• Journal of Microbiology and Biotechnology
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• 제23권5호
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• pp.699-706
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• 2013

We have previously reported that N-acetylcysteine (NAC) not only delayed apoptosis but also enhanced the production of recombinant erythropoietin (EPO) in Chinese hamster ovary (CHO) cell culture. To investigate the production enhancement mechanism, the effects of similar thiol-reducing agents were studied. Intriguingly, all mild reducing agents examined including mercaptoethanesulfonic acid (MESNA), thiolactic acid (TLA), and thioglycolate (TG) were shown to block apoptosis and increase EPO production. A pulse-chase study of EPO secretion revealed that all four thiol-reducing agents increased the EPO secretion rate; among them TLA showed the highest rate. In terms of product quality, the sialic acid content of the glycoprotein is one of the most important factors. It was reported that a number of glycoproteins produced by CHO cells often have incomplete sialylation, particularly under high-producing conditions. Human ${\alpha}2,3$-sialyltransferase (${\alpha}2,3$-ST) was introduced into EPO-producing CHO cells in order to compensate for the reduced sialylation during supplementation with NAC. When ${\alpha}2,3$-ST was expressed in the presence of NAC, reduced sialylation was restored and an even more sialylated EPO was produced. Thus, our study is significant in that it offers increased EPO production while still allowing the prevention of decreased sialylation of EPO.

• The Korean Journal of Pain
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• 제11권2호
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• pp.273-282
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• 1998

Background: Twelve years have passed since the Korean Pain Society was organized. Nowadays, there are so many problems to be solved in pain clinics including health insurance, pain education and public information etc. in Korea. The present study was designed to evaluate the current status of pain clinics in Korea. Methods: Eight hundred twenty regular members of Korean Pain Society were surveyed by questionnaire in October 1997. We compared the general characteristics, contents of diseases in pain clinic, treatment Methods, patients satisfaction, pain educations, problems in pain treatments, requests to Korean Pain Society among the 138 respondents. Results: Thirty seven percents of the respondents worked at university hospitals, 39% at non-university hospitals and 24% at private pain clinics. The most common diseases treated in pain clinics was low back pain(32% in university and non-university hospital and 28% in private pain clinic respectively). However, cancer pain was 10% in university and non-university hospital and 0.7% in private pain clinic. Epidural block was the most frequently used procedure in chronic pain treatments. And 74.6% of the respondents were studied and learned in Korea and Japan. And then, current problems in pain management and requests to Korean Pain Society were medical insurance problems, pain education and public information of pain clinics. Conclusions: These results suggest that the Korean Pain Society should make an effort to solve these current problems in order to activate pain medicine and increase the quality of life for those suffering from pain.

• 생물환경조절학회지
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• 제6권4호
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• pp.292-298
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• 1997

본 연구에서는 반사필름 멀칭과 북측면의 반사판설치에 의한 보광이 토마토의 광이용에 미치는 영향을 밝히기 위해 토양 및 수경재배를 통해 토마토의 엽온변화, 기공특성, 증산.광합성속도 등의 변화들을 중심으로 검토하였다. 보광 처리에 의해 토마토엽의 기공밀도는 증가하였으나 기공의 크기와 면적은 차이가 얼었다. 근권부의 삼투포텐셜이 낮으면 광반사에 의한 기공저항이 컸고 증산속도는 낮았으며 엽온은 40.62$^{\circ}C$까지 상승했다. 또한 보광에 의해 광합성속도도 저하했으나 엽록소 함량에는 차이가 없었다. 반사필름 멀칭으로 온실가루이의 기피효과는 있었다 약광기 동절기에 반사필름 멀칭 등의 보광처리에 의한 증수나 품질향상은 엽의 기공밀도의 증가로 활발한 증산 .광합성작용으로 체내의 물질대사나 생장에 영향을 주고 그 결과 간접적으로 무기성분의 흡수나 분배에 영향을 주어 생육 및 수량 둥이 양호했다고 생각된다.

