• 해양환경안전학회지
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• 제28권6호
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• pp.1078-1085
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• 2022

선박에 부착된 수중생물은 선체에서 성장하면서 선박의 저항을 크게 증가시킬 뿐만 아니라 부착생물이 배와 함께 이동하면서 지역의 해양 생태계 교란을 야기시키기도 한다. 이에 따라 국제해사기구에서는 선체부착생물의 이동을 막기 위해 선체부착생물 제거 및 청소성능 평가 논의를 시작해 오고 있다. 본 연구에서는 소형선박에 사용되는 FRP(Fiber Reinforced Plastic), HDPE((High Density Polyethylene), CFRP(Carbon Fiber Reinforced Plastic) 재료의 시편을 격포항(전락북도)에 약 80일간 양생시킨 후 물 제트 노즐을 이용하여 부착생물 제거실험을 수행하였다. 그 결과 김과 같은 해조류는 노즐과 시편과의 거리가 1.8cm, 100bar 일 때 제거되었지만, 따개비의 경우 200 bar 이상은 되어야 청소가 되는 것을 확인하였다.

• Genomics & Informatics
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• 제20권3호
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• pp.31.1-31.15
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• 2022

A pandemic of respiratory disease named coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is reported prostate cancer patients are susceptible to COVID-19 infection. To understand the possible causes of prostate cancer patients' increased vulnerability and mortality from COVID-19 infection, we focused on the two most important agents, transmembrane protease serine subtype 2 (TMPRSS2) and the C-X-C motif 10 (CXCL10). When SARS-CoV-2 binds to the host cell via S protein-angiotensin-converting enzyme-2 receptor interaction, TMPRSS2 contributes in the proteolytic cleavage of the S protein, allowing the viral and cellular membranes to fuse. CXCL10 is a cytokine found in elevated level in both COVID-19 and cancer-causing cytokine storm. We discovered that TMPRSS2 and CXCL10 are overexpressed in prostate cancer and COVID-19 using the UALCAN and GEPIA2 datasets. The functional importance of TMPRSS2 and CXCL10 in prostate cancer development was then determined by analyzing the frequency of genetic changes in their amino acid sequences using the cBioPortal online portal. Finally, we used the PANTHER database to examine the pathology of the targeted genes. We observed that TMPRSS2 and CXCL10, together with their often co-expressed genes, are important in the binding activity and immune responses in prostate cancer and COVID-19 infection, respectively. Finally, we found that TMPRSS2 and CXCL10 are two putative biomarkers responsible for the increased vulnerability and fatality of prostate cancer patients to COVID-19.

• Nuclear Engineering and Technology
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• 제54권10호
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• pp.3604-3613
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• 2022

The Physical Protection System (PPS) plays an important role and must effectively deal with various adversary attacks in nuclear security. In specific single adversary path scenarios, we can calculate the PPS effectiveness by EASI (Estimated Adversary Sequence Interruption) through Probability of Interruption (P_I) calculation. EASI uses a single value of the probability of detection (P_D) and the probability of alarm communications (P_C) in the PPS. In this study, we develop a multi-path analysis code based on EASI to evaluate the effectiveness of PPS. Our quantification method for P_I considers the variability and uncertainty of P_D and P_C value by Monte Carlo simulation. We converted the 2-D scheme of the nuclear facility into an Adversary Sequence Diagram (ASD). We used ASD to find the adversary path with the lowest probability of interruption as the most vulnerable paths (MVP). We examined a hypothetical facility (Hypothetical National Nuclear Research Facility - HNNRF) to confirm our code compared with EASI. The results show that implementing the variability extension can estimate the P_I value and its associated uncertainty. The multi-path analysis code allows the analyst to make it easier to assess PPS with more extensive facilities with more complex adversary paths. However, the variability of the P_D value in each protection element allows a significant decrease in the PI value. The possibility of this decrease needs to be an important concern for PPS designers to determine the P_D value correctly or set a higher standard for PPS performance that remains reliable.

