The factor whose level was higher in AMI, ICH, and SAM than in RCG was blood sugar. Factors whose levels were significantly higher in all the case groups than in RCG were earlobe crease, Quetelet index, white blood cell count, hemoglobin, hematocrit, and total cholesterol. The list of risk factors were somewhat different among the four diseases, though none of the risk factors to the one disease except prothrombin time acted as a preventive factor to the other diseases. The percent of grouped cases correctly classified was higher in the discrimination of ischemic diseases(AMI and IS) from hemorrhagic diseases(SAM and ICH) than in the discrimination of cerebrovascular disease from AMI. The factors concerned in the discrimination of ischemic diseases from hemorrhagic diseases were prothrombin time, earlobe crease, gender, age, uric acid, education, albumin, hemoglobin, the history of taking steroid, total cholesterol, and hematocrit according to the selection order through forward selection.

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Effect of Temperature Shock on Cultured Olive Flounder (Paralichthys olivaceus) and Black Rockfish (Sebastes schlegeli)

  • Lee Sang Jun;Lee Jong Hee;Kang Jeong Ha;Lee Jeong Ho;Min Kwang Sik;Myung Jeong In;Kim Yoon;Kong In Soo
    • Fisheries and Aquatic Sciences
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    • 제4권3호
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    • pp.112-119
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    • 2001
  • Aim of this research is to investigate the effect of temperature shocks on the physiological responses of cultured olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes schlegeli). Olive flounder and black rockfish were suffered with high and low temperature shocks for 4 and 8h, respectively, in laboratory conditions and then the changes in glucose, lactate, total protein, uric acid, and triglycerides-glycerol in blood plasma were analyzed. We observed that lactate and uric acid increased for up to 4h and then decreased for up to 8h by the high and low temperature shocks, and total protein decreased for up to 4h and then recovered for up to 8h by the high temperature shock in both fishes. Glucose by the high and low temperature shocks and triglycerides-glycerol by the low temperature shock increased for up to 4h, and then decreased in olive flounder, but increased for up to 8h in black rockfish. From the result, we speculated that the two fishes have an interspecific variation in the regulatory systems of glucose and triglycerides-glycero1. Glucose would play important role as an energy source during the temperature shocks and for an intermediate substance for low temperature tolerance, and glycerol of triglycerides-glycerol would play an important role for low temperature tolerance. In olive flounder, the turnover of chemical change by temperature shock took more than 4h, all chemicals returned almost to the initial level for up to 8h, but fish death followed only in 8h with the high temperature shocked group within two days. Therefore, we suggested that fish would be damaged severely by the longer time exposure of high temperature and mortality would occur after a certain time later than the shocked time as a post-effect.

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Mice를 이용한 혈액 및 생화학적 특성에 대한 Nitrogen Dioxide의 위해성 평가 (Risk Assessment of Nitrogen Dioxide for Hematological and Biochemical Parameter in Mice)

  • 정성욱;한용수;박흥재
    • 한국환경과학회지
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    • 제16권5호
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    • pp.665-670
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    • 2007
  • 본 연구에서는 실험동물을 이용하여, $NO_2$의 반복적으로 폭로($0.025mg/m^3$, 8h/day /4 weeks)하여, 실험군 및 대조군에서의 혈액학 및 생화학적 요인들의 변화와 상관성을 평가하였 였으며, 그 결과를 요약하면 다음과 같다. $NO_2$의 흡입 폭로로 인한 혈액학적 요인의 변화는 백혈구의 경우 동물실험에서의 폭로군에서 통계적으로 유의하게 증가하였다(p<0.05). hematocrit의 경우 폭로군에서 통계적으로 유의하게 감소하는 경향을 나타내었다. 또한 hemoglobin과 hematocrit는 전혈 중에서 적혈구의 비율을 나타내는 것이므로 3가지 종류 모두 유사한 경향을 나타내었다. methemoglobin의 경우 동물실험에서 폭로군에서 유의하게 증가하였다(p<0.05). 생화학적 요인에 대한 $NO_2$의 영향은 동물실험에서 total protein과 triglyceride이 동물 실험에서의 폭로군에서 감소하였으나 통계적으로 유의하지는 않았다. albumin이 폭로군에서 감소하였고, blood urea nitrogen과 creatinine의 경우 폭로군에서 높은 경향으로 나타났다. uric acid 및 혈청 중 lactate dehydrogenase의 경우 폭로군이 대조군 보다 높은 농도를 나타내어 $NO_2$의 폭로에 의해 호흡기 조직세포 내 이상을 일으킨 것으로 판단된다. 따라서 실내오염물질 중 산화가스의 하나인 $NO_2$에 대한 위해성 평가는 저농도에서의 폭로연구가 장기적이고 지속적으로 이루어져야 할 것으로 사료된다.