• 한국조경학회지
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• 제30권2호
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• pp.88-94
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• 2002

This study was conducted to select suitable turfarasses for use at 2002 world cup soccer fields in Korea. A 1/1000 scale Inchon worldcup soccer dome was constructed for this research. Species and seeding rates of cool-season grasses used inside and outside the dome were Kentuck bleugrass 10g/$m^2$ (KB), Kentucky bleugrass 10g/$m^2$+ perennial ryegrass 10g/$m^2$ mixture (KB+PR) and Kentucky bleugrass 6g/$m^2$+tall fescue 14g/$m^2$+ perennial ryegrass 4g/$m^2$ mixture (KB+TF+PR). Warm-season grasses also used in this study were Zoysia japonica 'Anyangjungzii' (ZA) and Zoysia japonica 'Zenith'(ZZ) which were layed as sod. So, total 5 types of grasses were used inside and outside the dome. The rootzone was constructed by the multi-layer method(United States Golf Association method). The plots were designed by randomized block design. Cool-season grasses(KB, KB+PR, KB+TF+PR) were found to be better performers for visual rating and visual color than the zoysiagrasses(ZA, ZZ). There were no significant differences in turf performance within cool-season grasses, while ZA showed better turf performances than ZZ within zoysiagrasses. The green color was maintained for about 10 months in the col-season grasses(KB, KB+PR, KB+TF+PR) compared to about 5~6 months in the zoysiagrasses. Root length and density data revealed higher values for KB, KB+PR and KB+TF+PR compared to ZA and ZZ. Root performance of 22 was better than ZA within zoysiagrasses which was the opposite result of turf performances. There was also no significant difference between U performance inside and outside the dome. However, the decreasing tendency of turf quality inside the dome at the end of the study showed that more proper maintenance technology was needed inside the d[me. It could be concluded by this study that cool-season grasses(KB, KB+PR, KB+TF+PR) were more suitable turfgrasses than waits-season zoysiagrasses(ZA, ZZ) for use at 2002 world cup soccer fields in Korea.

• International Journal of Naval Architecture and Ocean Engineering
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• 제9권3호
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• pp.315-325
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• 2017

The design dimension may not be satisfactory at the final stage due to the welding during the assembly stage, leading to cutting or adding the components in large structure constructions. The productivity is depend on accuracy of the welding quality especially at assembly stage. Therefore, it is of utmost importance to decide the component dimension during each assembly stage considering the above situations during the designing stage by exactly predicting welding deformation before the welding is done. Further, if the system that predicts whether welding deformation is equipped, it is possible to take measures to reduce deformation through FE analysis, helping in saving time for correcting work by arresting the parts which are prone to having welding deformation. For the FE analysis to predict the deformation of a large steel structure, calculation time, modeling, constraints in each assembly stage and critical welding length have to be considered. In case of fillet welding deformation, around 300 mm is sufficient as a critical welding length of the specimen as proposed by the existing researches. However, the critical length in case of butt welding is around 1000 mm, which is far longer than that suggested in the existing researches. For the external constraint, which occurs as the geometry of structure is changed according to the assembly stage, constraint factor is drawn from the elastic FE analysis and test results, and the magnitude of equivalent force according to constraint is decided. The comparison study for the elastic FE analysis result and measurement for the large steel structure based on the above results reveals that the analysis results are in the range of 80-118% against measurement values, both matching each other well. Further, the deformation of fillet welding in the main plate among the total block occupies 66-89%, making welding deformation in the main plate far larger than the welding deformation in the longitudinal and transverse girders.

• 대한전자공학회논문지SP
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• 제42권3호
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• pp.91-98
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• 2005

본 논문에서는 영상의 에지성분을 이용하여 손실된 프레임에서의 오류를 은닉하는 방법을 제안한다. 제안된 방법에서는 손실된 블록의 주변에 존재하는 상, 하, 좌, 우의 일정 부분을 에지 추출을 위한 영역으로 정의하고, 정의된 네 부분의 영역은 방향에 따라 선택적인 에지 연산자를 적용시켜 에지 성분을 추출한다. 이 에지정보는 영상이 복잡한 부분과 단순한 부분에 대해 복잡도를 결정하는 판단 기준이 되며 경계정합을 위한 마스크 폭을 조절하게 된다. 즉, 제시된 방법은 경계정합 수행시 정확도를 높이기 위하여 네 부분에서 추출된 에지성분의 양에 비례하여 방향에 따라 경계정합 마스크의 폭을 조절하고, 이에 따라 영상의 윤곽을 나타내는 에지 특성에 가중치를 적용함으로써, 개선된 움직임 벡터를 얻을 수 있도록 하였다. 기존의 방법들과 제안된 방법에 대한 오류은닉 결과를 비교함으로써 제안된 방법의 우수성 검증 및 장단점에 대해 분석한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8253-8258
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• 2016

