• Archives of Pharmacal Research
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• v.21 no.2
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• pp.164-167
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• 1998

Bis-${\gamma}$-lactones (1,2) having a perhydrofuro[3,4-c]furan-1,4-dione skeleton were designed as conformationally constrained diacylglycerol analogues. They were synthesized from D-apiose in 11 steps, and evaluated as $PKC-{\alpha}$ ligands by measuring their ability to displace bound $^3H$]PDBU from the enzyme. The compounds showed moderate binding affinities with $K_i$ values of 13.89 (${\pm}5.67$) ${\mu}M$ and 11.47 (${\pm}0.89$) ${\mu}M$, respectively. Their similar binding affinities indicate that these two bicyclic compounds were not effectively discriminated by $PKC-{\alpha}$ in terms of the direction of the side chain as other ligands built on similar bis-${\gamma}$-lactones.

• Fibers and Polymers
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• v.1 no.2
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• pp.67-70
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• 2000

Rosin maleic anhydride adduct (RMA)-bisester was prepared by the esterification of chlorinated RMA with hydroquinone. Phenylpyridinylcyclot.isiloxane ($D_3^{Ph,Py}$) was synthesized from phenylpyridinyldichlorosilane in the presence of zinc oxide catalyst, and amino group terminated polyphenylpyridinylsiloxane prepolymer was prepared by equilibrium polymerization of $D_3^{Ph,Py}$ with 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane. Rosinimide (PSMR) was prepared from the imidization of RMA-bisester with polyphenylpyridinylsiloxane prepolymer at 12$0^{\circ}C$ for 7 h using ${\gamma}$-butyrolactone/pyridine. It showed that PSMR had better thermal stalbility than rosinimide modified with polydimethylsiloxane.