• The Journal of Korean Physical Therapy
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• 제26권3호
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• pp.191-195
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• 2014

Purpose: The purpose of this study is to investigate whether types of sensory-stimuli cues in terms of visual, auditory, and visuoauditory cues can be affected to motor sequential learning in healthy adults, using serial reaction time task. Methods: Twenty four healthy subjects participated in this study, who were randomly allocated into three groups, in terms of visual-stimuli (VS) group, auditory-stimuli (AS) group, and visuoauditory-stimuli (VAS) group. In SRT task, eight Arabic numbers were adopted as presentational stimulus, which were composed of three different types of presentational modules, in terms of visual, auditory, and visuoauditory stimuli. On an experiment, all subjects performed total 3 sessions relevant to each stimulus module with a pause of 10 minutes for training and pre-/post-tests. At the pre- and post-tests, reaction time and accuracy were calculated. Results: In reaction time, significant differences were founded in terms of between-subjects, within-subjects, and interaction effect for group ${\times}$ repeated factor. In accuracy, no significant differences were observed in between-group and interaction effect for groups ${\times}$ repeated factor. However, a significant main effect of within-subjects was observed. In addition, a significant difference was showed in comparison of differences of changes between the pre- and post-test only in the reaction time among three groups. Conclusion: This study suggest that short-term sequential motor training on one day induced behavioral modification, such as speed and accuracy of motor response. In addition, we found that motor training using visual-stimuli cue showed better effect of motor skill acquisition, compared to auditory and visuoauditory-stimuli cues.

• 생물정신의학
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• 제7권2호
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• pp.115-122
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• 2000

The development of molecular biology has brought many changes in psychiatry. Molecular biology makes us possible to know the cause of mental disorders that provide the way to prevent the disorders, and to develop various accurate diagnostic and treatment methods for mental disorders. The author discusses the concept, cause, and treatment of mental disorders in the aspect of molecular biology. Importing the methods of molecular biology into psychiatry, we can anticipate to get a number of the goals of psychiatric genetics, including identification of specific susceptibility genes, clarification of the pathophysiological processes whereby these genes lead to symptoms, establishment of epigenetic factors that interact with these genes to produce disease, validation of nosological boundaries that more closely reflect the actions of these genes, and development of effective preventive and therapeutic interventions based on genetic counseling, gene therapy, and modification of permissive or protective environmental influences. In addition to their capacity to accelerate the discovery of new molecules participating in the nervous system's response to disease or to self-administered drugs, molecular biological strategies can also be used to determine how critical a particular gene product may be in mediating a cellular event with behavioral importance. Molecular biology probably enables us discover the environmental factors of mental disorders and allow rational drug design and gene therapies for mental disorders, by isolation of gene products that facilitate a basic understanding of the pathogenesis of these disorders. A specific genetic linkage may suggest a novel class of drugs that has not yet been tried. With respect to gene therapy, the hypothetical method would use a gene delivery system, most likely a modified virus, to insert a functional copy of a mutant gene into those brain cells that require the gene for normal function.

• The Korean Journal of Pain
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• 제31권3호
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• pp.155-173
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• 2018

Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain. The preventive strategies include modification of the surgical technique, good pain control throughout the perioperative period, and preoperative psychological intervention focusing on the psychosocial and cognitive risk factors. Appropriate management of CPSP patients is also necessary to reduce their suffering. CPSP usually has a neuropathic pain component; therefore, the current recommendations are based on data on chronic neuropathic pain. Hence, voltage-dependent calcium channel antagonists, antidepressants, topical lidocaine and topical capsaicin are the main pharmacological treatments. Paracetamol, NSAIDs and weak opioids can be used according to symptom severity, but strong opioids should be used with great caution and are not recommended. Other drugs that may be helpful are ketamine, clonidine, and intravenous lidocaine infusion. For patients with failed pharmacological treatment, consideration should be given to pain interventions; examples include transcutaneous electrical nerve stimulation, botulinum toxin injections, pulsed radiofrequency, nerve blocks, nerve ablation, neuromodulation and surgical management. Physical therapy, cognitive behavioral therapy and lifestyle modifications are also useful for relieving the pain and distress experienced by CPSP patients.

