• Title/Summary/Keyword: Benzyloxycarbonylation

Search Result 5, Processing Time 0.023 seconds

t-Butyl Benzotriazol-1-yl Carbonate and Benzyl Benzotriazol-1-yl Carbonate. Now Reactive Amino Protective Reagents for t-Butoxycarbonylation and Benzyloxycarbonylation of Amines and Amino Acids

  • Kim, Sung-Gak;Chang, Heung
    • Bulletin of the Korean Chemical Society
    • /
    • v.7 no.1
    • /
    • pp.70-73
    • /
    • 1986
  • New amino protective reagents, t-butyl benzotriazol-1-yl carbonate and benzyl benzotriazol-1-yl carbonate, for t-butoxycarbonylation and benzyloxycarbonylation of amines and amino acids have been developed. t-Butyl benzotriazol-1-yl carbonate reacts rapidly and cleanly with various amines and amino acids to afford N-Boc amines and N-Boc amino acids in high yields and benzyl benzotriazol-1-yl carbonate is also found to be very effective in the benzyloxycarbonylation of amino acids.

A Simple, Efficient, Catalyst-Free and Solvent-Less Microwave-Assisted Process for N-Cbz Protection of Several Amines

  • Aouf, Zineb;Mansouri, Rachida;Lakrout, Salah;Berredjem, Malika;Aouf, Nour-Eddine
    • Journal of the Korean Chemical Society
    • /
    • v.61 no.4
    • /
    • pp.151-156
    • /
    • 2017
  • A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, ${\beta}$-amino alcohols, ${\alpha}$-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxycarbamates compounds were obtained in short times without any side products.