• 한국컴퓨터정보학회논문지
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• 제26권4호
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• pp.85-91
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• 2021

재난과 사고로 인해 고속도로 일부 구간이 폐쇄되는 경우가 발생한다. 이런 상황에서 고속도로 망에 기능적으로 어떠한 상황이 발생하는지를 분석한다. 국내의 고속도로 망은 하나의 그래프로 표현할 수 있다. 고속도로의 일부 구간의 차단은 국가적인 재앙으로 번질 수 있다. 본 논문에서는 국내 고속도로 망의 강건성을 분석한다. 고속도로의 강건성은 일부 구간의 차단에 따라 국내 고속도로 망의 교통 통행 상황이 어느 정도 나빠지는지를 말한다. 강건성이 클수록 일부 차단의 효과가 작게 나타난다. 교통망의 하나의 구간의 혼잡도를 평가하기 위해 사용하는 방법으로 구간교통량(V)을 구간의 교통용량(C)으로 나누는 값을 사용한다. 본 연구는 국내 고속도로의 출발지점, 도착지점의 실제 교통량 데이터를 이용하여 고속도로의 강건성을 분석하고, 일부 차단에 따른 교통량의 변화를 실험계산을 통해 분석한다. 본 분석이 실제 국내 고속도로의 정확한 실상을 반영할 수는 없지만, 전체적인 망의 기초적인 강건성을 확인하는 목적으로 충분할 것으로 판단된다.

• International Journal of Computer Science & Network Security
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• 제24권1호
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• pp.226-234
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• 2024

The frequent handover problem and playing ping-pong effects in 5G (5th Generation) ultra-dense networking cannot be effectively resolved by the conventional handover decision methods, which rely on the handover thresholds and measurement reports. For instance, millimetre-wave LANs, broadband remote association techniques, and 5G/6G organizations are instances of group of people yet to come frameworks that request greater security, lower idleness, and dependable principles and correspondence limit. One of the critical parts of 5G and 6G innovation is believed to be successful blockage the board. With further developed help quality, it empowers administrator to run many systems administration recreations on a solitary association. To guarantee load adjusting, forestall network cut disappointment, and give substitute cuts in case of blockage or cut frustration, a modern pursuing choices framework to deal with showing up network information is require. Our goal is to balance the strain on BSs while optimizing the value of the information that is transferred from satellites to BSs. Nevertheless, due to their irregular flight characteristic, some satellites frequently cannot establish a connection with Base Stations (BSs), which further complicates the joint satellite-BS connection and channel allocation. SF redistribution techniques based on Deep Reinforcement Learning (DRL) have been devised, taking into account the randomness of the data received by the terminal. In order to predict the best capacity improvements in the wireless instruments of 5G and 6G IoT networks, a hybrid algorithm for deep learning is being used in this study. To control the level of congestion within a 5G/6G network, the suggested approach is put into effect to a training set. With 0.933 accuracy and 0.067 miss rate, the suggested method produced encouraging results.

• The Korean Journal of Physiology and Pharmacology
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• 제13권6호
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• pp.425-429
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• 2009

Intracranial headaches, including migraines, are mediated by nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. We previously demonstrated that selective blockage of spinal sigma-1 receptors (Sig-1R) produces a prominent antinociceptive effect in several types of pain models. This study evaluates whether the Sig-1R antagonist (BD1047) has an antinociceptive effect on capsaicin (a potent C-fiber activator) induced headache models in rats. Intracisternal infusion of capsaicin evoked pain behavior (face grooming), which was significantly attenuated by BD1047 pretreatment. BD1047 consistently reduced capsaicin-induced Fos-like immunoreactivity (Fos-LI), a neuronal activator, in the TNC in a dose-dependent manner. Moreover, capsaicininduced phosphorylation of N-methyl-D-aspartate receptor subunit 1 was reversed by BD1047 pretreatment in the TNC. These results indicate that the Sig-1R antagonist has an inhibitory effect on nociceptive activation of the TNC in the capsaicin-induced headache animal model.

• International Journal of Naval Architecture and Ocean Engineering
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• 제4권4호
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• pp.477-487
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• 2012

We investigated the aerodynamic characteristics of a three-dimensional (3D) wing with an endplate in the vicinity of the free surface by solving incompressible Navier-Stokes equations with the turbulence closure model. The endplate causes a blockage effect on the flow, and an additional viscous effect especially near the endplate. These combined effects of the endplate significantly reduce the magnitudes of the velocities under the lower surface of the wing, thereby enhancing aerodynamic performance in terms of the force coefficients. The maximum lift-to-drag ratio of a wing with an endplate is increased 46% compared to that of wing without an endplate at the lowest clearance. The tip vortex of a wing-with-endplate (WWE) moved laterally to a greater extent than that of a wing-without-endplate (WOE). This causes a decrease in the induced drag, resulting in a reduction in the total drag.

• 약학회지
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• 제57권2호
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• pp.119-124
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• 2013

The aim of this present study was to investigate the antifungal effect of tanshinones isolated from Salvia miltiorrhiza against Candida ablicans, a polymorphic fungus. For the work, tanshinone IIA (TSN), cryptotanshinone (CTS), and dihydrotanshinone I (DTS) were chosen. Initially, their antifungal effect was analyzed by in-vitro susceptibility test. Data from the susceptibility test showed that while all of these three compounds had antifungal activity, DTS was the most potent. At $100{\mu}g$ DTS/ml, there was about 80% CFU (colony forming unit) reduction as compared to DTS-untreated C. albicans yeast cells (P<0.05). Thus, DTS was selected to determine its antifungal activity in a murine model of disseminated candidiasis due to C. albicans. Results showed that DTS enhanced resistance of mice against disseminated candidiasis. During the entire period of 30-day observation, 60% of DTS-given mice groups survived whereas control animals all died within 14 days (P<0.05). Moreover, DTS inhibited the hyphal production, one of the virulence factors of this fungus, from the blastoconidial form of the fungus. Therefore, the tanshinone appears to have antifungal activity specific for C. albicans infection, which could possibly be mediated by the blockage of hyphal production.

