• Journal of the Korean Society of Radiology
• /
• v.17 no.6
• /
• pp.993-999
• /
• 2023

Bio materials of fibrinogen and collagen are widely used in tissue regeneration engineering. In this study, I aim to create a new dual-structure support using these two materials. Strategically, tissue regeneration takes priority over blood vessel regeneration, so by forming a fibrinogen support that helps blood vessel formation on the outside of the double support and placing collagen, which is more effective in tissue regeneration, in the center, a synergistic effect in new tissue regeneration is expected. Although these two materials have been used interchangeably in previous studies, there has been no report yet on making a support through the formation of a support structure for the core system. Therefore, the core of this study, the double scaffold, is to propose a method for manufacturing a core structure with a collagen scaffold on the inside and fibrinogen on the outside. The experimental results showed that the fibrinogen located on the outside of the scaffold resulted in rapid biodegradation and drug release due to strategic biodegradation of the dual structure scaffold. On the other hand, collagen scaffolds were found to be able to maintain drug release time relatively longer than fibrinogen scaffolds. In conclusion, it is believed that applying the method of creating a double scaffold will have a synergistic effect on defective tissue regeneration.