한우 및 돼지의 혈액화학치에 관한 연구 (Studies on the Blood Chemistry of Korean Native Cattle and Pigs)

  • 도재철;이창우;손재권;정종식
    • 한국동물위생학회지
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    • 제13권1호
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    • pp.49-53
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    • 1990
  • In order to know the range in blood chemical values and enzyme activities of korean native cattle and pigs being raised in kyongbuk province, the mean values of serum protein compositions, enzyme activities(GOT, GPT, ALP), cholesterol, glucose, bilirubin, creatinine, urea nitrogen and uric acid were determined and the results obtained were as follows ; 1. Mean contents of total protein, albumin, globulin and A / G ratio for the korean native male cattle were $7.28{\pm}0.86$ g / dl, 43.39{\pm}0.65$ g / dl, 43.83{\pm}0.92$ g / dl & 40.95{\pm}0.34$;for the male pigs were 47.39{\pm}0.84$ g / dl, 43.63{\pm}0.43$ g / dl, 43.77{\pm}0.88$ g / dl, 40.97{\pm}0.26$;for the female pigs were 47.60{\pm}0.68$ g/ dl, 43.54{\pm}0.58$ g / dl, 43.90{\pm}0.74$ g / dl, 41.02{\pm}0.34. 2.$ Mean activities of GOT, GPT and ALP for the korean native male cattle were 448.3{\pm}11.6$ U, 429.6{\pm}4.6$ U, 413.7{\pm}2.8$ U; for the male pigs were 458.6{\pm}10.6$ U, 438.6{\pm}5.3$ U, 424.9{\pm}9.2$ U; for the female pigs were 443.9{\pm}10.8$ U, 440.5{\pm}4.6$ U, 413.9{\pm}3.4$ U. 3. Mean contents of cholesterol, glucose and bilirubin for the korean native male cattle were 4108.7{\pm}31.8$ mg / dl, 488.2{\pm}26.4$ mg / dl, $0.69{\pm}0.52$ mg / dl; for the male pigs were 4105.9{\pm}18.3$ mg / dl, 4102.9{\pm}22.3$ mg / dl, 40.70{\pm}0.18$ mg / dl: for the female pigs were $113.1{\pm}20.9$ mg / dl , 4103.2{\pm}23.9$ mg / dl, 40.49{\pm}0.21$ mg / dl. 4. Mean contents of creatinine, urea nitrogen and uric acid for the korean native male cattle were 42.86{\pm}0.69$ mg / dl, $18.1{\pm}5.0$ mg / dl, 41.38{\pm}0.66$ mg /dl; for the male pigs were 42.20{\pm}0.51$ mg / dl, $18.2{\pm}4.3$ mg / dl, 40.29{\pm}0.10$ mg /dl: for the female pigs were 42.36{\pm}0.70$ mg / dl, $20.5{\pm}5.4$ mg / dl, 40.69{\pm}0.27$ mg / dl.

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비만환자(肥滿患者)의 체질적 특징(特徵)에 대한 임상적(臨床的) 고찰(考察) (A CLINICAL STUDY OF THE OBESITY PATIENTS ACCORDING TO SASANG CONSTITUTION (Focusing on the physical views and diagnosis results))

