• 대한핵의학회지
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• 제36권1호
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• pp.8-18
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• 2002

Early and accurate diagnosis of tumors using positron omission tomography (PET) has been the focus of considerable interest due to its high metastasis and mortality rates at late detection. PET radiopharmaceuticals-which exhibit a high tumor-to-background uptake ratio, and appropriate metabolic characteristics, and pharmacokinetics-are attractive tools for tumor imaging. Tumor imaging by these radiopharmaceuticals are based on metabolic and receptor imaging. The former is based on accelerated metabolism in tumor tissue compared to normal tissue and the rate roughly corresponding to the rate of growth of tumors. Radiopharmaceuticals for this purpose include radiolabeled sugars, amino acids, and nucleosides which detect increased glucose utilization, protein synthesis, and DNA synthesis, respectively. Tumor receptor imaging is based on the proliferation of tumor cells regulated by many hormones and growth factors, which bind to the corresponding receptors and exhibit the biological responses Radiopharmaceuticals used to image the tumor receptor systems may be ligands for the specific receptors and antibodies for the growth factor receptors. Some antitumor agents have been labeled with radionuclides and used to study in vivo biodistribution and pharmacokinetics in humans. This overview describes typical PET radiopharmaceuticals used for tumor imaging based on their uptake mechanisms.

• 대한핵의학회지
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• 제38권2호
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• pp.115-120
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• 2004

Molecular imaging is a rapidly growing field due to the advances in molecular biology and imaging technologies. With the introduction of imaging reporter genes into the cell, diverse cellular processes can be monitored, quantified and imaged non-invasively in vivo. These precesses include the gene expression, protein-protein interactions, signal transduction pathways, and monitoring of cells such as cancer cells, immune cells, and stem cells. In the near future, molecular imaging analysis will allow us to observe the incipience and progression of the disease. These will make us easier to give a diagnosis in the early stage of intractable diseases such as canter, neuro-degenerative disease, and immunological disorders. Additionally, molecular imaging method will be a valuable tool for the real-time evaluation of cells in molecular biology and the basic biological studies. As newer and more powerful molecular imaging tools become available, it will be necessary to corporate clinicians, molecular biologists and biochemists for the planning, interpretation, and application of these techniques to their fullest potential. in order for such a multidisciplinary team to be effective, it is essential that a common understanding of basic biochemical and molecular biologic techniques is achieved. Basic molecular techniques for molecular imaging methods are presented in this paper.

• 대한방사성의약품학회지
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• 제1권1호
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• pp.9-14
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• 2015

Hypoxia has been shown in many tumors because of a reduced oxygen condition. A useful approach to detect hypoxia is to use molecular imaging. Positron emission tomography (PET), one of the biomedical molecular imaging tools, is the most common non-invasive technique for providing information about physiological and biological events such as diseases. In order to use the PET technique for healthcare, promising molecular probes such as PET tracers required. [$^{18}F$]Fluoromisonidazole ([$^{18}F$]FMISO) is the most widely used in PET tracers for hypoxia. In this review, major developments of the synthetic method of [$^{18}F$]FMISO are discussed.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.265-270
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• 2007

Polarization imaging systems have been widely used to selectively characterize skin lesions. Nevertheless, current systems are used in single-mode due to the limitations of a fixed polarization mode and a single-working distance of light source, in which uniform light distribution is achieved on target area. To address such limitations, we developed a variable polarization imaging system based on multi-working distance of light source for various clinical diagnoses. In this study, we characterize the imaging system and present experiment results demonstrating its clinical usefulness. The imaging system consists of a CCD color camera, linear polarization filters, and a single-layered LED ring light source which provides uniform light distribution at multi-working distances. The first polarizer was placed on the light source and the second polarizer placed on objective lens provides continuous linear polarization angle from $0^{\circ}\;to\;90^{\circ}$. The clinical efficacy of the imaging system was investigated by acquiring and analyzing clinical images of skin wrinkle and dental plaque. With the experiments, we verified the potential usefulness of the imaging system for other clinical applications.

• 대한의용생체공학회:의공학회지
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• 제28권4호
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• pp.471-476
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• 2007

Various active microwave imaging techniques have been developed for cancer detection for past several decades. Both the microwave tomography and the UWB radar techniques, constituting functional microwave imaging systems, use the electrical property contrast between normal tissues and malignancies to detect the latter in an early development stage. Even though promising simulation results have been reported, the understanding of the functional microwave imaging diagnostics has been relied heavily on the complicated numerical results. We present a computationally efficient and physically instructive analytical electromagnetic wave channel models developed for functional microwave imaging system in order to detect especially the breast tumors as early as possible. The channel model covers the propagation factors that have been examined in the previous 2-D models, such as the radial spreading, path loss, partial reflection and transmission of the backscattered electromagnetic waves from the tumor cell. The effects of the system noise and the noise from the inhomogeneity of the tissue to the reconstruction algorithm are modeled as well. The characteristics of the reconstructed images of the tumor using the proposed model are compared with those from the confocal microwave imaging.