• 약학회지
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• 제57권6호
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• pp.383-387
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• 2013

In the present study, we determined the antifungal effect of obacunone isolated from Phellodendri Cortex against Candida ablicans, a pathogenic fungus. The antifungal effect was analyzed by an in-vitro susceptibility test and in a murine model of disseminated candidiasis. Possible mechanism of the antifungal activity was also examined. Analyses of data resulting from the susceptibility test revealed that the compound inhibited C. albicans growth. At 25 ${\mu}g$ obacunone/ml, there was app. 45% reduction of CFUs (colony forming units) as compared to obacunone-untreated C. albicans yeast cells (P<0.01). In the murine model of disseminated candidiasis due to C. albicans, obacunone enhanced resistance of mice against disseminated candidiasis. During an entire period of 30-day observation, control animals all died within 14 days, whereas 60% of obacunone-treated mice survived (P<0.05). In addition, obacunone inhibited the hyphal production, a major virulence factor of C. albicans, from the blastoconidial form. Thus, obacunone appears to have antifungal activity for C. albicans infection. This may possibly be mediated by the blockage of hyphal production.

• 한국수정란이식학회지
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• 제32권3호
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• pp.243-248
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• 2017

Antioxidants have been added to cryoprotectant or in vitro culture medium for sperm to reduce the detrimental damage, such as reactive oxygen species. However, curcumin, an antioxidant, shows dual effect on the viability and progressive motility of bovine sperm exposed to hydrogen peroxide. Low concentration of curcumin increases sperm viability and progressive motility, whereas high concentration of curcumin reduces them. This study was performed to identify whether TREK-1 channel is related to low sperm viability and motility induced by high concentration of curcumin. Curcumin reduced TREK-1 channel activity in a dose-dependent manner. TREK-1 channel was expressed in sperm obtained from Korean native bull. Treatment with TREK-1 channel blockers, such as curcumin, fluoxetine, $GdCl_3$, and spadin, significantly reduced sperm viability and motility (p < 0.05). However, TREK-1 channel activators showed different effect; linoleic acid showed an increase in sperm viability and motility, and wogonin did not affect them. These results show that TREK-1 channel is involved in the regulation of sperm viability and motility. In particular, high concentration of curcumin might reduce sperm viability and progressive motility of Korean native bull through blockage of TREK-1 channel.

• 한국터널지하공간학회 논문집
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• 제16권6호
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• pp.553-560
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• 2014

도로터널에서는 환기 및 제연을 목적으로 제연펜을 설치하고 있다. 제연펜 용량(제트팬 댓수)은 환기저항 및 승압력이 평형이 되는 상태에서 결정되게 된다. 터널에 운행중이거나 정지된 차량에 의한 승압력 및 저항력은 차량의 항력계수에 영향을 받게 된다. 터널에서의 항력계수는 슬립스트림 효과(또는 shadow effect)와 폐색효과에 영향을 받게 되며, 환기팬 및 제연팬 산정시 이와 같은 효과를 적절히 고려하지 못하고 있는 실정으로 교통 환기력를 과대평가하고 있다. 이에 본 연구에서는 화재시 차량의 차간간격을 반영한 항력계수와 등가저항면적을 산정하기 위해서 터널에 실제로 차량이 정차하는 조건으로 모델링하여 수치해석을 통해 항력계수를 검토하였다. 본 연구 결과, 항력계수에 대형차량 혼입률이 미치는 영향은 명확하지 않으며, 등가저항면적은 현행 도로설계편람기준에 대비 약 86%, 또 구 기준인 한국도로공사 환기설계기준 대비 62.2%수준으로 감소하는 것으로 분석되었다.

• 대한기계학회논문집B
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• 제20권8호
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• pp.2593-2600
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• 1996

A modified k-$\varepsilon$ turbulence model having a generality is proposed in the present study, in which the constant $C_{\varepsilon2}$in the $\varepsilon$-equation is simply changed as a functional form of a new parameter both satisfying the tensor invariant condition and representing the extra straining effect on complex shear flows. With this model turbulent shear flows over two-dimensional obstacles placed in a channel are numerically studied for different blockage ratios and aspect ratios. Comparing with the available experimental data, the predicted results with the present model provide definite improvements over the standard model's results and work fairly well with the experimental data on the size of the recirculation zone, as well as mean velocity, wall static pressure, turbulent kinetic energy and Reynolds stresses.

• 한국유체기계학회 논문집
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• 제3권2호
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• pp.36-43
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• 2000

This study presents the centrifugal compressor performance for three different vane stagger angles and wall pressure distribution within vaned diffuser channels, and is also discussed about the stability with respect to the compressor components. As the vane stagger angle decreases, the flow rate for the stall onset decreases, and higher pressure can be obtained at the low flow rate region, however, the effective operation range of the compressor decreases because of the blockage effect of the diffuser vane. Low pressure pocket within the vaned diffuser channel moves from the pressure side of leading edge to the suction side as the flow rate decreases. The compressor system stability mainly depends on that of the diffuser.