  • 조민상;고병희;송일병
    • 사상체질의학회지
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    • 제10권2호
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    • pp.485-511
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    • 1998
  • In orther to find the characteristics of each constitution, the examine of Kyung Hee medical center was diagnosed constitution, and resulted body measures and diagnosis. That was considered and the results are as follows 1. The obese patients is that there are the best many people(91.0%) to Taeumin. The frequency of Taeumin group is more than Soyangin group and Soeumin group. The degree of obesity grade is the highest in Taeumin. 2. The systolic blood & diastolic blood pressure of obese patients did not show any significant differences. Only, the obesity patients is the higher than nomal examine, without regard to Sasang constitution. 3. The hypertensive frequency of obese patients is that Taeumin group is more than Soyangin group and Soeumin group. there is not show any significant differences. specially, the hypertension of Soyangin group is caused by an ascending of diastolic pressure. 4. Glucose value of obese patients did not show any significant differences. generally, the frequency of Taeumin group is more than Soyangin group and Soeumin group. The diabetes of obese patients is the highest in Taeumin. 5. The serum lipids of obese patients did not show any significant differences. Total cholesterol, Triglyceride value of Taeumin group is more than Soyangin group and Soeumin group. HDL-cholesterol of obese patients is that Taeumin group is more than Soyangin group and Soeumin group. 6. The frequency of hyperlipidemia is the highest in Taeumin. 7. GOT, GPT of obese patients did not show any significant differences, but GGT is higher in Taeumin than Soyangin & Soeumin group. 8. Uric acid of obesity patients did not show any significant differences between Sasang constitution, but the value of obese patients is higher than nomal examine. The abnomality of Uric acid is higher in Taeumin than the other constitutions. The frequency of abnomality is the highest in Taeumin females. 9. Arteriosclerosis frequency of obese patients did not show any significant differences, the frequency of Sasang constitution is higher in Taeumin than Soyangin & Soeumin group. 10. Hemoglobin of obese patients did not show any significant differences, but Hematocrit is higher in Soyangin than Taeumin & Soeumin group. Anemia of obese patients did not show any significant differences. The frequency of anemia is higher in the females than the males. 11. BUN, creatinine of obese patients did not show any significant differences.

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원양항해 전과 후 선원의 혈액 및 소변의 생화학적 분석 (Biochemical Analysis of Crew's Blood and Urine before & after Long-Term Navigation)

  • 하해동;문성배;전승환;정은석;김재호
    • 한국항해항만학회지
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    • 제30권5호
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    • pp.415-420
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    • 2006
  • H대학 실습선 28명의 선원에 대하여 40일간 장기간 항해 전과 후의 혈액과 소변의 생화학적 분석을 실시하였다. 원앙 후 부원 및 모든 연령에서 요소질소와 요산수치(creatine 및 uric acid)가 증가된 것으로 보아 선상생활이 신장의 기능을 나쁘게 하거나 기능저하를 초래했다고 판단되어진다. 또 총콜레스테롤(TC)과 고밀도지단백콜레스테롤(HDL-C) 및 저밀도지단백콜레스테롤(LDL-C)은 원양 전보다 후에 유의하게 감소한 반면에 중성지방(TG)은 유의하게 상승하였다. 연령별로는 TC와 HDL-C가 30대, 40대에서 유의하게 감소하였고, TG는 30대가 유의하게 증가하였는데 특히 30대에서 몇몇 선원에 대해서는 원양 후 TG의 높은 증가를 보여 고지혈증이 의심되고 있다. 또한 소변검사에서도 간세포성기능 및 신장기능의 이상을 진단하는 담즙색소(UBG)와 요단백(PRO)에서 장기간 항해 전과 후 모두 양성반응이 나타난 선원이 각각 7명과 5명 이었다. 특히 우로빌리노겐(Urobilinogen : UBG)에서 양성반응이 크게 증가하여 한 달간 원앙을 통하여 간세포성기능이 저하되었거나 이상이 있음을 보여주고 있다.

원양항해 전과 후 선원의 혈액 및 소변의 생화학적 분석 (Biochemical Analysis of the seamen's blood and urine before & after the ocean navigation)

  • 하해동;문성배;전승환;정은석;김재호
    • 한국항해항만학회:학술대회논문집
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    • 한국항해항만학회 2006년도 춘계학술대회 및 창립 30주년 심포지엄(논문집)
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    • pp.5-11
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    • 2006
  • K대학 실습선 28명의 선원에 대하여 40일간 원양하기 전과 후의 혈액과 소변의 생화학적 분석을 통하여 볼 때 원양 후 부원 및 모든 연령에서 요소질소와 요산지수(Creatine 및 Uric acid)가 증가된 것으로 보아 선상생활이 신장의 기능을 나쁘게 하거나 기능저하를 초래했다고 판단되어진다. 또 총콜레스테롤(TC)과 고밀도지단백콜레스테롤(HDL-C) 및 저밀도지단백콜레스테롤(LDL-C)은 원양 전보다 후에 유의하게 감소한 반면에 중성지방(TG)은 유의하게 상승하였다. 한편 원양 전과 후 사관부와 부원 그리고 갑판부, 기관부, 사주부간에 증가와 감소의 현상은 보이지만 유의한 차이는 나타나지 않았다. 그러나 연령별로는 TC와 HDL-C가 30대, 40대에서 유의하게 감소하였고, TG는 30대가 유의하게 증가하였는데 특히 30대에서 몇몇 선원에 대해서는 원양 후 TG의 높은 증가를 보여 고지혈증이 의심되고 있다. 또한 소변검사에서도 간세포성기능 및 신장기능의 이상을 진단하는 담즙색소(UBG)와 요담백(PRO)에서 원양 전과 후 모두 양성반응이 나타난 선원이 각각 7명과 5명이었다. 특히 우로빌리노겐(Urobilinogen : UBG)이 원앙 전 1명이 양성이었으나 원양 후 7명이 양성반응이 나타나서 한 달간 원양을 통하여 간세포성기능이 저하되었거나 이상이 있음을 보여주고 있다.

