• Title/Summary/Keyword: Biomedical research

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Biotechnology and Biomedicine - a Case Study with Recombinant Limulus Factor C

  • Ling, Ding-Jeak;Ho-Bow
    • Biomedical Science Letters
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    • v.8 no.1
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    • pp.1-5
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    • 2002
  • Biotechnology "embraces everything from the production of recombinant proteins to the use of biological molecules as components of nanotechnology". Strategic-basic research in biotechnology is crucial to boosting world economy and creating jobs in the Life Sciences. Biotechnology will be the benefit to be drawn from biomedical life science research, which promises to be the new pillar of economy. Although the turnaround time for life science research products is painstakingly slow, the fruits of one such labour (Fig. 1), is being reaped fur worldwide biomedical applications.

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Counterion Effects on Transection Activity of Cationic Lipid Emulsion

  • Kim, Young-Jin;Kim, Tae-Woo;Hesson Chung;Kwon, Ik-Chan;Jeong, Seo -Young
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.6 no.4
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    • pp.279-283
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    • 2001
  • Cationic lipid emulsion system consisting of 1, 2-dioleoyl-sn-slycero-3-trimethyl-ammonium-propane(DOTAP) and plasmin DNA with various counterions in the lipid headgroups were prepared. The transfection activity of the cationic lipid emulsion systems was then investigated in vitro and in vivo. The complex formation of plasmid DNA lipid emulsion was affected by the counterions through charged headgroup repulsion and also by the salt concen-tration in the media. As such , the transfection activity of the DOTAP emulsion system can be controlled by changing the counterions.

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Extensive inflammatory reaction in facioscapulohumeral muscular dystrophy

  • Choi, Jae-Hwan;Park, Young-Eun;Shin, Jin-Hong;Lee, Chang-Hoon;Kim, Dae-Seong
    • Annals of Clinical Neurophysiology
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    • v.19 no.2
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    • pp.141-144
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    • 2017
  • In facioscapulohumeral muscular dystrophy (FSHD), prominent inflammatory cellular infiltrates mimicking inflammatory myopathies are often observed in muscle biopsies. We report extensive inflammatory changes in a 16-year-old girl who was genetically confirmed as to have FSHD. Immunohistochemical staining revealed that this could be clearly distinguished from inflammatory myopathies, both in terms of cell subsets and the expression of antigenic targets. Our observations strongly suggest that the inflammatory cellular infiltrates in FSHD differ from those observed in inflammatory myopathies.