• 제목/요약/키워드: Bilirubin

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Cigarette Smoking and Serum Bilirubin Subtypes in Healthy Korean Men: The Korea Medical Institute Study

  • Jo, Jae-Seong;Kimm, Hee-Jin;Yun, Ji-Eun;Lee, Kyu-Jang;Jee, Sun-Ha
    • Journal of Preventive Medicine and Public Health
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    • 제45권2호
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    • pp.105-112
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    • 2012
  • Objectives: Cigarette smoking is a modifiable risk factor for cardiovascular disease. Bilirubin is a potent antioxidant and its concentration decreases in smokers. However, studies about the association between cigarette smoking and bilirubin are scarce and most are limited to total bilirubin. Additionally, bilirubin is highly related to hemoglobin. Therefore, this study evaluates the association between bilirubin subtypes and cigarette smoking in healthy Korean men independently of hemoglobin. Methods: This study included 48 040 Korean men aged 30 to 87 years who visited the Korea Medical Institute for routine health examinations from January to December, 2007. The association of smoking with total, direct, and indirect bilirubin was assessed by logistic regression analysis taking into consideration differences in subjects and smoking characteristics. Results: Current smokers had lower bilirubin concentrations than never-smokers and ex-smokers. Smoking amount and duration were inversely significantly associated with total, direct, and indirect bilirubin. In a multivariable adjusted model, compared to never-smokers, the odds ratios (ORs) and 95% confidence intervals (CIs) of current smokers with the highest number of pack-years were 1.7 (1.6 to 1.9) for total, 1.5 (1.4 to 1.6) for direct, and 1.7 (1.6 to 1.9) for indirect bilirubin. After further adjustment for hemoglobin, this association became stronger (OR [95% CI], 2.1 [1.9 to 2.2] for total; 1.9 [1.8 to 2.0] for direct; 2.0 [1.9 to 2.2] for indirect bilirubin). Conclusions: In this study, bilirubin subtypes are inversely associated with smoking status, smoking amount, and smoking duration in healthy Korean men independently of hemoglobin. Further studies are needed to investigate this association in healthy Korean women.

Association Between Serum Bilirubin and Atrial Fibrillation: A Mendelian Randomization Study

  • Si-Woo Kim;Jung-Ho Yang;Sun-Seog Kweon;Young-Hoon Lee;Seong-Woo Choi;So-Yeon Ryu;Hae-Sung Nam;Hye-Yeon Kim;Min-Ho Shin
    • Korean Circulation Journal
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    • 제53권7호
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    • pp.472-479
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    • 2023
  • Background and Objectives: The association between bilirubin and atrial fibrillation (AF) has been evaluated previously in observational studies but with contradictory results. This study evaluated the causal association between serum bilirubin level and AF using Mendelian randomization (MR) analysis. Methods: This cross-sectional study includes 8,977 participants from the Dong-gu Study. In the observational analysis, multivariate logistic regression was performed to evaluate the association between bilirubin and prevalent AF. To evaluate the causal association between bilirubin and AF, MR analysis was conducted by using the UGT1A1 rs11891311 and rs4148323 polymorphisms as instrumental variables. Results: Elevated serum bilirubin levels were associated with an increased risk for AF in observational analysis (total bilirubin: odds ratio [OR], 1.31; 95% confidence interval [95% CI], 1.15-1.48 per 1 standard deviation [SD]; direct bilirubin: OR, 1.31; 95% CI, 1.18-1.46 per 1 SD), whereas the genetically predicted serum bilirubin levels in MR analysis did not show this association (total bilirubin: OR, 1.02; 95% CI, 0.67-1.53 per 1 SD; direct bilirubin: OR, 1.03; 95% CI, 0.61-1.73 per 1 SD). Conclusions: Genetically predicted bilirubin levels were not associated with prevalent AF. Thus, the observational association between serum bilirubin levels and AF may be noncausal and affected by reverse causality or unmeasured confounding.

Syntheses of Silica Gel Bound Hemin, Biliverdin, and Bilirubin

  • Park, Yong-Tae;David A. Lightner
    • Bulletin of the Korean Chemical Society
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    • 제6권2호
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    • pp.112-115
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    • 1985
  • 3-Aminopropylsilated silica gel bound hemin, biliverdin, and bilirubin were synthesized by reacting 3-aminopropyl silated silica gel with hemin, biliverdin and bilirubin respectively. The aspects of binding of bilirubin to amino group of 3-aminopropylsilated silica gel were studied using the above synthetic silica immobilized hemin, biliverdin and bilirubin, and oxodipyrromethene.