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Rat에 caffeine 경구투여후 시간경과별로 혈액과 간조직에서 혈액화학성분, 지질 및 단백질 구성성분의 변화 (Changes of the blood chemistry, lipid and protein components in blood and liver tissue according to the time lapsed of the rat after oral administration of caffeine)

  • 도재철;허린수
    • 대한수의학회지
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    • 제36권4호
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    • pp.795-807
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    • 1996
  • This study was conducted to identify the effects of caffeine on the lipid and protein components or blood chemistry levels of the serum as well as the total homogenate, mitochondrial and microsomal fraction of the rat(Sprague-Dawley, female) liver. Acute test were conducted to determine those effects. The acute test was conducted by dividing rats into 7 groups according to the time lapsed after a single oral administration of 100mg/kg caffeine(that is control, 2hrs, 4hrs, 8hrs, 24hrs, 48hrs and 72hrs lapsed group). The concentrations of glucose, urea nitrogen, uric acid, creatinine, total protein, albumin, A/G ratio, triglyceride, total cholesterol, HDL-cholesterol, free fatty acid, phospholipid as well as the activities of alanine aminotransferase(ALT), aspartate aminotransferase(AST) and alkaline phosphatase(ALP) were measured in the serum of each experimental groups. The concentrations of the carbonyl group, malondialdehyde(MDA) and the patterns of the SDS-PAGE(Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis) were analyzed to determine the oxidative damages and metabolic changes on the lipid and protein components in the serum, and total homogenate, mitochondrial and microsomal fractions of the rat liver. The results obtained from this study were summarized as follows; 1. The concentrations of serum glucose were significantly higher(p<0.01) between 4(143.0mg/dl) and 8hrs(138.0mg/dl) in comparison to that of the control(101.1mg/dl) after a single oral administration of caffeine(100mg/kg). While on the other, there were no significant differences in the concentrations of urea nitrogen, uric acid, creatinine, total protein, albumin and albumin/globulin(A/G) ratio in comparison to those of the control. 2. The concentrations of total cholesterol and HDL-cholesterol in serum were significantly higher(p<0.01) between 4(77.4mg/dl, total cholesterol) and 8hrs(64.7mg/dl, HDL-cholesterol) in comparison to those of the control(62.8, 46.7mg/dl) after a single oral administration of caffeine(100mg/kg). On the other hand, the concentrations of triglyceride in serum were significantly lower(p<0.01) after 8hrs(38.8mg/dl) in comparison to that of the control(66.5mg/dl). 3. The activities of AST in serum was significantly higher(p<0.05) from 2hrs(149U/L) to 8hrs(178U/L) in comparison to the control(112U/L) after a single oral administration of caffeine(100mg/kg). The activities of ALT in serum were significantly higher(p<0.01) at 4(45.5U/L), 24(49.3U/L), 48(46.8U/L) and 72 hrs(42.3U/L) in comparison to that of the control(39.7U/L) after a single oral administration of caffeine(100mg/kg). On the other hand, there were no significant differences in the activities of ALP in comparison to that of the control. 4. The concentrations of free fatty acid in serum were significantly higher(p<0.01) at 8hrs(65.0mg/dl) in comparison to that of the control(37.6mg/dl) after a single oral administration of caffeine(100mg/kg). However, there were no significant differences in the concentrations of carbonyl group and malondialdehyde within serum, and liver homogenate, mitochondrial and microsomal fractions in comparison to that of the control. 5. The patterns of SDS-PAGE in serum, mitochondrial and microsomal fraction of the liver showed no significant differences.

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