• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.3 no.3
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• pp.14-21
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• 2010

For the ubiquitous healthcare environment, real-time measurement of biomedical signals and accuracy of the measured biomedical information are very important. In addition, it is important to develop a healthcare device with low power In this paper, the synchronized pulse in a heartbeat was detected from the radial artery using the piezo film sensor, in order to eliminate inconvenience to wear a pulse detection finger probe. We can get a best output after applying the adaptive noise canceller using two piezo film sensor signals, pulse signal having motion artifacts and motion artifacts reference signal. To detect heartbeat, we use maximum point detection method from pulse removed motion artifacts.

• Journal of Animal Science and Technology
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• v.59 no.11
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• pp.24.1-24.14
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• 2017

Over the past decades, in vitro culture media have been developed to successfully support IVF embryo growth in a variety of species. Advanced reproductive technologies, such as somatic cell nuclear transfer (SCNT), challenge us with a new type of embryo, with special nutritional requirements and altered physiology under in vitro conditions. Numerous studies have successfully reconstructed cloned embryos of domestic animals for biomedical research and livestock production. However, studies evaluating suitable culture conditions for SCNT embryos in wildlife species are scarce (for both intra- and interspecies SCNT). Most of the existing studies derive from previous IVF work done in conventional domestic species. Extrapolation to non-domestic species presents significant challenges since we lack information on reproductive processes and embryo development in most wildlife species. Given the challenges in adapting culture media and conditions from IVF to SCNT embryos, developmental competence of SCNT embryos remains low. This review summarizes research efforts to tailor culture media to SCNT embryos and explore the different outcomes in diverse species. It will also consider how these culture media protocols have been extrapolated to wildlife species, most particularly using SCNT as a cutting-edge technical resource to assist in the preservation of endangered species.

• Journal of the Korean Applied Science and Technology
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• v.35 no.3
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• pp.695-701
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• 2018

The purpose of this study was to verify prprioception perception and compare between collegiate golfers and non-golfers using tilting platform. Thirty golfers and twenty-eight non-golfers were participated. All participants were performed perception test on the tilting platform. Frequency analysis was performed using SPSS(ver. 24.0) to determine the perception response according to the grade, and performed using independent t-test. Most participants were perceived from $1^{\circ}$ to $2^{\circ}$ of slopes and perceived left-right slope than forward-backward slope. Repeated practice such as walking on the uneven ground or standing on sloped ground might help to improve proprioception perception. Future research using a tilting platform will be to develop the training program.

• Fisheries and Aquatic Sciences
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• v.21 no.5
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• pp.14.1-14.8
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• 2018

The objective of this study was to investigate the anti-inflammatory effects of the pepsinolytic hydrolysate from the fish frame, Johnius belengerii, on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. The J. belengerii frame hydrolysate (JFH) significantly suppressed nitric oxide (NO) secretion on LPS-stimulated RAW264.7 macrophages. Moreover, the JFH markedly inhibited the levels of protein and mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, the LPS-stimulated mRNA expression of pro-inflammatory cytokines, including tumor necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$, and IL-6 was downregulated when cells were cultured with the JFH. The JFH significantly reduced the phosphorylation of c-Jun N-terminal kinase (JNK) and the translocation of nuclear factor-kappa B ($NF-{\kappa}B$) in macrophages. As the result, the JFH has the potential anti-inflammatory activity via blocking the JNK and $NF-{\kappa}B$ signal pathways.

• Journal of Biomedical Engineering Research
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• v.31 no.1
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• pp.20-26
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• 2010

The aim of this study was to test the feasibility of a wireless transceiver that can be inserted into the ear canal. The wireless technology could minimize the cosmetic problems of patients, and it can be applied to binaural hearing aids for improving speech perception. In order to implement the ear canal insertable transceiver, simple finite-difference time-domain (FDTD) simulations were carried out to determine the feasibility, and the hardware of the transceiver was implemented within the ear shell. The size of the implemented transceiver was only $7{\times}7mm$, and it could successfully transmit signals to external devices. In order to measure the radiation pattern, a simple RF phantom was used, and the maximum attenuation from the phantom was observed to be 23 dB when the reference antenna was placed at a distance of 2 m from the transmitter.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.5
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• pp.491-496
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• 2015

Electric handbike can be easily detachable to various sizes of manual wheelchair and the elderly and people with disabilities can use them easily. Therefore, connectors used for coupling between the handbike and manual wheelchair must secure structural stability for occupant safety. However, related research is rare. The aim of this study is to find the connector with highly structural stability by comparing static and dynamic mechanical characteristics among three typical connectors(a snatch lock, a slide latch, and a fastener) by computational simulations. To perform static and dynamic simulation, we referred to durability test based on Korean Standards and then calculated mechanical stresses in connectors. The results showed that the snatch lock addressed the lowest von-mises stress under the same mechanical condition. Therefore when using the combination of a handbike and a wheelchair, we concluded that the snatch lock is considered as the structurally stable connector to structural stability and usability.

