• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.267-274
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• 2021

Medical care practices include gathering a wide range of student data that are with manic episodes and depression which would assist the specialist with diagnosing a health condition of the students correctly. In this way, the instructors of the specific students will also identify those students and take care of them well. The data which we collected from the students could be straightforward indications seen by them. The artificial intelligence has been utilized with Naive Baye's classification, Random forest classification algorithm, SVM algorithm to characterize the datasets which we gathered to check whether the student is influenced by Bipolar illness or not. Performance analysis of the disease data for the algorithms used is calculated and compared. Also, a sequential deep learning model is builded using Keras. The consequences of the simulations show the efficacy of the grouping techniques on a dataset, just as the nature and complexity of the dataset utilized.

• 생물정신의학
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• 제13권1호
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• pp.32-37
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• 2006

Background : Several studies have suggested that alterations of cytokine level could be related to the pathophysiology of bipolar disorder. In this study, we measured plasma level of Interleukin-12(IL-12), a pro-inflammatory cytokine and transforming growth factor-${\beta}$1(TGF-${\beta}$1), an anti-inflammatory cytokine before and after treatment in acute manic patients. Methods : The plasma concentrations of IL-12 and TGF-${\beta}$1 were measured using quantitative ELISA in 18 bipolar disorder patients and 25 normal controls at admission and 6 weeks later. The psychopathology was measured by Brief Psychiatric Rating Scale(BPRS) and Young Mania Rating Scale(YMRS). Results : IL-12 levels were significantly higher in bipolar manic patients than in controls before treatment. Following the 6-week treatment, the IL-12 level was decreased than before treatment, but sustained still higher level than normal control. TGF-${\beta}$1 level was not significant different between manic patients and normal controls before treatment, but was increased after treatment comparing with before treatment in bipolar patients. The ratio of IL-12 and TGF-${\beta}$1 was significantly decreased after treatment. Conclusion : Cytokine abnormalities in bipolar disorder might be involved in the pathophysiology of the illness. It is possible that TGF-${\beta}$1 plays an important role in the regulation of immunological imbalance in bipolar disorder.

• 생물정신의학
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• 제23권4호
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• pp.185-192
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• 2016

Objectives Treatment response of bipolar disorders (BDs) to long-term mood stabilizers maintenance has not been well explored because of complicated clinical and treatment courses. This study aims at investigating long-term clinical response of BDs to lithium and/or valproate in a naturalistic setting of a tertiary-care university-affiliated hospital. Methods Subjects were 65 patients with bipolar I (BD-I) disorders who had been treated with lithium and/or valproate for more than two years at single bipolar disorder clinic. Long-term response to the best treatment based on treatment algorithms and the current clinical standard of care was retrospectively evaluated using the Alda Scale and the Clinical Global Impression Scale for use in bi-polar illness (CGI-BP). Patients were classified into full responder and partial/non responder groups based on the total score of the Alda Scale with the cut-off score generated from the frequentist mixture analysis of the authors' previous study. Results The mean duration of treatment with the index medication was 69.2 months. Baseline demographic and clinical characteristics were not different among three mood stabilizer groups (valproate, lithium, and combination groups). Twenty-one subjects were classified into full responder group (32.3%). Treatment response assessed by the Alda Scale and CGI-BP scores was not different between lithium and valproate groups. The Alda Scale scores were well correlated with the CGI-BP scores (p < 0.05). Conclusions One third of the patients showed a full response to the long-term lithium and/or valproate treatment in BD-I. The degree of response was similar between lithium and valproate groups.

• 생물정신의학
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• 제7권1호
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• pp.99-106
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• 2000

Background : In spite of relative high risk of extrapyramidal side effect and tardive dyskinesia, it is common clinical practice to use antipyschotics in treatment of bipolar I disorder. But in Korea, there has been few study about clinical factors related with antipsychotics treatment in bipolar disorder patients. So the author studied about the clinical factors related with antipsychotics treatment in bipolar inpatients focusing on the comparison of risperidone and classical antipsychotics. Method : By reviewing medical record retrospectively, datas about patient-related, illness-related, and treatment-related clinical factors on antipsychotics use were collected. Association between antipsychotics dose and duration and clinical factors were analysed by statistical method. Results : Aggressive behavior was only statistically significant factor associated with antipsychotics use. And in the case of aggression, maintenance dose of risperidone was not changed(p=0.84), but dose of classical antipsychotics was increased significantly(p=0.005). Total hospital days and antipsychotics treatment duration showed no difference between risperidone and classical antipsychotics treatment groups. Conclusion : Clinical factors associated with antipsychotics use was aggressive behavior. In the case of aggression, risperidone required lesser dose increment compared with classical antipsychotics.

