• 대한한의학회지
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• 제27권3호
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• pp.241-250
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• 2006

Backgrounds: Blood stasis is hon as an important pathologic factor for vascular disorder in Oriental medicine. Despite its clinical importance there have been few objective tests for diagnosing blood stasis. Objectives: This study was designed to examine the relationship between blood stasis and arterial stiffness measured by cardio-ankle vascular index (CAVI). Methods: The subjects were 104 ischemic stroke patients with onset after 14 days. Their general characteristics, lipid profiles and uric acid were recorded. The degree of arterial stiffness was assessed by CAVI, and blood stasis was evaluated by diagnostic criteria. The data were analyze4 by chi-square test, student t-test, spearman correlation analysis, and pearson correlation analysis. Then, stepwise multiple logistic regression analysis was applied in order to exclude the interactions among several factors. Results: There were significant differences in right, left and higher CAVI between the blood stasis group and the non blood stasis group (p-value<0.01). Age, systolic blood pressure, triglyceride and CAVI had relationships with blood static scores. In multiple logistic regression analysis, the adjusted odds ratio of blood stasis for arterial stiffness with CAVI above 9 were 7.091 (95% confidence interval, $1.641\sim30.638$). Conclusions: The results demonstrated the relationship between blood stasis and arterial stiffness measured by CAVI. Therefore, we suggest that CAVI should be one of the objective tests for diagnosing blood stasis.

• 한국의학물리학회지:의학물리
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• 제8권1호
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• pp.75-82
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• 1997

인체의 생리기관의 운동은 매우 복잡하고 불규칙적인 운동을 보이고 있다. 특히 말초 혈관의 운동은 매우 민감하고 복잡한 운동특성을 보이고 있다. 그중에서도 당 (glucose)에 의한 운동은 매우 민감한 변화의 운동을 반응한다. 이런 운동을 분석하기에는 기존의 선형적인 분석방법으로 복잡한 혈류운동을 분석하고 예측하기에는 많은 문제점을 가지고 있다. 그래서 비선형적 운동계의 분석방법인 카오스이론의 시계열분석방법으로 분석하는 것이 적합하다. 이런 맥락으로 본 연구는 당의 주입에 의한 토끼의 말초혈류량의 스칼라적 데이터를 획득하여 시계열분석방법으로 다차원의 벡터로 재정의하여 말초혈관의 혈류운동이 카오스적 운동임을 재확인하고 비선형적분석방법의 적합성을 확인하고자 하였다. 그 결과 당 주입에 따른 혈당치의 변화에 따라 기존의 주파수분석 및 평균치분석에서 차이가 나타나지 않았지만 비선형적분석방법으로 분석한 결과 그 차이를 확인할수 있었고, 말초 혈류의운동이 카오스적현상을 보임을 확인하였다.

• 지역사회간호학회지
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• 제11권1호
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• pp.105-116
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• 2000

The purpose of this study is to evaluate the relationship of blood pressure with dietary habit and level of physical fitness of middle-aged male workers by age. The study subjects included 511 male employees who have worked at a company in C City, whose age was more than 40 years old. Between April 10 and May 30. 1998, all of the study subjects measured physical fitness (Balance, strength, power, agility, flexibility and endurance) and blood pressure. A questionnair was administered for dietary habit and socio-demographic characteristics. The average age (SD) of the study subjects was 46.61(3.98) years. The study subjects were classified by age into 3 groups; 40-44 aged group(34.6%), 45-49 aged group(41.3%), and 50-54 aged group (24.1%). The score of dietary habit of 40-44 aged group was $69.77{\pm}5.82$. that of 45-49 aged group was $69.77{\pm}5.83$, and that of 50-54 aged group was $71.85{\pm}6.82$(p=0.005). But age of health physical fitness tend to weaken in the age of 40-44. Systolic(p=.011) and Diastolic blood pressure (p= .011) were significantly increased with age increment. Diastolic blood pressure and dietary habit of 45-49 aged group showed the significant negative-correlation(r= .280. P<0.05). and Diastolic blood pressure and age of health physical fitness of 40-44 aged group showed the significant positive-correlation(r= .182. P<0.05). On the basis of the results of this study. I hope occupational nurses should play an active role to improve dietary habit and physical fitness for prevention of hypertension with increase of age in middle-aged male workers.

• 동의생리병리학회지
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• 제27권2호
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• pp.246-252
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• 2013

A descriptive, comparative study was performed using female college students as experimental subjects. The primary objective was to compare the changes in pulse waves that take place during normalcy and during menstruation. The second objective was to compare the pulse waves of experimental subjects with severe menstrual pain and experimental subjects with minor or no menstrual pain during menstruation and during normalcy. The subjects of this experiment were female college students attending D University, located in Pusan, and the data were collected from September 2011 to February 2012. Their blood circulation index and pulse-wave factors were measured. During normalcy, these data were gauged a week to ten days after menstruation, and during menstruation, they were gauged two to three days after the start of menstruation, when the menstrual pain was at its peak. The results was as follows. In the characteristics of the blood circulation index, the index increased during menstruation, resulting in an increase in only the blood volume of the left ventricle. And the pulse energy of the left Chon, Kwan, Cheok and right Cheok were significantly higher during menstruation. Additionally, the average pulse energy in the left hand was distinctively lower in the menstrual group than in the normalcy group. There is a difference in blood pulse factors between normalcy and during menstruation, as well as a difference in blood pulse factors in experiment group without menstrual pain and experiment group with menstrual pain. These differences were particularly observed in the blood circulation index, pulse energy.