• Journal of Nutrition and Health
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• 제29권3호
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• pp.307-320
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• 1996

The enforcement and its effect of weight control program including nutrition education, exercise and behavioral modification therapy during 20 weeks were studied in primary school obese children. The sample consisted of treatment group(n=19) and control group (n=23). To evaluate the effects of weight control program, treatment group took pretest and posttest for nutrition knowledge, attitude and food habits. Nutrient intakes, serum lipid levels and anthropometric values were also measured. After weight control program, body weight of treatment group significantly decreased from 47.0$\pm$9.0kg to 45.9$\pm$8.5kg(p<0.001), but than of control group increased from 47.8$\pm$8.1kg to 49.0$\pm$8.7kg (p$\leq$0.05). Obesity index showed decline of 8.6% for treatment group and gain of 0.7% for control group. After self-control period, body weight and relate index in both groups were increased. For the nutrition knowledge test results, the posttest mean scores of treatment group showed the significant increase(p<0.001). For the attitude toward nutrition and food habit results, the posttest mean scores increased significantly (p<0.05, p<0.01). There was a decline of 28% in serum triglycerides, whereas serum total cholesterol increased 11% of baseline. These findings suggest that well-combined weight control program for obese children may result in a substantial loss of body weight during 14 weeks. In addition, these reuslts indicate that weight redution through weight control program can be a viable approach to help normalize serum lipids in obese children. Finally, these data suggest that it may be important to identify that affect weight loss and maintenance, and to examine how to manipulate these factors in weight control program.

• The Korean Journal of Physiology and Pharmacology
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• 제18권3호
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• pp.191-200
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• 2014

We investigated the anxiolytic-like activity of ${\alpha}$-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.

• 보건교육건강증진학회지
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• 제32권4호
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• pp.37-46
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• 2015

Objectives: This study was conducted to expand evidence-base for the effectiveness of lifestyle intervention programs to prevent the onset of diabetes and cardiovascular diseases. Methods: Seven intervention studies between 2006 and 2014 at Korea Association of Health Promotion were analyzed. All the studies were randomized controlled trials(RCTs) and included multi-component behavioral interventions. The participants of the programs were 2,172 adults with risk factors regarding metabolic syndrome criteria. The proportions of normalized participants were compared within and across the studies using odds ratio effect sizes. Results: The reductions in the prevalence of metabolic syndrome were from 49.6% to 65.1% in intervention groups, and from 38.7% to 52.3% in comparison groups. Significant differences in effectiveness between groups were found in two studies, one in 2006 with odds ratio of 1.69(p<0.01) and another in 2009 with odds ratio of 2.36(p<0.001). Proportions of normalized participants were higher in blood pressure(31.9% to 52.5% in the intervention groups and 23.0% to 43.3% in comparison groups) than other risk factors. Abdominal obesity showed weakest improvement after the intervention in both groups. Conclusions: Lifestyle modification program is an effective method to reduce diabetes and cardiovascular risks in adults by decreasing the prevalence of metabolic syndrome and its components.

• 한국지진공학회논문집
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• 제6권3호
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• pp.1-10
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• 2002

비록 제한된 범위내에서나마 일련의 유한요소해석을 통하여 비보강 조적조 벽체의 면내방향 내진성능을 조사하였다. 이를 위하여 비보강 조적벽체는 연속체로 가정하여 등방성 평면응력요소로 취급하였으며, 비보강 조적조의 균열거동을 위하여 균열특성이 요소내에 분포하는 것으로 가정하는 분포균열모델을 사용하였다. 모두 70가지 서로 다른 경우의 비보강 조적벽체 모델을 해석하였는데, 축력비, 형상비 및 유효단면적비 등의 변수를 고려하였다. 해석결과 이들 변수가 비보강 조적벽체의 극한강도에 지대한 영향을 미치며 상호 작용하는 것으로 확인되었다. 비보강 조적벽체의 여러 가지 취성적 요인과 복합적인 파괴형태의 가능성을 감안하여 현재 우리 나라 규준에서 사용하고 있는 반응수정계수의 크기를 재고하여야 함이 지적되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3505-3510
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• 2016

