• Proceedings of the Zoological Society Korea Conference
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• 한국동물학회 2001년도 한국생물과학협회 학술발표대회
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• pp.113.2-113
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• 2001

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• Advances in Traditional Medicine
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• 제7권5호
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• pp.485-493
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• 2008

The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether ($60\;-\;80^{\circ}C$) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.

• Korean Journal of Biological Psychiatry
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• 제2권2호
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• pp.252-256
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• 1995

Corticotropin-releasing factor(CRF)를 분비하는 배양세포주는 CRF의 세포내 조절을 연구하는데 있어 훌륭한 체계가 된다. BE(2)-M17 및 BE(2)-C 세포주는 CRF를 생산하고 분비하며 forskolin 처치에 반응하는 것으로 알려져 있다. 저자들은 이들 세포주에 phorbol 에스테르, 즉 phorbol 12-myristate 13-acetate(TPA) 0.8, 4, 10, 20 nM, 및 nitric oxide(NO)의 신호전달 경로의 자극제(1-${\mu}M$ nitroprusside)와 차단제($1{\mu}M$ nitroprusside+$300{\mu}M$ $N^G$-methyl-D-arginine), 그리고 interleukin-$1{\alpha}$ (IL $1{\alpha}$ ; 4, 20, 100, 500 pM)를 처치하여 CRF를 의미있게 증가시켰으나 세포외 분비는 C 세포에서만 변화되었다. NOS계의 자극제와 차단제는 C 세포의 forskolin 효과를 의미있게 변화시켰다. IL$1{\alpha}$는 두 세포주에 대한 영향이 없었다. 상기 제제들에 대한 이들 세포의 반응이 중추신경계 CRF 신경들과 관련하여 논의되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제13권5호
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• pp.357-360
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• 2009

It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data from various behavioral experiments testing animals' cognitive as well as emotional functions. For example, laboratory mice which had restricted environment showed different synaptic potentiation properties with wild mice (Zhao MG et al., 2009). While performing behavioral experiments, however, it is sometimes inevitable that the researcher changes the animals' environments, as by switching the cages in which experimental animals are housed and separating animals raised together into small experimental groups. In this study, we investigated the effect of environmental changes on mice's emotional behaviors by socially isolating them or reducing the size of their cage. We found that social isolation selectively increases the animals' levels of anxiety, while leaving depression-like behaviors unchanged. On the other hand, alteration of the housing dimensions affected neither their anxiety levels nor their depression-like behaviors. These results suggest that environmental variables may have a prominent impact on experimental animals' emotional behaviors and possibly their psychological states, leading to bias in the behavioral data produced from experiments.

• Journal of Fisheries and Marine Sciences Education
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• 제20권1호
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• pp.46-57
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• 2008

In an attempt to help improve school bullying victims' self-esteem and interpersonal skills, this study explored the effects of a cognitive-behavioral group counselling program on the victims. The subjects of this study were six middle school female students who were identified as bullying victims by their teachers. They had T-scores of 65 or more on one or more scales in the MMPI-A. The cognitive-behavioral group counselling program was developed to improve their self-esteem and interpersonal skills and was administered twice a week from November 28 to December 30, 2005, totalling ten occasions. Major findings of the study include the following: First, there was a significant difference in self-esteem between pre- and post-tests. All the scores on six tests given on a period-by-period basis showed significant changes at the significance level of 0.1%. Secondly, there was a significant difference in interpersonal skills between pre- and post-tests at the level of 5%. All the scores on six tests given on a period-by-period basis also showed significant changes at the significance level of 0.1%. These findings demonstrate that cognitive-behavioral group counselling is effective in improving school bullying victims' self-esteem and interpersonal skills.