• 대한지역사회영양학회지
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• 제18권3호
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• pp.269-282
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• 2013

This study was carried out to investigate bone mineral density (BMD), blood pressure, calcium, sodium intake and related biochemical variables, and to analyze the relationship between BMD, and blood pressure, physical characteristics, nutrient intakes of Korean adult women. The study subjects were 30~80years old, 513 women living in Seoul and Kyunggi area who participated in 2011 KNHANES. The study subjects were divided into three BMD groups; normal, n = 259 (50.4%), osteopenia, n = 169 (32.9%), and osteoporosis, n = 85 (16.7%). Average height and weight and fat free mass decreased with a decrease in BMD. Average BMD of normal, osteopenia, osteoporosis were 0.87, 0.79, $0.70g/cm^2$, and T-score were 0.42, -0.66, -1.62, respectively. Higher systolic blood pressure, alkaline phosphatase, and triglyceride were significantly associated with a decrease in the BMD. The rates of hypertension were significantly increased from normal to osteoporosis. i.e. 18.5% in normal, 34.3% in osteopenia and 63.5% in osteoporosis. Average nutrientintakes such as protein, fat, calcium, phosphorus, iron, sodium, potassium, vitamin A, vitamin B, vitamin B2, and vitamin C were significantly lower in subjects with lower BMD.n. Average calcium intake of normal, osteopernia and osteoporosis were 528.50, 416.96, 389.56 mg, respectively. There were significant negative correlations between calcium, phosphorus and age, systolic blood pressure, triglyceride. Also, there were negative correlation systolic blood pressure (incomplete sentence). In this study, we found low BMD according to low calcium intake increase the risk of osteoporosis and hypertension rather than sodium intake, also calcium intake decreased with increase age. Therefore, in order to prevent osteoporosis and hypertension, subjects need to be educated regarding the importance of calcium nutrients in diet.

• 한국환경보건학회지
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• 제44권4호
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• pp.380-390
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• 2018

Objective: A significant association between blood lead levels and hypertension has been reported in many studies. The relationship between cadmium and hypertension has been debated as well. We aimed to study the association of lead, cadmium, and both with hypertension in the Korean general population. Methods: We examined 5,967 adult men and 6,074 women who participated in the Korea National Health and Nutrition Examination Survey III-VI (2005, 2008-2013 years). Logistic regression models were used to examine the relationship between blood lead concentration and blood cadmium concentration and hypertension using logtransformed blood lead and cadmium concentrations as independent variables after covariate adjustment. Results: Adjusted for general characteristics, the odds ratio of log-lead to hypertension was 2.71 (1.82-4.03), and log-cadmium to hypertension was 2.52 (1.83-3.47). Estimates were found to be statistically significant (p<0.001). When a multiple logistic model was applied, the odds ratio of log-lead and log-cadmium for hypertension were 2.24 (1.50-3.36) and 2.24 (1.62-3.10), respectively. The standardized estimate coefficients of log-lead and logcadmium for hypertension were 4.77 and 6.65, respectively. Conclusion: We observed the association of blood lead concentration, blood cadmium concentration, and both with hypertension. This study suggests that exposure to lead and exposure to cadmium are both risk factors for hypertension.

• Biomolecules & Therapeutics
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• 제25권4호
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• pp.441-451
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• 2017

Imperatorin, a major bioactive furanocoumarin with multifunctions, can be used for treating neurodegenerative diseases. In this study, we investigated the characteristics of imperatorin transport in the brain. Experiments of the present study were designed to study imperatorin transport across the blood-brain barrier both in vivo and in vitro. In vivo study was performed in rats using single intravenous injection and in situ carotid artery perfusion technique. Conditionally immortalized rat brain capillary endothelial cells were as an in vitro model of blood-brain barrier to examine the transport mechanism of imperatorin. Brain distribution volume of imperatorin was about 6 fold greater than that of sucrose, suggesting that the transport of imperatorin was through the blood-brain barrier in physiological state. Both in vivo and in vitro imperatorin transport studies demonstrated that imperatorin could be transported in a concentration-dependent manner with high affinity. Imperatorin uptake was dependent on proton gradient in an opposite direction. It was significantly reduced by pretreatment with sodium azide. However, its uptake was not inhibited by replacing extracellular sodium with potassium or N-methylglucamine. The uptake of imperatorin was inhibited by various cationic compounds, but not inhibited by TEA, choline and organic anion substances. Transfection of plasma membrane monoamine transporter, organic cation transporter 2 and organic cation/carnitine transporter 2/1 siRNA failed to alter imperatorin transport in brain capillary endothelial cells. Especially, tramadol, clonidine and pyrilamine inhibited the uptake of [$^3H$]imperatorin competitively. Therefore, imperatorin is actively transported from blood to brain across the blood-brain barrier by passive and carrier-mediated transporter.

