• Journal of Ginseng Research
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• 제31권2호
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• pp.109-116
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• 2007

Korean red ginseng has broad efficacious effects against hypertension, diabetes, nociception, and cancer, and it counteracts weakness. It has been reported that Korean red ginseng is able to normalize blood pressure, improve cholesterol and lower blood glucose levels. We have recently reported that Korean red ginseng extract (KRGE) significantly prevented rat carotid arterial thrombosis in vivo, and inhibited platelet aggregation ex vivo and in vitro in a dose-dependent manner. The purpose of this study was to examine the effects of KRGE on blood circulation in human by measuring ex vivo platelet aggregation, plasma coagulation and serum lipid profiles in healthy volunteers. Subjects were randomly divided into three groups (placebo-group, KRGE-low dose group, KRGE-high dose group). Administration of KRGE to subjects significantly inhibited ADP-induced platelet aggregations both in KRGE-low dose group from $72.79{\pm}20.53$ to $62.00{\pm}23.06%$ (p=0.0009), and in KRGE-high dose group from $75.14{\pm}21.86$ to $64.52{\pm}24.72%$ (p=0.0039), respectively. Administration of KRGE to subjects also significantly inhibited collagen-induced platelet aggregations both in KRGE-low dose group from $85.52{\pm}12.57$ to $79.62{\pm}20.47%$ (p=0.0916), and in KRGE-high dose group from $80.24{\pm}18.11$ to $70.31{\pm}25.93%$ (p=0.0565), respectively. Whereas, KRGE has no significant effects on coagulation system, such as prothrombin time (PT) and activated partial thromboplastin time (APTT), and serum lipid profiles, such as total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol and triglyceride. KRGE also has no significant effects on hematological and serum biochemical profiles. These results suggest that KRGE has a potential to improve blood circulation through antiplatelet activity in human, and KRGE intake may be beneficial for the individuals with high risks of thrombotic and cardiovascular diseases.

• 대한한방내과학회지
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• 제15권2호
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• pp.383-417
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• 1994

By making use of the EAV(Electroacupuncture acc. Voll) combined meridian theory of oriental medicine with electronics which was contrived to recognize the physiological and pathological changes of human body, the following conclusions were made in comparison with EAV measurements and types of symptoms(anxiety & headache, fatigue, palpitation, dizzness, abdominal distension. nausea, gastric disturbance. constipation & diarrhea, fatty liver, cva), QSCC, and blood type test. 367 patients including 124 with nervous gastrointestinal problems were selected for this research. 1. From the point of variance of the tested patients 124 nervous gastrointestinal patients, Liver meridian and Spleen meridian showed hyperenergia and Large intestine meridian, Circulation meridian, Triple warmer meridian showed hypoergia 2. In each symptom as the nervous gastrointestinal symptom Liver meridian showed hyperenergia, Large intestine meridian, Circulation meridian and Triple warmer meridian showed hypoergia . 3. In an objective comparison with other symptoms, firstly among the headache & anxiety group left Gall Bladder, Triple warmer and Stomach meridian showed remarkable hypoergia, secondly among fatigue group showed hypoergia in Triple warmer meidian and hyperenergia of Stomach meridian. and thirdly among palpitation group showed hypoergia of Kidney meridian, and lastly among dizzness group showed hypoergia of Gall Bladder, Stomach, Circulation and Small intestine meridian. 4. All of gastric disturbance, nausea, abdominal distention, constipation and diarrhea group showed hyperenergia in Stomach meridian and Spleen meridian. gastric disturbance group showed remarkably hypoergia in Circulation. Small intestine, Lung and Large intestine meridian. Nausea group showed hypoergia in Gall bladder and Urinary bladder meridian. Abdominal distenton group showed hypoergia of Large intestine. Constipation and diarrhea group showed hypoergia of Kidney and left Circulation meridian. 5. Fatty liver group showed hyperenergia of Liver meridian of 83.3%, Gall Bladder, Stomach and Spleen meridian. Urinary bladder and Kidney meridian showed hypoergia 6. CVA group showed hyperenergia in Liver and Circulation meridian. 7. Blood type in typical classification had no significant bearings on each other. 8. QSCC for the attempt of objective materials of constitutional diagnosis had no correlativity in comparison with EAV measurements. In conclusion EAV is thought be used as a diagnostic method in oriental medicine and further research is needed regarding it can be used as a useful method for verifying the characteristics and early finding of symptoms.

