• Journal of Biomedical Engineering Research
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• v.40 no.2
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• pp.62-67
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• 2019

The purpose of this study was to evaluate the performance of deep neural network model in order to determine whether there is a risk factor for coronary artery disease based on the cardiac variation parameter. The study used unidentifiable 297 data to evaluate the performance of the model. Input data consists of heart rate parameters, which are SDNN (standard deviation of the N-N intervals), PSI (physical stress index), TP (total power), VLF (very low frequency), LF (low frequency), HF (high frequency), RMSSD (root mean square of successive difference) APEN (approximate entropy) and SRD (successive R-R interval difference), the age group and sex. Output data are divided into normal and patient groups, and the patient group consists of those diagnosed with diabetes, high blood pressure, and hyperlipidemia among the various risk factors that can cause coronary artery disease. Based on this, a binary classification model was applied using Deep Neural Network of deep learning techniques to classify normal and patient groups efficiently. To evaluate the effectiveness of the model used in this study, Kernel SVM (support vector machine), one of the classification models in machine learning, was compared and evaluated using same data. The results showed that the accuracy of the proposed deep neural network was train set 91.79% and test set 85.56% and the specificity was 87.04% and the sensitivity was 83.33% from the point of diagnosis. These results suggest that deep learning is more efficient when classifying these medical data because the train set accuracy in the deep neural network was 7.73% higher than the comparative model Kernel SVM.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.526-538
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• 2021

Machine and deep learning-based models are emerging techniques that are being used to address prediction problems in biomedical data analysis. DNA sequence prediction is a critical problem that has attracted a great deal of attention in the biomedical domain. Machine and deep learning-based models have been shown to provide more accurate results when compared to conventional regression-based models. The prediction of the gene sequence that leads to cancerous diseases, such as prostate cancer, is crucial. Identifying the most important features in a gene sequence is a challenging task. Extracting the components of the gene sequence that can provide an insight into the types of mutation in the gene is of great importance as it will lead to effective drug design and the promotion of the new concept of personalised medicine. In this work, we extracted the exons in the prostate gene sequences that were used in the experiment. We built a Deep Neural Network (DNN) and Bi-directional Long-Short Term Memory (Bi-LSTM) model using a k-mer encoding for the DNA sequence and one-hot encoding for the class label. The models were evaluated using different classification metrics. Our experimental results show that DNN model prediction offers a training accuracy of 99 percent and validation accuracy of 96 percent. The bi-LSTM model also has a training accuracy of 95 percent and validation accuracy of 91 percent.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.14 no.5
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• pp.413-420
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• 2021

This study is about a machine learning model for predicting insufficient parameters through other parameters when one of the collected parameters is insufficient. A regression model was created to predict time, temperature, humidity, CO2, and light quantity data through the machine learning regression analysis function in Matlab. In addition, the three models with the lowest RMSE values for each parameter were selected and verified. For verification, the predicted values were obtained by applying the test data to the prediction model derived from each parameter, and the correlation coefficient and error average between the measured values and the obtained predicted values were obtained and then compared.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.9
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• pp.2495-2511
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• 2024

State of the art machine learning methods can enhance the analysis of clinical data and improve the ability to predict patient outcomes because data collected from clinical records, such as heart failure mortality studies, are often high dimensional, heterogeneous and give challenges to traditional statistical analysis techniques. To address this challenge, this study conducted a survival analysis based on a dataset of 299 patients with heart failure, using Python libraries. Cox regression was used to model and analyse mortality, and to find which features are strongly associated with this outcome. The Kaplan-Meier survival curve approach was used to show the patterns of patient survival over time. The analysis showed that age, ejection fraction, and serum creatinine level were significantly (p≤0.001) associated with mortality. Anaemia and creatinine phosphokinase also reached statistical significance (p-values 0.026 and 0.007, respectively). The Cox model showed good concordance (0.77) with the data, suggesting that the identified variables are useful for predicting mortality in patients with heart failure.

• The Journal of Advanced Prosthodontics
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• v.10 no.6
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• pp.395-400
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• 2018

PURPOSE. This study tried to find the most significant factors predicting implant prognosis using machine learning methods. MATERIALS AND METHODS. The data used in this study was based on a systematic search of chart files at Seoul National University Bundang Hospital for one year. In this period, oral and maxillofacial surgeons inserted 667 implants in 198 patients after consultation with a prosthodontist. The traditional statistical methods were inappropriate in this study, which analyzed the data of a small sample size to find a factor affecting the prognosis. The machine learning methods were used in this study, since these methods have analyzing power for a small sample size and are able to find a new factor that has been unknown to have an effect on the result. A decision tree model and a support vector machine were used for the analysis. RESULTS. The results identified mesio-distal position of the inserted implant as the most significant factor determining its prognosis. Both of the machine learning methods, the decision tree model and support vector machine, yielded the similar results. CONCLUSION. Dental clinicians should be careful in locating implants in the patient's mouths, especially mesio-distally, to minimize the negative complications against implant survival.