• Korean Journal of Psychosomatic Medicine
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• 제24권1호
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• pp.109-116
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• 2016

Objectives : This study aimed to investigate the effects of resilience on posttraumatic stress symptoms and dissociation and whether depression mediates the relationships between resilience and posttraumatic stress symptoms and dissociation. Methods : A total of 115 firefighters participated in the study. Data were collected via the Life Events Checklist, Impact of Event Scale-Revised, Dissociative Experience Scale, Beck Depression Inventory, and Connor-Davidson Resilience Scale. Structural equation modeling and path analysis were applied to estimate the relationships between resilience, depression, posttraumatic stress symptoms, and dissociation. Results : Greater resilience was associated with lower posttraumatic stress symptoms and dissociation, and the relationship between them was fully mediated by depression. Conclusions : Specific aspects of depression may help explain the relationships between resilience and posttraumatic stress symptoms and dissociation. Tailored prevention programs and treatments based on resilience and depression may prevent posttraumatic stress symptoms and dissociation in firefighters and improve treatments outcomes among firefighters with posttraumatic stress symptoms and/or dissociation.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5995-5998
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• 2012

Background: Colorectal cancer is one of most common cancers in women and men and one of the major causes of death due to neoplasia. Colonoscopy is considered as the most accurate diagnostic procedure to detect colorectal cancer at the earlier stages. Objectives: The current study aimed to evaluate the effects of an education program using the Theory of Planned Behavior on promoting behavioral intention among first degree relatives of colorectal cancer patients. Materials and Methods: A quasi-experimental study conducted to evaluate the effectiveness of an educational program to promote attitudinal factors associated with early detection of colorectal cancer in 99 first degree relatives of colorectal cancer patients aged more than 20 years in Yazd city, Iran. A researcher made questionnaire forwhich validity and reliability were confirmed by expert point of view and pilot testing was employed for data collection. Questionnaires were filled in before and after educational intervention. The registered data were transferred to SPSS 19 and analyzed by paired T-test, Man-Whitney and Wilcaxon. Results: Mean scores of knowledge, attitude, perceived behavioral control and intention regarding colorectal cancer increased after education significantly (P<0.05). Conclusions: Application of the Theory of Planned Behavior has positive influence on promoting intention behavior. It is therefore recommended to apply educational programs to promote behavioral intention.

• BMB Reports
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• 제56권4호
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• pp.209-215
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• 2023

Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory inputs and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their receptors have multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrient-sensing, and CO₂-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuroendocrine systems.

• Korean Journal of Pharmacognosy
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• 제8권4호
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• pp.139-148
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• 1977

It is the purpose of this article to present a brief and systematical behavioral methods in recent developed behavioral pharmacology. Specifically, the present review has been organized around three major topics reflecting both current research emphasis in behavioral pharmacology and methodological applications to the study of psychopharmacological actions of crude drug or herb medicine. The first major topic focuses upon the appropriate experimental design especially in the study of psychopharmacology. A large number of factors should be controlled to have a bearing on design of studies reflecting to psychological effects of drugs. The second section presents several recent methodological developments in behavioral pharmacology involving Turner's screening methods and several types of conditioning techniques. The last section calls specific attention to the observation of behavioral development processes in relation to the activity of pharmacological agents and emphasizes critical period of drug treatment.

• Korean Journal of Biological Psychiatry
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• 제3권2호
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• pp.295-301
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• 1996

We investigated the characteristics of cognitive-behavioral response to auditory hallucinations in 27 schizophrenic patients. The results were as follows : 1) The most frequent cognitive and behavioral response was healthy cognitive one such as suppression or ignoring and increasing physiological arousal, respectively. 2) The characteristics of auditory hallucinations in good/fair copers was that if was more likely to be mild in severity and insight-oriented And increasing physiological arousal was used more frequently in good/fair copers and unhealthy cognitive-behavioral response was used more frequently in poor copers. 3) Out of 3 variables(duration, insight and severity of auditory hallucinations), the insight of auditory hallucinations was the only factor which made difference in unhealthy cognitive response. In conclusion, there were quite a diverse and unique cognitive-behavioral response to auditory hallucinations in schizophrenia.