• Genomics & Informatics
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• 제21권2호
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• pp.22.1-22.15
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• 2023

Kidney renal clear cell carcinoma (KIRC) is one of the most aggressive cancer type of the urinary system. Metastatic KIRC patients have poor prognosis and limited therapeutic options. Ankyrin 3 (ANK3) is a scaffold protein that plays important roles in maintaining physiological function of the kidney and its alteration is implicated in many cancers. In this study, we investigated differential expression of ANK3 in KIRC using GEPIA2, UALCAN, and HPA databases. Survival analysis was performed by GEPIA2, Kaplan-Meier plotter, and OS-kirc databases. Genetic alterations of ANK3 in KIRC were assessed using cBioPortal database. Interaction network and functional enrichment analyses of ANK3-correlated genes in KIRC were performed using GeneMANIA and Shiny GO, respectively. Finally, the TIMER2.0 database was used to assess correlation between ANK3 expression and immune infiltration in KIRC. We found that ANK3 expression was significantly decreased in KIRC compared to normal tissues. The KIRC patients with low ANK3 expression had poorer survival outcomes than those with high ANK3 expression. ANK3 mutations were found in 2.4% of KIRC patients and were frequently co-mutated with several genes with a prognostic significance. ANK3-correlated genes were significantly enriched in various biological processes, mainly involved in peroxisome proliferator-activated receptor (PPAR) signaling pathway, in which positive correlations of ANK3 with PPARA and PPARG expressions were confirmed. Expression of ANK3 in KIRC was significantly correlated with infiltration level of B cell, CD8+ T cell, macrophage, and neutrophil. These findings suggested that ANK3 could serve as a prognostic biomarker and promising therapeutic target for KIRC.

• 대한통합의학회지
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• 제12권3호
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• pp.101-120
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• 2024

Purpose : This study aimed to carry out a scoping review to investigate the research trends in non-pharmacological interventions for physical rehabilitation following breast cancer treatment. Methods : A scoping review was conducted according to the five steps outlined by Arksey and O'Malley and PRISMA-ScR. We searched three domestic databases (ScienceOn, Riss, KCI) and two international databases (PubMed, Cochrane Central) between January 2014 and April 2024. The keywords used were 'breast cancer surgery', 'breast cancer treatment', 'breast cancer lymphedema', 'intervention', 'management', 'therapy', 'disorder', and 'dysfunction'. Results : In terms of publication, the number of studies in the past five years has increased compared to the previous five years, with most studies focusing on patients aged 41 to 60 and who underwent surgical treatment for breast cancer. A total of 43 different types of non-pharmacological interventions were applied: 21 single interventions and 22 combination interventions. Among the intervention methods, complete decongestive treatment (CDT), resistance training, and manual lymphatic drainage were the most frequently utilized. The most common duration of intervention turned out to be 4~5 weeks and more than 8 weeks, with frequencies of 2~3 sessions per week and more than 4 sessions per week. The most frequently used dependent variables included range of motion (ROM) and disabilities of the arm, shoulder and hand (DASH) for the function and disorder of the upper limb category; arm circumference or volume and bio-impedance for the lymphedema category; visual analogue scale (VAS) and numerical rating scale (NRS) for the pain category; and the European organization for research and treatment of cancer quality of life questionnaire breast cancer module (EORTC QLQ) and functional assessment of cancer therapy-breast (FACT-B) for the quality of life category. Conclusion : The findings of this scoping review provide valuable mapping data for non-pharmacological interventions for physical rehabilitation following breast cancer treatment. We recommend further research, particularly systematic reviews and meta-analyses, to build upon these findings.