• Journal of Chest Surgery
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• 제13권3호
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• pp.186-197
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• 1980

We attempted to evaluate the effectiveness of cold blood potassium cardioplegia [Group B] compared with that of intermittent aortic cross clamp with topical hypothermia [Group A] in each six dogs. The studies were performed under the extracorporeal circulation with moderate hypothermia by using Mongrel dogs. 1. In Group A [6], it was difficult to maintain the temperature below 20?. but in Group B [6], it was possible to maintain the temperature. 2. In blood pressure and myocardial recovery ability, Group B was more excellent than Group A. 3. There was no significant difference in Na+, Ca++ and Cl- between both groups, but in K+ level, Group A was mild decreased and Group B was nearly normal level. 4. In serum LDH level, Group A was higher than Group B, but in SGOT level there was no significance between both groups. 5. On electromicroscopical study, Group A showed severe change in mitochondria, but Group B was nearly normal view. Thus we suggest that cold blood potassium cardioplegia would be more effective than intermittent aortic cross clamp with topical hypothermia for myocardial protection in open heart surgery.

• International Journal of Vascular Biomedical Engineering
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• 제4권2호
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• pp.7-12
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• 2006

The present study investigated the effects of the osmotic environment on the rheological properties of erythrocytes and their suspensions. In an iso-osmotic medium, erythrocytes forming a biconcave discocyte under resting conditions, exhibited high deformability. In a low-osmotic medium, the deformability of erythrocytes, which swelled and exhibited a spherical shape, significantly decreased at a high shear stress and the high-shear viscosity of the cell suspension was slightly higher than that of normal blood. Hyper-osmotic stress, however, which caused to form echinocytes, decreased cell deformability but exhibited smaller viscosity in low shear rates than iso-osmotic blood viscosity. These results showed a close relation with the aggregability measurements, in that hypertonic blood showed lower aggregability than the hypotonic and isotonic RBC suspensions. These findings indicate that the physicochemical environment has a strong influence on the rheological properties of the erythrocyte and its suspensions.

• 대한예방한의학회지
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• 제6권2호
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• pp.86-94
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• 2002

Ligusticum Chuanxiong and its components were reviewed in terms of pharmacodynamic mechanisms. Three components of about 40 chemical components in Chuanxiong tetramethylpyrazine, ferulinolol and Butylidenephthalide have mainly been studied for its pharmacodynamic mechanisms which are focused on the increase in blood flow and anti-oxidative stress. The mechanisms for the effects of Chuanxiong on the increase in blood flow can be summarized as four ways, 1) anti-coagulation 2) blocker of ${\beta}1$ adrenergic receptor 3) cellular control of Ca++ level 4) collagen synthesis. Chuanxiong also showed the effectiveness on free radical-induced injury. It seems that its effectiveness is also related to the mechanisms for the increase in blood flow.

• 한방안이비인후피부과학회지
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• 제29권4호
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• pp.1-13
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• 2016

Objectives : The purpose of this study is to compare hair and alopecia of Korean Medicine with those of western medicine. Methods : We studied relationships between hair and essense(精), qi(氣), blood(血), five vicera(五臟) and meridians(經絡) through literature review about hair and alopecia. We compared Korean medicine with western medicine on physiology of hair and treatment of alopecia based on the study. Results & Conclusion : 1. Congenital essense(先天之精) is related with genetic factor and acquired essence(後天之精) is connected with nutritional factor. Defending function of Defense qi(衛氣) is related with immune reaction and qi stagnation(氣鬱) is associated with stress reaction. Atrophy of vascular tissues observed in alopecia scalp means deep relationship between blood(血) and alopecia, further deficiency of blood can cause telogen effluvium. 2. Kidney qi(腎氣) is related with inhibiting combination of Androgen receptor and Dihydrotestosterone(DHT) or activating hair growth factior. Pi(脾) is connected with alopecia seborrheica caused by damp-heat(濕熱) and alopecia areata caused by excessive prudence(思慮過度). Heart(心) is associated with atrophy in vascular tissue of scalp and liver(肝) is connected with metabolism. 3. Armpit hair and pubic hair as secondary sex characteristics are realated with Yangming Meridian(陽明經) and beard and hair at crown part where Type II $5{\alpha}$-reductase is activated much are associated with Taiyang Meridian(太陽經). 4. Juglandis Semen pharmacopuncture and Ganoderma lucidum pharmacopucture have better effects on inhibit $5{\alpha}$-reductase than Finasteride. Minoxidil and PRP are similar with promoting blood flow and removing stasis(活血祛瘀). Seven-star needling(七星針) is similar with microneedling. 5. Alopecia can be caused by due to lack of circulation Views we need solution to improve circulation coincide in opinion with Korean Medicine and Western medicine.

