• IMMUNE NETWORK
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• v.13 no.4
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• pp.116-122
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• 2013

This study was conducted to determine whether CD4 T cell responses to citrullinated fibrinogen occur in patients with rheumatoid arthritis (RA), especially in HLA-DR4-positive subjects. Whole peripheral blood mononuclear cells (PBMCs) of RA patients and control subjects were stimulated with citrullinated fibrinogen peptides, and T-cell production of proliferation and proinflammatory cytokines, such as interferon-${\gamma}$(IFN-${\gamma}$) and interleukin-17A (IL-17A), were measured. In addition, CD4 T cells from RA patients were stimulated with the citrullinated fibrinogen peptide, $Fib-{\alpha}$ R84Cit, identified as a DRB1*0401-restricted T cell epitope in HLA-DR4 transgenic mice, and the degree of T cell activation was examined similarly. No proliferative responses to the citrullinated fibrinogen peptides were observed in whole PBMCs or CD4 T cells from RA patients. Furthermore, no increased production of IFN-${\gamma}$ or IL-17A was found in whole PBMCs or CD4 T cells stimulated with the citrullinated fibrinogen peptides, although these cells responded to recall antigen, a mixture of tetanus toxoid, purified protein derivative (PPD) from Mycobacterium tuberculosis, and Candida albicans. The results of this study indicate that anti-citrulline immunity in RA patients may be mediated by fibrinogen because there is no evidence of CD4 T cell-mediated immune responses to citrullinated fibrinogen peptides.

• Journal of Microbiology and Biotechnology
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• v.17 no.9
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• pp.1477-1482
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• 2007

Gluconacetobacter diazotrophicus strain PA15 exhibited a minimum inhibitory concentration value of 11 mM in an LGI medium amended with $ZnCl_2$. When an LGI medium was amended with Zn metal, solubilization halos were observed in a plate assay, and further solubilization was confirmed in a broth assay. The maximum solubilization was recorded after 120 h with a 0.1% Zn metal amendment. During solubilization, the culture growth and pH of the broth were indirectly correlated. Using a Fourier Transform Infrared Spectroscopy analysis, one of the agents solubilizing the Zn metal was identified as gluconic acid. When the Zn-amended broth was observed under a bright field microscope, long involution cells were observed, and further analysis with Atomic Force Microscopy revealed highly deformed, pleomorphic, aggregate-like cells.

• Progress in Medical Physics
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• v.28 no.1
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• pp.22-26
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• 2017

We have developed an analytic software that can easily analyze the spot position and width of proton beam therapy nozzles in a periodic quality assurance. The developed software consists of an image processing method that conducts an analysis using center-of-spot geometry and a Gaussian fitting method that conducts an analysis through Gaussian fitting. By using the software, an analysis of 210 proton spots with energies 150, 190, and 230 MeV showed a deviation of approximately 3% from the mean. The software we developed to analyze proton spot positions and widths provides an accurate analysis and reduces the time for analysis.

• Journal of information and communication convergence engineering
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• v.4 no.4
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• pp.158-161
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• 2006

[ $Bi_2Sr_2Ca_nCu_{n+1}O_y(n{\geq}0)$ ] thin film is fabricatedvia two different processes using an ion beam sputtering method i.e. co-deposition and layer-by-layer deposition. A single phase of Bi2212 can be fabricated via the co-deposition process. While it cannot be obtained by the layer-by-layer process. Ultra-low growth rate in our ion beam sputtering system brings out the difference in Bi element adsorption between the two processes and results in only 30% adsorption against total incident Bi amount by layer-by-layer deposition, in contrast to enough Bi adsorption by co-deposition.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.175-177
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• 1996

본 논문에서는 일반 심전도 모니터링 장비가 갖는 이동성 및 상시성의 제한을 극복하여 공중무선망을 이용한 심전도 모니터링 장치에 관한것으로서 특히, 활동중인 사람의 심전도 데이터를 공중 무선 통신망에서 제공하는 망써비스를 이용하여 원거리 모니터링 센터에서 모니터링 및 응급조치를 하는 시스템에 관한 것이다.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.301-307
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• 2005

We introduce a new multimedia telemedicine system which is called Telemedicine for Real-time Emergency Multi-consultation(TREM), based on multiple connection between medical specialists. Due to the subdivision of medical specialties, the existing one-to-one telemedicine system needs be modified to a simultaneous multi-consulting system. To facilitate the consultation the designed system includes following modules: high-quality video, video conferenceing, bio-signal transmission, and file transmission. In order to enhance the operability of the system in different network environment, we made it possible for the user to choose appropriate data acquisition sources of multimedia data and video resolutions. We have tested this system set up in three different places: emergency room, radiologist's office, and surgeon's office. All three communicating systems were successful in making connections with the multi-consultation center to exchange data simultaneously in real-time.