N,N-Dimethylformamide 용액 중에서 Zn(II)-Bilirubin 착물의 전기화학적 거동 (Electrochemical Behavior of Zn(II)-Bilirubin Complex in N,N-Dimethylformamide)

  • 배준웅;이흥락;박태명;서무룡
    • 대한화학회지
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    • 제37권7호
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    • pp.672-676
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    • 1993
  • DMF 용액 중에서 zinc(II) 이온과 copper(II) 이온의 bilirubin과의 착물형성 여부를 조사하고 Zn(II)-bilirubin(이하 Zn(II)-BR로 줄임) 착물의 전기화학적 성질을 여러가지 전기화학적인 방법으로 조사하였다. Zn(II)는 DMF 용액 중에서 bilirubin과 착물을 형성하였으나, Cu(II)는 bilirubin과 착물을 형성하지 않고 오히려 bilirubin의 산화를 촉진시켰다. Zn-BR 착물은 3단계의 환원과정을 거치며, 제1파와 제2파의 환원전류는 반응성 전류가 약간 포함된 환산전류이었으며, 제3파의 환원전류는 확산지배적인 전류이었다.

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Penicillium sp. LAM 91-89가 생산하는 bilirubin oxidase의 특성 (Properties of a bilirubin oxidase from Penicillium sp. LAM 91-89)

  • 이동희;이동호;김중배;이노운
    • Applied Biological Chemistry
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    • 제36권3호
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    • pp.158-162
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    • 1993
  • 토양에서 분리한 bilirubin oxidase를 생산하는 Penicillium sp. LAM 91-89의 배양액으로부터 효소를 정제하여 여러가지 성질을 조사하였다. LAM 91-89 billirubin oxidase는 $ethanol(40{\sim}80%)$ 추출 및 2회의 Sephadex G-200 column chromatography로 약 70배 정제하였으며 회수율은 12%였다. 이 효소는 분자량이 약 53,000 dalton이었으며 $40^{\circ}C$, pH 8.5에서 최대의 활성을 보였고 pH 6에서 10까지의 넓은 범위와 $40^{\circ}C$ 이하에서 안정하였다. 또 효소의 활성이 $Mg^{2+}$에 의해서 증가하였으며 $Ag^+,\;Hg^{2+},\;Mn^{2+},\;Pb^{2+}$, p-CMB, iodoacetate 및 SDS에 의해서 저해되었다. 그리고 이 효소는 bilirubin에 대한 특이성이 컸으며 bilirubin에 대한 $K_m$값은 $6.67{\mu}M$이였다.

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경주마(競走馬) 혈청(血淸)의 단백질(蛋白質), Bilirubin, Sodium 및 Potassium 농도(濃度)와 Thymol Turbidity (Concentrations of Total Protein, Bilirubin, Sodium and Potassium in Blood Sera and Thymol Turbidity of Race Horses)

  • 신광순;나동진;문희주;조종후
    • 대한수의학회지
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    • 제14권1호
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    • pp.23-27
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    • 1974
  • Concentration of total protein, bilirubin, sodium and potassium in blood sera, and thymol turbidity of race horses, 78 males and 57 females aging from 2 to 5 years, were estimated. The results obtained were as follows: 1. Serum of race horses was low in protein concentrations as mean values of $5.48{\pm}0.77$ g/100ml. 2. Serum bilirubin was in normal range as mean values of total bilirubin, direct bilirubin and indirect bilirubin were $1.05{\pm}0.57$, $0.12{\pm}0.05$ and $0.93{\pm}0.58$ mg/100ml, respectively. 3. Mean value of serum thymol turbidity was $1.41{\pm}0.72$ S-H unit. 4. Mean values of serum sodium and potassium of race horses from Australia were $143{\pm}8.7$ and $3.85{\pm}0.53$ mEq/liter, respectively, and mean values of serum sodium and patassium of race horses from Japan were $142{\pm}9.4$ and $3.58{\pm}0.60$ mEq/liter, respectively.

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급성 파라콰드중독후 생존한 15예 환자의 임상적 고찰 (Clinical study of the 15patients survived after acute paraquat intoxication)

