• Korean Journal of Cognitive Science
• /
• v.20 no.3
• /
• pp.357-381
• /
• 2009

Although it is known that there are personality characteristic variances in the sensitivity to environmental feedback, the trait individual difference has scarcely been explored in the context of recognition memory decision. The present study investigated this issue by examining the relationship between the feedback-based adaptive flexibility of recognition criterion positioning and personality differences in general sensitivity to non-laboratory outcomes. Experiment 1 demonstrated that veridical feedback itself had little effect on the recognition decision criterion whereas Experiment 2 demonstrated that biased feedback manipulations selectively restricted to high confidence errors, induced shifts even in the overall Old/New category criterion. Critically, individual differences in stable personality characteristic linked to reward seeking(Behavioral Activation System-BAS) and anxiety avoidance (Behavioral Inhibition System-BIS) has been shown to predict the sensitivity of subjects to this form of feedback-induced criterion learning. This data further support the idea that incremental reinforcement-based learning mechanism not often considered important during explicit recognition decisions may play a key role in criterion setting.

• Anxiety and mood
• /
• v.10 no.1
• /
• pp.44-51
• /
• 2014

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous functional neuroimaging studies. Methods : Resting-state functional magnetic resonance imaging data was obtained in 19 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and perigenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality in superficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.5
• /
• pp.876-880
• /
• 2011

Gammakdaejo-Tang (GMT) is a traditional oriental medicinal formula, a mixture of 3 crude drugs, and it has been clinically used for treating mild depressive disorders. The purpose of the study was to examine the effect of Gammakdaejo-Tang (GMT) on repeated stress-induced alterations of learning and memory on a passive avoidance test (PAT) test and also the anxiety-related behavior on the elevated pulse maze (EPM) in ovariectomized female rats. We assessed the changes in the reactivity of the cholinergic system by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral testing. The rats were exposed to the immobilization (IMO) stress for 14 days (2hours/day), and Gammakdaejo-Tang (400 mg/kg, p.o.) was administered 30 min before IMO stress. Treatments with GMT caused significant reversals of the stress-induced deficits in learning and memory on a working memory test, and it also produced an anxiolytic-like effect on the EPM, and increased the ChAT reactivities (p<0.001, respectively). These results suggest that Gammakdaejo-Tang might prove to be an effective antidepressant agent.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.3
• /
• pp.431-437
• /
• 2011

Recently, there are so many studies that herbal composition has the effect on enhancing the memorial ability. But there are few studies whether it has effect on enhancing attentional ability. The purpose of present study is to prove the effects of a herbal composition(ChongA 100) on enhancing not only memorial but also attentional ability. The memorial ability interfered by amyloid-${\beta}$ was evaluated with passive avoidance test Y-maze task. The attentional ability was studied with attentional set-shifting task(ASST). The 200mg/kg of ChongA100 could significantly recover the shortened latency of passive avoidance test and the interfered alternation of Y-maze task. The number of trials in ASST was significantly reduced as well. Our study suggests that it has effects on enhancing both memorial and attentional ability.

• Archives of Pharmacal Research
• /
• v.23 no.4
• /
• pp.413-417
• /
• 2000

The effect of ischemia/reperfusion-induced neuronal damage on the memory impairment were investigated using active avoidance and Morris water maze tasks in Wistar rats. Focal ischemia was induced by 1 h occlusion of the right middle cerebral artery (MCA) of Wistar male rats. Reperfusion was induced by releasing the occlusion and restoring the blood circulation for 24 h. The acquisition and preservation memory tested by active avoidance showed a significant difference between the sham and ischemia/reperfusion group. The water maze acquisition performance was also significant difference between sham and ischemia/repefusion groups in both latency and moving distance. The infarction volume was increased by the ischemia/reperfusion. Furthermore, the cresyl violet staining of the ischemia/reperfusion brain showed severe neuronal damage (pyramidal cell loss) in the cortex in addition to the striatum lesion of brain. This study shows that pyramidal cell damage in the cortex lesion may be partially related to memorial disturbance in the ischemia/reperfusion brain injury.

• Korean Journal of Pharmacognosy
• /
• v.5 no.3
• /
• pp.159-166
• /
• 1974

The Yellow needle crystal was isolated from Atractylis Rhizoma, having mp $124{\sim}126^{\circ}C$(decomp.), the chemical composition $C_{16}H_{21}N_{3}O_{6}$, and its m.w. 251. The pharmacological actions of this alkaloid were studied by various psycopharmacological experiments. 1) In order to see the effect of this Atractylis(=At.) alkaloid on gross general behaviors in mice, a behavioral analysis experiment was adapted. The occurrence number of sleep and lying in At. alkaloidal animals with the doses 10mg/kg or 20mg/kg was increased but the number of jumping, exploration, rearing and defecation was significantly decreased than those of placebo. 2) The effect of the At. alkaloid on unlearned emotional behaviors of mice was studied with an open-field method. The At. alkaloidal groups with the doses 20mg/kg or 30mg/kg showed less often the frequency of locomotion than that of placebo. 3) To know the effect of the At. alkaloid on the learning, a standard water maze experiment and conditioned avoidance response were conducted. As compared to placebo control, the aquisition rate of the maze learning in the alkaloidal mice with the dose of 10mg/kg or 20mg/kg was significantly impaired and the speed of swimming was also signficantly delayed. In the conditioned avoidance response, the extinction performances of the alkaloidal rats with doses of 20mg/kg or 30mg/kg did not differ significantly than that of placebo.

