• Biomolecules & Therapeutics
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• v.31 no.2
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• pp.148-160
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• 2023

Depression is a neuropsychiatric disorder associated with persistent stress and disruption of neuronal function. Persistent stress causes neuronal atrophy, including loss of synapses and reduced size of the hippocampus and prefrontal cortex. These alterations are associated with neural dysfunction, including mood disturbances, cognitive impairment, and behavioral changes. Synaptic plasticity is the fundamental function of neural networks in response to various stimuli and acts by reorganizing neuronal structure, function, and connections from the molecular to the behavioral level. In this review, we describe the alterations in synaptic plasticity as underlying pathological mechanisms for depression in animal models and humans. We further elaborate on the significance of phytochemicals as bioactive agents that can positively modulate stress-induced, aberrant synaptic activity. Bioactive agents, including flavonoids, terpenes, saponins, and lignans, have been reported to upregulate brain-derived neurotrophic factor expression and release, suppress neuronal loss, and activate the relevant signaling pathways, including TrkB, ERK, Akt, and mTOR pathways, resulting in increased spine maturation and synaptic numbers in the neuronal cells and in the brains of stressed animals. In clinical trials, phytochemical usage is regarded as safe and well-tolerated for suppressing stress-related parameters in patients with depression. Thus, intake of phytochemicals with safe and active effects on synaptic plasticity may be a strategy for preventing neuronal damage and alleviating depression in a stressful life.

• Nutritional Sciences
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• v.8 no.2
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• pp.104-110
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• 2005

The purpose of this study was to examine dietary frequencies among Korean American adolescents in California, including the correlation of acculturation and parental dietary Consumption. This study was drawn from cross-sectional telephone surveys based on data from a larger study of Korean Americans in California using random sampling of residential phone listings. A total of 494 Korean American adolescents, ages 12 through 17, in California were collected with dietary frequencies and acculturation and one parents' demographic and dietary consumption information. Three-quarters of adolescents were classified as 'more acculturated group' into the U.S. society with a lower preference to Korean foods, frequent snacking, and lower consumptions of rice and kimchi. Other quarter of adolescents was classified as 'less acculturated group'. However, the most frequent food items by both groups were rice and kimchi. Fruit and vegetable consumption was associated between adolescents and parents in both groups, but rice and kimchi were associated only among the more-acculturated group. In conclusion, dietary frequencies of Korean American adolescents were influenced by acculturation and parental dietary consumption. These findings should inform future epidemiological researches as well as efforts to enhance the diet of Koreans and other immigrants.

• Nutritional Sciences
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• v.5 no.3
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• pp.161-167
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• 2002

Research on diet, acculturation, and ethnicity has suggested that immigrants dietary patterns differ from people who do not have immigration experience. The purpose of this paper is to present preliminary descriptive findings concerning consumption of foods that are common in Korean and American diets, by people of Korean descent residing in California. Adults (18 years of age or older, N=1334) of Korean descent who could be reached by listed residential telephone number in California were randomly selected and telephone-interviewed by closely supervised bilingual (Korean-English) interviewers who were specially trained for this task. This study found that dietary patterns of Koreans living in California differed according to age and gender; also, the frequency of consumption of foods differed according to number of years of residence and acculturation. Koreans who reported higher levels of acculturation to American society ate less of traditional Korean foods such as Kimchi and ate significantly more higher-fat foods common in the American diet. Increased acculturation was also related to an increased frequency of alcohol drinking. Older Koreans tended to eat slightly more of traditional foods such as rice, Kimchi, fruits, and fish, compared to younger Koreans. Women tended to eat healthier foods than men, consuming green vegetables, Kimchi, milk, cheese/yogurt, fruits, and bread more frequently. Koreans reporting longer residences in the United States reported a greater consumption of pork, bread, and soda.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5861-5865
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• 2013

We investigated the distribution of HPV genotypes in Uyghur women in Xinjiang region of China, and behavioral factors which could predispose them to HPV infection. In this cross-sectional study, women aged 15-59 years were recruited by cluster sampling method in Yutian region in 2009. Liquid-based cytology samples were analyzed centrally for HPV genotype with a linear array detector. Univariate and multivariate logistic regression analyses were performed to identify behavioral risk factors for HPV infection. A total of 883 Uyghur women were recruited successfully. The prevalence of high-risk HPV and low-risk HPV were 7.25% and 1.58%, respectively; the most common HPVs were HPV16, 51, 31, 39 and 58. We found that age of first sexual intercourse was a strong predictor for HPV infection (odds ratio of 4.01 for ${\leq}15$ years versus ${\geq}25$). Having sexual partners ${\geq}3$ was the second predictor (OR 3.69, 95% CI 2.24-7.16). Cleaning the vagina after sex showed an increased risk of HPV infection (OR 2.72; 95% CI 1.98-5.13); Using the condom showed protective factors for HPV infection (OR 0.36; 95%CI0.12-0.53). HPV16, 51, 31, 39 and 58 were the priority types; the age of first sexual intercourse was identified as a major risk factor for HPV infection. Other notable risks were number of sexual partners and cleaning the vagina after sex. Changing these behavioral risk factors could help to reduce the occurrence of cervical cancer in this population.

