• Journal of Audiology & Otology
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• 제24권2호
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• pp.99-102
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• 2020

Trichofolliculoma (TF) is a follicular hamartoma in which hairs protruding out of single orifice. To the best of my knowledge, only two auricular TF has been reported in the English literature. Moreover, clinically TF have been described to mimic malignancy. I present a case of an adult female with mass at the intertragal notch of the left auricle for several years. The clinical diagnosis was thought to be epidermoid cyst, accessory tragus, and other benign skin adnexal tumor. To prevent recurrence, the wide local excision of the mass was performed. The final diagnosis of TF was made. No recurrence was noted during the follow-up of 1 year. It is important for otologists to be familiar with the clinical and pathologic characterization of TF, to make the correct diagnosis.

• 한국임상수의학회지
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• 제26권6호
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• pp.556-562
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• 2009

피부와 유선 종양은 개에서 매우 빈번히 발생하는 종양으로, 종양 발생의 위험은 나이가 증가함에 따라 종양의 발생률은 증가하며, 발병률과 발병부위의 분포는 종양의 종류마다 다르다. 피부와 유선종양의 발생은 공기오염, 식생활 등 환경의 변화와도 관련이 있어 이들 종양들의 발생양상은 그 사회의 환경을 반영할 수 있어 시대와 지역에 따라 다양하게 다르게 나타날 수 있다. 따라서, 그 동안의 많은 보고들에도 불구하고, 피부와 유선종양발생에 대한 자료들은 종양에 대한 수의임상학적 진단과 치료를 위한 중요한 정보를 제공한다. 본 연구에서는 2005년 1월 1일부터 2006년 12월 31일까지 수의과학검역원과 강원대학교에 의뢰된 128증례의 개 피부종양과 240증례의 개 유선종양을 Goldschmidt와 Misdorp의 형태학적 기준에 의해 조직병리학적으로 진단하여, 종별, 성별 및 부위별로 각각 분류하여 국내에서 이들 종양의 발생양상을 체계적으로 분석하였다. 피부종양에서는 피부상피세포종양, 샘종양 및 간질종양이 각각 14.1%, 41.4%와 44.5%였다. Cutaneous histiocytoma가 피부종양에서 가장 빈번하게 관찰되어 전체 피부종양의 25.0%를 차지하였으며, 기름샘종 (sebaceous gland adenoma; 15.6%), 기저세포종(basal cell tumor; 8.6%), 항문둘레샘종 (perianal gland adenoma; 6.3%)와 지방종 (lipoma; 6.3%)순으로 높았다. 그 외에 비만세포종, 모낭세포종과 중층편평상피암 등이 관찰되었다. 이러한 피부종양들은 품종, 성과 나이 또는 부위에 따라 유사하거나 다른 양상을 나타내었다. 유선종양의 경우 양성과 악성이 201/240, 39/240으로 양성발생률이 현저히 높았으며, 양성혼합종 (benign mixed tumor)이 검사한 품종 모두에서 가장 높은 발생률 (35.0%)을 나타내었다. Complex adenoma는 Maltese와 Poodle에서 특히 높았으며, 악성종양에서는 simple carcinoma와 complex carcinoma가 각각 6.7%로, 악성 중 41.0%를 차지하여 가장 높은 발생률을 나타내었다. 본 연구결과는 최근 우리나라에서 여러 품종의 반려견에서 발생한 피부와 유선종양의 발생양상을 조직병리학적으로 진단 분석한 것으로, 임상수의사들이 지속적으로 증가추세에 있는 개의 피부와 유선종양을 진단하고 치료하는데 유용하게 활용될 수 있기를 기대한다.

• 대한두개안면성형외과학회지
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• 제18권1호
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• pp.46-49
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• 2017

Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. A 61-year-old male patient was admitted to our hospital for a $4cm\times2.5cm$ growing tumor in a verrucous form arising within a periauricular nevus sebaceus in the post auricle of the left ear that had developed 30 years earlier. The nodule was diagnosed as 3 different types of tumors: trichilemmoma, desmoplastic trichilemmoma, and basal cell carcinoma. To our knowledge, this is the first report of the coexistence of three different tumors arising from nevus sebaceous. It contain malignant neoplasm also. Surgeons should be aware of the need for close monitoring and early complete surgical excision of sebaceous nevus in order to improve patient outcomes.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7635-7638
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• 2013

Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters. Materials and Methods: This cross-sectional study was performed at a tertiary women's referral center in Ankara, Turkey. Preoperative serum samples were collected from patients surgically treated for endometrial cancer between June 2012-April 2013. Similar aged women with a biopsy proven benign endometrium were used as controls. Serum SPAG9 levels were measured with an enzyme-linked immunosorbent assay (ELISA) method and assessed for links with clinicopathological factors. Receiver operating characteristic (ROC) curve analysis was performed to assess power of SPAG9 levels for EC prediction. P values less than 0.05 were considered statistically significant. Results: A total of 63 women with EC and 27 with benign endometrium were included in the study. Mean age in the EC group was $58.7{\pm}1.1$. Median SPAG9 levels in the EC and control groups were 18.3 (range, 12.7-53.8) and 14.1 (range, 4.3-65.3), respectively (p<0.001). A cut-off value of 17 ng/ml for SPAG9 predicted presence of malignant endometrium with 74% sensitivity and 83% specificity [Area under curve (AUC)=0.82, p<0.001]. SPAG9 levels did not demonstrate any significant association with histological type, FIGO stage, tumor grade, size, myometrial invasion, lymphovascular space invasion, cervical involvement, adnexal involvement, peritoneal cytology or lymph node status (all p>0.05). Conclusions: Testing for SPAG9 may be useful for early detection of EC in asymptomatic high-risk women. Its role in post-treatment follow-up and early detection of recurrence should be assessed in future trials.