• Title/Summary/Keyword: Biological effect

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Meta-Analysis of Spiritual Intervention Studies on Biological, Psychological, and Spiritual Outcomes (영적중재의 신체적, 심리적, 영적 효과크기에 대한 메타분석)

  • Oh, Pok-Ja;Kim, Young-Hyun
    • Journal of Korean Academy of Nursing
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    • v.42 no.6
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    • pp.833-842
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    • 2012
  • Purpose: The purpose of this study was to evaluate the effectiveness of spiritual intervention studies by examining biological, psychological, and spiritual outcomes. Methods: From electronic databases 2522 studies were retrieved, of which 21 studies met the inclusion criteria. These studies had 1411 participants. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data were analyzed using the RevMan 5.1 program of the Cochrane library. Results: Overall effect size of spiritual intervention on spiritual and psychological (depression and anxiety) outcomes were moderate (d= -0.65 to d= -0.76, p<.001). The effects on biological outcomes (pain and functional status) ranged from -0.51 to -0.39, respectively. No publication bias was detected as evaluated by a funnel plot. Spiritual intervention had a moderate effect on psychological and spiritual outcomes and a smaller effect on biological outcomes. Conclusion: The results of this study suggest that spiritual intervention can relieve depression and anxiety. Further randomized controlled trials studies are needed to evaluate the effects of spiritual intervention on biological outcomes.

Synthesis and Biological Activity of Aspirin Derivatives

  • Cha, Bae-Cheon;Lee, Seung-Bae
    • Archives of Pharmacal Research
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    • v.23 no.2
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    • pp.116-120
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    • 2000
  • Aspirin has been widely used as analgesic and anti-inflammatory drug. Recently, it was elucidated that aspirin have anti-coaggregatory effect in low dose. This study was carried out to investigate the synthesis of aspirin derivatives from aspirin and aromatic compound of antioxidant and its biological activities. Synthesis of aspirin derivatives was prepared by esterification in the presence of 1, 1-carbonyldiimidazole. Biological activities was examined using effect of anti-coagulant on bleeding time, effect of antioxidant and effect of anti-platelet aggregation. As a result, SJ-101 showed strong antioxidative activity and anti-coagulant activity among four compounds. Anti-platelet aggregation of SJ-101 was examined by collagen, ADP, PAF method. SJ-101 exhibited more stronger activity to aspirin at collagen aggregation reaction. These finding demonstrates that SJ-101 is usefull as care drug of aging and old-disease because of its has antioxidant activity, anti-coagulant activity and anti-platelet activity.

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Nonlinear Time Series Analysis of Biological Chaos (생체 카오스의 비선형 시계열 데이터 분석)

  • 이병채;이명호
    • Journal of Biomedical Engineering Research
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    • v.15 no.3
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    • pp.347-354
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    • 1994
  • This paper describes a diagnostic protocol of nonlinear dynamic characteristics of biological system using chaos theory. An integrated chaos analysis system for the diagnosis of biological system was designed. We suggest a procedure of attractor reconstruction for reliable qualitative and quantitative analysis. The effect of autonomic nervous system activity on heart rate variability with power spectral analysis and its characteristics of chaotic attractors are investigated. The results show the applicability to evaluate the mental and physical conditions using nonlinear characteristics of biological signal.

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The Effect of Roots Extract from Potentilla chinensis as Cosmeceutical Material (화장품 소재로써의 딱지꽃(Potentilla chinensis) 뿌리 추출물의 효과)

  • You, Jae Chon;Jung, Hae Soo;Kim, Hyoung Shik;Lee, Jeong Hun;Moh, Sang Hyun
    • Journal of Applied Biological Chemistry
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    • v.59 no.1
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    • pp.13-17
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    • 2016
  • As natural plant-based industry has been expanded, the use of oriental medicinal plants as cosmeceutical material received a lot of attentions in the cosmetic industry. Among various medicinal plants, Potentilla chinensis have drawn interests for its biological effects. Although several attempts were tried to study its biological effect as medicinal plant, only limited results were reported to evaluate its biological effect as cosmeceutical material. In this study, we examined the possibility of root extract from Potentilla chinensis as a cosmeceutical material because the root part has been reported to have several kinds of health promoting effects. After extraction of roots, biological evaluation including anti-inflammation, anti-wrinkle, whitening effect and moisturizing effect was performed. As a result, the root extract showed remarkable biological activities through stimulating synthesis of elastin and aquaporin-3, and inhibiting melanin synthesis, cyclooxygenase-2 expression and expression of metallopeptidase-1.