• Journal of Advanced Marine Engineering and Technology
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• 제39권6호
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• pp.620-625
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• 2015

IMO MEPC에서는 지구온난화를 늦추기 위해서, 선박에서 배출되는 GHG(Green House Gas)인 $CO_2$를 줄이기 위한 방안으로 선속을 다운시켜 운항할 것을 제안한바 있으며, 해운회사에서도 연료비 절감을 위해서 자발적으로 감속운항(Low steaming)을 하고 있어, 국제항해에 종사하고 있는 대부분의 컨테이너선들이 감속운항을 하고 있다. 또한, 날로 증가되고 있는 해운 물동량 증가로 선박의 연료비 부담이 증가되고 있어 연료비 절감 기술개발이 절실히 요구되고 있다. 따라서 본 연구에서는 디젤엔진의 성능을 향상시킬 수 있는 연료첨가제(유용성 칼슘계 유기금속화합물)를 일정량 투입(사용 연료량의 0.025%) 하여 연료비를 절감하는 방법을 시도하였다. 실험의 정확도를 위해서 육상 발전소에 설치된 2행정 대형 디젤엔진을 실험 대상으로 하였다. 실험 엔진의 부하는 저, 중 및 고 부하(50, 75, 100%)로 나누어서 실시하였으며, 연료첨가제의 투입 전과 투입 후의 엔진성능(출력, 연료소비율, 최고연소압력(P-max), 배기온도)을 비교 분석 하였다. 본 실험을 통해서 연료첨가제를 투입함으로써 저부하(50%) 에서 2% 이상의 연료비 절감 효과를 확인 할 수 있었으며, 최고연소압력은 상승하는 반면에 배기온도는 하강함을 알 수 있었다.

• 산경연구논집
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• 제11권6호
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• pp.29-39
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• 2020

Purpose: The purpose of this study is, in the situation where rapid response to the rapidly changing environment is required due to the development of the fourth industrial revolution such as artificial intelligence, virtual reality, and the internet of things, robotics, big data, additive manufacturing, bio-health, sharing economy and in the organizational culture aspiring toward the innovation of a major company, small business and a public institution, to analyze what influence a job-engagement and stress make, and what influence individual's self-efficacy as a moderator mediator makes, and to offer basic data for improving job-engagement and lowering job-stress. Research design, data, and methodology: For doing this, the literature and the empirical studies were combined. Deriving innovation-oriented organizational culture as factors affecting the job engagement and job stress through the literature, and have established hypotheses to verify them. We have collected data of 281 from ex,ecutives and staff-members working in areas including major company, small business and officials (the central government, a local public service, the prosecution, the police, and school). And these data were analyzed by SPSS 23 version. Results: Based on these data, the results of analysis were as follows; First, the innovation-oriented organizational culture which was recognized by organizational members had effect on job-stress. Second, the innovation-oriented organizational culture which was recognized by organizational members influenced job-stress. Third, in the relationship between the innovation-oriented organizational culture and job-engagement, self-efficacy did not influenced job-engagement. Finally, in the relationship between the innovation-oriented organizational culture and job-stress, self-efficacy influenced job-stress. Conclusions: Innovation-oriented organizational culture places importance on the organization's adaptability and flexibility in the external environment, so companies need to establish an innovation-oriented organizational culture favorable to achieving survival and successful innovation, and to develop and disseminate programs of positive and continuous organizations to improve task enthusiasm, reduce task stress, and enhance organizational performance. In the future, it will be necessary to verify the effectiveness of various organizational culture types through comparative analysis with companies that actively maintain an innovation-oriented organizational culture (Google, Kakao, etc.) and companies that prefer hierarchy-oriented organizational culture, relationship-oriented organizational culture, and market-oriented organizational culture.