• Journal of Convergence Korean Medicine
• /
• v.5 no.1
• /
• pp.25-44
• /
• 2023

Objectives: Gaming disorder has been viewed as a disease in the DSM-5 and ICD-11. Its essential symptoms are loss of control over gaming, gaming becoming a markedly prioritized activity over other activities of daily living, and continued and excessive use of gaming despite negative problems occurring. Methods: Children and adolescents are especially vulnerable to gaming disorder because the striatal pathways related to reward develop earlier than the control regions of the prefrontal cortex. It is also associated with decreased dopamine D2 receptors. Addiction is related to 'want' and is explained by incentive-sensitization. In addition, allostasis, in which homeostasis is continuously achieved at a new target value, is also related to gaming disorder. In addition, personality causes, unchangeable factors, and external factors can influence on the onset of gaming disorder. Results: Prevention is the best solution for gaming disorder, and the role of parents is important. For gaming disorder, bupropion is used, cognitive-behavioral therapy and family-based therapy are also beneficial. Herbal medicine treatment such as Antler velvet and ginseng can be effective. Electroacupuncture and acupuncture using PC6, SP6, and LR3 has a correlation with relieving Internet craving. Ear-acupuncture was also effective in treating addiction. Conclusion: Psychologically, 'want' is an intense longing for reward and motivation, and is related to addiction. This 'want' may rather be related to avoidance, and game addiction in children and adolescents may be due to wanting to escape from academic stress or avoidance of comparison. Therefore, the importance of 'like', which gives pleasure in itself, increases. It can also be explained with Sasang Constitutional Medicine.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.1
• /
• pp.254-261
• /
• 2005

The effects on memory and learning ability of the Korean herbal medicine, Xingyo-tang(XGT, 神交湯), which consists of Ginseng Radix(人蔘) 4 g, Liriopis Tuber(麥門冬) 40 g, Morindae Officinalis Radix(巴戟天) 40 g, Biotae Semen(柏子仁) 20 g, Dioscoreae Rhizoma(山藥) 40 g, Euryales Semen(?實) 20 g, Scrophulariae Radix(玄蔘) 40 g, Salviae Miltiorrhizae Radix(丹蔘) 12 g, Poria(茯神) 12 g, Cuscutae Semen(免絲子) 40 g, was investigated. The effects of XGT on learning and memory performance were examined in normal or memory impaired mice by using avoidance tests, Pentobarbital -induced sleep test, fear conditioning task, novel object recognition task, and water maze task. Hot water extract from XGT was used for the studies. Learning ability and memory are based on modifications of synaptic strength among neurons that are simultaneously active. Enhanced synaptic coincidence detection leads to better learning and memory. The XGT-treated (30 mg/100 g and 60 mg/100 g, p.o.) mice exhibit superior ability in learning and memorizing when performing various behavioral tasks. XGT did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests, and the ambulatory activity of normal mice in normal condition. In contrast, XGT produced ameliorating effects on the memory retrieval impairment induced by ethanol. XGT also improved the memory consolidation disability induced by electric convulsive shock (ECS). XGT extended the sleeping time induced by pentobarbital dose-dependently, suggesting its transquilizing or antianxiety action. These results suggest that XGT has an improving effect on the impaired learning through the effects on memory registration and retrieval.

• The Journal of the Korea Contents Association
• /
• v.18 no.9
• /
• pp.346-356
• /
• 2018

The Purpose of this study is to examine the effect of communication competence and empathy on stress coping in college students. The research problems were verified by correlation analysis and multivariate regression analysis. A questionnaire survey was conducted on 292 college students. The findings are as follows. First, college students who have high communication competence show more problem-focused coping, social-support seeking coping, and self-soothing coping in stressful conditions, but less emotion-oriented coping and avoidance-oriented coping. Particularly, it is found that behavioral flexibility in communication competence has the greatest effect on problem-focused coping and emotion-oriented coping. Similarly, affiliation/support influences social support seeking coping, interaction management influences self-soothing coping and avoidance-oriented coping. Second, college students who have high empathy are also found more problem-focused coping, social-support seeking coping, and self-soothing coping in stressful conditions. Especially it is found that role-taking in empathy has the greatest effect on problem-focused coping self-soothing coping. Similarly, emotion recognition influences avoidance-oriented coping, emotional resonance influences emotion-oriented coping, authenticity influences social-support seeking coping.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.14 no.5
• /
• pp.2236-2257
• /
• 2020

Ransomware is malicious software that encrypts the user-related files and data and holds them to ransom. Such attacks have become one of the serious threats to cyberspace. The avoidance techniques that ransomware employs such as obfuscation and/or packing makes it difficult to analyze such programs statically. Although many ransomware detection studies have been conducted, they are limited to a small portion of the attack's characteristics. To this end, this paper proposed a framework for the behavioral-based dynamic analysis of high survivable ransomware (HSR) with integrated valuable feature sets. Term Frequency-Inverse document frequency (TF-IDF) was employed to select the most useful features from the analyzed samples. Support Vector Machine (SVM) and Artificial Neural Network (ANN) were utilized to develop and implement a machine learning-based detection model able to recognize certain behavioral traits of high survivable ransomware attacks. Experimental evaluation indicates that the proposed framework achieved an area under the ROC curve of 0.987 and a few false positive rates 0.007. The experimental results indicate that the proposed framework can detect high survivable ransomware in the early stage accurately.