• 제목/요약/키워드: BioInformatics

검색결과 580건 처리시간 0.028초

Inhibitory Effect Against Akt by Cyclic Dipeptides Isolated from Bacillus sp.

  • Hong, Sung-Won;Moon, Byoung-Ho;Yong, Yeon-Joong;Shin, Soon-Young;Lee, Young-Han;Lim, Yoong-Ho
    • Journal of Microbiology and Biotechnology
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    • 제18권4호
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    • pp.682-685
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    • 2008
  • Among thirteen strains of the genus Bacillus isolated from Shrimp-jeotkal in our laboratory, a strain BA34 showing good antifungal activity against Phytophthora infestans in a previous experiment was tested for the inhibitory effect against Akt, protein kinase B. Since Akt is known to play an important role in controlling apoptosis, its inhibitors can be used as potential apoptosis-inducing agents in the treatment of cancer. Two active compounds were isolated and their structures were determined. They have similar structures, despite showing different inhibitory effects. In order to elucidate the reasons for these different effects, three-dimensional studies were carried out.

AN IMPROVED ALGORITHM FOR RNA SECONDARY STRUCTURE PREDICTION

  • Namsrai Oyun-Erdene;Jung Kwang Su;Kim Sunshin;Ryu Keun Ho
    • 대한원격탐사학회:학술대회논문집
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    • 대한원격탐사학회 2005년도 Proceedings of ISRS 2005
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    • pp.280-282
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    • 2005
  • A ribonucleic acid (RNA) is one of the two types of nucleic acids found in living organisms. An RNA molecule represents a long chain of monomers called nucleotides. The sequence of nucleotides of an RNA molecule constitutes its primary structure, and the pattern of pairing between nucleotides determines the secondary structure of an RNA. Non-coding RNA genes produce transcripts that exert their function without ever producing proteins. Predicting the secondary structure of non-coding RNAs is very important for understanding their functions. We focus on Nussinov's algorithm as useful techniques for predicting RNA secondary structures. We introduce a new traceback matrix and scoring table to improve above algorithm. And the improved algorithm provides better levels of performance than the originals.

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