• 한국콘텐츠학회논문지
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• 제17권7호
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• pp.579-591
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• 2017

회복지향질병관리(Illness Management and Recovery: IMR) 프로그램은 정신과 환자의 질병에 대한 자가 관리 및 회복을 촉진하기 위해 개발되었다. 본 연구에서는 한국판 IMR 프로그램이 입원한 만성 중증정신과 환자의 회복, 정신질환 지식, 희망에 미치는 영향을 살펴보았다. 연구 대상자는 조현병, 양극성장애, 조현형정동장애로 진단 받은 사람들로 실험군(51명)은 IMR 프로그램에 참여하였으며, 대조군(41명)은 기존의 치료를 유지하였다. 자료 수집은 2015년 5월부터 2016년 12월까지 이루어졌다. 정신건강회복척도, 정신장애 지식척도, 한국판 희망척도를 사전과 중재 이후에 실시하였다. 연구결과 IMR 프로그램에 참여한 사람들이 기존 치료를 유지한 대조군에 비해 자신의 회복 추구와 정신장애에 대한 지식이 향상하였다. 그러나 두 그룹 모두 희망에 대한 변화는 유의하지 않았다. 본 연구는 한국에서 처음 시행된 IMR 프로그램의 효과성 연구이다. 본 연구 결과는 한국판 IMR 프로그램이 우리나라 정신보건 임상에서 만성 정신과 환자의 회복을 촉진시키는 효과적인 중재로 활용될 가능성을 지지한다.

• 감성과학
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• 제21권2호
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• pp.145-158
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• 2018

본 연구의 목적은 정신 질환을 진단받지 않은 일반인들이 양극성 장애 경향성에 따라 변화하는 시공간 주의집중력과 정서 지각 능력을 탐구하는 것이다. 양극성 장애 경향성을 측정하기 위해 한국형 자기보고형 양극성 장애 검사(K-MDQ)를 사용하였고, 시공간 주의집중력와 정서 지각 능력을 측정하기 위해서는 시공간 주의 과제(useful field of view task)와 정서 지각 과제(emotional perception task)를 사용하였다. 또한 본 연구에는 정신 질환 혹은 기타 의학적 문제가 없는 참가자들만 참여하였고 K-MDQ 점수에 따라 세 집단으로 나뉘어졌다. 시공간 주의 과제 수행 결과, K-MDQ 점수가 높은 집단이 다른 집단들에 비해 수행 수준이 낮았다. 이는 양극성 장애 경향성이 높은 일반인은 시공간 주의집중력의 저하가 나타난 것을 의미했다. 또한 정서 지각 과제 수행 결과, K-MDQ 점수가 높은 집단이 다른 집단들에 비해 부정적 정서 지각 편향성이 높게 나타났다. 이는 양극성 장애 경향성이 높은 일반인은 부정적 정서 지각 편향성이 높게 나타났으며 즉, 양극성 장애 경향성이 높은 일반인은 정서 지각 능력이 저하되었음을 의미했다. 이러한 결과는 양극성 장애 환자가 아닌 일반인이 양극성 장애 경향성이 높아지면 양극성 장애 환자에게 나타난 시공간 주의집중력과 정서 지각 능력의 저하가 점진적으로 나타난다는 것을 함의한다.

• 생물정신의학
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• 제12권2호
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• pp.207-215
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• 2005

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

• 생물정신의학
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• 제24권4호
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• pp.225-234
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• 2017

Objectives Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I. Methods Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates. Results The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I. Conclusions Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.

• 생물정신의학
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• 제26권1호
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• pp.22-31
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• 2019

Objectives Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.

• 생물정신의학
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• 제22권2호
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• pp.29-33
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• 2015

The brain maintains homeostasis and normal microenvironment through dynamic interactions of neurons and neuroglial cells to perform the proper information processing and normal cognitive functions. Recent post-mortem investigations and animal model studies demonstrated that the various brain areas such as cerebral cortex, hippocampus and amygdala have abnormalities in neuroglial numbers and functions in subjects with mental illnesses including schizophrenia, dementia and mood disorders like major depression and bipolar disorder. These findings highlight the putative role and involvement of neuroglial cells in mental disorders. Herein I discuss the physiological roles of neuroglial cells such as astrocytes, oligodendrocytes, and microglia in maintaining normal brain functions and their abnormalities in relation to mental disorders. Finally, all these findings could serve as a useful starting point for potential therapeutic concept and drug development to cure unnatural behaviors and abnormal cognitive functions observed in mental disorders.