• 대한한의학원전학회지
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• 제33권2호
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• pp.91-108
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• 2020

Objectives : To study the shu points selection of the Four Seas in the 「Hailun」 chapter of 『Lingshu』. Methods : The effects and main indications of each shu point, their anatomical position, characteristics along with similarities of disease patterns according to excessiveness and deficiency of the Four Seas were examined. Results : The selection of shu points of the Four Seas were deeply related to the effects and main indications, and the common similarity among conditions due to excessiveness and deficiency was the presence of psychological aspects. Also, when the Four Seas are connected to the Jing-Qi-Shen and Blood, marrow sea[髓海] is connected to Jing & Shen, qi sea[氣海] is connected to Qi, blood sea[血海] is connected to Blood, and sea of water and grain[水穀之海] replenishes Jing-Qi-Shen and Blood. When connected to the Four Qi Intersections, the marrow sea is connected to 'head qi with intersection', qi sea is connected to 'chest qi with intersection', sea of water and grain or blood sea is connected to 'stomach qi with intersection', otherwise sea of water and grain is connected to 'shin qi with intersection'. Conclusions : The Four Seas are designated to the shu points due to their accumulation of Qi when the main elements of Jing-Qi-Shen and Blood are deficient or excessive, allowing for the most convenient management and manipulation of the condition of these main elements. In clinical practice, the shu points of the Four Seas will likely increase treatment efficacy for conditions that include psychological aspects.

• Journal of Preventive Medicine and Public Health
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• 제35권3호
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• pp.214-220
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• 2002

Objectives : To investigate the relationship of serum uric acid to cardiovascular risk factors in Korean male workers. Methods : We screened 522 male workers at an electrical manufacturing company by a periodic health examination and a questionnaire survey in 2000. We collected data relating to age, smoking status, alcohol drinking status, body mass index (BMI), blood pressure, serum lipid, fasting blood glucose and serum uric acid. The data were analyzed using a variety of methods, including ANOVA, Pearson's correlation, and multivariate regression analyses. to examine the association between uric acid and cardiovascular risk factors with a cross-sectional study design. Results : The concentration of serum uric acid showed positive associations with BMI, total cholesterol, triglyceride, and LDL-cholesterol; it was also significantly correlated to systolic and diastolic blood pressures. Life-style characteristics, such as smoking and alcohol drinking showed no significant association. From the multivariate regression analyses, BMI, total cholesterol and fasting blood glucose levels were found to be independent positive predictors of uric acid; while age, blood pressure and smoking status give no independent contribution explaining the variability of serum uric acid levels. Conclusions : This study demonstrates that serum uric acid level have a significant association with cardiovascular risk factors, such as BMI, total cholesterol and blood glucose in some Korean male workers.

• 동아시아식생활학회지
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• 제4권2호
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• pp.17-26
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• 1994

This study was an attempt to investigate various factions, such as the calorie, nutrient intake, physical activity, blood lipids, obesity prevalence and body fat distribution on NIDDM male diabetics. General characteristics, physical activity and exercise levels of subjects were invesigated by interviewing, daily calorie and nutrient intake were measured by convenient method. The following anthropometric measurements were made on all participats : weight, height. Also waist and hip circumference were measured on 174 male diabetics to get waist-to-hip circumference ratio as index of the body fat distribution. For measurement of plasma lipids, 12-hour fasting blood samples were drawn The results of this study were summarized as follows : 1. At the onset of diabetes, the major self-diagnosed symptoms were polydipsia, fatigue, and body weight redution 2. The average of daily energy intake of male diabetics was 2106 Kcal which is 96% of the RDA Percentage of energy is that carbohydrate:protein : pat=70:14:16. 3. Among the NIDDM male subjects, 59% was exercise regularly. 4. Obese subjects above in the ideal body weight of 120% are presently 17%, but 39% of subjects were reported to be obese in the past. The mean BMI of the male NIDDM diabetics is 23.3${\pm}$2.6 and the past mean BMI was 25.2${\pm}$2.7 The mean WHR was 0.93${\pm}$0.10. 5. When diabetics were divided into obese and nonobese group according to RBW, energy intake, blood pressure, blood glucose and total cholesterol were not significantly different between the two groups, but LDL and VLDL-cholesterol were significantly higher in the obese group. 6. RBW did not correlate with cholesterol and triglyceride, but WHR correlated significantly with cholesterol and triglyceride. In conclusion, these results from a present study support previous findings indicating that not only the degree of obesity but also the localization of fat is a risk factor for diabetes.