• 한국식품영양과학회지
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• 제41권9호
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• pp.1191-1196
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• 2012

주박 추출물을 열수 및 에탄올로 추출하여 tyrosinase와 xanthine oxidase, ACE, 아질산염 소거능을 실험하였다. 주박 열수 및 에탄올 추출물의 tyrosinase 저해 효과는 85% 이상이었다. 아질산염의 경우에는 pH 4.2과 pH 6.0보다 pH 1.2가 높았으며, pH 1.2에서 열수 및 에탄올 추출물 모두 90% 이상의 소거능을 가지고 있었다. 주박 열수 및 에탄올 추출물의 xanthine oxidase 저해 효과는 매우 낮았고, 효과는 열수와 에탄올에 의해 차이가 없었다. 주박 열수와 에탄올 추출물의 ACE 저해 효과는 각각 약 43~53%와 36~47%를 보였다. 전체적으로 주박의 열수 및 에탄올 추출물은 tyrosinase저해, ACE 저해 그리고 아질산염 소거 효과를 가지고 있었으나, xanthine oxidase 저해 효과는 없는 것으로 나타났다. 따라서 주박은 화장품 원료로 가능성이 있으며, 추가적으로 식품 첨가물로써 사용 가능성이 있을 것으로 사료된다.

• 농촌지도와개발
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• 제20권3호
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• pp.643-678
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• 2013

본 연구의 목적은 5 16 군정기 지방행정의 많은 환경변화 속에서 각 도가 추진한 '모범부락조성사업'을 통해 초기 농촌마을개발사업에 대한 모습, 특히 지방행정이 사업의 주체가 되기 위해 추진한 방법을 검토하여 시사점을 찾는데 있다. 군정기(1961~1963) 지방행정은 시군을 기초자치단체로 하는 행정체계 개편, 국가기획제도 도입, 지방세제 개편, 새로운 농촌기구 설립으로 인한 농촌지도 다원화 등의 여러 변화요인을 맞게 되었다. 이러한 환경 속에서 지역의 개발행정 주축은 지방자치단체로 옮겨져 갔고, 각 도는 '보고가는 마을(전북)', '빛나는 마을(충남)'등의 각종 명칭으로 모범부락조성사업을 추진하였다. 또한 내무부는 지역개발의 장기적인 종합계획으로서 군 건설계획의 작성과 추진을 지시하였다. 본 연구는 국가 정책을 중심으로 한 농촌지역개발사에서 도 단위의 지방사를 발굴하고 이를 지방행정 환경변화와 연계하여 분석하였다는 측면에서 향후 관련 연구의 기초자료로 활용될 수 있으리라 판단된다.

• Genomics & Informatics
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• 제16권2호
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• pp.22-29
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• 2018

Incorporation of unique barcodes into fission yeast gene deletion collections has enabled the identification of gene functions by growth fitness analysis. For fine tuning, it is important to examine barcode sequences, because mutations arise during strain construction. Out of 8,708 barcodes (4,354 strains) covering 88.5% of all 4,919 open reading frames, 7,734 barcodes (88.8%) were validated as high-fidelity to be inserted at the correct positions by Sanger sequencing. Sequence examination of the 7,734 high-fidelity barcodes revealed that 1,039 barcodes (13.4%) deviated from the original design. In total, 1,284 mutations (mutation rate of 16.6%) exist within the 1,039 mutated barcodes, which is comparable to budding yeast (18%). When the type of mutation was considered, substitutions accounted for 845 mutations (10.9%), deletions accounted for 319 mutations (4.1%), and insertions accounted for 121 mutations (1.6%). Peculiarly, the frequency of substitutions (67.6%) was unexpectedly higher than in budding yeast (~28%) and well above the predicted error of Sanger sequencing (~2%), which might have arisen during the solid-phase oligonucleotide synthesis and PCR amplification of the barcodes during strain construction. When the mutation rate was analyzed by position within 20-mer barcodes using the 1,284 mutations from the 7,734 sequenced barcodes, there was no significant difference between up-tags and down-tags at a given position. The mutation frequency at a given position was similar at most positions, ranging from 0.4% (32/7,734) to 1.1% (82/7,734), except at position 1, which was highest (3.1%), as in budding yeast. Together, well-defined barcode sequences, combined with the next-generation sequencing platform, promise to make the fission yeast gene deletion library a powerful tool for understanding gene function.