  • 김동웅
    • 대한예방한의학회지
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    • 제3권1호
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    • pp.36-36
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    • 1999
  • From January 1994 to April 1997, there was 15 survivals who was admitted to the department of internal medicine, Wonkwang Oriental Medicine' Hospital in Cheun-ju, after ingestion of paraquat, and treated with Oriental and western medicine therapy. For the patients, I investigated clinical symptoms, gastroduodenoscopy, intake by oral and parenteral route, and output by urine and stool, serum ALP, AST. ALT, Bilirubin, BUN, Creatinine level and urine analysis. On admission day, the LFT level was as follows. The serum mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin was 10.05${\pm}$2.75 KAU, 66.67${\pm}$9.88 IU/L, 43.80${\pm}$7.74 IU/L, 1.89${\pm}$1.22 ㎎/dl and 1.10${\pm}$1.14 ㎎/dl respectively. After that day, administered Gamdutang and checked the mean LFT level regullary. Until the 3rd day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 11.0l${\pm}$3.16 KAU, 56.47${\pm}$7.19 IU/L, 59.00${\pm}$7.57 IU/L, 2.54${\pm}$1.78 ㎎/dl, 1.64${\pm}$1.59 ㎎/dl respectively. From 4th day to 7th day, the mean ALP; AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.51${\pm}$3.49 KAU, 77.85${\pm}$7.17 IU/L, 58.00${\pm}$9.09 IU/L, 2.54${\pm}$1.97 ㎎/dl, and 1.80${\pm}$1.81 ㎎/dl respectively. From 8th day to 10th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.43${\pm}$3.14 KAU, 41.13${\pm}$6.49 IU/L, 50.40${\pm}$7.17 IU/L, 1.66${\pm}$1.90 ㎎/dl and 1.14${\pm}$1.50 ㎎/dl respectively. From 11th day to 14th day, the mean ALP, AST, ALT, Total Bilirubin and Direct Bilirubin level was 12.30${\pm}$3.25 KAU, 31.07${\pm}$3.85 IU/L, 43.33${\pm}$5.49 IU/L, 1.62${\pm}$1.95 ㎎/dl, 1.17${\pm}$1.71 ㎎/dl respectvely. On admission day, the mean RFT level as follows. Serum BUN and Creatinine level was 28.73${\pm}$5.19 ㎎/dl and 1.82${\pm}$1.27 ㎎/dl respectively. After that day, administered Gamdutang and checked the mean RFT level regullary. Until the 3rd day, the mean BUN and Creatinine level was 32.12${\pm}$5.65 ㎎/dl and 2.31${\pm}$0.45 ㎎/dl respectively. From 4th day to 7th day, the mean BUN and Creatinine level was 31.07${\pm}$5.47 ㎎/dl and 1.92${\pm}$0.79 ㎎/dl respectively. From 7th day to 10th day, the mean BUN and Creatinine level was 17.47${\pm}$3.57 ㎎/dl and 1.33${\pm}$0.59 ㎎/dl respectively. From 11th day to 14th day, the mean BUN and Creatinine level was 11,93${\pm}$3.16 ㎎/dl, 1.27${\pm}$0.38 ㎎/dl respectively.

체외순환후의 고빌리루빈증의 검토 (Hyperbilirubinemia after Open Heart Surgery)

  • 박종호
    • Journal of Chest Surgery
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    • 제26권3호
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    • pp.170-179
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    • 1993
  • Three hundred consecutive adult patients having cardioaortic surgery under the cardiopulmonary bypass for a variety of cardioaortic lesions were evaluated retrospectively for postoperative hyperbilirubinemia[above 5mg/100ml].We found twenty eight patients with postoperative hyperbilirubinemia and divided them into two groups according to the postoperative day of peak s-bilirubin .Group A was the patients with a peak s-bilirubin level within three days ,and group B above three days postoperatively.Group B was divided into group S[survive] and group D[death] . We had compaired the survival & death group and observed the correlation between the decreasing tendency of postoperative s-bilirubin & the nutrition per os in group B. The incidence of postoperative hyperbilirubinemia,as defined by a s-bilirubin concentration of 5.0mg/100ml or greater,was 9.3%.The mortality rates of group A & B were 0.0% and 35.7% respectively.Important contributing factors between group A & B were the age,duration of ICU,Max.DOAB[maximum dose of catecholamine used],amount of blood transfused during or shortly after surgery and preoperative pulmonary hypertension[main pulmonary artery pressure > 30mmHg] and backward heart failure. The risking factors of group D compared to group S were as follows the age,preoperative & postoperative SGOT[serum glutamic-oxaloacetic trasaminase],postoperative total & indirect bilirubin,cardiopulmonary bypass time,duration of ICU & mechanical ventilation ,Max.DOAB,preoperative pulmonary hypertension and backward heart failure.The six patients in group B showed good correlation between the decreasing point of s-bilirubin and the starting day of oral or tube feeding.

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Bilirubin의 전압전류법적 파라미터에 미치는 압력의 영향 (Effect of High Pressure on Voltammetric Parameters of Bilirubin)

  • 배준웅;이흥락;김경호;박태명
    • 대한화학회지
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    • 제34권4호
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    • pp.340-344
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    • 1990
  • 미소 백금전극을 작업전극으로 사용하여 0.1 M TEAP-DMSO 용액 중에서 Bilirubin(BR)의 산화반응의 전압전류법적 파라미터에 미치는 압력의 영향을 조사하였다. 1기압에서 1,800기압까지 압력을 증가함에 따라 산화파의 봉우리 전위는 양전위쪽으로 이동하였다. 또 압력의 증가에 따라 봉우리 전류는 계속적으로 감소하였다. BR의 산화전류는 확산지배적인 전류임을 알 수 있었다. 압력증가에 따라서 산화반응의 가역성은 거의 영향을 받지 않았다. 또한 실험 압력범위내(1~1,800기압)에서 산화파의 봉우리 전류와 Bilirubin의 농도 사이에는 좋은 직선성이 성립하였다.

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