• 대한의용생체공학회:의공학회지
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• 제13권2호
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• pp.155-164
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• 1992

Attachment and growth of mouse flbroblast cells on block copolypeptides were studied in the pres once or absence of serum proteins. Cells are rapidly attached to she polymer surface within 30 min regardless of substrate in the presence of serum. The number of flbroblast cells attached on the poly mer surface coated by collagen was larger than thats on the bare surface. Attachment of cells Is as a whole suppressed to a low level by the addltion of sodium azide in the absence of serum. Thls suE gests that the active attachment of cells requires the biological metabolism taking place on polymer substrates. In the presence of serum protein, flbroblast cells are more rapidly grown on the bolck co polymer consisting of poly(T-benzyl L-glutamate) (PBLG) and polyoxypropylene(POP) than on other block copolymers. These results were in agreement wish the data obatlned by an Inverted ml croscope.

• 대한화학회지
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• 제55권2호
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• pp.230-234
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• 2011

4,5-Dihydro-6-(4-methoxy-3-methylphenyl)-3(2H)-pyridazinone derivative계 화합물의 합성연구를 수행하였다. 첫 번째로, 4,5-dihydro-6-(4-methoxy-3-methylphenyl)-3(2H)-pyridazinone (1)은 o-cresyl methyl ether와 succinic anhydride를 Friedel-Crafts 아실화 반응을 통하여 얻은 다음에, 고리화 반응을 통하여 합성하였다. 얻어진 화합물 1을, NaOEt조건 하에서, 방향족 알데히드와 반응시켜서 4-substituted benzyl pyridazinones (3a-d)을 합성하였으며, 화합물 1을 탈수소화반응을 시켜서 화합물 4를 얻었다. 한편 pyridazine 5는 화합물 1과 1,3-diphenyl-2-propen-1-one을 Michael 첨가반응을 이용하여 합성하였다. N-Dialkylaminomethyl 화합물 6a-b는 pyridazinone 1과 formaldehyde 및 2차 amine을 바능시켜서 얻은 반면에, 화합물 7은 pyridazinone 1을 반응시켜서 얻었으며, 화합물 8은 pyridazinone 3b를 phosphorus oxychloride 와 반응시켜서 얻었다.