• Biomedical Engineering Letters
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• v.8 no.4
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• pp.337-344
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• 2018

Additive manufacturing (AM) is an alternative metal fabrication technology. The outstanding advantage of AM (3D-printing, direct manufacturing), is the ability to form shapes that cannot be formed with any other traditional technology. 3D-printing began as a new method of prototyping in plastics. Nowadays, AM in metals allows to realize not only net-shape geometry, but also high fatigue strength and corrosion resistant parts. This success of AM in metals enables new applications of the technology in important fields, such as production of medical implants. The 3D-printing of medical implants is an extremely rapidly developing application. The success of this development lies in the fact that patient-specific implants can promote patient recovery, as often it is the only alternative to amputation. The production of AM implants provides a relatively fast and effective solution for complex surgical cases. However, there are still numerous challenging open issues in medical 3D-printing. The goal of the current research review is to explain the whole technological and design chain of bio-medical bone implant production from the computed tomography that is performed by the surgeon, to conversion to a computer aided drawing file, to production of implants, including the necessary post-processing procedures and certification. The current work presents examples that were produced by joint work of Polygon Medical Engineering, Russia and by TechMed, the AM Center of Israel Institute of Metals. Polygon provided 3D-planning and 3D-modelling specifically for the implants production. TechMed were in charge of the optimization of models and they manufactured the implants by Electron-Beam Melting ($EBM^{(R)}$), using an Arcam $EBM^{(R)}$ A2X machine.

• Journal of Biomedical Engineering Research
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• v.29 no.3
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• pp.173-178
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• 2008

Recent advancements in the electrospinning method enable the production of ultrafine solid and continuous fibers with diameters ranging from a few nanometers to a few hundred nanometers with controlled surface and morphological features. A wide range of biopolymers can be electrospun into mats with a specific fiber arrangement and structural integrity. These features of nanofiber mats are morphologically similar to the extracellular matrix of natural tissues, which are characterized by a wide pore diameter distribution, a high porosity, effective mechanical properties, and specific biochemical properties. This has resulted in various kinds of applications for polymer nanofibers in the field of biomedicine and biotechnology. The current emphasis of research is on exploiting these properties and focusing on determining the appropriate conditions for electrospinning various biopolymers for biomedical applications, including scaffolds used in tissue engineering, wound dressing, drug delivery, artificial organs, and vascular grafts, and for protective shields in specialty fabrics. This paper reviews the research on biomedical applications of electrospun nanofibers.

• IE interfaces
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• v.21 no.2
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• pp.209-220
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• 2008

Recently, innovative medical services are fast emerging, which include customized medical services based on bio-informatics, composition of cure and well-being exploiting ubiquitous technology, hospital supply chain management using RFID, and so forth. However, conventional approaches for new service development hardly give us systematic model to analyze and produce creative medical services. Because most of them are static and concentrate on microscopic tools or techniques. Thus, it is highly desirable to suggest an integrative framework to organize the whole transformation process from technology to medical service. The objective of this study is to propose a medical service engineering model based on the dynamic innovation theory. The proposed model contains objectives of service system, strategies of hospital, stages, activities required to deal with medical service life cycle, which incorporates the acquisition of new technology, transformation to the product, penetration into market, and adoption of consumers. In addition, the usefulness and applicability of the newly proposed model are provided using catholic medical center example.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.66 no.1
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• pp.107-113
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• 2017

Unlike regular images, there is no ground truth for bio surface images. Result of biosurface imaging is not only significantly affected by the environment and the condition of the bio surface, it requires more detailed expression than regular images. Therefore, unlike algorithms tested on regular images, studies on bio surface images requires a highly precise optimization process. We aim to optimize the graph cut algorithm, known to be the most outstanding among the stereo visions, by considering baseline, lambda, and disparity range. Optimal results were in the range of 1~10 for lambda. The disparity ranged from -30 to -50, indicating an optimal value in a slightly higher range. Furthermore, we verified the tested optimization data using SIFT.