• Journal of the Korean Society of Radiology
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• v.83 no.6
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• pp.1208-1218
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• 2022

In the medical field, artificial intelligence has been used in various ways with many developments. However, most artificial intelligence technologies are developed so that one model can perform only one task, which is a limitation in designing the complex reading process of doctors with artificial intelligence. Multi-task learning is an optimal way to overcome the limitations of single-task learning methods. Multi-task learning can create a model that is efficient and advantageous for generalization by simultaneously integrating various tasks into one model. This study investigated the concepts, types, and similar concepts as multi-task learning, and examined the status and future possibilities of multi-task learning in the medical research.

• Journal of Biomedical Engineering Research
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• v.45 no.2
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• pp.90-94
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• 2024

Diagnosing wounds presents a significant challenge in clinical settings due to its complexity and the subjective assessments by clinicians. Wound deep learning algorithms quantitatively assess wounds, overcoming these challenges. However, a limitation in existing research is reliance on specific datasets. To address this limitation, we created a comprehensive dataset by combining open dataset with self-produced dataset to enhance clinical applicability. In the annotation process, machine learning based on Gradient Vector Flow (GVF) was utilized to improve objectivity and efficiency over time. Furthermore, the deep learning model was equipped U-net with residual blocks. Significant improvements were observed using the input dataset with images cropped to contain only the wound region of interest (ROI), as opposed to original sized dataset. As a result, the Dice score remarkably increased from 0.80 using the original dataset to 0.89 using the wound ROI crop dataset. This study highlights the need for diverse research using comprehensive datasets. In future study, we aim to further enhance and diversify our dataset to encompass different environments and ethnicities.

• Korean Journal of Radiology
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• v.21 no.6
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• pp.660-669
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• 2020

Objective: To evaluate the accuracy of a deep learning-based automated segmentation of the left ventricle (LV) myocardium using cardiac CT. Materials and Methods: To develop a fully automated algorithm, 100 subjects with coronary artery disease were randomly selected as a development set (50 training / 20 validation / 30 internal test). An experienced cardiac radiologist generated the manual segmentation of the development set. The trained model was evaluated using 1000 validation set generated by an experienced technician. Visual assessment was performed to compare the manual and automatic segmentations. In a quantitative analysis, sensitivity and specificity were calculated according to the number of pixels where two three-dimensional masks of the manual and deep learning segmentations overlapped. Similarity indices, such as the Dice similarity coefficient (DSC), were used to evaluate the margin of each segmented masks. Results: The sensitivity and specificity of automated segmentation for each segment (1-16 segments) were high (85.5-100.0%). The DSC was 88.3 ± 6.2%. Among randomly selected 100 cases, all manual segmentation and deep learning masks for visual analysis were classified as very accurate to mostly accurate and there were no inaccurate cases (manual vs. deep learning: very accurate, 31 vs. 53; accurate, 64 vs. 39; mostly accurate, 15 vs. 8). The number of very accurate cases for deep learning masks was greater than that for manually segmented masks. Conclusion: We present deep learning-based automatic segmentation of the LV myocardium and the results are comparable to manual segmentation data with high sensitivity, specificity, and high similarity scores.

• Journal of Preventive Medicine and Public Health
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• v.35 no.2
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• pp.83-91
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• 2002

Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic and postgenomic data means that many of the challenges in biomedical research are now challenges in computational sciences. Clinical informatics has long developed methodologies to improve biomedical research and clinical care by integrating experimental and clinical information systems. The informatics revolutions both in bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics, and prognostics. Postgenome informatics, powered by high throughput technologies and genomic-scale databases, is likely to transform our biomedical understanding forever much the same way that biochemistry did a generation ago. The paper describes how these technologies will impact biomedical research and clinical care, emphasizing recent advances in biochip-based functional genomics and proteomics. Basic data preprocessing with normalization, primary pattern analysis, and machine learning algorithms will be presented. Use of integrated biochip informatics technologies, text mining of factual and literature databases, and integrated management of biomolecular databases will be discussed. Each step will be given with real examples in the context of clinical relevance. Issues of linking molecular genotype and clinical phenotype information will be discussed.

• Phonetics and Speech Sciences
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• v.15 no.4
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• pp.109-118
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• 2023

Cardiac arrest is a critical medical emergency where immediate response is essential for patient survival. This is especially true for Out-of-Hospital Cardiac Arrest (OHCA), for which the actions of emergency medical services in the early stages significantly impact outcomes. However, in Korea, a challenge arises due to a shortage of dispatcher who handle a large volume of emergency calls. In such situations, the implementation of a machine learning-based OHCA detection program can assist responders and improve patient survival rates. In this study, we address this challenge by developing a machine learning-based OHCA detection program. This program analyzes transcripts of conversations between responders and callers to identify instances of cardiac arrest. The proposed model includes an automatic transcription module for these conversations, a text-based cardiac arrest detection model, and the necessary server and client components for program deployment. Importantly, The experimental results demonstrate the model's effectiveness, achieving a performance score of 79.49% based on the F1 metric and reducing the time needed for cardiac arrest detection by 15 seconds compared to dispatcher. Despite working with a limited dataset, this research highlights the potential of a cardiac arrest detection program as a valuable tool for responders, ultimately enhancing cardiac arrest survival rates.