• 대한의용생체공학회:의공학회지
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• 제33권3호
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• pp.105-113
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• 2012

Biopsy is a type of histopathological examinations, in which a physician samples cells or tissues from a patient's suspicious lesion. Such a lesion frequently resides deep inside human body, and then a percutaneous biopsy is therefore performed using a thick needle with the assistance of medical imaging such as computed tomography(CT) and magnetic resonance imaging(MRI). Recently modern robotic technology is being introduced to percutaneous biopsy in order to reduce any possible human error and hazard on physicians caused by medical imaging. After medical imaging locates the exact location of lesion, an optimization algorithm plans the path for a biopsy needle. Subsequently, a robot system moves the biopsy needle to the lesion in accurate and safe way with the control of a practitioner or automatically. In this article, we try to look into the state-of-art of percutaneous biopsy using such robotic technology. We classified percutaneous biopsy robots by mechanical characteristics and by imaging technology. Then, advantage and disadvantage of each class type are described as well as the basic description, and a few representative designs for each type are introduced. Current research issues of robotized percutaneous biopsy are subjectively selected for the readers' convenience. We emphasize the basic technology of actuator and sensors compatible with imaging technology to conclude this review.

• Bulletin of the Korean Chemical Society
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• 제35권3호
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• pp.938-940
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• 2014

This paper discusses a coherence-gated three-dimensional imaging system based on photorefractive holography, which was applied to imaging through turbid media with a view to developing biomedical instrumentation. A rapid response photorefractive device doped with 2,4,7-trinitro-9-fluorenylidene malononitrile was used to generate the hologram grating. The estimated depth resolution was $20{\mu}m$, which corresponds to the coherence length of the light source. In this coherence imaging system, tomographic imaging of a 3-dimensional object composed of a $50{\mu}m$ thick cylindrical layer was achieved. The proposed coherence imaging system using an organic photorefractive material can be used as an optical tomography system for biological applications.

• 대한의용생체공학회:의공학회지
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• 제19권3호
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• pp.243-250
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• 1998

초고속 자기공명 영상 기법의 일종인 나선 주사 영상의 재구성을 위하여 k-공간에서 극좌표와 직각 좌표계를 기초로한 재구성방법들을 분석하였다. 나선 주사 영상의 재구성은 나선 궤적상에서 측정된 데이터를 극좌표나 직각 좌표계로 변환시키기 위하여 보간 기술들이 사용된다. 나선주사 영상의 다양한 재구성 알고리즘들을 시험하여 보았고, 재구성된 영상의 질을 비교하였다. 본 연구진이 제안한 투영 영역에서 dc-offset보정을 한 향상된 재구성 알고리즘이 시뮬레이션을 통하여 가장 우수한 것으로 나타났다. 또한, 기존의 재구성 방법들에서 나타났던 영상 artifact도 제안된 방법에서는 완전히 사라짐을 확인할 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.165-172
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• 1999

본 연구에서는 MRI 영상에서 위상을 조절하여 영상 대조를 증가 시키는 방법을 제안 하였다 영상하고자 하는 물체 자체가 갖는 위상에 따라 영상의 대조가 변하기 때문에 본 방법은 자화율 영상이나 유속 영상에 유용하게 쓰일 수가 있다. 본 논문에서는 위상 분포에 따른 영상의 대조를 증가 시키기 위하여 RF 펄스를 복셀 내에서 위상을 갖도록 디자인 하였다. 따라서 복셀에서의 신호의 크기는 물체자체의 위상과 RF 펄스에의하여 가해준 위상이 결합에 의하여 결정된다. 외부위상 변화에 따른 신호의 변화를 분석하였고 그때 디자인된 RF 펄스를 이용하여 자화율만의 영상과 유속만의 영상을 얻었다. 컴퓨터 시뮬레이션의 결과는 제안된 알고리즘이 복셀내에 위상을 갖는 물체의 영상에 유용하고 그런 물체만을 영상하는데 유용함을 보였다.

• 대한의용생체공학회:의공학회지
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• 제27권3호
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• pp.117-124
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• 2006

Recently, active research has been going on to measure the elastic modulus of human soft tissue with medical ultrasound imaging systems for the purpose of diagnosing cancers or tumors which have been difficult to detect with conventional B-mode imaging techniques. In this paper, a real-time ultrasonic elasticity imaging system is implemented in software on a Pentium processor-based ultrasonic diagnostic imaging system. Soft tissue is subjected to external vibration, and the resulting tissue displacements change the phase of received echoes, which is in turn used to estimate tissue elasticity. It was confirmed from experiment with a phantom that the implemented elasticity imaging system could differentiate between soft and hard regions, where the latter is twice harder than the former, while operating at an adequate frame rate of 20 frames/s.