• Archives of Pharmacal Research
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• 제25권5호
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• pp.561-571
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• 2002

The action mechanisms of several chemopreventive agents derived from herbal medicine and edible plants have become attractive issues in cancer research. Tea is the most widely consumed beverage worldwide. Recently, the cancer chemopreventive actions of tea have been intensively investigated. It have been demonstrated that the active principles of tea were attributed to their tea polyphenols. Recently, tremendous progress has been made in elucidating the molecular mechanisms of cancer chemoprevention by tea and tea polyphenols. The suppression of various tumor biomarkers including growth factor receptor tyrosine kinases, cytokine receptor kinases, P13K, phosphatases, ras, raf, MAPK cascades, NㆍFB, IㆍB kinase, PKA, PKB, PKC, c-jun, c-fos, c-myc, cdks, cyclins, and related transducing proteins by tea polyphenols has been studied in our laboratory and others. The IㆍB kinase (IKK) activity in LPS-activated murine macrophages (RAW 264.7 cells) was found to be inhibited by various tea polyphenols including (-) epigallocatechin-3-gallate (EGCG), theaflavin (TF-1), theaflavin-3-gal-late (TF-2) and theaflavin-3,3'-digallate (TF-3). TF-3 inhibited IKK activity in activated macrophages more strongly than did the other tea polyphenols. TF-3 inhibited both IKK1 and IKK2 activity and prevented the degradation of IㆍBㆍand IㆍBㆍin activated macrophage cells. The results suggested that the inhibition of IKK activity by TF-3 and other tea polyphenols could occur by a direct effect on IKKs or on upstream events in the signal transduction pathway. TF-3 and other tea polyphenols blocked phosphorylation of IB from the cytosolic fraction, inhibited NFB activity and inhibited increases in inducible nitric oxide synthase levels in activated macrophage. TF-3 and other tea polyphenols also inhibited strongly the activities of xanthine oxidase, cyclooxygenase, EGF-receptor tyrosine kinase and protein kinase C. These results suggest that TF-3 and other tea polyphenols may exert their cancer chemoprevention through suppressing tumor promotion and inflammation by blocking signal transduction. The mechanisms of this inhibition may be due to the blockade of the mitogenic and differentiating signals through modulating EGFR function, MAPK cascades, NFkB activation as wll as c-myc, c-jun and c-fos expression.

• 한국통신학회논문지
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• 제37권5B호
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• pp.338-347
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• 2012

본 논문에서는 OFDMA 기반의 기업형 펨토셀 네트워크 환경에서 펨토셀의 성능 향상을 위한 협력 통신 기법(cooperative transmission scheme; CTS)을 제안한다. 제안된 알고리즘에서 UE(user equipment)는 현재 접속 중인 fBS(serving femtocell base station)에서 뿐만 아니라 주변 fBS에서 원하는 신호(desired signal)를 받게 된다. 따라서 UE는 동기화된 두 개의 신호에 의해 향상된 신호 대 간섭 잡음 비(SINR)를 얻게 된다. 알고리즘의 성능 평가를 위해 콜 레벨 QoS(quality of service)와 패킷 레벨 QoS를 성능 지표로 나타낸다. 먼저 다양한 offered load에서 하향 링크 자원에 대한 호 차단 확률과 자원 사용률을 측정한다. 그리고 측정된 값을 사용하여 시스템의 outage 확률과 시스템 처리량(effective throughput)을 시뮬레이션 한다. 시뮬레이션 결과를 통해 제안된 알고리즘이 기존 시스템에 비해 시스템 처리량에서 향상된 성능을 가짐을 보인다.

• 한국음향학회지
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• 제33권1호
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• pp.54-59
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• 2014

본 논문은 비정상 (nonstationary)특성을 가지는 잡음환경에서 마이크간 전달함수 비 (RTF, Relative Transfer Function) 추정 알고리즘을 제안한다. 음성을 이용한 다양한 기기에 다중 마이크를 이용한 잡음제거 기술은 널리 사용되며, 이때 각 마이크간의 입력 신호 사이의 관계는 필수적으로 추정되어야 한다. 본 논문에서는 기존의 OM-LSA(Optimally-Modified Log-Spectral Amplitude)기반의 추정 방식에 CASA (Computational Auditory Scene Analysis)를 접목시킨 방식을 제안한다. 제안한 방법의 성능 검증을 위하여 비정상 백색 잡음 (nonstationary white Gaussian noise) 환경에서 10명 화자 발음을 이용한 마이크간 전달함수 비 추정 성능 평가 실험을 수행하였다. 잡음 신호가 초당 8dB 증감하는 환경에서 SBF (Signal Blocking Factor)가 평균 2.65dB 개선됨을 확인하였다.

• 생약학회지
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• 제30권4호
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• pp.404-408
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• 1999

SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

• 한국멀티미디어학회논문지
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• 제6권1호
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• pp.105-113
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• 2003

CDMA 셀룰러 시스템 내에서 고속이동체에 대한 비효율적인 채널할당으로 호 블록킹 확률이 높아진다. 이를 위하여 고속이동체의 속도에 따른 전용 채널과 큐를 할당하여 계층셀에 적용해 속도에 따른 QoS를 보장하는 방식이 제안되었다. 본 논문에서는 현재 위치한 셀에서의 이동체의 수신 신호세기에 따라 HA에 트래픽이 적을 때에 FA 내에 고속 핸드오프 전용 채널을 할당하였다 또한 FA 내 신호세기가 약한 고속 핸드오프 호에 대하여 새로운 환형 큐 LiFA를 생성하여 고속 핸드오프 호를 LiFA에 호 지속시간 동안 대기시켜 호 강제종료율을 개선하였다.

