• Title/Summary/Keyword: Biological sciences

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Conformational change of organic cofactor PLP is essential for catalysis in PLP-dependent enzymes

  • Ngo, Ho-Phuong-Thuy;Nguyen, Diem Quynh;Park, Hyunjae;Park, Yoon Sik;Kwak, Kiwoong;Kim, Taejoon;Lee, Jang Ho;Cho, Kyoung Sang;Kang, Lin-Woo
    • BMB Reports
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    • v.55 no.9
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    • pp.439-446
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    • 2022

  • Pyridoxal 5'-phosphate (PLP)-dependent enzymes are ubiquitous, catalyzing various biochemical reactions of approximately 4% of all classified enzymatic activities. They transform amines and amino acids into important metabolites or signaling molecules and are important drug targets in many diseases. In the crystal structures of PLP-dependent enzymes, organic cofactor PLP showed diverse conformations depending on the catalytic step. The conformational change of PLP is essential in the catalytic mechanism. In the study, we review the sophisticated catalytic mechanism of PLP, especially in transaldimination reactions. Most drugs targeting PLP-dependent enzymes make a covalent bond to PLP with the transaldimination reaction. A detailed understanding of organic cofactor PLP will help develop a new drug against PLP-dependent enzymes.

  • https://doi.org/10.5483/BMBRep.2022.55.9.090 인용 PDF KSCI

New Records of Aspergillus allahabadii and Penicillium sizovae from Crop Field Soil in Korea

  • Tagele, Setu Bazie;Adhikari, Mahesh;Gurung, Sun Kumar;Lee, Hyun Gu;Kim, Sang Woo;Kim, Hyun Seung;Ju, Han Jun;Gwon, Byeong Heon;Kosol, San;Lee, Hyang Burm;Lee, Youn Su
    • Mycobiology
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    • v.46 no.4
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    • pp.297-304
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    • 2018

  • Two new records of Trichocomaceae, namely Aspergillus allahabadii and Penicillium sizovae, were isolated in 2016 during a survey of fungal diversity in different crop fields locations in Gyeongnam, Korea. These species were identified based on morphological characters and phylogenetic analysis using internal transcribed spacer region and ${\beta}-tubulin$-encoding gene sequence data. A. allahabadii and P. sizovae have not yet been reported in Korea. Thus, this is the first report of these species in Korea, and their descriptions as well as details of their morphological characters are presented.

  • https://doi.org/10.1080/12298093.2018.1538069 인용 PDF KSCI