• Tuberculosis and Respiratory Diseases
• /
• v.72 no.1
• /
• pp.77-81
• /
• 2012

Blastomyces dermatitidis is a dimorphic fungus that causes the systemic pyogranulomatous disease known as blastomycosis. Blastomycosis most often involves the lungs, skin, and may involve nearly every organ in the body. It is difficult, however, to diagnose blastomycosis in the early stage of pulmonary disease because clinical manifestations are varied from subclinical infection to acute respiratory distress syndrome. Since blastomycosis is often accompanied by granulomatous inflammation in histopathologic findings, differentiation from other etiologic diseases is important. We report a case of a 45-year-old male with pulmonary blastomycosis who had been misdiagnosed with tuberculosis for 3 months.

• Journal of Korean Foot and Ankle Society
• /
• v.9 no.2
• /
• pp.216-219
• /
• 2005

We report a patient who presented with three months of foot pain, lytic navicular bone lesions in the foot, and a painless ipsilateral leg skin ulcer. Bone and skin biopsies revealed organisms compatible with Blastomyces. Systemic blastomycosis is very rare, especially with bone involvement in the foot.

• Korean Journal of Veterinary Research
• /
• v.23 no.1
• /
• pp.91-94
• /
• 1983

An adult male rhesus monkey (Macaca mulata) developed anorexia, ataxia, dullness, coughing, and some elevated body temperature and died a week after the initiation of such symptoms. At necropsy the monkey's physical condition was found to be normal. Body weight was 18.3kg and the only notable gross lesion was the appearance of acute pneumonia with multiple nodules. Histopathologic observation of the tissues obtained from this animal revealed the features of acute primary pulmonary blastomycosis.

• Tuberculosis and Respiratory Diseases
• /
• v.58 no.6
• /
• pp.619-623
• /
• 2005

Blastomycosis is a systemic pyogranulomatous disease that is caused by a thermally dimorphic fungus, Blastomyces dermatitidis. it's the disease is endemic in the south-eastern and south central states of the USA, which border the Mississippi and Ohio Rivers, the mid-western states and Canadian provinces bordering the Great Lakes as well as in a small area of New York and Canada adjacent to the St. Lawrence River. We encountered a case of blastomycosis, representing as a pulmonary manifestation after traveling around a nonendemic area and report it with a brief review of the relevant literature.

• Journal of the Korean Chemical Society
• /
• v.43 no.6
• /
• pp.676-681
• /
• 1999

Itraconazole is an important drug for oral treatment of histoplasmosis and blastomycosis. ltraconazole has been the targets of many synthetic efforts due to their diverse antifungal activities. ln this study, an efficient synthetic route for Itraconazole intermediates has been developed using new procedures. Also, ltraconazole analogues introducing 2- and 3-methoxy group instead of ltraconazole intermediates with 4-methoxy group were synthesized.