• Archives of Pharmacal Research
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• 제28권1호
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• pp.1-15
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• 2005

Cancer is still a major global health concern even after an everlasting strive in conquering this dread disease. Emphasis is now given to chemoprevention to reduce the risk of cancer and also to improve the quality of life among cancer afflicted individuals. Recent progress in molecular biology of cancer has identified key components of the cellular signaling network, whose functional abnormality results in undesired alterations in cellular homeostasis, creating a cellular microenvironment that favors premalignant and malignant transformation. Multiple lines of evidence suggest an elevated expression of cyclooxygenase-2 (COX-2) is causally linked to cancer. In response to oxidative/pro-inflammatory stimuli, turning on unusual signaling arrays mediated through diverse classes of kinases and transcription factors results in aberrant expression of COX-2. Population-based as well as laboratory studies have explored a broad spectrum of chemopreventive agents including selective COX-2 inhibitors and a wide variety of anti-inflammatory phytochemicals, which have been shown to target cellular signaling molecules as underlying mechanisms of chemoprevention. Thus, unraveling signaling pathways regulating aberrant COX-2 expression and targeted blocking of one or more components of those signal cascades may be exploited in searching chemopreventive agents in the future.

• 대한전자공학회논문지SP
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• 제38권1호
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• pp.43-53
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• 2001

JPEG의 부호화 기법에서 DCT의 단점인 블록효과를 제거하기 위해 웨이브릿 변환을 사용하였다. 기존의 JPEG과 호환성 유지하기 위하여, JPEG 부호화 기법과 동일한 기법을 사용할 수 있는 부호화기를 제안한다. 이를 위하여 웨이브릿 변환영역에서 각 대역의 신호를 8×8로 재구성하였고, 각 대역의 에러분석과 인간 시각특성을 고려하여 양자화 가중치를 구하여 양자화 하였다. 실험을 통하여 웨이브릿을 사용한 제안한 기법이 기존의 JPEG 보다 (Peak Signal to Noise Ratio), WMSE(Weighted Mean Square Error) 척도에서 다소 우수함을 보였다.

• Natural Product Sciences
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• 제23권1호
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• pp.1-4
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• 2017

Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism remain unknown. To explore the mediator and cellular inflammatory response of sinensetin, we examined its influence on phorbol 12-myristate 13-acetate (PMA) plus A23187 induced inflammatory mediator production in a human mast cell line. In this study, interleukin (IL)-6 production was measured using the enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction. Sinensetin inhibited PMA plus A23187 induced IL-6 production in a dose-dependent manner as well as IL-4, IL-5 and IL-8 mRNA expression. Furthermore, sinensetin inhibited signal transducer and activator of transcription 3 (STAT3) phosphorylation, suggesting that sinensetin inhibits the production of inflammatory mediators by blocking STAT3 phosphorylation. Moreover, sinensetin was found to inhibit nuclear factor kappa B activation. These findings suggest that sinensetin may be involved in the regulation of mast cell-mediated inflammatory responses.

• 정보처리학회논문지C
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• 제13C권3호
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• pp.323-330
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• 2006

본 논문은 차등 RSSI(DRSSI: Differential Received Signal Strength Indicator)를 이용하여 자원을 효율적으로 사용할 수 있는 핸드오프 처리 방안에 대해 제안한다. DRSSI는 이동국의 이동 방향을 예측하는데 사용할 수 있다. 즉, 이동국의 움직임이 바뀌는 경우 DRSSI의 극성(+, -)이 바뀌는 특성을 이용하여 이동국이 셀 사이의 중첩 지역에 머무는 동안 극성의 변화를 우선적으로 판단하여 다수의 단말기의 방향을 예측함으로써 핸드오프 및 자원을 예약할 이동국을 예측하고, 자원의 우선적인 사용권을 부여하는 방안을 제시하여 자원의 유효 상태를 극대화하는 방안을 제시한다. 또한, 수학적 모델링 분석을 통해 핸드오프 차단 확률이 기존의 방법보다 우수함을 보여준다.

• 한국전기전자재료학회논문지
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• 제33권3호
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• pp.201-207
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• 2020

With the expansion in the use of DC power systems and increased need for system maintenance, the development of measurement devices for maintenance requires high stability. Of the different kinds of DC current measurement devices, the single-shot measurement device causes the input signal of the current measuring unit to initially generate a high inrush current. The high inrush current flows into the signal processor of the meter, shortening the life of the internal fuses and causing failure. Therefore, in this study, the I²t value for increasing the durability of the fuse is designed using the available wire diameter. Operating characteristics for 210~400% over-current of the rated current, which is relatively low over-current, are realized by the plating of low melting tin metal. As a result, a method of designing a fuse element for a DC power supply, which improves the safety of the DC current measurement device by blocking the failure caused by the inrush current, is presented.