Elevated levels of soluble CD30 (sCD30) are linked with various T-cell neoplasms. However, the relationship between sCD30 levels and the development of adult T-cell leukemia (ATL) in human T-cell leukemia virus type 1 (HTLV-1) carriers remains to be clarified. We here investigated whether plasma sCD30 is associated with risk of ATL in a nested case-control study within a cohort of HTLV-1 carriers. We compared sCD30 levels between 11 cases (i.e., HTLV-1 carriers who later progressed to ATL) and 22 age-, sex- and institution-matched control HTLV-1 carriers (i.e., those with no progression). The sCD30 concentration at baseline was significantly higher in cases than in controls (median 65.8, range 27.2-134.5 U/mL vs. median 22.2, range 8.4-63.1 U/mL, P=0.001). In the univariate logistic regression analysis, a higher sCD30 (${\geq}30.2U/mL$) was significantly associated with ATL development (odds ratio 7.88 and the 95% confidence intervals 1.35-45.8, P = 0.02). Among cases, sCD30 concentration tended to increase at the time of diagnosis of aggressive-type ATL, but the concentration was stable in those developing the smoldering-type. This suggests that sCD30 may serve as a predictive marker for the onset of aggressive-type ATL in HTLV-1 carriers.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2009년도 제33회 추계학술대회논문집
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• pp.590-593
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• 2009

모델 스크램제트 엔진의 3차원 유동특성 이해를 위하여 다단의 충격파를 발생 시키는 흡입구부터(외부 유동영역) 공동형 보염기, 연소기, 노즐이 포함되는 엔빈 내부 전영역을 통합한 수치해석을 수행하였다. $k-{\omega}$ SST 난류모델과 Sarkar모델이 적용된 저 레이놀즈 수 k-e 난류모델의 해석결과를 실험 결과와 비교하였으며, 흡입구의 측면효과(intake side wall effects)를 살펴보기 위하여 측면의 유무에 따른 유동특성을 관찰하였다. 본 연구에 소요되는 계산시간의 효율성을 위하여 계산영역을 다중블럭으로 구성하였으며, MPI(Massage Passing Interface) 병렬 계산 기법을 적용하였다.

• 전자공학회논문지CI
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• 제44권6호
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• pp.30-35
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• 2007

H.264/AVC 표준은 복호된 영상의 블록간 경계면에서 발생하는 왜곡 및 불연속성을 보정하기 위하여 디블록킹 필터를 사용하여 더 나은 품질을 제공하였다. 하지만 이 과정에서 수많은 메모리 참조연산이 불가피하였으며, 이로 인해 전체 복호기의 처리 시간을 지연시키는 결과를 초래하였다. 본 논문에서는 이러한 디블록킹 필터의 처리 속도를 높이기 위한 자료 재사용 알고리즘을 제안한다. 자료 재사용을 위하여, 새로운 필터링 순서를 제안하여 메모리 참조를 감소시키고 디블록킹 필터의 처리 속도를 높인다. 제안된 알고리즘을 모델링하여 ARM ADS1.2에서 컴파일하고 ARM966E-S프로세서 시스템을 Armulator를 이용하여 시뮬레이션 하였다. 실험 결과, H.264/AVC 표준보다 매크로블록 당 실행 사이클, 메모리 참조 사이클에서 각각 58.45%, 57.93%의 성능 향상을 보였다.

• 설비공학논문집
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• 제19권4호
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• pp.321-327
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• 2007

In an apartment house that is generally air-tight and well insulated, the combustion gas from cooking devices is the major source of air pollution in the kitchen. It spreads throughout the house affecting the overall Indoor all quality. In this study, the performance of the kitchen range hood which employs air induction and air curtain was investigated by numerical simulation. The results are compared with that of two other kitchen range hoods which are in general use. The two general types of range hoods considered in the present calculations are box and plate type range hoods. The former has a large capture space between the filter and suction duct, while the latter has little. It was found that the capture efficiency of the kitchen range hood with air induction and air curtain Is higher than that of the general types of range hoods by 20% approximately The reason may be because the air induction and the air curtain block the air stream escaping from the front and the side part of range hoods effectively and because an additional fan for air induction and air curtain increases suction flow rates.