Cervical cancer is a major public health problem in Thailand, being ranked second only to breast cancer. Thai women have been reported to have a low rate of cervical cancer screening (27.7% of the 80% goal of WHO). We therefore aimed to apply the social marketing theory and health belief model in promoting cervical cancer screening in Kanthararom District, Sisaket Province. A total of 92 from 974 targeted women aged 30-60 years were randomly divided into two groups. The experimental group underwent application of social marketing theory and a health belief model program promoting cervical cancer screening while the control group received normal services. Two research tools were used: (1) application of social marketing theory and health belief model program and (2) questionnaire used to evaluate perceptions of cervical cancer. Descriptive and inferential statistics including paired sample t-test and independent t-test were used to analyze the data. After the program had been used, the mean score of perception of cervical cancer of experimental group was at a higher level (${\bar{x}}=4.09$; S.D.=0.30), than in the control group (${\bar{x}}=3.82$; S.D.=0.20) with statistical significance (p<0.001). This research demonstrated an appropriate communication process in behavioral modification to prevent cervical cancer. It can be recommended that this program featuring social marketing and the health belief model be used to promote cervical cancer screening in targeted women and it can be promoted as a guideline for other health services, especially in health promotion and disease prevention.

• 한국콘텐츠학회논문지
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• 제11권8호
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• pp.23-32
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• 2011

만성질환자가 증가함에 따라서 유헬스 서비스는 특정 질병의 치료 및 관리에서 서비스 대상자에 대한 행동수정기반의 예방서비스로 진화하고 있다. 기존의 유헬스 서비스는 원격진료나 상담을 통한 서비스나 생체정보의 모니터링만을 제공하여 대사증후군 등 만성질환자를 예방하거나 관리하는 것에는 한계가 있다. 이에 본 논문에서는 만성질환자의 건강관리를 위한 멀티플랫폼 기반의 유헬스 서비스 모델를 제안한다. 멀티플랫폼 기반의 유헬스 서비스는 PC와 스마트폰을 통하여 사용자의 위치와 제한없이 지속적으로 건강 정보 및 식이, 운동에 대한 서비스가 가능하다. 또한 임상정보를 바탕으로 CDS(Clinical Decision Support) 모듈을 활용한 처방 서비스를 의사와 간호사에게 제공한다. 의사는 행동수정 프로그램을 통해 서비스 대상자의 생활패턴을 파악하고 맞춤화된 서비스의 제공이 가능하다. 본 유헬스 서비스 모델은 서비스 대상자에게 멀티플랫폼 환경에서 효과적인 서비스를 제공하여 만성질환자의 건강증진에 기여할 것으로 기대된다.

• 대한지역사회영양학회지
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• 제6권4호
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• pp.657-667
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• 2001

This study was designed to develop a website for providing nutrition information and education for college women and young women. The website focuses on two topics ; general nutrition and desirable weight control. This program is located at http : // www.ezydiet.co.kr. This program is composed of 5 major sections. The first two sections were designed to provide information ; one for general nutrition, and the other for providing information regarding weight control. The first section includes information regarding young adult women's diet, nutrition standards, such as the RDA or Korean Food Pyramid, drinking and smoking. The second section coveres information regarding desirable control, foods with high or low calories, eating disorders and popularly used dieting methods. The third section is for simple nutrition assessment, consisting of assessment of ideal body weight and obesity, energy requirements, and eating habits. The fourth section was designed to introduce and help users to apply behavioral modification techniques, such as monitoring, goal setting, stimulus control and reinforcement. The final section was designed for meal planning, by introducing a food exchange list and menu examples for one week. The characteristics of this web-based program are as follows ; 1) provide nutrition information systematically, 2) involve sections for the participation of the user, 3) include food pictures to help understanding of nutrition information, 4) include management modules for some sections to revise or update the information. One-hundred and ten female university students participated in the evaluation of this website. The evaluation results were favorable. About 90% of subjects rated that this program covers major topics 'well ' or 'very well', and that it was 'easy'to 'very easy'to understand the contents on website. Two-thirds of subjects rated quite positively on questions regarding attractiveness, overall quality and technical quality of website. In addition, about three-fourths of subjects answered that this website was helpful in increasing nutrition knowledge and in applying nutrition information into daily life. These results suggested the possibility of using a website as a means of providing nutrition information and education for young adult women.