• Journal of Sensor Science and Technology
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• v.27 no.1
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• pp.6-12
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• 2018

In this paper, a 32-variable pulse position modulation (32-VPPM) scheme is proposed to support a red-green-blue light-emitting-diode (RGB-LED)-based optical camera communication (OCC) system. Our proposed modulation scheme is designed to enhance the OCC data transmission rate, which is targeted for the wearable biomedical data monitoring system. The OCC technology has been utilized as an alternative solution to the radio frequency (RF) wireless system for long-term self-healthcare monitoring. Different biomedical signals, such as electrocardiograms, photoplethysmograms, and respiration signals are being monitored and transmitted wirelessly from the wearable biomedical device to the smartphone receiver. A common 30 frames per second (fps) smartphone camera with a CMOS image sensor is used to record a transmitted optical signal. Moreover, the overall proposed system architecture, modulation scheme, and data demodulation are discussed in this paper. The experimental result shows that the proposed system is able to achieve > 9 kbps using only a common smartphone camera receiver.

• Annual Conference on Human and Language Technology
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• 2007.10a
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• pp.128-133
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• 2007

Focused crawling은 검색시스템의 구축을 위한 웹 문서 수집단계에서, 미리 정의된 토픽 집합들과 관련성을 가지는 웹 문서를 수집하기 위하여 제안되었다. 이러한 focused crawling 연구에서 보다 효과적인 웹 문서 수집을 위해 주어진 토픽에 대한 양질의 배경지식을 제공할 수 있도록 온톨로지가 활발히 활용되어왔다. 그러나 기존의 온톨로지 기반 focused crawling 연구는 토픽과 웹 문서 간의 관련성 측정을 위하여, 주어진 토픽과 관련있는 온톨로지 내 각 개념들에 직관에 의존한 가중치를 부여하여 활용하였다. 하지만 이러한 직관에 의존한 가중치부여 기법은 안정된 수집결과를 도출할 수 있는 최적화된 가중치 값을 얻기가 힘든 한계가 있다. 따라서 본 논문에서는 이러한 개념에 대한 가중치가 학습에 의하여 자동으로 결정되도록, 인공신경망을 적용한 온톨로지 기반 focused crawling 기법을 제안한다. 웹 상에서 제안된 시스템의 성능을 실험한 결과 기존의 온톨로지 기반 수집 기법에 비하여 보다 향상된 결과를 보임을 알 수 있었다.

• Molecules and Cells
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• v.41 no.6
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• pp.603-611
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• 2018

Triglyceride homeostasis is a key process of normal development and is essential for the maintenance of energy metabolism. Dysregulation of this process leads to metabolic disorders such as obesity and hyperlipidemia. Here, we report a novel function of the Drosophila flightless-I (fliI) gene in lipid metabolism. Drosophila fliI mutants were resistant to starvation and showed increased levels of triglycerides in the fat body and intestine, whereas fliI overexpression decreased triglyceride levels. These flies suffered from metabolic stress indicated by increased levels of trehalose in hemolymph and enhanced phosphorylation of eukaryotic initiation factor 2 alpha ($eIF2{\alpha}$). Moreover, upregulation of triglycerides via a knockdown of fliI was reversed by a knockdown of desat1 in the fat body of flies. These results indicate that fliI suppresses the expression of desat1, thereby inhibiting the development of obesity; fliI may, thus, serve as a novel therapeutic target in obesity and metabolic diseases.

• BMB Reports
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• v.55 no.3
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• pp.113-124
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• 2022

Single-cell RNA sequencing (scRNA-seq) has greatly advanced our understanding of cellular heterogeneity by profiling individual cell transcriptomes. However, cell dissociation from the tissue structure causes a loss of spatial information, which hinders the identification of intercellular communication networks and global transcriptional patterns present in the tissue architecture. To overcome this limitation, novel transcriptomic platforms that preserve spatial information have been actively developed. Significant achievements in imaging technologies have enabled in situ targeted transcriptomic profiling in single cells at single-molecule resolution. In addition, technologies based on mRNA capture followed by sequencing have made possible profiling of the genome-wide transcriptome at the 55-100 ㎛ resolution. Unfortunately, neither imaging-based technology nor capture-based method elucidates a complete picture of the spatial transcriptome in a tissue. Therefore, addressing specific biological questions requires balancing experimental throughput and spatial resolution, mandating the efforts to develop computational algorithms that are pivotal to circumvent technology-specific limitations. In this review, we focus on the current state-of-the-art spatially resolved transcriptomic technologies, describe their applications in a variety of biological domains, and explore recent discoveries demonstrating their enormous potential in biomedical research. We further highlight novel integrative computational methodologies with other data modalities that provide a framework to derive biological insight into heterogeneous and complex tissue organization.