• Journal of Microbiology and Biotechnology
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• 제26권2호
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• pp.295-308
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• 2016

This study investigated the effects of a flavonoid-rich ethanol extract of persimmon leaf (PL), an ethanol extract of Citrus junos Sieb (CJS), and a PL-CJS mixture (MPC) on mice fed a high-fat diet (HFD). We sought to elucidate the mechanisms of biological activity of these substances using measurements of blood coagulation indices and lipid metabolism parameters. C57BL/6J mice were fed a HFD with PL (0.5% (w/w)), CJS (0.1% (w/w)), or MPC (PL 0.5%, CJS 0.1% (w/w)) for 10 weeks. In comparison with data obtained for mice in the untreated HFD group, consumption of MPC remarkably prolonged the activated partial thromboplastin time (aPTT) and prothrombin time (PT), whereas exposure to PL prolonged aPTT only. Lower levels of plasma total cholesterol, hepatic cholesterol, and erythrocyte thiobarbituric acid-reactive substances, hepatic HMG-CoA reductase, and decreased SREBP-1c gene expression were observed in mice that received PL and MPC supplements compared with the respective values detected in the untreated HFD animals. Our results indicate that PL and MPC may have beneficial effects on blood circulation and lipid metabolism in obese mice.

• Journal of Acupuncture Research
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• 제17권2호
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• pp.85-93
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• 2000

We came to the conclusion after considering all the information from many kinds of books on the circulation courses, cross-link points, functions and the symptoms of disease of Chongmai. The results were as follows : 1. The Chongmai that starts from a Uterus flows to Dazhu through the inside of vertebra after joining Renmai and Duimai at Huiyin. The Chongmais up-line that comes out from Qichong into a surface of body arrives and is scattered at a chest through an abdomen. One strand of them goes upward again and is connected to a throat and lips area. After coming out from Qichong, separated down-line is divided into two parts when it arrives a inner part of a heel through the inner part of a leg. One is for an instep, the other is for the sole of a foot. 2. We call it "Sea of Twelve Meridians" or "Meridian's Sea". Because Chongmai controls all of Meridian by acquired "Basic energy" as getting Stomach's energy, Kidney's energy and air-energy, and there are responsible of physiological phenomenon control. And also we name it "Sea of Blood", because it starts from and provides a nutrition to Uterus. 3. All of these four Meridian such as Renmai, Kidney Meridian, Stomach Meridian and Spleen Meridian are ones that flow around the part of a chest and an abdomen. Chongmai makes energy and blood circulation of a chest and an abdomen be stronger and be controlled. Therefore it makes viscera, bowels and body surface be warm and given a nutrition. So Chongmai becomes "Sea of Viscera and Bowels". 4. Chongmai provides a nutrition for ligament and muscle and makes legs get warm as making energy and blood circulate from head to foot. If Chongmai is energetic, hair is completely easy to grow. 5. To see in pathological phase, Chongmais failure or weakness causes like a chest pain, stomachache, heart attack, a menstrual irregularity and sterility and so on. And also if Chongmai is damaged, it happens that giving a nutrition for lips area is stopped, and then mustache doesn't grow any more.

• 대한한방부인과학회지
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• 제31권1호
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• pp.57-83
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• 2018

Purpose: This research has been carried out to find out correlation between test results of ABR-2000 and other diagnostic equipments to enhance significance of accurate diagnosis and clinical usage of ABR-2000. Methods: Duration of the 31 months from December 2012 to June 2015, records of 564 outpatients at gynecology department have been selected. The 564 patients were tested, using all 3 different test equipments of ABR-2000, DSOM, and 3D Blood Pressure Pulse Analyzer (3D-MAC) without test errors or mis-recordings. Correlation between 3D Blood pressure Pulse Analyzer, DSOM and ABR-2000 were analyzed by frequency & ratio factor of statistic data records of patients groups devided by 8 different disease symptom and by comparison of the groups in the form of Regulation and Graph presented on ABR-2000 equipment. Results: 1. The indicator L in all 1, 2, and 3 quadrant in the graph means the activity and reactivity of the upper body biodynamics detection rate is low and which result is very common symptom among gynecological patients. 2. The portion of patients with hypermenorrhea, endometritis, and menstrual pain symptom among the indicator L group in the reactivity 1-3 quadrantin is significantly high. 3. When 3D Mac analyzer indicates H, diastole decreases while systole increases and tachycardia increases then the blood circulation is expected to increase. In case of indication L, diastole increases and systole decreases then, the blood circulation is expected to decrease.

• 순환기질환의공학회:학술대회논문집
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• 순환기질환의공학회 2004년도 제4회 학술대회 초록집
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• pp.36-37
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• 2004