• Biomolecules & Therapeutics
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• v.20 no.1
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• pp.125-131
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• 2012

Impulsiveness is an important component of many psychiatric disorders including Attention-deficit/hyperactivity disorder (ADHD). Although the neurobiological basis of ADHD is unresolved, behavioral tests in animal models have become indispensable tools for improving our understanding of this disorder. In the punishment/extinction paradigm, impulsivity is shown by subjects that persevere with responding despite punishment or unrewarded responses. Exploiting this principle, we developed a new behavioral test that would evaluate impulsivity in the most validated animal model of ADHD of the Spontaneously Hypertensive rat (SHR) as compared with the normotensive "control" strain, the Wistar Kyoto rat (WKY). In this paradigm we call the Electro-Foot Shock aversive water Drinking test (EFSDT), water-deprived rats should pass over an electrified quadrant of the EFSDT apparatus to drink water. We reasoned that impulsive animals show increased frequency to drink water even with the presentation of an aversive consequence (electro-shock). Through this assay, we showed that the SHR was more impulsive than the WKY as it demonstrated more "drinking attempts" and drinking frequency. Methylphenidate, the most widely used ADHD medication, significantly reduced drinking frequency of both SHR and WKY in the EFSDT. Thus, the present assay may be considered as another behavioral tool to measure impulsivity in animal disease models, especially in the context of ADHD.

• Journal of the Korea Society of Computer and Information
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• v.28 no.5
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• pp.171-177
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• 2023

This study aims to provide useful information for prevention of doping by investigating and verifying relationships among demographic factors such as athletic career and experience of anti-doping education, controlled motivation, attitude toward anti-doping, perceived behavioral control factors and doping intentions to verify factors affecting doping intentions of domestic elite athletes based on the advance studies that have been carried out various theoretical approaches so far. Method: This study analyzed using SPSS 27.0 program. First, this study confirmed a multicollinearity problem by conducting Pearson's correlation analysis to examine correlation between variables. And this study conducted stepwise multiple linear regression to confirm how the variables affect doping intentions. Result: Study results show that all factors such as athletic career, experience of anti-doping education, controlled motivation, attitude toward anti-doping and perceived behavioral control have a significant impact on doping intentions, and this study verified significant impact by putting variables in order of each influence. As a result of verification, this study confirmed that controlled motivation has the greatest influence, and perceived behavioral control toward doping, experience of anti-doping education, attitude toward and athletic career came next in order.

• Animal cells and systems
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• v.2 no.1
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• pp.65-69
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• 1998

The hippocampus and prefrontal cortex are regarded as the highest-order association cortices. The hippocampus has been proposed to store "cognitive maps" of external environments, and the prefrontal cortex is known to be involved in the planning of behavior, among other functions. Considering the prominent functional roles played by these structures, it is not surprising to find direct monosynaptic projections from the hippocampus to the prefrontal cortex. Rhythmic stimulation of this projection patterned after the hippocampal EEG theta rhythm induced stable long-term potentiation of field potentials in the prefrontal cortex. Comparison of behavioral correlates of hippocampal and prefrontal cortical neurons during an a-arm radial maze, working memory task shows a striking contrast. Hippocampal neurons exhibit clear place-specific firing patterns, whereas prefrontal cortical neurons do not show spatial selectivity, but are correlated to different stages of the behavioral task. These data lead to the hypothesis that the role of hippocampal projection to the prefrontal cortex is not to impose spatial representations upon prefrontal activity, but to provide a mechanism for learning the spatial context in which particular behaviors are appropriate.propriate.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.804-809
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• 2004

Intelligence is thought to be related to interaction rather than a deep but passive thinking. Interactive tangible media "iT_Media" is proposed to explore these issues. Personal robotics is a major area to investigate these ideas. A new design methodology for personal and emotional robotics is proposed. Sciences of the artificial and intelligence have been investigated. A short history of artificial intelligence is presented in terms of logic, heuristic, and mobility; a science of intelligence is presented in terms of imitation and understanding; intelligence issues for robotics and intelligence measures are described. A design methodology for personal robots based on science of emotion is investigated. We investigate three different aspects of design: visceral, behavioral, reflective. We also discuss affect and emotion in robots, robots that sense emotion, robots that induce emotion in people, and implications and ethical issues of emotional robots. Personal robotics for the elderly seems to be a major area in which to explore these ideas.

• Advances in Traditional Medicine
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• v.8 no.4
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• pp.365-373
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• 2008

Murraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

• Journal of Environmental Science International
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• v.23 no.7
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• pp.1213-1221
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• 2014

In the background of rapid urbanization and frequent earthquakes, earthquake disaster prevention planning has become an important topic of current research. Universities are irreplaceable disaster shelter, as they are public institutions with a lot of open space. This article puts forward the concept of "disaster prevention campus". With the refuge behavioral and psychological characteristics of people in the campus when the earthquake happens, it integrated uses GIS spatial analysis technique, takes Shandong Agricultural University as an example, and studies the spatial pattern of earthquake disaster prevention planning in campus from five aspects. The aspects include building distribution, population distribution, analysis of service radius, infrastructure configuration and choice of the optimal refuge path. On the basis of researches above, reform proposals and specific strategies are put forward to build the safe and harmonious disaster prevention campus.